DrLLPS - Data resource of LLPS

Overview
Property
Classification
Function
Cross Reference
Sequence
GO
Annotation
Orthology
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LLPS-Hos-2316
CHEK1

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1
Gene Name:	CHEK1, CHK1
Ensembl Gene:	ENSG00000149554.12
Ensembl Protein:	ENSP00000435371.1
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Others

PDB: 1NVS (A, B) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Centrosome/Spindle pole body	"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."	N/A	15311285, 15483402
Chromatin	Predicted from orthologs	N/A	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-1027	O35280	Client	Chromatin, Centrosome/Spindle pole body	90.03	0.0	715

▼ FUNCTION

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA. May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes. May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000534070.5	ENSP00000435371.1
Ensembl	ENST00000531607.5	ENSP00000477588.1
Ensembl	ENST00000532669.5	ENSP00000434646.2
Ensembl	ENST00000526937.5	ENSP00000431815.1
Ensembl	ENST00000544373.5	ENSP00000442317.2
Ensembl	ENST00000438015.5	ENSP00000388648.1
Ensembl	ENST00000534685.5	ENSP00000432470.1
Ensembl	ENST00000498122.4	ENSP00000481614.1
Ensembl	ENST00000533778.6	ENSP00000433103.1
Ensembl	ENST00000525396.5	ENSP00000434141.2
Ensembl	ENST00000427383.6	ENSP00000391090.2
Ensembl	ENST00000524737.5	ENSP00000432890.1
Ensembl	ENST00000527013.5	ENSP00000431525.1
Ensembl	ENST00000532449.5	ENSP00000481616.1
Ensembl	ENST00000428830.6	ENSP00000412504.2
Ensembl	ENST00000278916.7	ENSP00000278916.3
UniProt		O14757, CHK1_HUMAN, A8K934, B4DDD0, B4DSK3, B5BTY6, F5H7S4, H2BI51
GeneBank	AB032387, AB451222, AF016582, AK293143, BC017575, AK292549, AF527555, AF032874, AK299783, BC004202, CH471065, JF289264, AP001132, AB451345	BAG56691.1, BAG61665.1, AAH17575.1, BAF85238.1, BAG70036.1, AAB88852.1, BAG70159.1, EAW67644.1, AAC51736.1, BAA84577.1, AEB71796.1, AAM78553.1, AAH04202.1
RefSeq	NM_001114121.2, NM_001114122.2, NM_001244846.1, NM_001274.5, NM_001330428.1, XM_017017146.1	NP_001107593.1, NP_001107594.1, NP_001231775.1, NP_001265.2, NP_001317357.1, XP_016872635.1
Entrez	1111

▼ SEQUENCE

Protein Sequence (FASTA)
1 MRSAVLKSLQ PGSLPDCKAA LGGSGNISTS PFWSRRHSEG QDTGTRAVLL YGAGARVCGS 60 61 VTPSSFGGKS AAFGFLQWWA KDSPPRCSVE SWQCPLWKTG TWCKPWEKVP MEKPDIGMPE 120 121 PDAQRFFHQL MAGVVYLHGI GITHRDIKPE NLLLDERDNL KISDFGLATV FRYNNRERLL 180 181 NKMCGTLPYV APELLKRREF HAEPVDVWSC GIVLTAMLAG ELPWDQPSDS CQEYSDWKEK 240 241 KTYLNPWKKI DSAPLALLHK ILVENPSARI TIPDIKKDRW YNKPLKKGAK RPRVTSGGVS 300 301 ESPSGFSKHI QSNLDFSPVN SASSEENVKY SSSQPEPRTG LSLWDTSPSY IDKLVQGISF 360 361 SQPTCPDHML LNSQLLGTPG SSQNPWQRLV KRMTRFFTKL DADKSYQCLK ETCEKLGYQW 420 421 KKSCMNQVTI STTDRRNNKL IFKVNLLEMD DKILVDFRLS KGDGLEFKRH FLKIKGKLID 480 481 IVSSQKIWLP AT 492
Nucleotide CDS Sequence (FASTA)
1 ATGGCAGTGC CCTTTGTGGA AGACTGGGAC TTGGTGCAAA CCCTGGGAGA AGGTGCCTAT 60 61 GGAGAAGTTC AACTTGCTGT GAATAGAGTA ACTGAAGAAG CAGTCGCAGT GAAGATTGTA 120 121 GATATGAAGC GTGCCGTAGA CTGTCCAGAA AATATTAAGA AAGAGATCTG TATCAATAAA 180 181 ATGCTAAATC ATGAAAATGT AGTAAAATTC TATGGTCACA GGAGAGAAGG CAATATCCAA 240 241 TATTTATTTC TGGAGTACTG TAGTGGAGGA GAGCTTTTTG ACAGAATAGA GCCAGACATA 300 301 GGCATGCCTG AACCAGATGC TCAGAGATTC TTCCATCAAC TCATGGCAGG GGTGGTTTAT 360 361 CTGCATGGTA TTGGAATAAC TCACAGGGAT ATTAAACCAG AAAATCTTCT GTTGGATGAA 420 421 AGGGATAACC TCAAAATCTC AGACTTTGGC TTGGCAACAG TATTTCGGTA TAATAATCGT 480 481 GAGCGTTTGT TGAACAAGAT GTGTGGTACT TTACCATATG TTGCTCCAGA ACTTCTGAAG 540 541 AGAAGAGAAT TTCATGCAGA ACCAGTTGAT GTTTGGTCCT GTGGAATAGT ACTTACTGCA 600 601 ATGCTCGCTG GAGAATTGCC ATGGGACCAA CCCAGTGACA GCTGTCAGGA GTATTCTGAC 660 661 TGGAAAGAAA AAAAAACATA CCTCAACCCT TGGAAAAAAA TCGATTCTGC TCCTCTAGCT 720 721 CTGCTGCATA AAATCTTAGT TGAGAATCCA TCAGCAAGAA TTACCATTCC AGACATCAAA 780 781 AAAGATAGAT GGTACAACAA ACCCCTCAAG AAAGGGGCAA AAAGGCCCCG AGTCACTTCA 840 841 GGTGGTGTGT CAGAGTCTCC CAGTGGATTT TCTAAGCACA TTCAATCCAA TTTGGACTTC 900 901 TCTCCAGTAA ACAGTGCTTC TAGTGAAGAA AATGTGAAGT ACTCCAGTTC TCAGCCAGAA 960 961 CCCCGCACAG GTCTTTCCTT ATGGGATACC AGCCCCTCAT ACATTGATAA ATTGGTACAA 1020 1021 GGGATCAGCT TTTCCCAGCC CACATGTCCT GATCATATGC TTTTGAATAG TCAGTTACTT 1080 1081 GGCACCCCAG GATCCTCACA GGTTACTATA TCAACAACTG ATAGGAGAAA CAATAAACTC 1140 1141 ATTTTCAAAG TGAATTTGTT AGAAATGGAT GATAAAATAT TGGTTGACTT CCGGCTTTCT 1200 1201 AAGGGTGATG GATTGGAGTT CAAGAGACAC TTCCTGAAGA TTAAAGGGAA GCTGATTGAT 1260 1261 ATTGTGAGCA GCCAGAAGAT TTGGCTTCCT GCCACATGA 1299

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0025	Alternative splicing
KW-0067	ATP-binding
KW-0131	Cell cycle
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0206	Cytoskeleton
KW-0227	DNA damage
KW-0234	DNA repair
KW-1017	Isopeptide bond
KW-0418	Kinase
KW-0547	Nucleotide-binding
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0723	Serine/threonine-protein kinase
KW-0808	Transferase
KW-0832	Ubl conjugation

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005813	Cellular Component	Centrosome
GO:0000785	Cellular Component	Chromatin
GO:0000794	Cellular Component	Condensed nuclear chromosome
GO:0005737	Cellular Component	Cytoplasm
GO:0005829	Cellular Component	Cytosol
GO:0005615	Cellular Component	Extracellular space
GO:0043231	Cellular Component	Intracellular membrane-bounded organelle
GO:0005654	Cellular Component	Nucleoplasm
GO:0005634	Cellular Component	Nucleus
GO:0032991	Cellular Component	Protein-containing complex
GO:0005524	Molecular Function	ATP binding
GO:0035402	Molecular Function	Histone kinase activity (H3-T11 specific)
GO:0016301	Molecular Function	Kinase activity
GO:0019904	Molecular Function	Protein domain specific binding
GO:0004672	Molecular Function	Protein kinase activity
GO:0004674	Molecular Function	Protein serine/threonine kinase activity
GO:0006915	Biological Process	Apoptotic process
GO:0007049	Biological Process	Cell cycle
GO:0006974	Biological Process	Cellular response to DNA damage stimulus
GO:0071260	Biological Process	Cellular response to mechanical stimulus
GO:0048096	Biological Process	Chromatin-mediated maintenance of transcription
GO:0000077	Biological Process	DNA damage checkpoint
GO:0006975	Biological Process	DNA damage induced protein phosphorylation
GO:0006281	Biological Process	DNA repair
GO:0006260	Biological Process	DNA replication
GO:0035556	Biological Process	Intracellular signal transduction
GO:0070317	Biological Process	Negative regulation of G0 to G1 transition
GO:0045839	Biological Process	Negative regulation of mitotic nuclear division
GO:0018107	Biological Process	Peptidyl-threonine phosphorylation
GO:0045787	Biological Process	Positive regulation of cell cycle
GO:0006468	Biological Process	Protein phosphorylation
GO:0010569	Biological Process	Regulation of double-strand break repair via homologous recombination
GO:2000615	Biological Process	Regulation of histone H3-K9 acetylation
GO:0046602	Biological Process	Regulation of mitotic centrosome separation
GO:1901796	Biological Process	Regulation of signal transduction by p53 class mediator
GO:0010767	Biological Process	Regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0090399	Biological Process	Replicative senescence
GO:0072425	Biological Process	Signal transduction involved in G2 DNA damage checkpoint

▼ KEGG

hsa:1111

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
PROSITE	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	mUbiSiDa	PTMcode

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	TRRUST	BindingDB
RAIN	Mentha	PINA	IID	iRefIndex
MIST	DifferentialNET	RNAct

Disease
ClinVar	PTMD	PancanQTL	TumorFusions	OMIM
DisGeNET	ActiveDriverDB

Drug
DrugBank	TTD	GRAC	DGIdb	CTD

Physicochemical
Compute pI/Mw	AAindex

Function
THANATOS	iEKPD	CORUM	CellMarker

Proteomics
THPA	HPM

Structure
PDB	MMDB

Localization
COMPARTMENTS

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TissGDB	TISSUES	BioXpress	THPA

Element
UTRdb	circBase	CircNet	miRTarBase	miRWalk
miRcode	RAID	microRNA.org	m6AVar

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Pat-4142	Pan troglodytes	99.18	0.0	997
LLPS-Nol-3860	Nomascus leucogenys	96.95	0.0	989
LLPS-Gog-1334	Gorilla gorilla	96.93	0.0	785
LLPS-Pap-0910	Pan paniscus	96.93	0.0	785
LLPS-Chs-1303	Chlorocebus sabaeus	96.42	0.0	776
LLPS-Maf-1618	Macaca fascicularis	96.42	0.0	781
LLPS-Man-0863	Macaca nemestrina	96.15	0.0	978
LLPS-Cea-0969	Cercocebus atys	95.94	0.0	972
LLPS-Aim-1370	Ailuropoda melanoleuca	95.44	0.0	869
LLPS-Urm-0927	Ursus maritimus	94.88	0.0	769
LLPS-Caj-2216	Callithrix jacchus	94.7	0.0	954
LLPS-Fec-1757	Felis catus	94.63	0.0	771
LLPS-Mup-0986	Mustela putorius furo	94.37	0.0	768
LLPS-Sus-0234	Sus scrofa	94.37	0.0	766
LLPS-Caf-0316	Canis familiaris	94.37	0.0	768
LLPS-Cas-0871	Carlito syrichta	94.12	0.0	765
LLPS-Eqc-0459	Equus caballus	93.61	0.0	763
LLPS-Orc-1101	Oryctolagus cuniculus	93.61	0.0	762
LLPS-Mal-4018	Mandrillus leucophaeus	93.1	0.0	935
LLPS-Paa-2825	Papio anubis	93.1	0.0	937
LLPS-Fud-3309	Fukomys damarensis	92.84	0.0	757
LLPS-Loa-1935	Loxodonta africana	92.58	0.0	753
LLPS-Otg-1817	Otolemur garnettii	92.43	0.0	837
LLPS-Myl-1940	Myotis lucifugus	92.37	0.0	749
LLPS-Bot-2858	Bos taurus	92.33	0.0	753
LLPS-Ova-0881	Ovis aries	92.33	0.0	754
LLPS-Dio-1015	Dipodomys ordii	91.56	0.0	750
LLPS-Mea-1876	Mesocricetus auratus	91.05	0.0	745
LLPS-Mod-0285	Monodelphis domestica	90.54	0.0	741
LLPS-Mum-1027	Mus musculus	90.03	0.0	715
LLPS-Sah-2443	Sarcophilus harrisii	89.77	0.0	738
LLPS-Poa-3527	Pongo abelii	87.98	0.0	696
LLPS-Ora-1316	Ornithorhynchus anatinus	85.93	0.0	705
LLPS-Cap-0190	Cavia porcellus	84.14	0.0	671
LLPS-Pes-2151	Pelodiscus sinensis	83.38	0.0	675
LLPS-Ict-0623	Ictidomys tridecemlineatus	82.1	0.0	628
LLPS-Meg-0506	Meleagris gallopavo	79.59	0.0	655
LLPS-Anp-1915	Anas platyrhynchos	79.28	0.0	660
LLPS-Fia-0313	Ficedula albicollis	78.77	0.0	651
LLPS-Anc-1483	Anolis carolinensis	77.49	0.0	644
LLPS-Tag-2869	Taeniopygia guttata	76.94	0.0	587
LLPS-Lac-0480	Latimeria chalumnae	72.63	0.0	599
LLPS-Xet-2092	Xenopus tropicalis	71.21	0.0	581
LLPS-Leo-1865	Lepisosteus oculatus	66.75	0.0	560
LLPS-Scf-0795	Scleropages formosus	62.69	2e-175	509
LLPS-Aon-1560	Aotus nancymaae	61.71	1e-138	413
LLPS-Asm-2354	Astyanax mexicanus	61.64	4e-173	503
LLPS-Icp-3002	Ictalurus punctatus	60.36	4e-168	490
LLPS-Scm-0616	Scophthalmus maximus	59.34	1e-155	458
LLPS-Gaa-1945	Gasterosteus aculeatus	58.78	9e-149	441
LLPS-Dar-1318	Danio rerio	58.38	4e-150	442
LLPS-Orn-2089	Oreochromis niloticus	58.38	2e-146	435
LLPS-Orl-0085	Oryzias latipes	58.31	1e-153	453
LLPS-Xim-3461	Xiphophorus maculatus	58.16	2e-155	457
LLPS-Ten-1608	Tetraodon nigroviridis	58.08	3e-156	460
LLPS-Pof-0292	Poecilia formosa	57.54	2e-148	439
LLPS-Tar-2156	Takifugu rubripes	56.52	3e-143	426
LLPS-Spr-0899	Sporisorium reilianum	48.54	3e-49	184
LLPS-Usm-1165	Ustilago maydis	47.95	5e-48	181
LLPS-Cis-1569	Ciona savignyi	47.48	7e-110	341
LLPS-Crn-1453	Cryptococcus neoformans	47.06	8e-45	169
LLPS-Cii-0910	Ciona intestinalis	47.01	1e-102	322
LLPS-Drm-0392	Drosophila melanogaster	44.42	8e-99	314
LLPS-Kop-0972	Komagataella pastoris	43.9	4e-30	127
LLPS-Sac-0027	Saccharomyces cerevisiae	42.6	3e-28	122
LLPS-Fus-1526	Fusarium solani	42.42	2e-29	125
LLPS-Chc-1066	Chondrus crispus	42.11	7e-30	125
LLPS-Cogr-0633	Colletotrichum graminicola	41.82	3e-30	129
LLPS-Beb-0941	Beauveria bassiana	41.82	1e-29	126
LLPS-Sot-0650	Solanum tuberosum	41.42	3e-32	131
LLPS-Trv-1287	Trichoderma virens	41.42	1e-29	127
LLPS-Trr-1185	Trichoderma reesei	41.42	1e-29	126
LLPS-Coo-1397	Colletotrichum orbiculare	41.21	9e-30	127
LLPS-Yal-0727	Yarrowia lipolytica	41.18	6e-29	124
LLPS-Blg-0735	Blumeria graminis	41.07	9e-29	124
LLPS-Mao-0805	Magnaporthe oryzae	40.83	6e-30	128
LLPS-Gag-1166	Gaeumannomyces graminis	40.61	2e-29	126
LLPS-Map-1369	Magnaporthe poae	40.61	1e-29	126
LLPS-Nec-0056	Neurospora crassa	40.24	1e-28	124
LLPS-Asg-1349	Ashbya gossypii	40.11	2e-33	136
LLPS-Mel-1245	Melampsora laricipopulina	40.11	6e-31	129
LLPS-Scs-0667	Sclerotinia sclerotiorum	39.88	5e-28	122
LLPS-Sei-0798	Setaria italica	39.76	5e-31	128
LLPS-Scc-0225	Schizosaccharomyces cryophilus	39.64	2e-28	122
LLPS-Lem-0657	Leptosphaeria maculans	39.43	3e-29	126
LLPS-Ere-0560	Erinaceus europaeus	39.39	1e-28	122
LLPS-Cae-0220	Caenorhabditis elegans	39.39	8e-29	125
LLPS-Mam-2599	Macaca mulatta	39.39	3e-28	122
LLPS-Rhb-3507	Rhinopithecus bieti	39.39	3e-28	122
LLPS-Cym-1130	Cyanidioschyzon merolae	39.36	1e-31	130
LLPS-Dos-1280	Dothistroma septosporum	39.11	4e-29	125
LLPS-Pug-1511	Puccinia graminis	39.08	4e-29	125
LLPS-Lep-2156	Leersia perrieri	38.86	3e-28	121
LLPS-Phn-1502	Phaeosphaeria nodorum	38.86	6e-29	122
LLPS-Arl-1065	Arabidopsis lyrata	38.82	2e-29	124
LLPS-Art-2601	Arabidopsis thaliana	38.82	1e-29	125
LLPS-Viv-1220	Vitis vinifera	38.82	3e-29	124
LLPS-Orbr-0158	Oryza brachyantha	38.64	2e-28	121
LLPS-Put-0490	Puccinia triticina	38.58	2e-40	157
LLPS-Orb-2279	Oryza barthii	38.55	3e-28	121
LLPS-Sob-1429	Sorghum bicolor	38.55	2e-30	127
LLPS-Orm-0713	Oryza meridionalis	38.17	1e-28	122
LLPS-Bro-1072	Brassica oleracea	38.15	1e-28	122
LLPS-Orgl-0300	Oryza glumaepatula	38.12	5e-28	121
LLPS-Orni-0188	Oryza nivara	38.12	5e-28	121
LLPS-Scp-1189	Schizosaccharomyces pombe	38.07	7e-29	123
LLPS-Pyt-1611	Pyrenophora teres	38.01	7e-29	124
LLPS-Pytr-1405	Pyrenophora triticirepentis	38.01	1e-28	124
LLPS-Ori-0641	Oryza indica	37.7	2e-28	121
LLPS-Orr-1376	Oryza rufipogon	37.63	3e-28	120
LLPS-Ors-2364	Oryza sativa	37.63	3e-28	120
LLPS-Aso-1468	Aspergillus oryzae	37.5	8e-28	121
LLPS-Asf-1515	Aspergillus flavus	37.5	8e-28	121
LLPS-Hov-1778	Hordeum vulgare	37.37	1e-29	125
LLPS-Sol-1999	Solanum lycopersicum	37.1	7e-29	122
LLPS-Coc-1456	Corchorus capsularis	36.99	3e-29	124
LLPS-Nia-2028	Nicotiana attenuata	36.93	2e-28	121
LLPS-Brd-0942	Brachypodium distachyon	36.57	4e-28	120
LLPS-Php-0103	Physcomitrella patens	36.57	6e-29	123
LLPS-Brr-2260	Brassica rapa	36.0	2e-28	121
LLPS-Dac-1428	Daucus carota	35.27	1e-28	122
LLPS-Miv-0937	Microbotryum violaceum	33.12	4e-42	162
LLPS-Asfu-1276	Aspergillus fumigatus	32.85	2e-46	174
LLPS-Phv-0901	Phaseolus vulgaris	31.52	8e-40	153
LLPS-Cus-1926	Cucumis sativus	31.15	2e-42	161
LLPS-Asni-0929	Aspergillus niger	31.01	4e-42	162
LLPS-Ast-0431	Aspergillus terreus	30.92	9e-42	161
LLPS-Pot-2144	Populus trichocarpa	30.89	2e-37	147
LLPS-Thc-2198	Theobroma cacao	30.83	3e-38	150
LLPS-Asc-1261	Aspergillus clavatus	30.79	1e-43	166
LLPS-Mae-1984	Manihot esculenta	30.79	2e-38	150
LLPS-Via-1019	Vigna angularis	30.62	3e-38	149
LLPS-Tum-1385	Tuber melanosporum	30.6	3e-43	166
LLPS-Nef-0099	Neosartorya fischeri	30.54	2e-43	166
LLPS-Met-1636	Medicago truncatula	30.52	8e-37	145
LLPS-Glm-2191	Glycine max	30.52	6e-39	152
LLPS-Mua-1730	Musa acuminata	30.29	7e-37	145
LLPS-Org-0879	Oryza glaberrima	30.29	5e-39	152
LLPS-Scj-0036	Schizosaccharomyces japonicus	30.26	2e-46	174
LLPS-Sem-1591	Selaginella moellendorffii	30.08	1e-39	154
LLPS-Brn-2176	Brassica napus	30.05	2e-37	147
LLPS-Gor-2757	Gossypium raimondii	29.95	1e-37	148
LLPS-Prp-0520	Prunus persica	29.78	7e-37	145
LLPS-Orp-0226	Oryza punctata	29.71	7e-36	143
LLPS-Hea-2139	Helianthus annuus	29.51	2e-34	139
LLPS-Asn-0668	Aspergillus nidulans	29.4	8e-38	149
LLPS-Tra-0901	Triticum aestivum	29.3	4e-36	144
LLPS-Tru-1075	Triticum urartu	29.3	1e-35	146
LLPS-Cog-0622	Colletotrichum gloeosporioides	29.01	1e-40	158
LLPS-Amt-0049	Amborella trichopoda	28.53	5e-33	134
LLPS-Ved-0338	Verticillium dahliae	28.51	6e-42	162
LLPS-Fuo-0065	Fusarium oxysporum	27.71	2e-39	154
LLPS-Fuv-0386	Fusarium verticillioides	27.47	1e-38	152

LLPS-Hos-2316CHEK1

Protein Sequence

Nucleotide Sequence

LLPS-Hos-2316
CHEK1