LLPS-Hos-2134
CEP83

▼ OVERVIEW

Status: Reviewed
Protein Name: Centrosomal protein of 83 kDa
Gene Name: CEP83, CCDC41
Ensembl Gene: ENSG00000173588.14
Ensembl Protein: ENSP00000380909.3
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A23530209, 20540739

▼ FUNCTION

Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVVSTFTDMD  TFPNNFPPGG  DSGLTGSQSE  FQKMLIDERL  RCEHHKANYQ  TLKAEHTRLQ  60
61    NEHVKLQNEL  KHLFNEKQTQ  QEKLQLLLEE  LRGELVEKTK  DLEEMKLQIL  TPQKLELLRA  120
121   QIQQELETPM  RERFRNLDEE  VEKYRAVYNK  LRYEHTFLKS  EFEHQKEEYA  RILDEGKIKY  180
181   ESEIARLEED  KEELRNQLLN  VDLTKDSKRV  EQLAREKVYL  CQKLKGLEAE  VAELKAEKEN  240
241   SEAQVENAQR  IQVRQLAEMQ  ATVRSLEAEK  QSANLRAERL  EKELQSSSEQ  NTFLINKLHK  300
301   AEREINTLSS  KVKELKHSNK  LEITDIKLET  ARAKSELERE  RNKIQSELDG  LQSDNEILKA  360
361   AVEHHKVLLV  EKDRELIRKV  QAAKEEGYQK  LVVLQDEKLE  LENRLADLEK  MKVEHDVWRQ  420
421   SEKDQYEEKL  RASQMAEEIT  RKELQSVRLK  LQQQIVTIEN  AEKEKNENSD  LKQQISSLQI  480
481   QVTSLAQSEN  DLLNSNQMLK  EMVERLKQEC  RNFRSQAEKA  QLEAEKTLEE  KQIQWLEEKH  540
541   KLHERITDRE  EKYNQAKEKL  QRAAIAQKKR  KSLHENKLKR  LQEKVEVLEA  KKEELETENQ  600
601   VLNRQNVPFE  DYTRLQKRLK  DIQRRHNEFR  SLILVPNMPP  TASINPVSFQ  SSAMVPSMEL  660
661   PFPPHMQEEQ  HQRELSLLRK  RLEELETTQR  KQLEELGSSG  E  701
Nucleotide CDS Sequence (FASTA)
1     ATGGTTGTCA  GCACATTTAC  CGATATGGAC  ACTTTTCCCA  ATAATTTTCC  TCCTGGTGGA  60
61    GACAGTGGAT  TGACAGGTTC  TCAGTCGGAG  TTCCAGAAAA  TGTTAATTGA  TGAAAGGTTA  120
121   CGATGTGAGC  ATCATAAAGC  TAATTATCAG  ACACTGAAGG  CTGAACACAC  AAGGTTGCAG  180
181   AATGAACATG  TAAAGTTACA  AAATGAACTC  AAGCACCTGT  TTAATGAAAA  GCAAACTCAG  240
241   CAGGAAAAAC  TTCAGCTCCT  GCTTGAAGAA  CTAAGAGGAG  AATTAGTAGA  GAAAACTAAA  300
301   GATTTAGAAG  AAATGAAACT  GCAGATATTA  ACTCCACAAA  AATTGGAATT  GCTAAGAGCC  360
361   CAAATACAAC  AAGAATTAGA  AACTCCAATG  AGAGAACGTT  TTAGGAATCT  AGATGAAGAG  420
421   GTAGAAAAGT  ATAGAGCTGT  ATATAATAAG  CTTCGCTATG  AACATACATT  TCTCAAGTCA  480
481   GAATTTGAAC  ACCAGAAGGA  AGAGTATGCA  CGTATTTTAG  ATGAAGGAAA  AATAAAATAT  540
541   GAATCAGAGA  TTGCAAGACT  GGAGGAAGAT  AAAGAAGAAC  TACGTAACCA  GCTGCTTAAT  600
601   GTTGATCTCA  CAAAAGACAG  CAAACGAGTG  GAACAACTTG  CTCGAGAAAA  AGTCTATTTG  660
661   TGTCAAAAAT  TAAAAGGTTT  AGAGGCTGAA  GTAGCGGAAT  TAAAGGCTGA  AAAGGAGAAT  720
721   TCTGAGGCTC  AGGTGGAAAA  TGCCCAAAGA  ATACAGGTGC  GGCAGTTGGC  TGAGATGCAG  780
781   GCTACAGTCA  GATCCCTGGA  GGCTGAAAAA  CAATCAGCTA  ATTTACGGGC  AGAACGTTTG  840
841   GAAAAAGAGC  TACAATCAAG  CAGTGAACAA  AATACCTTTT  TAATTAATAA  ATTGCATAAA  900
901   GCTGAACGAG  AAATAAATAC  ATTGTCCAGT  AAAGTAAAAG  AACTTAAACA  TTCAAACAAA  960
961   CTGGAAATAA  CAGACATCAA  ACTGGAGACA  GCAAGAGCTA  AGAGTGAGCT  AGAAAGAGAA  1020
1021  AGGAATAAGA  TTCAAAGTGA  ACTGGATGGA  TTACAGTCAG  ACAATGAAAT  TCTCAAAGCA  1080
1081  GCTGTTGAAC  ATCACAAAGT  GCTCTTAGTA  GAAAAGGATC  GTGAATTAAT  ACGTAAAGTA  1140
1141  CAAGCTGCCA  AAGAAGAAGG  TTATCAAAAA  CTTGTGGTAT  TACAAGATGA  AAAGTTAGAA  1200
1201  CTCGAGAACA  GATTAGCAGA  TTTGGAGAAA  ATGAAAGTGG  AACATGATGT  CTGGAGGCAA  1260
1261  TCTGAAAAGG  ATCAGTATGA  AGAGAAATTG  CGGGCTTCAC  AGATGGCAGA  AGAGATCACC  1320
1321  AGGAAGGAGC  TTCAGAGTGT  TAGGTTAAAA  CTTCAGCAAC  AAATTGTGAC  TATTGAAAAT  1380
1381  GCAGAGAAGG  AAAAAAATGA  AAATTCTGAC  CTAAAACAGC  AAATCAGTAG  TTTGCAGATC  1440
1441  CAAGTGACTT  CACTTGCACA  GTCAGAGAAT  GACTTGCTGA  ATTCAAACCA  AATGCTGAAG  1500
1501  GAAATGGTGG  AGAGATTAAA  ACAAGAATGC  CGAAATTTTA  GAAGCCAAGC  TGAAAAAGCG  1560
1561  CAACTAGAAG  CTGAAAAGAC  ATTGGAAGAG  AAACAGATAC  AGTGGTTGGA  AGAAAAGCAT  1620
1621  AAGCTTCATG  AGCGTATCAC  AGACAGAGAA  GAAAAGTACA  ATCAAGCTAA  GGAGAAACTG  1680
1681  CAGCGAGCTG  CAATTGCCCA  GAAAAAGAGA  AAATCTCTTC  ATGAAAACAA  ATTGAAAAGA  1740
1741  CTACAAGAGA  AAGTAGAAGT  CTTGGAGGCA  AAGAAAGAAG  AATTGGAAAC  AGAAAATCAG  1800
1801  GTCTTAAATA  GACAAAATGT  TCCTTTTGAA  GACTATACAA  GGCTTCAAAA  AAGACTAAAA  1860
1861  GATATACAGA  GAAGACATAA  TGAATTTCGA  AGTCTAATTT  TGGTTCCTAA  CATGCCTCCA  1920
1921  ACAGCATCTA  TCAATCCTGT  TAGCTTTCAG  TCATCAGCCA  TGGTTCCAAG  CATGGAACTA  1980
1981  CCATTTCCTC  CTCATATGCA  GGAGGAACAA  CATCAAAGGG  AACTCTCTCT  ACTTCGCAAA  2040
2041  AGACTAGAAG  AACTGGAAAC  AACACAAAGA  AAACAACTAG  AGGAACTTGG  ATCTTCCGGA  2100
2101  GAATGA  2106

▼ KEYWORD

ID
Family
Alternative splicing
Ciliopathy
Cilium biogenesis/degradation
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Nephronophthisis
Phosphoprotein
Polymorphism
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centriole
Cellular Component
Ciliary transition fiber
Cellular Component
Cytosol
Cellular Component
Golgi apparatus
Biological Process
Ciliary basal body-plasma membrane docking
Biological Process
Cilium assembly
Biological Process
Establishment of centrosome localization
Biological Process
Protein localization to centrosome
Biological Process
Vesicle docking

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-3663Gorilla gorilla99.710.01237
LLPS-Poa-4302Pongo abelii99.430.01233
LLPS-Pap-0838Pan paniscus99.430.01231
LLPS-Pat-4946Pan troglodytes99.290.01229
LLPS-Nol-3887Nomascus leucogenys99.00.01223
LLPS-Chs-2855Chlorocebus sabaeus98.720.01222
LLPS-Mam-3753Macaca mulatta98.430.01221
LLPS-Mal-1351Mandrillus leucophaeus98.430.01220
LLPS-Maf-1403Macaca fascicularis98.430.01221
LLPS-Man-1388Macaca nemestrina98.290.01217
LLPS-Cea-2327Cercocebus atys98.290.01219
LLPS-Paa-2684Papio anubis98.150.01212
LLPS-Caj-0903Callithrix jacchus94.580.01172
LLPS-Aon-2621Aotus nancymaae93.440.01160
LLPS-Eqc-0150Equus caballus90.870.01114
LLPS-Loa-3327Loxodonta africana90.330.01095
LLPS-Aim-3214Ailuropoda melanoleuca89.50.01069
LLPS-Caf-4121Canis familiaris89.440.01090
LLPS-Ict-4682Ictidomys tridecemlineatus89.180.01072
LLPS-Urm-3412Ursus maritimus88.730.01082
LLPS-Fec-1220Felis catus88.450.01080
LLPS-Ova-3545Ovis aries87.730.01066
LLPS-Rhb-3935Rhinopithecus bieti87.590.01039
LLPS-Bot-3136Bos taurus87.160.01053
LLPS-Mup-4180Mustela putorius furo87.160.01060
LLPS-Sus-2931Sus scrofa87.020.01066
LLPS-Otg-4431Otolemur garnettii86.760.01045
LLPS-Myl-2814Myotis lucifugus86.290.01028
LLPS-Cas-3631Carlito syrichta85.940.0 872
LLPS-Orc-3739Oryctolagus cuniculus85.880.01043
LLPS-Ran-2354Rattus norvegicus85.710.01019
LLPS-Fud-0784Fukomys damarensis85.450.01048
LLPS-Dio-2549Dipodomys ordii84.560.01023
LLPS-Cap-2037Cavia porcellus84.270.01007
LLPS-Mea-4512Mesocricetus auratus84.270.0 988
LLPS-Mum-4406Mus musculus83.980.0 998
LLPS-Mod-4288Monodelphis domestica80.030.0 980
LLPS-Ora-0348Ornithorhynchus anatinus78.060.0 937
LLPS-Pes-3320Pelodiscus sinensis75.220.0 868
LLPS-Sah-0527Sarcophilus harrisii74.470.0 890
LLPS-Anp-1981Anas platyrhynchos70.320.0 813
LLPS-Anc-2723Anolis carolinensis68.920.0 790
LLPS-Fia-3663Ficedula albicollis67.830.0 646
LLPS-Gaga-3433Gallus gallus66.670.0 751
LLPS-Meg-3279Meleagris gallopavo66.050.0 739
LLPS-Tag-1039Taeniopygia guttata65.80.0 771
LLPS-Leo-3615Lepisosteus oculatus63.920.0 626
LLPS-Xet-3021Xenopus tropicalis63.70.0 697
LLPS-Lac-3079Latimeria chalumnae61.10.0 615
LLPS-Dar-2536Danio rerio55.950.0 603
LLPS-Asm-3844Astyanax mexicanus54.580.0 590
LLPS-Scf-3732Scleropages formosus54.390.0 599
LLPS-Gaa-2168Gasterosteus aculeatus53.950.0 558
LLPS-Orn-3713Oreochromis niloticus53.030.0 580
LLPS-Orl-2053Oryzias latipes51.955e-165 499
LLPS-Scm-2859Scophthalmus maximus51.20.0 542
LLPS-Icp-3890Ictalurus punctatus50.452e-173 521
LLPS-Xim-0433Xiphophorus maculatus50.165e-170 512
LLPS-Pof-2538Poecilia formosa49.854e-178 533
LLPS-Tar-3746Takifugu rubripes43.455e-61 214
LLPS-Ten-3016Tetraodon nigroviridis39.581e-90 303
LLPS-Cis-1830Ciona savignyi38.061e-48 179
LLPS-Cii-1551Ciona intestinalis32.829e-70 247