LLPS-Hos-2145
FOS

▼ OVERVIEW

Status: Reviewed
Protein Name: Proto-oncogene c-Fos; Cellular oncogene fos; G0/G1 switch regulatory protein 7
Gene Name: FOS, G0S7
Ensembl Gene: ENSG00000170345.9
Ensembl Protein: ENSP00000442268.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 1S9K (A, B, C, D, E) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Paraspeckle
"...In total, we identified 325 proteins localized to distinct nuclear bodies, including nucleoli, promyelocytic leukemia nuclear bodies, nuclear speckles, paraspeckles, Cajal bodies, Sam68 nuclear bodies, Polycomb bodies, and uncharacterized nuclear bodies."
HeLa cells24127217
NucleolusPredicted from orthologsN/A(View)

▼ FUNCTION

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MMFSGFNADY  EASSSRCSSA  SPAGDSLSYY  HSPADSFSSM  GSPVNAQDFC  TDLAVSSANF  60
61    IPTVTAISTS  PDLQWLVQPA  LVSSVAPSQT  RAPHPFGVPA  PSAGAYSRAG  VVKTMTGGRA  120
121   QSIGRRGKVE  QLSPEEEEKR  RIRRERNKMA  AAKCRNRRRE  LTDTLQAETD  QLEDEKSALQ  180
181   TEIANLLKEK  EKLEFILAAH  RPACKIPDDL  GFPEEMSVAS  LDLTGGLPEV  ATPESEEAFT  240
241   LPLLNDPEPK  PSVEPVKSIS  SMELKTEPFD  DFLFPASSRP  SGSETARSVP  DMDLSGSFYA  300
301   ADWEPLHSGS  LGMGPMATEL  EPLCTPVVTC  TPSCTAYTSS  FVFTYPEADS  FPSCAAAHRK  360
361   GSSSNEPSSD  SLSSPTLLAL  380
Nucleotide CDS Sequence (FASTA)
1     ATGATGTTCT  CGGGCTTCAA  CGCAGACTAC  GAGGCGTCAT  CCTCCCGCTG  CAGCAGCGCG  60
61    TCCCCGGCCG  GGGATAGCCT  CTCTTACTAC  CACTCACCCG  CAGACTCCTT  CTCCAGCATG  120
121   GGCTCGCCTG  TCAACGCGCA  GGACTTCTGC  ACGGACCTGG  CCGTCTCCAG  TGCCAACTTC  180
181   ATTCCCACGG  TCACTGCCAT  CTCGACCAGT  CCGGACCTGC  AGTGGCTGGT  GCAGCCCGCC  240
241   CTCGTCTCCT  CCGTGGCCCC  ATCGCAGACC  AGAGCCCCTC  ACCCTTTCGG  AGTCCCCGCC  300
301   CCCTCCGCTG  GGGCTTACTC  CAGGGCTGGC  GTTGTGAAGA  CCATGACAGG  AGGCCGAGCG  360
361   CAGAGCATTG  GCAGGAGGGG  CAAGGTGGAA  CAGTTATCTC  CAGAAGAAGA  AGAGAAAAGG  420
421   AGAATCCGAA  GGGAAAGGAA  TAAGATGGCT  GCAGCCAAAT  GCCGCAACCG  GAGGAGGGAG  480
481   CTGACTGATA  CACTCCAAGC  GGAGACAGAC  CAACTAGAAG  ATGAGAAGTC  TGCTTTGCAG  540
541   ACCGAGATTG  CCAACCTGCT  GAAGGAGAAG  GAAAAACTAG  AGTTCATCCT  GGCAGCTCAC  600
601   CGACCTGCCT  GCAAGATCCC  TGATGACCTG  GGCTTCCCAG  AAGAGATGTC  TGTGGCTTCC  660
661   CTTGATCTGA  CTGGGGGCCT  GCCAGAGGTT  GCCACCCCGG  AGTCTGAGGA  GGCCTTCACC  720
721   CTGCCTCTCC  TCAATGACCC  TGAGCCCAAG  CCCTCAGTGG  AACCTGTCAA  GAGCATCAGC  780
781   AGCATGGAGC  TGAAGACCGA  GCCCTTTGAT  GACTTCCTGT  TCCCAGCATC  ATCCAGGCCC  840
841   AGTGGCTCTG  AGACAGCCCG  CTCCGTGCCA  GACATGGACC  TATCTGGGTC  CTTCTATGCA  900
901   GCAGACTGGG  AGCCTCTGCA  CAGTGGCTCC  CTGGGGATGG  GGCCCATGGC  CACAGAGCTG  960
961   GAGCCCCTGT  GCACTCCGGT  GGTCACCTGT  ACTCCCAGCT  GCACTGCTTA  CACGTCTTCC  1020
1021  TTCGTCTTCA  CCTACCCCGA  GGCTGACTCC  TTCCCCAGCT  GTGCAGCTGC  CCACCGCAAG  1080
1081  GGCAGCAGCA  GCAATGAGCC  TTCCTCTGAC  TCGCTCAGCT  CACCCACGCT  GCTGGCCCTG  1140
1141  TGA  1143

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Endoplasmic reticulum
Isopeptide bond
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Endoplasmic reticulum
Cellular Component
Membrane
Cellular Component
Neuron projection
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Cellular Component
Protein-DNA complex
Cellular Component
Transcription factor AP-1 complex
Molecular Function
Chromatin binding
Molecular Function
DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function
DNA-binding transcription factor activity
Molecular Function
DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function
Protein heterodimerization activity
Molecular Function
R-SMAD binding
Molecular Function
RNA polymerase II activating transcription factor binding
Molecular Function
RNA polymerase II core promoter sequence-specific DNA binding
Molecular Function
RNA polymerase II proximal promoter sequence-specific DNA binding
Molecular Function
Transcription factor binding
Molecular Function
Transcription regulatory region DNA binding
Biological Process
Aging
Biological Process
Cellular response to cadmium ion
Biological Process
Cellular response to calcium ion
Biological Process
Cellular response to extracellular stimulus
Biological Process
Cellular response to hormone stimulus
Biological Process
Cellular response to reactive oxygen species
Biological Process
Conditioned taste aversion
Biological Process
Cytokine-mediated signaling pathway
Biological Process
DNA methylation
Biological Process
Fc-epsilon receptor signaling pathway
Biological Process
Female pregnancy
Biological Process
Inflammatory response
Biological Process
Nervous system development
Biological Process
Positive regulation of neuron death
Biological Process
Positive regulation of osteoclast differentiation
Biological Process
Positive regulation of pri-miRNA transcription by RNA polymerase II
Biological Process
Positive regulation of transcription by RNA polymerase II
Biological Process
Positive regulation of transcription, DNA-templated
Biological Process
Regulation of DNA-binding transcription factor activity
Biological Process
Regulation of transcription by RNA polymerase II
Biological Process
Response to cAMP
Biological Process
Response to cold
Biological Process
Response to corticosterone
Biological Process
Response to gravity
Biological Process
Response to immobilization stress
Biological Process
Response to light stimulus
Biological Process
Response to lipopolysaccharide
Biological Process
Response to muscle stretch
Biological Process
Response to progesterone
Biological Process
Response to toxic substance
Biological Process
Skeletal muscle cell differentiation
Biological Process
Sleep
Biological Process
SMAD protein signal transduction
Biological Process
Transcription by RNA polymerase II
Biological Process
Transforming growth factor beta receptor signaling pathway

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-3643Gorilla gorilla99.740.0 625
LLPS-Pap-2931Pan paniscus99.740.0 625
LLPS-Pat-2450Pan troglodytes99.740.0 625
LLPS-Poa-2945Pongo abelii99.470.0 623
LLPS-Nol-2640Nomascus leucogenys98.950.0 619
LLPS-Paa-1375Papio anubis98.420.0 616
LLPS-Mam-2714Macaca mulatta98.420.0 616
LLPS-Rhb-0186Rhinopithecus bieti98.420.0 616
LLPS-Man-3343Macaca nemestrina98.420.0 616
LLPS-Mal-0289Mandrillus leucophaeus98.160.0 615
LLPS-Cea-3133Cercocebus atys98.160.0 614
LLPS-Chs-1154Chlorocebus sabaeus98.160.0 614
LLPS-Maf-1810Macaca fascicularis98.160.0 614
LLPS-Aim-3363Ailuropoda melanoleuca97.370.0 611
LLPS-Mup-0411Mustela putorius furo97.110.0 607
LLPS-Aon-2661Aotus nancymaae97.110.0 609
LLPS-Caf-0412Canis familiaris97.110.0 608
LLPS-Urm-2253Ursus maritimus97.110.0 609
LLPS-Eqc-1824Equus caballus97.018e-179 509
LLPS-Sus-1444Sus scrofa96.840.0 607
LLPS-Bot-2734Bos taurus96.320.0 607
LLPS-Ict-1679Ictidomys tridecemlineatus96.320.0 603
LLPS-Dio-1787Dipodomys ordii96.050.0 603
LLPS-Cap-2035Cavia porcellus95.790.0 598
LLPS-Otg-2794Otolemur garnettii95.790.0 601
LLPS-Mea-4066Mesocricetus auratus95.010.0 594
LLPS-Ova-0747Ovis aries95.00.0 592
LLPS-Fud-2704Fukomys damarensis95.00.0 599
LLPS-Tut-2162Tursiops truncatus94.470.0 566
LLPS-Ran-3323Rattus norvegicus94.210.0 593
LLPS-Orc-0816Oryctolagus cuniculus93.950.0 589
LLPS-Myl-0692Myotis lucifugus93.680.0 587
LLPS-Mum-2378Mus musculus93.680.0 590
LLPS-Cas-0707Carlito syrichta92.110.0 548
LLPS-Sah-2986Sarcophilus harrisii88.980.0 543
LLPS-Mod-3289Monodelphis domestica88.980.0 548
LLPS-Caj-2986Callithrix jacchus88.680.0 550
LLPS-Fec-0251Felis catus87.680.0 586
LLPS-Ora-1890Ornithorhynchus anatinus86.223e-166 476
LLPS-Ere-0335Erinaceus europaeus84.21e-176 504
LLPS-Pes-0568Pelodiscus sinensis77.462e-153 445
LLPS-Gaga-0219Gallus gallus74.816e-131 387
LLPS-Fia-1984Ficedula albicollis72.994e-128 380
LLPS-Tag-0958Taeniopygia guttata72.923e-129 383
LLPS-Anp-2704Anas platyrhynchos65.51e-69 226
LLPS-Xet-0821Xenopus tropicalis65.084e-105 321
LLPS-Anc-0139Anolis carolinensis65.023e-115 348
LLPS-Lac-1596Latimeria chalumnae64.159e-121 362
LLPS-Cis-2040Ciona savignyi62.646e-1683.2
LLPS-Leo-1428Lepisosteus oculatus61.312e-100 310
LLPS-Scf-0295Scleropages formosus59.641e-97 302
LLPS-Xim-3079Xiphophorus maculatus57.594e-31 125
LLPS-Tar-2502Takifugu rubripes57.412e-31 127
LLPS-Dar-3186Danio rerio55.831e-29 121
LLPS-Asm-2526Astyanax mexicanus55.716e-75 243
LLPS-Pof-1697Poecilia formosa55.01e-28 117
LLPS-Orn-3257Oreochromis niloticus54.615e-78 252
LLPS-Scm-2212Scophthalmus maximus54.52e-77 250
LLPS-Ten-1039Tetraodon nigroviridis54.212e-77 250
LLPS-Gaa-1969Gasterosteus aculeatus53.071e-37 144
LLPS-Orl-0397Oryzias latipes51.862e-72 237
LLPS-Loa-0541Loxodonta africana50.61e-27 115
LLPS-Meg-3115Meleagris gallopavo50.05e-38 144
LLPS-Icp-1559Ictalurus punctatus47.411e-57 198
LLPS-Cii-1583Ciona intestinalis38.894e-1889.7