LLPS-Hos-2319
SCIN

▼ OVERVIEW

Status: Reviewed
Protein Name: Adseverin; Scinderin
Gene Name: SCIN, KIAA1905
Ensembl Gene: ENSG00000006747.14
Ensembl Protein: ENSP00000341375.5
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 5A1K (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...Finally, 221 proteins were found as nucleolar with No/Cyto > 1 and No/Nuc > 1."
HCT116 cells20026476
Nucleolus
"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."
N/A26980300
Nucleolus
"...Finally, 221 proteins were found as nucleolar with No/Cyto > 1 and No/Nuc > 1."
HCT116 cells20026476
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MARELYHEEF  ARAGKQAGLQ  VWRIEKLELV  PVPQSAHGDF  YVGDAYLVLH  TAKTSRGFTY  60
61    HLHFWLGKEC  SQDESTAAAI  FTVQMDDYLG  GKPVQNRELQ  GYESNDFVSY  FKGGLKYKAG  120
121   GVASGLNHVL  TNDLTAKRLL  HVKGRRVVRA  TEVPLSWDSF  NKGDCFIIDL  GTEIYQWCGS  180
181   SCNKYERLKA  NQVATGIRYN  ERKGRSELIV  VEEGSEPSEL  IKVLGEKPEL  PDGGDDDDII  240
241   ADISNRKMAK  LYMVSDASGS  MRVTVVAEEN  PFSMAMLLSE  ECFILDHGAA  KQIFVWKGKD  300
301   ANPQERKAAM  KTAEEFLQQM  NYSKNTQIQV  LPEGGETPIF  KQFFKDWRDK  DQSDGFGKVY  360
361   VTEKVAQIKQ  IPFDASKLHS  SPQMAAQHNM  VDDGSGKVEI  WRVENNGRIQ  VDQNSYGEFY  420
421   GGDCYIILYT  YPRGQIIYTW  QGANATRDEL  TTSAFLTVQL  DRSLGGQAVQ  IRVSQGKEPV  480
481   HLLSLFKDKP  LIIYKNGTSK  KGGQAPAPPT  RLFQVRRNLA  SITRIVEVDV  DANSLNSNDV  540
541   FVLKLPQNSG  YIWVGKGASQ  EEEKGAEYVA  SVLKCKTLRI  QEGEEPEEFW  NSLGGKKDYQ  600
601   TSPLLETQAE  DHPPRLYGCS  NKTGRFVIEE  IPGEFTQDDL  AEDDVMLLDA  WEQIFIWIGK  660
661   DANEVEKKES  LKSAKMYLET  DPSGRDKRTP  IVIIKQGHEP  PTFTGWFLGW  DSSKW  715
Nucleotide CDS Sequence (FASTA)
1     ATGGCGCGGG  AGCTATACCA  CGAAGAGTTC  GCCCGGGCGG  GCAAGCAGGC  GGGGCTGCAG  60
61    GTCTGGAGGA  TTGAGAAGCT  GGAGCTGGTG  CCCGTGCCCC  AGAGCGCTCA  CGGCGACTTC  120
121   TACGTCGGGG  ATGCCTACCT  GGTGCTGCAC  ACGGCCAAGA  CGAGCCGAGG  CTTCACCTAC  180
181   CACCTGCACT  TCTGGCTCGG  AAAGGAGTGT  TCCCAGGATG  AAAGCACAGC  TGCTGCCATC  240
241   TTCACTGTTC  AGATGGATGA  CTATTTGGGT  GGCAAGCCAG  TGCAGAATAG  AGAACTTCAA  300
301   GGATATGAGT  CTAATGACTT  TGTTAGCTAT  TTCAAAGGCG  GTCTGAAATA  CAAGGCTGGA  360
361   GGCGTGGCAT  CTGGATTAAA  TCATGTTCTT  ACGAACGACC  TGACAGCCAA  GAGGCTCCTA  420
421   CATGTGAAGG  GTCGTAGAGT  GGTGAGAGCC  ACAGAAGTTC  CCCTTAGCTG  GGACAGTTTC  480
481   AACAAGGGTG  ACTGCTTCAT  CATTGACCTT  GGCACCGAAA  TTTATCAGTG  GTGTGGTTCC  540
541   TCGTGCAACA  AATATGAACG  TCTGAAGGCA  AACCAGGTAG  CTACTGGCAT  TCGGTACAAT  600
601   GAAAGGAAAG  GAAGGTCTGA  ACTAATTGTC  GTGGAAGAAG  GAAGTGAACC  CTCAGAACTT  660
661   ATAAAGGTCT  TAGGGGAAAA  GCCAGAGCTT  CCAGATGGAG  GTGATGATGA  TGACATTATA  720
721   GCAGACATAA  GTAACAGGAA  AATGGCTAAA  CTATACATGG  TTTCAGATGC  AAGTGGCTCC  780
781   ATGAGAGTGA  CTGTGGTGGC  AGAAGAAAAC  CCCTTCTCAA  TGGCAATGCT  GCTGTCTGAA  840
841   GAATGCTTTA  TTTTGGACCA  CGGGGCTGCC  AAACAAATTT  TCGTATGGAA  AGGTAAAGAT  900
901   GCTAATCCCC  AAGAGAGGAA  GGCTGCAATG  AAGACAGCTG  AAGAATTTCT  ACAGCAAATG  960
961   AATTATTCCA  AGAATACCCA  AATTCAAGTT  CTTCCAGAAG  GAGGTGAAAC  ACCAATCTTC  1020
1021  AAACAGTTTT  TTAAGGACTG  GAGAGATAAA  GATCAGAGTG  ATGGCTTCGG  GAAAGTTTAT  1080
1081  GTCACAGAGA  AAGTGGCTCA  AATAAAACAA  ATTCCCTTTG  ATGCCTCAAA  ATTACACAGT  1140
1141  TCTCCGCAGA  TGGCAGCCCA  GCACAATATG  GTGGATGATG  GTTCTGGCAA  AGTGGAGATT  1200
1201  TGGCGTGTAG  AAAACAATGG  TAGGATCCAA  GTTGACCAAA  ACTCATATGG  TGAATTCTAT  1260
1261  GGTGGTGACT  GCTACATCAT  ACTCTACACC  TATCCCAGAG  GACAGATTAT  CTACACGTGG  1320
1321  CAAGGAGCAA  ATGCCACACG  AGATGAGCTG  ACAACATCTG  CGTTCCTGAC  TGTTCAGTTG  1380
1381  GATCGGTCCC  TTGGAGGACA  GGCTGTGCAG  ATCCGAGTCT  CCCAAGGCAA  AGAGCCTGTT  1440
1441  CACCTACTGA  GTTTGTTCAA  AGACAAACCG  CTCATTATTT  ACAAGAATGG  AACATCAAAG  1500
1501  AAAGGAGGTC  AGGCACCTGC  TCCCCCTACA  CGCCTCTTTC  AAGTCCGGAG  AAACCTGGCA  1560
1561  TCTATCACCA  GAATTGTGGA  GGTTGATGTT  GATGCAAATT  CACTGAATTC  TAACGATGTT  1620
1621  TTTGTCCTGA  AACTGCCACA  AAATAGTGGC  TACATCTGGG  TAGGAAAAGG  TGCTAGCCAG  1680
1681  GAGGAGGAGA  AAGGAGCAGA  GTATGTAGCA  AGTGTCCTAA  AGTGCAAAAC  CTTAAGGATC  1740
1741  CAAGAAGGCG  AGGAGCCAGA  GGAGTTCTGG  AATTCCCTTG  GAGGGAAAAA  AGACTACCAG  1800
1801  ACCTCACCAC  TACTGGAAAC  CCAGGCTGAA  GACCATCCAC  CTCGGCTTTA  CGGCTGCTCT  1860
1861  AACAAAACTG  GAAGATTTGT  TATTGAAGAG  ATTCCAGGAG  AGTTCACCCA  GGATGATTTA  1920
1921  GCTGAAGATG  ATGTCATGTT  ACTAGATGCT  TGGGAACAGA  TATTTATTTG  GATTGGCAAA  1980
1981  GATGCTAATG  AAGTTGAGAA  AAAAGAATCT  CTGAAGTCTG  CCAAAATGTA  CCTTGAGACA  2040
2041  GACCCTTCTG  GAAGAGACAA  GAGGACACCA  ATTGTCATCA  TAAAACAGGG  CCATGAGCCA  2100
2101  CCCACATTCA  CAGGCTGGTT  CCTGGGCTGG  GATTCCAGCA  AGTGGTAA  2148

▼ KEYWORD

ID
Family
3D-structure
Actin capping
Actin-binding
Alternative splicing
Calcium
Cell junction
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Brush border
Cellular Component
Cell cortex
Cellular Component
Cell junction
Cellular Component
Cell projection
Cellular Component
Cytoplasm
Cellular Component
Extracellular exosome
Cellular Component
Plasma membrane
Cellular Component
Podosome
Molecular Function
1-phosphatidylinositol binding
Molecular Function
Actin binding
Molecular Function
Actin filament binding
Molecular Function
Calcium ion binding
Molecular Function
Phosphatidylinositol-4,5-bisphosphate binding
Molecular Function
Phosphatidylserine binding
Biological Process
Actin filament capping
Biological Process
Actin filament severing
Biological Process
Actin nucleation
Biological Process
Calcium ion regulated exocytosis
Biological Process
Negative regulation of cell population proliferation
Biological Process
Positive regulation of actin nucleation
Biological Process
Positive regulation of apoptotic process
Biological Process
Positive regulation of megakaryocyte differentiation
Biological Process
Positive regulation of secretion
Biological Process
Regulation of chondrocyte differentiation
Biological Process
Sequestering of actin monomers

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-2867Pan paniscus99.720.01454
LLPS-Pat-4439Pan troglodytes99.580.01455
LLPS-Gog-0992Gorilla gorilla99.30.01451
LLPS-Poa-1528Pongo abelii98.880.01444
LLPS-Nol-2127Nomascus leucogenys98.040.01435
LLPS-Mam-1351Macaca mulatta98.040.01435
LLPS-Paa-0951Papio anubis98.040.01435
LLPS-Chs-3311Chlorocebus sabaeus98.040.01434
LLPS-Maf-1712Macaca fascicularis98.040.01435
LLPS-Man-4316Macaca nemestrina97.90.01434
LLPS-Mal-2557Mandrillus leucophaeus97.90.01432
LLPS-Rhb-0302Rhinopithecus bieti97.760.01433
LLPS-Aon-2666Aotus nancymaae95.660.01414
LLPS-Caj-4625Callithrix jacchus95.380.01404
LLPS-Cea-3049Cercocebus atys93.580.01345
LLPS-Aim-3834Ailuropoda melanoleuca93.010.01380
LLPS-Eqc-2284Equus caballus92.860.01373
LLPS-Mup-3262Mustela putorius furo92.730.01373
LLPS-Sus-4462Sus scrofa92.590.01370
LLPS-Ict-2201Ictidomys tridecemlineatus92.450.01373
LLPS-Bot-4796Bos taurus92.170.01367
LLPS-Otg-3413Otolemur garnettii92.030.01369
LLPS-Fec-1478Felis catus91.890.01361
LLPS-Ran-4020Rattus norvegicus91.890.01362
LLPS-Loa-0488Loxodonta africana91.750.01368
LLPS-Fud-3539Fukomys damarensis91.510.01228
LLPS-Mum-4010Mus musculus91.470.01362
LLPS-Cas-0278Carlito syrichta90.550.01255
LLPS-Cap-3760Cavia porcellus90.350.01347
LLPS-Myl-4389Myotis lucifugus90.210.01341
LLPS-Urm-1233Ursus maritimus89.650.01296
LLPS-Orc-1377Oryctolagus cuniculus89.360.01335
LLPS-Mea-1932Mesocricetus auratus87.630.01224
LLPS-Ova-0413Ovis aries87.20.01285
LLPS-Dio-3190Dipodomys ordii84.970.01254
LLPS-Meg-2473Meleagris gallopavo81.650.01223
LLPS-Fia-0532Ficedula albicollis80.910.01133
LLPS-Anc-1596Anolis carolinensis80.90.01225
LLPS-Tag-3437Taeniopygia guttata80.70.01224
LLPS-Gaga-2801Gallus gallus80.70.01226
LLPS-Pes-0161Pelodiscus sinensis80.280.01219
LLPS-Leo-2547Lepisosteus oculatus77.360.01176
LLPS-Lac-1742Latimeria chalumnae74.60.0 991
LLPS-Xet-2125Xenopus tropicalis74.120.01121
LLPS-Scf-1112Scleropages formosus74.120.01135
LLPS-Sah-2297Sarcophilus harrisii73.690.0 993
LLPS-Orn-1604Oreochromis niloticus73.420.01108
LLPS-Scm-0852Scophthalmus maximus72.330.01097
LLPS-Icp-0671Ictalurus punctatus72.170.01109
LLPS-Asm-2790Astyanax mexicanus71.890.01104
LLPS-Dar-3184Danio rerio71.090.01101
LLPS-Mod-3562Monodelphis domestica70.620.01043
LLPS-Ora-2108Ornithorhynchus anatinus67.820.0 795
LLPS-Tar-0543Takifugu rubripes63.20.0 930
LLPS-Orl-3660Oryzias latipes57.880.0 857
LLPS-Gaa-3571Gasterosteus aculeatus57.00.0 854
LLPS-Pof-2998Poecilia formosa56.440.0 735
LLPS-Xim-3485Xiphophorus maculatus55.240.0 815
LLPS-Caf-2444Canis familiaris49.310.0 686
LLPS-Tut-1205Tursiops truncatus47.513e-108 340
LLPS-Phv-2297Phaseolus vulgaris33.747e-118 384
LLPS-Tra-2077Triticum aestivum32.241e-107 357
LLPS-Sob-0940Sorghum bicolor32.231e-109 362