LLPS-Hos-2132
CENPJ
▼ PROPERTY
▼ Classification
▼ FUNCTION
| Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000418179.1 | ENSP00000399334.1 |
| Ensembl | ENST00000381884.8 | ENSP00000371308.4 |
| Ensembl | ENST00000616936.4 | ENSP00000477511.1 |
| Ensembl | ENST00000545981.5 | ENSP00000441090.2 |
| UniProt | Q9HC77, CENPJ_HUMAN, Q2KHM6, Q5JPD5, Q5T6R5, Q96KS5, Q9C067 | |
| GeneBank | AF139625, AL354798, BC113664, CH471075, BC113110, AL833182, AJ303006, BC024209, AF141337, BC113662 | AAH24209.3, EAX08354.1, CAI46195.1, AAI13663.1, AAG49440.1, AAI13665.1, AAI13111.1, AAG21074.1, CAC80028.1 |
| RefSeq | NM_018451.4 | NP_060921.3 |
| Entrez | 55835 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MFLMPTSSEL NSGQNFLTQW MTNPSRAGVI LNRGFPILEA DKEKRAAVDI STSFPIKGTH 60 61 FSDSFSFINE EDSLLEEQKL ESNNPYKPQS DKSETHTAFP CIKKGPQVAA CHSAPGHQEE 120 121 NKNDFIPDLA SEFKEGAYKD PLFKKLEQLK EVQQKKQEQL KRQQLEQLQR LMEEQEKLLT 180 181 MVSGQCTLPG LSLLPDDQSQ KHRSPGNTTT GERATCCFPS YVYPDPTQEE TYPSNILSHE 240 241 QSNFCRTAHG DFVLTSKRAS PNLFSEAQYQ EAPVEKNNLK EENRNHPTGE SILCWEKVTE 300 301 QIQEANDKNL QKHDDSSEVA NIEERPIKAA IGERKQTFED YLEEQIQLEE QELKQKQLKE 360 361 AEGPLPIKAK PKQPFLKRGE GLARFTNAKS KFQKGKESKL VTNQSTSEDQ PLFKMDRQQL 420 421 QRKTALKNKE LCADNPILKK DSKARTKSGS VTLSQKPKML KCSNRKSLSP SGLKIQTGKK 480 481 CDGQFRDQIK FENKVTSNNK ENVTECPKPC DTGCTGWNKT QGKDRLPLST GPASRLAAKS 540 541 PIRETMKESE SSLDVSLQKK LETWEREKEK ENLELDEFLF LEQAADEISF SSNSSFVLKI 600 601 LERDQQICKG HRMSSTPVKA VPQKTNPADP ISHCNRSEDL DHTAREKESE CEVAPKQLHS 660 661 LSSADELREQ PCKIRKAVQK STSENQTEWN ARDDEGVPNS DSSTDSEEQL DVTIKPSTED 720 721 RERGISSRED SPQVCDDKGP FKDTRTQEDK RRDVDLDLSD KDYSSDESIM ESIKHKVSEP 780 781 SRSSSLSLSK MDFDDERTWT DLEENLCNHD VVLGNESTYG TPQTCYPNNE IGILDKTIKR 840 841 KIAPVKRGED LSKSRRSRSP PTSELMMKFF PSLKPKPKSD SHLGNELKLN ISQDQPPGDN 900 901 ARSQVLREKI IELETEIEKF KAENASLAKL RIERESALEK LRKEIADFEQ QKAKELARIE 960 961 EFKKEEMRKL QKERKVFEKY TTAARTFPDK KEREEIQTLK QQIADLREDL KRKETKWSST 1020 1021 HSRLRSQIQM LVRENTDLRE EIKVMERFRL DAWKRAEAIE SSLEVEKKDK LANTSVRFQN 1080 1081 SQISSGTQVE KYKKNYLPMQ GNPPRRSKSA PPRDLGNLDK GQAASPREPL EPLNFPDPEY 1140 1141 KEEEEDQDIQ GEISHPDGKV EKVYKNGCRV ILFPNGTRKE VSADGKTITV TFFNGDVKQV 1200 1201 MPDQRVIYYY AAAQTTHTTY PEGLEVLHFS SGQIEKHYPD GRKEITFPDQ TVKNLFPDGQ 1260 1261 EESIFPDGTI VRVQRDGNKL IEFNNGQREL HTAQFKRREY PDGTVKTVYA NGHQETKYRS 1320 1321 GRIRVKDKEG NVLMDTEL 1338 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTTCCTGA TGCCAACCTC TTCAGAGTTA AACAGTGGGC AGAACTTCCT AACCCAGTGG 60 61 ATGACCAATC CTTCTCGGGC TGGGGTCATA TTAAATCGTG GATTTCCTAT TTTGGAAGCA 120 121 GACAAAGAGA AGCGAGCAGC TGTGGACATT TCTACCAGCT TTCCTATTAA AGGCACACAT 180 181 TTTTCTGATA GCTTCAGCTT TATAAATGAA GAAGATTCAC TTCTTGAAGA ACAGAAGTTG 240 241 GAGTCAAACA ACCCTTACAA ACCACAGTCA GATAAATCTG AAACCCATAC AGCCTTTCCT 300 301 TGCATTAAAA AGGGACCACA GGTAGCGGCA TGTCACAGTG CTCCTGGACA CCAGGAAGAA 360 361 AACAAAAATG ACTTCATCCC AGATCTTGCG AGTGAATTCA AAGAAGGGGC TTATAAAGAC 420 421 CCACTTTTTA AAAAACTTGA ACAGCTGAAA GAAGTACAAC AGAAGAAGCA GGAACAATTG 480 481 AAGAGGCAAC AGTTGGAGCA ACTACAGAGA CTCATGGAAG AACAAGAGAA GCTGCTCACC 540 541 ATGGTGTCTG GGCAGTGCAC ACTTCCAGGT TTGAGTTTAC TGCCTGATGA TCAGAGCCAG 600 601 AAGCACAGGT CTCCAGGAAA TACCACCACT GGAGAGAGAG CCACATGCTG CTTCCCATCA 660 661 TATGTCTACC CGGACCCAAC CCAGGAAGAA ACATACCCGT CCAACATTTT ATCCCATGAG 720 721 CAAAGCAACT TCTGTAGAAC TGCTCATGGA GATTTTGTCT TAACTTCAAA ACGTGCGTCT 780 781 CCTAATTTAT TTTCTGAGGC ACAGTATCAA GAAGCACCTG TGGAAAAAAA TAATTTAAAA 840 841 GAAGAAAACC GTAACCATCC TACAGGAGAA AGTATCTTAT GTTGGGAGAA AGTGACAGAA 900 901 CAGATTCAGG AAGCAAATGA TAAGAACTTA CAAAAACATG ATGATTCCTC AGAAGTGGCT 960 961 AATATTGAAG AAAGGCCCAT TAAAGCTGCT ATTGGAGAAA GGAAACAGAC CTTTGAAGAT 1020 1021 TACTTAGAAG AACAAATTCA GTTGGAAGAG CAAGAACTGA AGCAAAAACA GCTGAAGGAA 1080 1081 GCAGAAGGAC CATTGCCAAT CAAAGCAAAA CCAAAACAAC CATTTTTAAA ACGAGGAGAA 1140 1141 GGTTTAGCTA GATTTACTAA TGCCAAATCT AAGTTTCAAA AAGGCAAAGA AAGTAAACTA 1200 1201 GTGACTAACC AGAGCACTTC CGAGGACCAG CCGCTGTTTA AAATGGATAG ACAGCAACTC 1260 1261 CAGCGGAAAA CCGCTCTTAA AAATAAAGAG CTGTGTGCAG ACAACCCTAT CCTTAAAAAG 1320 1321 GACAGTAAAG CTAGAACCAA GAGTGGTTCT GTCACCCTCA GTCAGAAGCC GAAAATGCTG 1380 1381 AAGTGTAGTA ACAGGAAAAG TCTTTCTCCG TCAGGATTGA AAATACAGAC GGGGAAGAAA 1440 1441 TGTGATGGGC AGTTTAGAGA CCAGATCAAA TTTGAAAACA AAGTCACATC TAATAATAAA 1500 1501 GAAAATGTAA CTGAGTGTCC AAAACCTTGC GATACTGGCT GCACAGGGTG GAATAAGACA 1560 1561 CAAGGTAAAG ACAGACTTCC TCTTTCAACA GGGCCGGCCA GCCGGCTGGC TGCTAAGAGC 1620 1621 CCCATAAGGG AGACCATGAA AGAGTCTGAA TCTTCTCTTG ACGTTTCTCT TCAGAAAAAG 1680 1681 TTAGAGACTT GGGAACGAGA AAAGGAAAAG GAAAATTTGG AATTAGATGA ATTTTTGTTT 1740 1741 TTAGAACAAG CTGCTGATGA AATATCATTT TCTAGTAATT CCTCATTTGT ACTGAAAATC 1800 1801 TTAGAAAGGG ATCAACAGAT CTGCAAAGGT CACCGGATGT CTTCCACCCC TGTCAAAGCT 1860 1861 GTGCCACAGA AGACAAATCC GGCAGATCCC ATTAGTCATT GTAACCGCAG TGAGGATTTG 1920 1921 GACCACACTG CACGTGAGAA GGAGAGTGAG TGTGAAGTCG CACCCAAACA ACTTCATTCA 1980 1981 TTGTCCTCAG CTGATGAATT GAGGGAACAG CCTTGTAAAA TCAGGAAAGC CGTCCAAAAG 2040 2041 AGCACTTCTG AAAATCAGAC TGAATGGAAT GCACGTGACG ATGAAGGTGT TCCAAATAGT 2100 2101 GACAGTAGCA CTGACTCTGA GGAACAGCTT GATGTTACCA TAAAACCATC GACTGAGGAT 2160 2161 AGAGAGAGGG GCATCAGCAG CAGAGAGGAT AGCCCACAAG TCTGTGATGA TAAGGGGCCT 2220 2221 TTTAAGGACA CCAGGACCCA AGAAGATAAA AGGAGAGATG TTGATCTGGA TTTGTCTGAT 2280 2281 AAAGATTACA GTAGCGATGA GTCTATCATG GAAAGCATAA AACATAAAGT GTCTGAGCCC 2340 2341 TCGAGATCCT CATCCCTAAG TCTGAGTAAA ATGGACTTTG ATGATGAAAG AACTTGGACT 2400 2401 GACCTTGAAG AGAATTTGTG TAACCATGAT GTTGTTCTTG GGAATGAATC CACTTATGGG 2460 2461 ACGCCGCAGA CATGCTACCC TAATAATGAA ATAGGTATCC TGGACAAAAC AATAAAAAGG 2520 2521 AAGATTGCAC CAGTCAAGAG GGGAGAAGAC TTGAGCAAGT CCAGGAGGAG CAGAAGTCCT 2580 2581 CCTACATCGG AGCTGATGAT GAAATTCTTT CCTTCTTTGA AACCAAAACC AAAGTCAGAT 2640 2641 TCACACTTGG GAAATGAACT CAAGTTAAAC ATAAGTCAAG ACCAACCACC TGGTGACAAT 2700 2701 GCTCGATCCC AGGTTTTGAG AGAGAAAATT ATTGAATTGG AAACAGAAAT AGAAAAGTTT 2760 2761 AAAGCTGAGA ACGCATCTTT AGCTAAACTT CGCATTGAAC GAGAAAGTGC CTTGGAAAAA 2820 2821 CTCAGGAAAG AAATTGCAGA CTTCGAACAA CAGAAAGCAA AAGAATTAGC TCGAATAGAA 2880 2881 GAGTTTAAAA AGGAGGAGAT GAGGAAGCTA CAAAAGGAAC GTAAAGTTTT TGAAAAGTAT 2940 2941 ACTACAGCTG CAAGAACTTT TCCAGATAAA AAGGAACGTG AAGAAATACA GACTTTAAAA 3000 3001 CAGCAAATAG CAGATTTACG GGAAGATTTG AAAAGAAAGG AAACCAAATG GTCAAGTACA 3060 3061 CACAGCCGTC TCAGAAGCCA GATACAAATG TTAGTCAGAG AGAACACAGA CCTCCGGGAA 3120 3121 GAAATAAAAG TGATGGAAAG ATTCCGACTG GATGCCTGGA AGAGAGCAGA AGCCATAGAG 3180 3181 AGCAGCCTCG AGGTGGAGAA GAAGGACAAG CTTGCGAACA CATCTGTTCG ATTTCAAAAC 3240 3241 AGTCAGATTT CTTCAGGAAC CCAGGTAGAA AAATACAAGA AAAATTATCT TCCAATGCAA 3300 3301 GGCAATCCAC CTCGAAGATC CAAGTCTGCA CCTCCTCGTG ATTTAGGCAA TTTGGATAAG 3360 3361 GGACAAGCTG CCTCTCCCAG GGAGCCACTT GAACCACTGA ACTTCCCAGA TCCTGAATAT 3420 3421 AAAGAGGAGG AGGAAGACCA AGACATACAG GGAGAAATCA GTCATCCTGA TGGAAAGGTG 3480 3481 GAAAAGGTTT ATAAGAATGG GTGCCGTGTT ATACTGTTTC CCAATGGAAC TCGAAAGGAA 3540 3541 GTGAGTGCAG ATGGGAAGAC CATCACTGTC ACTTTCTTTA ATGGTGACGT GAAGCAGGTC 3600 3601 ATGCCAGACC AAAGAGTGAT CTACTACTAT GCAGCTGCCC AGACCACTCA CACGACATAC 3660 3661 CCGGAGGGAC TGGAAGTCTT ACATTTCTCA AGTGGACAAA TAGAAAAACA TTACCCAGAT 3720 3721 GGAAGAAAAG AAATCACGTT TCCTGACCAG ACTGTTAAAA ACTTATTTCC TGATGGACAA 3780 3781 GAAGAAAGCA TTTTCCCAGA TGGTACAATT GTCAGAGTAC AACGTGATGG CAACAAACTC 3840 3841 ATAGAGTTTA ATAATGGCCA AAGAGAACTA CATACTGCCC AGTTCAAGAG ACGGGAATAC 3900 3901 CCAGATGGCA CTGTTAAAAC CGTATATGCA AACGGTCATC AAGAAACGAA GTACAGATCC 3960 3961 GGTCGGATAA GAGTTAAGGA CAAGGAGGGT AATGTGCTAA TGGACACGGA GCTGTGA 4017 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Centriole | |
Cellular Component | Centrosome | |
Cellular Component | Ciliary basal body | |
Cellular Component | Cytosol | |
Cellular Component | Gamma-tubulin small complex | |
Cellular Component | Microtubule | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Cellular Component | Plasma membrane | |
Molecular Function | Identical protein binding | |
Molecular Function | Protein domain specific binding | |
Molecular Function | Protein kinase binding | |
Molecular Function | Transcription corepressor activity | |
Molecular Function | Tubulin binding | |
Biological Process | Cell division | |
Biological Process | Centriole elongation | |
Biological Process | Centriole replication | |
Biological Process | Ciliary basal body-plasma membrane docking | |
Biological Process | G2/M transition of mitotic cell cycle | |
Biological Process | Microtubule nucleation | |
Biological Process | Microtubule polymerization | |
Biological Process | Motile cilium assembly | |
Biological Process | Non-motile cilium assembly | |
Biological Process | Positive regulation of centriole elongation | |
Biological Process | Positive regulation of establishment of protein localization | |
Biological Process | Positive regulation of non-motile cilium assembly | |
Biological Process | Regulation of centriole replication | |
Biological Process | Regulation of G2/M transition of mitotic cell cycle | |
Biological Process | Smoothened signaling pathway |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Structure | ||||
| PDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-2061 | Pan troglodytes | 98.66 | 0.0 | 2332 |
| LLPS-Pap-1922 | Pan paniscus | 98.58 | 0.0 | 2329 |
| LLPS-Gog-2041 | Gorilla gorilla | 98.58 | 0.0 | 2333 |
| LLPS-Aon-4630 | Aotus nancymaae | 95.65 | 4e-77 | 256 |
| LLPS-Nol-2898 | Nomascus leucogenys | 95.23 | 0.0 | 2233 |
| LLPS-Poa-2784 | Pongo abelii | 92.76 | 0.0 | 2151 |
| LLPS-Urm-3070 | Ursus maritimus | 92.03 | 6e-75 | 250 |
| LLPS-Mam-3115 | Macaca mulatta | 91.87 | 0.0 | 2149 |
| LLPS-Rhb-1334 | Rhinopithecus bieti | 91.66 | 0.0 | 2153 |
| LLPS-Cea-2955 | Cercocebus atys | 91.57 | 0.0 | 2139 |
| LLPS-Paa-2112 | Papio anubis | 91.49 | 0.0 | 2135 |
| LLPS-Mal-2935 | Mandrillus leucophaeus | 91.42 | 0.0 | 2145 |
| LLPS-Maf-3481 | Macaca fascicularis | 91.42 | 0.0 | 2137 |
| LLPS-Man-1433 | Macaca nemestrina | 91.34 | 0.0 | 2138 |
| LLPS-Chs-2970 | Chlorocebus sabaeus | 91.34 | 0.0 | 2138 |
| LLPS-Caj-0685 | Callithrix jacchus | 89.86 | 0.0 | 2057 |
| LLPS-Anp-0460 | Anas platyrhynchos | 82.16 | 5e-95 | 308 |
| LLPS-Tag-1277 | Taeniopygia guttata | 81.08 | 1e-93 | 305 |
| LLPS-Otg-0965 | Otolemur garnettii | 79.85 | 0.0 | 1758 |
| LLPS-Lac-3566 | Latimeria chalumnae | 79.21 | 3e-89 | 291 |
| LLPS-Cas-2707 | Carlito syrichta | 79.18 | 0.0 | 1754 |
| LLPS-Fec-1673 | Felis catus | 78.06 | 0.0 | 1773 |
| LLPS-Ict-0560 | Ictidomys tridecemlineatus | 77.22 | 0.0 | 1741 |
| LLPS-Caf-2778 | Canis familiaris | 77.12 | 0.0 | 1781 |
| LLPS-Mup-1619 | Mustela putorius furo | 76.68 | 0.0 | 1727 |
| LLPS-Aim-0810 | Ailuropoda melanoleuca | 76.11 | 0.0 | 1759 |
| LLPS-Eqc-4783 | Equus caballus | 75.83 | 0.0 | 1714 |
| LLPS-Myl-0792 | Myotis lucifugus | 75.44 | 0.0 | 1696 |
| LLPS-Loa-0944 | Loxodonta africana | 74.23 | 0.0 | 1667 |
| LLPS-Orc-1923 | Oryctolagus cuniculus | 73.82 | 0.0 | 1650 |
| LLPS-Dio-0131 | Dipodomys ordii | 73.42 | 0.0 | 1592 |
| LLPS-Fud-1354 | Fukomys damarensis | 72.84 | 0.0 | 1378 |
| LLPS-Ova-0591 | Ovis aries | 72.67 | 0.0 | 1597 |
| LLPS-Mum-3286 | Mus musculus | 72.55 | 0.0 | 1568 |
| LLPS-Bot-2854 | Bos taurus | 72.53 | 0.0 | 1615 |
| LLPS-Pof-3643 | Poecilia formosa | 72.43 | 1e-73 | 273 |
| LLPS-Orn-2426 | Oreochromis niloticus | 72.13 | 2e-74 | 276 |
| LLPS-Mea-1839 | Mesocricetus auratus | 71.39 | 0.0 | 1357 |
| LLPS-Xim-1408 | Xiphophorus maculatus | 71.35 | 3e-73 | 271 |
| LLPS-Cap-1066 | Cavia porcellus | 71.14 | 0.0 | 1564 |
| LLPS-Asm-2690 | Astyanax mexicanus | 71.04 | 1e-72 | 269 |
| LLPS-Scm-2288 | Scophthalmus maximus | 70.33 | 5e-73 | 271 |
| LLPS-Tar-1293 | Takifugu rubripes | 68.85 | 6e-69 | 258 |
| LLPS-Sus-3306 | Sus scrofa | 68.22 | 0.0 | 1489 |
| LLPS-Ran-1000 | Rattus norvegicus | 67.94 | 0.0 | 1469 |
| LLPS-Xet-3153 | Xenopus tropicalis | 66.3 | 2e-72 | 245 |
| LLPS-Mod-0889 | Monodelphis domestica | 61.56 | 0.0 | 1240 |
| LLPS-Sah-1708 | Sarcophilus harrisii | 60.33 | 0.0 | 1189 |
| LLPS-Ora-2352 | Ornithorhynchus anatinus | 56.77 | 2e-28 | 129 |
| LLPS-Anc-1762 | Anolis carolinensis | 55.75 | 2e-163 | 532 |
| LLPS-Pes-3434 | Pelodiscus sinensis | 54.06 | 0.0 | 809 |
| LLPS-Orl-1767 | Oryzias latipes | 49.83 | 5e-126 | 429 |
| LLPS-Gaa-3402 | Gasterosteus aculeatus | 49.09 | 4e-107 | 353 |
| LLPS-Ten-2114 | Tetraodon nigroviridis | 48.57 | 6e-130 | 431 |
| LLPS-Gaga-2100 | Gallus gallus | 48.04 | 0.0 | 713 |
| LLPS-Sem-1648 | Selaginella moellendorffii | 45.78 | 7e-09 | 64.3 |
| LLPS-Icp-2713 | Ictalurus punctatus | 45.66 | 5e-115 | 395 |
| LLPS-Fia-0171 | Ficedula albicollis | 45.65 | 0.0 | 703 |
| LLPS-Drm-0250 | Drosophila melanogaster | 45.21 | 3e-34 | 146 |
| LLPS-Dar-2252 | Danio rerio | 44.91 | 7e-111 | 382 |
| LLPS-Meg-2172 | Meleagris gallopavo | 44.85 | 0.0 | 769 |
| LLPS-Scf-2911 | Scleropages formosus | 41.05 | 2e-133 | 449 |
| LLPS-Leo-1483 | Lepisosteus oculatus | 40.29 | 7e-44 | 175 |
| LLPS-Chr-1690 | Chlamydomonas reinhardtii | 34.31 | 3e-14 | 82.4 |
| LLPS-Cis-0683 | Ciona savignyi | 34.05 | 6e-59 | 215 |
| LLPS-Osl-0824 | Ostreococcus lucimarinus | 29.57 | 5e-17 | 89.0 |