LLPS-Hos-2202
ARL3

▼ OVERVIEW

Status: Reviewed
Protein Name: ADP-ribosylation factor-like protein 3
Gene Name: ARL3, ARFL3
Ensembl Gene: ENSG00000138175.8
Ensembl Protein: ENSP00000260746.4
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A16525022

▼ FUNCTION

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). Required for normal cytokinesis and cilia signaling (PubMed:22085962). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E (PubMed:30269812). Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (PubMed:22085962). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGLLSILRKL  KSAPDQEVRI  LLLGLDNAGK  TTLLKQLASE  DISHITPTQG  FNIKSVQSQG  60
61    FKLNVWDIGG  QRKIRPYWKN  YFENTDILIY  VIDSADRKRF  EETGQELAEL  LEEEKLSCVP  120
121   VLIFANKQDL  LTAAPASEIA  EGLNLHTIRD  RVWQIQSCSA  LTGEGVQDGM  NWVCKNVNAK  180
181   KK  182
Nucleotide CDS Sequence (FASTA)
1     ATGGGCTTGC  TCTCAATTTT  GCGCAAGTTG  AAAAGTGCAC  CAGACCAGGA  GGTGAGAATA  60
61    CTTCTCCTGG  GCTTGGATAA  TGCTGGCAAG  ACCACTCTTC  TGAAGCAGCT  TGCATCTGAA  120
121   GACATCAGCC  ACATCACACC  TACACAGGGT  TTCAACATCA  AAAGTGTACA  ATCACAAGGT  180
181   TTTAAACTGA  ATGTATGGGA  CATTGGTGGA  CAGAGGAAAA  TCAGACCATA  CTGGAAGAAT  240
241   TATTTTGAAA  ATACCGATAT  TCTTATATAT  GTAATCGACA  GTGCAGACAG  AAAAAGATTT  300
301   GAAGAGACGG  GTCAGGAACT  AGCGGAATTA  CTGGAGGAAG  AAAAACTAAG  TTGTGTGCCA  360
361   GTGCTCATCT  TTGCTAATAA  GCAGGATTTG  CTCACAGCAG  CCCCTGCCTC  TGAAATTGCA  420
421   GAAGGACTGA  ACCTGCATAC  CATCCGCGAC  CGAGTCTGGC  AGATCCAGTC  TTGCTCAGCT  480
481   CTCACAGGAG  AGGGCGTTCA  GGATGGCATG  AACTGGGTCT  GCAAAAATGT  CAATGCAAAG  540
541   AAGAAATAA  549

▼ KEYWORD

ID
Family
Cell cycle
Cell division
Cell projection
Ciliopathy
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Golgi apparatus
GTP-binding
Joubert syndrome
Lipoprotein
Magnesium
Membrane
Metal-binding
Myristate
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centrosome
Cellular Component
Cilium
Cellular Component
Cytoplasmic microtubule
Cellular Component
Extracellular exosome
Cellular Component
Golgi apparatus
Cellular Component
Golgi membrane
Cellular Component
Microtubule cytoskeleton
Cellular Component
Midbody
Cellular Component
Nucleus
Cellular Component
Photoreceptor connecting cilium
Cellular Component
Spindle microtubule
Molecular Function
GDP binding
Molecular Function
GTP binding
Molecular Function
GTPase activating protein binding
Molecular Function
GTPase activity
Molecular Function
Magnesium ion binding
Molecular Function
Microtubule binding
Biological Process
Cilium assembly
Biological Process
Golgi to plasma membrane transport
Biological Process
Intraciliary transport
Biological Process
Kidney development
Biological Process
Mitotic cytokinesis
Biological Process
Photoreceptor cell development
Biological Process
Post-Golgi vesicle-mediated transport
Biological Process
Protein localization to ciliary membrane
Biological Process
Protein localization to cilium
Biological Process
Small GTPase mediated signal transduction
Biological Process
Smoothened signaling pathway

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Poa-0243Pongo abelii100.04e-117 337
LLPS-Pap-3924Pan paniscus100.04e-117 337
LLPS-Gog-3923Gorilla gorilla100.04e-117 337
LLPS-Ict-2257Ictidomys tridecemlineatus99.451e-116 336
LLPS-Rhb-2399Rhinopithecus bieti99.451e-116 336
LLPS-Urm-2608Ursus maritimus99.451e-116 336
LLPS-Fec-3091Felis catus99.451e-116 336
LLPS-Loa-1688Loxodonta africana99.451e-115 333
LLPS-Aim-2432Ailuropoda melanoleuca99.459e-116 333
LLPS-Mup-1627Mustela putorius furo99.451e-116 336
LLPS-Dio-3472Dipodomys ordii99.451e-116 336
LLPS-Fud-3522Fukomys damarensis99.451e-115 333
LLPS-Caj-1712Callithrix jacchus99.451e-116 336
LLPS-Caf-0500Canis familiaris99.42e-103 303
LLPS-Sus-3094Sus scrofa99.41e-102 301
LLPS-Orc-1357Oryctolagus cuniculus98.92e-116 335
LLPS-Paa-2484Papio anubis98.93e-116 335
LLPS-Maf-3162Macaca fascicularis98.94e-116 334
LLPS-Eqc-1557Equus caballus98.685e-92 273
LLPS-Ova-3364Ovis aries98.353e-115 332
LLPS-Mum-3605Mus musculus98.356e-116 334
LLPS-Bot-0589Bos taurus98.341e-113 328
LLPS-Chs-3292Chlorocebus sabaeus98.341e-114 330
LLPS-Nol-4307Nomascus leucogenys97.84e-115 332
LLPS-Xet-1304Xenopus tropicalis97.792e-114 330
LLPS-Cap-4360Cavia porcellus97.796e-114 329
LLPS-Myl-2662Myotis lucifugus97.791e-113 328
LLPS-Leo-3001Lepisosteus oculatus97.795e-113 332
LLPS-Mod-1926Monodelphis domestica97.251e-111 330
LLPS-Tut-2356Tursiops truncatus97.251e-114 331
LLPS-Ora-1085Ornithorhynchus anatinus97.254e-115 332
LLPS-Lac-2306Latimeria chalumnae97.141e-109 318
LLPS-Gaga-0460Gallus gallus96.71e-113 328
LLPS-Fia-1981Ficedula albicollis96.79e-114 328
LLPS-Ran-0646Rattus norvegicus96.72e-114 330
LLPS-Asm-2786Astyanax mexicanus96.79e-114 328
LLPS-Pes-2845Pelodiscus sinensis96.692e-113 328
LLPS-Meg-1283Meleagris gallopavo96.691e-112 325
LLPS-Icp-2857Ictalurus punctatus96.695e-112 325
LLPS-Sah-0129Sarcophilus harrisii96.692e-113 327
LLPS-Tag-2242Taeniopygia guttata96.135e-112 324
LLPS-Ere-0764Erinaceus europaeus95.812e-98 289
LLPS-Anp-1554Anas platyrhynchos95.031e-111 323
LLPS-Mam-0701Macaca mulatta94.863e-103 302
LLPS-Dar-3960Danio rerio94.512e-112 325
LLPS-Scm-1265Scophthalmus maximus93.968e-112 323
LLPS-Orl-1755Oryzias latipes93.968e-112 323
LLPS-Orn-2435Oreochromis niloticus93.928e-111 321
LLPS-Pof-1206Poecilia formosa93.922e-110 320
LLPS-Xim-2644Xiphophorus maculatus93.922e-109 318
LLPS-Mea-3685Mesocricetus auratus93.411e-109 318
LLPS-Gaa-1878Gasterosteus aculeatus93.337e-109 316
LLPS-Ten-1941Tetraodon nigroviridis92.312e-110 320
LLPS-Otg-3784Otolemur garnettii92.182e-104 305
LLPS-Tar-2242Takifugu rubripes91.711e-108 315
LLPS-Scf-3210Scleropages formosus90.661e-108 315
LLPS-Cea-2581Cercocebus atys84.628e-103 300
LLPS-Man-4202Macaca nemestrina84.073e-102 298
LLPS-Aon-1363Aotus nancymaae78.297e-70 216
LLPS-Pat-2262Pan troglodytes76.89e-76 231
LLPS-Cis-1938Ciona savignyi76.89e-90 268
LLPS-Cii-2328Ciona intestinalis76.376e-86 258
LLPS-Anc-3909Anolis carolinensis73.483e-87 261
LLPS-Cas-1444Carlito syrichta70.113e-71 220
LLPS-Drm-2037Drosophila melanogaster65.547e-76 232
LLPS-Php-2145Physcomitrella patens63.898e-70 217
LLPS-Chr-1434Chlamydomonas reinhardtii63.843e-69 215
LLPS-Cae-1509Caenorhabditis elegans63.393e-73 225
LLPS-Sem-1846Selaginella moellendorffii52.258e-54 176
LLPS-Gor-1003Gossypium raimondii50.834e-53 174
LLPS-Mae-0707Manihot esculenta50.282e-51 170
LLPS-Coc-1505Corchorus capsularis50.01e-43 151
LLPS-Blg-1033Blumeria graminis50.07e-44 150
LLPS-Scs-0605Sclerotinia sclerotiorum50.01e-45 154
LLPS-Hov-2068Hordeum vulgare49.721e-51 172
LLPS-Ori-0569Oryza indica49.729e-50 165
LLPS-Trr-0348Trichoderma reesei49.441e-50 167
LLPS-Org-2251Oryza glaberrima49.174e-51 169
LLPS-Tra-2776Triticum aestivum49.173e-52 172
LLPS-Asfu-0617Aspergillus fumigatus49.092e-45 154
LLPS-Trv-1403Trichoderma virens48.898e-49 162
LLPS-Bro-2164Brassica oleracea48.625e-45 153
LLPS-Scc-1520Schizosaccharomyces cryophilus48.622e-47 159
LLPS-Brn-3034Brassica napus48.625e-45 153
LLPS-Zem-2064Zea mays48.483e-45 154
LLPS-Orr-2145Oryza rufipogon48.486e-46 155
LLPS-Orbr-0281Oryza brachyantha48.487e-46 155
LLPS-Ors-2090Oryza sativa48.487e-46 155
LLPS-Brd-1923Brachypodium distachyon48.481e-45 155
LLPS-Lep-0792Leersia perrieri48.486e-46 155
LLPS-Asc-1633Aspergillus clavatus48.485e-45 153
LLPS-Orb-1040Oryza barthii48.486e-46 155
LLPS-Glm-2110Glycine max48.289e-44 149
LLPS-Tum-0971Tuber melanosporum48.152e-45 154
LLPS-Tru-1000Triticum urartu47.885e-45 153
LLPS-Orm-0936Oryza meridionalis47.881e-44 154
LLPS-Prp-1454Prunus persica47.887e-45 152
LLPS-Amt-1093Amborella trichopoda47.886e-45 153
LLPS-Phv-1201Phaseolus vulgaris47.887e-45 152
LLPS-Nia-1909Nicotiana attenuata47.882e-45 154
LLPS-Viv-2049Vitis vinifera47.887e-45 153
LLPS-Art-0760Arabidopsis thaliana47.882e-45 154
LLPS-Pot-1932Populus trichocarpa47.882e-45 154
LLPS-Orp-0909Oryza punctata47.885e-44 154
LLPS-Cus-1520Cucumis sativus47.882e-45 154
LLPS-Met-2100Medicago truncatula47.882e-45 154
LLPS-Vir-1926Vigna radiata47.886e-45 152
LLPS-Arl-2736Arabidopsis lyrata47.886e-45 152
LLPS-Via-2415Vigna angularis47.887e-45 152
LLPS-Orgl-1388Oryza glumaepatula47.882e-45 154
LLPS-Sot-2247Solanum tuberosum47.882e-45 154
LLPS-Hea-0819Helianthus annuus47.881e-44 153
LLPS-Asn-0113Aspergillus nidulans47.886e-45 153
LLPS-Thc-2398Theobroma cacao47.886e-45 152
LLPS-Mua-1165Musa acuminata47.888e-45 154
LLPS-Orni-1877Oryza nivara47.884e-45 153
LLPS-Dac-0065Daucus carota47.886e-44 150
LLPS-Sol-0593Solanum lycopersicum47.886e-45 152
LLPS-Cogr-0464Colletotrichum graminicola47.512e-44 151
LLPS-Brr-0483Brassica rapa47.513e-43 149
LLPS-Osl-0459Ostreococcus lucimarinus47.276e-45 153
LLPS-Map-0153Magnaporthe poae46.35e-43 148
LLPS-Mel-1406Melampsora laricipopulina46.066e-44 150
LLPS-Crn-1263Cryptococcus neoformans46.065e-44 150
LLPS-Yal-0226Yarrowia lipolytica45.911e-43 150
LLPS-Mal-4556Mandrillus leucophaeus45.783e-43 148
LLPS-Usm-1520Ustilago maydis45.455e-43 148
LLPS-Pug-1314Puccinia graminis45.454e-43 148
LLPS-Spr-1314Sporisorium reilianum44.917e-44 150