LLPS-Hos-1921
SERPINB12

▼ OVERVIEW


Status: Reviewed
Protein Name: Serpin B12
Gene Name: SERPINB12
Ensembl Gene: ENSG00000166634.6
Ensembl Protein: ENSP00000269491.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...Comparing protein relative abundances between the sorted and pre-sorted fractions, we identified 125 proteins as significantly enriched in P-bodies."
HEK293 cells28965817

▼ FUNCTION


Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MDSLVTANTK  FCFDLFQEIG  KDDRHKNIFF  SPLSLSAALG  MVRLGARSDS  AHQIDEVLHF  60
61    NEFSQNESKE  PDPCLKSNKQ  KVLADSSLEG  QKKTTEPLDQ  QAGSLNNESG  LVSCYFGQLL  120
121   SKLDRIKTDY  TLSIANRLYG  EQEFPICQEY  LDGVIQFYHT  TIESVDFQKN  PEKSRQEINF  180
181   WVECQSQGKI  KELFSKDAIN  AETVLVLVNA  VYFKAKWETY  FDHENTVDAP  FCLNANENKS  240
241   VKMMTQKGLY  RIGFIEEVKA  QILEMRYTKG  KLSMFVLLPS  HSKDNLKGLE  ELERKITYEK  300
301   MVAWSSSENM  SEESVVLSFP  RFTLEDSYDL  NSILQDMGIT  DIFDETRADL  TGISPSPNLY  360
361   LSKIIHKTFV  EVDENGTQAA  AATGAVVSER  SLRSWVEFNA  NHPFLFFIRH  NKTQTILFYG  420
421   RVCSP  425
Nucleotide CDS Sequence (FASTA)
1     ATGGACTCTC  TTGTTACAGC  AAACACCAAA  TTTTGCTTTG  ATCTTTTTCA  AGAGATAGGC  60
61    AAAGATGATC  GTCATAAAAA  CATATTTTTC  TCTCCCCTGA  GCCTCTCAGC  TGCCCTTGGT  120
121   ATGGTACGCT  TGGGTGCTAG  AAGTGACAGT  GCACATCAGA  TTGATGAGGT  ACTACACTTC  180
181   AACGAATTTT  CCCAGAATGA  AAGCAAAGAA  CCTGACCCTT  GTCTGAAAAG  CAACAAACAA  240
241   AAAGCTGGGT  CCTTAAACAA  TGAGAGCGGA  CTGGTCAGCT  GCTACTTTGG  GCAGCTTCTC  300
301   TCCAAATTAG  ACAGGATCAA  GACTGATTAC  ACACTGAGTA  TTGCCAACAG  GCTTTATGGA  360
361   GAGCAGGAAT  TCCCAATCTG  TCAGGAATAC  TTAGATGGTG  TGATTCAATT  TTACCACACG  420
421   ACGATTGAAA  GTGTTGATTT  CCAAAAAAAC  CCTGAAAAAT  CCAGACAAGA  GATTAACTTC  480
481   TGGGTTGAAT  GTCAATCCCA  AGGTAAAATC  AAGGAACTCT  TCAGCAAGGA  CGCTATTAAT  540
541   GCTGAGACTG  TGCTGGTACT  GGTGAATGCT  GTTTACTTCA  AGGCCAAATG  GGAAACATAC  600
601   TTTGACCATG  AAAACACGGT  GGATGCACCT  TTCTGTCTAA  ATGCGAATGA  AAACAAGAGT  660
661   GTGAAGATGA  TGACGCAAAA  AGGCCTCTAC  AGAATTGGCT  TCATAGAGGA  GGTGAAGGCA  720
721   CAGATCCTGG  AAATGAGGTA  CACCAAGGGG  AAGCTCAGCA  TGTTCGTGCT  GCTGCCATCT  780
781   CACTCTAAAG  ATAACCTGAA  GGGTCTGGAA  GAGCTTGAAA  GGAAAATCAC  CTATGAAAAA  840
841   ATGGTGGCCT  GGAGCAGCTC  AGAAAACATG  TCAGAAGAAT  CGGTGGTCCT  GTCCTTCCCC  900
901   CGGTTCACCC  TGGAAGACAG  CTATGATCTC  AATTCCATTT  TACAAGACAT  GGGCATTACG  960
961   GATATCTTTG  ATGAAACGAG  GGCTGATCTT  ACTGGAATCT  CTCCAAGTCC  CAATTTGTAC  1020
1021  TTGTCAAAAA  TTATCCACAA  AACCTTTGTG  GAGGTGGATG  AAAACGGTAC  CCAGGCAGCT  1080
1081  GCAGCCACTG  GGGCTGTTGT  CTCGGAAAGG  TCACTACGAT  CTTGGGTGGA  GTTTAATGCC  1140
1141  AACCACCCTT  TTCTCTTTTT  CATTAGACAC  AACAAAACCC  AAACCATTCT  CTTTTATGGC  1200
1201  AGGGTCTGCT  CTCCTTAA  1218

▼ KEYWORD


ID
Family
Alternative splicing
Complete proteome
Cytoplasm
Polymorphism
Protease inhibitor
Reference proteome
Serine protease inhibitor

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Collagen-containing extracellular matrix
Cellular Component
Cytoplasm
Cellular Component
Extracellular space
Cellular Component
Ficolin-1-rich granule membrane
Cellular Component
Plasma membrane
Molecular Function
Enzyme binding
Molecular Function
Serine-type endopeptidase inhibitor activity
Biological Process
Hematopoietic progenitor cell differentiation
Biological Process
Negative regulation of endopeptidase activity
Biological Process
Negative regulation of protein catabolic process
Biological Process
Neutrophil degranulation

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-2895Pan troglodytes99.530.0 825
LLPS-Pap-4558Pan paniscus99.290.0 822
LLPS-Gog-2062Gorilla gorilla99.290.0 822
LLPS-Poa-2491Pongo abelii97.650.0 810
LLPS-Man-4009Macaca nemestrina95.530.0 790
LLPS-Nol-3821Nomascus leucogenys95.530.0 785
LLPS-Maf-3719Macaca fascicularis95.290.0 787
LLPS-Mam-4259Macaca mulatta95.060.0 783
LLPS-Chs-4468Chlorocebus sabaeus95.060.0 792
LLPS-Cea-4471Cercocebus atys94.820.0 784
LLPS-Mal-4335Mandrillus leucophaeus94.590.0 781
LLPS-Paa-1525Papio anubis94.350.0 780
LLPS-Rhb-2088Rhinopithecus bieti94.120.0 781
LLPS-Aon-2153Aotus nancymaae91.530.0 757
LLPS-Caj-1479Callithrix jacchus90.350.0 747
LLPS-Aim-2490Ailuropoda melanoleuca82.820.0 689
LLPS-Fec-4168Felis catus81.650.0 686
LLPS-Mup-4455Mustela putorius furo81.650.0 682
LLPS-Cas-3219Carlito syrichta80.710.0 671
LLPS-Caf-4049Canis familiaris80.710.0 675
LLPS-Eqc-4093Equus caballus80.470.0 658
LLPS-Urm-1635Ursus maritimus79.760.0 658
LLPS-Bot-1999Bos taurus78.590.0 656
LLPS-Sus-1915Sus scrofa77.880.0 644
LLPS-Dio-3266Dipodomys ordii77.650.0 634
LLPS-Ova-3256Ovis aries76.940.0 636
LLPS-Fud-1813Fukomys damarensis76.240.0 621
LLPS-Cap-1377Cavia porcellus75.290.0 603
LLPS-Otg-1559Otolemur garnettii75.060.0 625
LLPS-Orc-1142Oryctolagus cuniculus75.060.0 625
LLPS-Myl-1464Myotis lucifugus74.590.0 606
LLPS-Ere-0884Erinaceus europaeus73.650.0 620
LLPS-Mea-0969Mesocricetus auratus72.940.0 575
LLPS-Loa-0104Loxodonta africana72.490.0 573
LLPS-Mum-3331Mus musculus71.830.0 591
LLPS-Ran-2540Rattus norvegicus71.530.0 575
LLPS-Mod-1525Monodelphis domestica64.41e-178 513
LLPS-Sah-1296Sarcophilus harrisii64.080.0 519
LLPS-Anp-2282Anas platyrhynchos36.714e-88 280
LLPS-Meg-1666Meleagris gallopavo36.241e-83 268
LLPS-Gaga-0002Gallus gallus36.05e-83 266
LLPS-Fia-2902Ficedula albicollis35.536e-83 266
LLPS-Lac-3902Latimeria chalumnae33.19e-55 193
LLPS-Tut-0438Tursiops truncatus31.843e-54 191
LLPS-Ict-1502Ictidomys tridecemlineatus31.762e-54 192
LLPS-Ora-1964Ornithorhynchus anatinus30.681e-42 159
LLPS-Xet-1170Xenopus tropicalis29.742e-38 148
LLPS-Pes-2851Pelodiscus sinensis29.475e-45 167
LLPS-Orn-0621Oreochromis niloticus29.153e-36 142
LLPS-Pof-1247Poecilia formosa27.939e-39 149
LLPS-Orl-0560Oryzias latipes27.764e-40 154
LLPS-Dar-0926Danio rerio27.462e-43 162
LLPS-Icp-2283Ictalurus punctatus27.469e-42 157
LLPS-Xim-1545Xiphophorus maculatus27.466e-37 144
LLPS-Scm-2114Scophthalmus maximus27.271e-40 155
LLPS-Anc-2941Anolis carolinensis27.192e-42 160
LLPS-Tag-0679Taeniopygia guttata27.121e-42 160
LLPS-Leo-1436Lepisosteus oculatus27.012e-41 157
LLPS-Asm-3246Astyanax mexicanus26.891e-41 157
LLPS-Tar-1956Takifugu rubripes26.829e-42 157
LLPS-Scf-3516Scleropages formosus26.712e-41 157
LLPS-Gaa-1434Gasterosteus aculeatus25.595e-39 150