LLPS-Hos-2143
DNAJB13

▼ OVERVIEW

Status: Reviewed
Protein Name: DnaJ homolog subfamily B member 13; Testis and spermatogenesis cell-related protein 6; Testis spermatocyte apoptosis-related gene 6 protein; Testis spermatogenesis apoptosis-related gene 3 protein; Testis spermatogenesis apoptosis-related gene 6 protein
Gene Name: DNAJB13, TSARG3, TSARG6
Ensembl Gene: ENSG00000187726.8
Ensembl Protein: ENSP00000439711.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."
N/A26980300

▼ FUNCTION

Plays a role in the formation of the central complex of ciliary and flagellar axonemes.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGQDYYSVLG  ITRNSEDAQI  KQAYRRLALK  HHPLKSNEPS  SAEIFRQIAE  AYDVLSDPMK  60
61    RGIYDKFGEE  GLKGGIPLEF  GSQTPWTTGY  VFHGKPEKVF  HEFFGGNNPF  SEFFDAEGSE  120
121   VDLNFGGLQG  RGVKKQDPQV  ERDLYLSLED  LFFGCTKKIK  ISRRVLNEDG  YSSTIKDKIL  180
181   TIDVKPGWRQ  GTRITFEKEG  DQGPNIIPAD  IIFIVKEKLH  PRFRRENDNL  FFVNPIPLGK  240
241   ALTCCTVEVR  TLDDRLLNIP  INDIIHPKYF  KKVPGEGMPL  PEDPTKKGDL  FIFFDIQFPT  300
301   RLTPQKKQML  RQALLT  316
Nucleotide CDS Sequence (FASTA)
1     ATGGGCCAGG  ATTATTACTC  TGTGCTCGGG  ATCACTCGCA  ATTCAGAGGA  TGCCCAGATC  60
61    AAGCAGGCGT  ACCGCAGACT  CGCCCTTAAG  CACCACCCGT  TGAAGTCAAA  TGAGCCGTCT  120
121   TCAGCAGAGA  TTTTCAGGCA  AATAGCAGAG  GCCTACGACG  TGCTGAGTGA  CCCCATGAAG  180
181   AGAGGCATCT  ACGACAAGTT  TGGAGAAGAG  GGCCTGAAGG  GTGGGATTCC  TTTGGAGTTT  240
241   GGATCCCAGA  CCCCATGGAC  AACTGGTTAC  GTCTTCCATG  GCAAACCTGA  AAAGGTGTTC  300
301   CACGAGTTCT  TTGGTGGAAA  CAACCCCTTC  AGTGAGTTTT  TTGATGCAGA  AGGAAGTGAG  360
361   GTAGATTTGA  ACTTTGGGGG  GCTCCAGGGC  CGAGGGGTCA  AGAAGCAGGA  CCCCCAAGTC  420
421   GAACGGGATC  TCTACCTGTC  CCTGGAGGAC  TTATTCTTTG  GCTGCACCAA  AAAAATTAAG  480
481   ATCTCCAGAA  GGGTGCTGAA  CGAGGATGGG  TACTCCTCCA  CCATCAAGGA  CAAGATCCTG  540
541   ACCATTGATG  TGAAGCCCGG  TTGGAGGCAG  GGCACACGCA  TCACCTTTGA  GAAGGAAGGG  600
601   GACCAGGGCC  CCAACATCAT  CCCAGCAGAC  ATCATTTTCA  TCGTAAAGGA  GAAGCTACAC  660
661   CCTCGCTTCC  GCAGGGAGAA  TGACAACCTC  TTCTTCGTGA  ACCCCATCCC  TCTTGGCAAG  720
721   GCTCTCACCT  GCTGCACTGT  GGAGGTGAGG  ACCCTAGATG  ACCGTCTGCT  CAACATCCCC  780
781   ATCAATGACA  TCATCCACCC  CAAATACTTC  AAGAAGGTGC  CAGGGGAGGG  GATGCCATTG  840
841   CCGGAGGACC  CCACTAAGAA  AGGGGATCTC  TTCATCTTCT  TCGACATCCA  GTTCCCCACC  900
901   CGCCTCACAC  CCCAGAAGAA  GCAGATGCTG  CGCCAGGCAT  TGCTGACATG  A  951

▼ KEYWORD

ID
Family
Alternative splicing
Cell projection
Chaperone
Ciliopathy
Cilium
Cilium biogenesis/degradation
Complete proteome
Disease mutation
Flagellum
Primary ciliary dyskinesia
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axoneme
Cellular Component
Cytosol
Cellular Component
Motile cilium
Cellular Component
Sperm connecting piece
Cellular Component
Sperm flagellum
Molecular Function
Chaperone binding
Molecular Function
Unfolded protein binding
Biological Process
Axonemal central apparatus assembly
Biological Process
Chaperone cofactor-dependent protein refolding

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-1089Pan troglodytes99.370.0 644
LLPS-Pap-2574Pan paniscus99.370.0 640
LLPS-Gog-2389Gorilla gorilla99.050.0 640
LLPS-Maf-3537Macaca fascicularis98.10.0 636
LLPS-Mal-3879Mandrillus leucophaeus97.780.0 634
LLPS-Paa-1598Papio anubis97.470.0 632
LLPS-Rhb-2738Rhinopithecus bieti97.470.0 632
LLPS-Cea-2829Cercocebus atys96.840.0 627
LLPS-Caj-4547Callithrix jacchus95.570.0 624
LLPS-Chs-3300Chlorocebus sabaeus95.420.0 592
LLPS-Mam-4409Macaca mulatta95.420.0 592
LLPS-Aon-1740Aotus nancymaae94.940.0 619
LLPS-Loa-3208Loxodonta africana93.990.0 613
LLPS-Caf-0962Canis familiaris93.670.0 612
LLPS-Aim-4172Ailuropoda melanoleuca93.350.0 610
LLPS-Urm-1583Ursus maritimus93.040.0 609
LLPS-Mup-1581Mustela putorius furo92.410.0 608
LLPS-Fud-0485Fukomys damarensis92.410.0 605
LLPS-Sus-4703Sus scrofa92.410.0 605
LLPS-Mea-2118Mesocricetus auratus92.150.0 557
LLPS-Ova-1419Ovis aries92.090.0 601
LLPS-Bot-2262Bos taurus92.090.0 603
LLPS-Eqc-0284Equus caballus92.090.0 600
LLPS-Ran-4261Rattus norvegicus91.460.0 603
LLPS-Cap-1565Cavia porcellus91.460.0 600
LLPS-Myl-1337Myotis lucifugus90.820.0 595
LLPS-Ict-2635Ictidomys tridecemlineatus90.510.0 593
LLPS-Mum-4231Mus musculus89.870.0 591
LLPS-Cas-3147Carlito syrichta89.290.0 565
LLPS-Otg-1453Otolemur garnettii87.540.0 590
LLPS-Poa-2947Pongo abelii86.710.0 545
LLPS-Man-1567Macaca nemestrina81.960.0 510
LLPS-Dio-0984Dipodomys ordii79.819e-178 501
LLPS-Anc-1043Anolis carolinensis75.950.0 518
LLPS-Sah-4111Sarcophilus harrisii72.244e-159 454
LLPS-Fia-1171Ficedula albicollis70.383e-162 462
LLPS-Gaga-1549Gallus gallus69.32e-160 457
LLPS-Cis-1548Ciona savignyi66.822e-97 294
LLPS-Lac-2164Latimeria chalumnae66.777e-153 439
LLPS-Leo-1145Lepisosteus oculatus66.241e-155 446
LLPS-Cii-1654Ciona intestinalis64.764e-146 421
LLPS-Icp-1926Ictalurus punctatus63.696e-146 421
LLPS-Dar-2987Danio rerio62.031e-146 422
LLPS-Scf-3377Scleropages formosus61.926e-134 390
LLPS-Orn-2566Oreochromis niloticus60.191e-138 402
LLPS-Ten-1672Tetraodon nigroviridis59.815e-134 391
LLPS-Scm-0105Scophthalmus maximus59.743e-133 388
LLPS-Gaa-2577Gasterosteus aculeatus57.788e-128 375
LLPS-Orl-2390Oryzias latipes57.643e-129 379
LLPS-Tar-3326Takifugu rubripes57.412e-123 364
LLPS-Pof-0204Poecilia formosa54.699e-114 340
LLPS-Xim-4137Xiphophorus maculatus53.829e-121 358
LLPS-Meg-1601Meleagris gallopavo52.524e-107 322
LLPS-Asm-2152Astyanax mexicanus51.912e-105 316
LLPS-Fec-1287Felis catus49.119e-95 291
LLPS-Tut-0596Tursiops truncatus48.223e-93 287
LLPS-Pes-1501Pelodiscus sinensis48.21e-98 301
LLPS-Orp-1991Oryza punctata47.344e-89 276
LLPS-Sem-1028Selaginella moellendorffii46.461e-91 282
LLPS-Ora-2125Ornithorhynchus anatinus46.314e-92 285
LLPS-Orni-2410Oryza nivara45.941e-87 272
LLPS-Orr-1110Oryza rufipogon45.941e-87 273
LLPS-Nol-0619Nomascus leucogenys45.834e-95 292
LLPS-Sob-0705Sorghum bicolor45.798e-92 283
LLPS-Ere-0975Erinaceus europaeus45.675e-92 284
LLPS-Brn-2086Brassica napus45.451e-83 262
LLPS-Bro-1191Brassica oleracea45.283e-84 263
LLPS-Sei-1531Setaria italica45.123e-92 285
LLPS-Orc-1676Oryctolagus cuniculus45.12e-93 288
LLPS-Tag-3337Taeniopygia guttata44.973e-94 290
LLPS-Anp-3048Anas platyrhynchos44.975e-92 284
LLPS-Gor-1536Gossypium raimondii44.847e-86 268
LLPS-Mod-0333Monodelphis domestica44.673e-94 291
LLPS-Lep-2345Leersia perrieri44.618e-83 261
LLPS-Orbr-0401Oryza brachyantha44.571e-84 265
LLPS-Arl-1453Arabidopsis lyrata43.931e-82 259
LLPS-Viv-2059Vitis vinifera43.863e-85 267
LLPS-Cus-2370Cucumis sativus43.796e-86 269
LLPS-Ori-0753Oryza indica43.482e-83 262
LLPS-Nia-1933Nicotiana attenuata43.394e-83 261
LLPS-Cae-1834Caenorhabditis elegans43.073e-85 266
LLPS-Met-2627Medicago truncatula42.824e-83 261
LLPS-Amt-2040Amborella trichopoda42.431e-82 260
LLPS-Sot-0638Solanum tuberosum42.069e-84 263
LLPS-Dac-1158Daucus carota42.043e-82 258
LLPS-Phv-1894Phaseolus vulgaris41.913e-82 259
LLPS-Xet-0526Xenopus tropicalis39.542e-83 262