LLPS-Hos-2082
GTF2I
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli." | HeLa cells | 15635413 |
| Nuclear speckle | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000614986.4 | ENSP00000484526.1 |
| Ensembl | ENST00000443166.5 | ENSP00000404240.1 |
| Ensembl | ENST00000621734.4 | ENSP00000482476.1 |
| Ensembl | ENST00000432143.2 | ENSP00000405022.1 |
| Ensembl | ENST00000620879.4 | ENSP00000477837.1 |
| Ensembl | ENST00000573035.5 | ENSP00000460070.1 |
| UniProt | P78347, GTF2I_HUMAN, O14743, O15359, O43546, O43588, O43589, Q75M85, Q75M86, Q75M87, Q75M88, Q86U51, Q9BSZ4 | |
| GeneBank | AF015553, BC070484, AC004883, U77948, AF038967, Y14946, AF038969, BT007450, AF035737, AC083884, CH471200, AF038968, AC005231, BC004472 | AAS07461.1, AAS07462.1, AAH04472.1, AAB70791.1, EAW69598.1, AAS07464.1, AAH70484.1, AAB48826.1, AAS07460.1, AAS07463.1, CAA75163.1, AAP36118.1, AAL93085.1, AAC08313.1, AAC08315.1, AAC08314.1, AAC08312.1 |
| RefSeq | NM_001163636.2, NM_001280800.1, NM_001518.4, NM_032999.3, NM_033000.3, NM_033001.3 | NP_001157108.1, NP_001267729.1, NP_001509.3, NP_127492.1, NP_127493.1, NP_127494.1 |
| Entrez | 2969 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 60 61 RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 120 121 CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 180 181 SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 240 241 EESEDPDYYQ YNIQAGPSET DDVDEKQPLS KPLQGSHHSS EGNEGTEMEV PAEDSTQHVP 300 301 SETSEDPEVE VTIEDDDYSP PSKRPKANEL PQPPVPEPAN AGKRKVREFN FEKWNARITD 360 361 LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE 420 421 RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE 480 481 ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR 540 541 PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF 600 601 ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVI SYLPPGMASK 660 661 INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNNNPQTSA VRTPTQTNGS NVPFKPRGRE 720 721 FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF 780 781 RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG 840 841 VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN 900 901 PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQSESE 960 961 GPVIQESAEP SQLEVPATEE IKETDGSSQI KQEPDPTW 998 |
| Nucleotide CDS Sequence (FASTA) |
1 Sequence u navailable 20 |
▼ KEYWORD
ID | Family |
3D-structure | |
Acetylation | |
Alternative splicing | |
Complete proteome | |
Cytoplasm | |
Direct protein sequencing | |
DNA-binding | |
Isopeptide bond | |
Nucleus | |
Phosphoprotein | |
Polymorphism | |
Reference proteome | |
Repeat | |
Transcription | |
Transcription regulation | |
Ubl conjugation | |
Williams-Beuren syndrome
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Membrane | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity | |
Biological Process | Negative regulation of angiogenesis | |
Biological Process | Negative regulation of cytosolic calcium ion concentration | |
Biological Process | Signal transduction | |
Biological Process | Transcription by RNA polymerase II | |
Biological Process | Transcription initiation from RNA polymerase II promoter |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Cea-0893 | Cercocebus atys | 100.0 | 0.0 | 692 |
| LLPS-Pat-1545 | Pan troglodytes | 100.0 | 0.0 | 2004 |
| LLPS-Pap-0023 | Pan paniscus | 100.0 | 0.0 | 2004 |
| LLPS-Maf-1063 | Macaca fascicularis | 99.8 | 0.0 | 2001 |
| LLPS-Paa-3958 | Papio anubis | 99.8 | 0.0 | 1998 |
| LLPS-Mam-3656 | Macaca mulatta | 99.7 | 0.0 | 1999 |
| LLPS-Mal-2483 | Mandrillus leucophaeus | 99.6 | 0.0 | 1998 |
| LLPS-Caj-3097 | Callithrix jacchus | 99.4 | 0.0 | 1994 |
| LLPS-Chs-3499 | Chlorocebus sabaeus | 98.8 | 0.0 | 1957 |
| LLPS-Eqc-2950 | Equus caballus | 98.45 | 0.0 | 1883 |
| LLPS-Sus-1879 | Sus scrofa | 98.4 | 0.0 | 1951 |
| LLPS-Fec-2079 | Felis catus | 98.4 | 0.0 | 1946 |
| LLPS-Caf-0469 | Canis familiaris | 98.3 | 0.0 | 1946 |
| LLPS-Otg-0190 | Otolemur garnettii | 98.14 | 0.0 | 1883 |
| LLPS-Mea-3532 | Mesocricetus auratus | 98.11 | 4e-90 | 291 |
| LLPS-Fud-3776 | Fukomys damarensis | 98.0 | 0.0 | 1921 |
| LLPS-Aim-2855 | Ailuropoda melanoleuca | 98.0 | 0.0 | 1942 |
| LLPS-Urm-3189 | Ursus maritimus | 97.9 | 0.0 | 1942 |
| LLPS-Myl-1616 | Myotis lucifugus | 97.89 | 0.0 | 1896 |
| LLPS-Ict-0079 | Ictidomys tridecemlineatus | 97.8 | 0.0 | 1940 |
| LLPS-Cas-3405 | Carlito syrichta | 97.8 | 0.0 | 1930 |
| LLPS-Ova-2409 | Ovis aries | 97.7 | 0.0 | 1938 |
| LLPS-Bot-1929 | Bos taurus | 97.6 | 0.0 | 1937 |
| LLPS-Poa-2274 | Pongo abelii | 97.6 | 0.0 | 1920 |
| LLPS-Loa-2035 | Loxodonta africana | 97.3 | 0.0 | 1929 |
| LLPS-Orc-0200 | Oryctolagus cuniculus | 96.89 | 0.0 | 1902 |
| LLPS-Ran-2571 | Rattus norvegicus | 96.7 | 0.0 | 1900 |
| LLPS-Mum-0538 | Mus musculus | 96.6 | 0.0 | 1900 |
| LLPS-Mup-1467 | Mustela putorius furo | 96.3 | 0.0 | 1895 |
| LLPS-Aon-0902 | Aotus nancymaae | 95.59 | 0.0 | 1871 |
| LLPS-Cap-1677 | Cavia porcellus | 95.11 | 0.0 | 1875 |
| LLPS-Dio-4279 | Dipodomys ordii | 95.09 | 0.0 | 1863 |
| LLPS-Nol-3023 | Nomascus leucogenys | 94.19 | 0.0 | 1858 |
| LLPS-Gog-4620 | Gorilla gorilla | 93.17 | 5e-178 | 526 |
| LLPS-Man-0636 | Macaca nemestrina | 92.83 | 1e-177 | 525 |
| LLPS-Mod-3228 | Monodelphis domestica | 91.98 | 0.0 | 1800 |
| LLPS-Rhb-0797 | Rhinopithecus bieti | 87.68 | 0.0 | 1651 |
| LLPS-Ora-3197 | Ornithorhynchus anatinus | 87.57 | 0.0 | 1667 |
| LLPS-Pes-1876 | Pelodiscus sinensis | 82.93 | 0.0 | 1640 |
| LLPS-Anp-2778 | Anas platyrhynchos | 81.63 | 0.0 | 1619 |
| LLPS-Gaga-0093 | Gallus gallus | 80.13 | 2e-72 | 243 |
| LLPS-Meg-0532 | Meleagris gallopavo | 77.57 | 0.0 | 1522 |
| LLPS-Sah-0781 | Sarcophilus harrisii | 74.68 | 0.0 | 1397 |
| LLPS-Lac-2579 | Latimeria chalumnae | 71.81 | 0.0 | 1258 |
| LLPS-Xet-1556 | Xenopus tropicalis | 67.5 | 0.0 | 1306 |
| LLPS-Tag-0786 | Taeniopygia guttata | 63.89 | 0.0 | 1056 |
| LLPS-Fia-0902 | Ficedula albicollis | 61.48 | 0.0 | 1177 |
| LLPS-Anc-2661 | Anolis carolinensis | 57.69 | 7e-21 | 99.4 |
| LLPS-Leo-0456 | Lepisosteus oculatus | 47.48 | 2e-65 | 236 |