LLPS-Hos-1921
SERPINB12
▼ OVERVIEW
Status: | Reviewed |
Protein Name: | Serpin B12 |
Gene Name: | SERPINB12 |
Ensembl Gene: | ENSG00000166634.6 |
Ensembl Protein: | ENSP00000269491.1 |
Organism: | Homo sapiens |
Taxa ID: | 9606 |
LLPS Type: | Client |
▼ Classification
Condensates:
Condensate | Description | Tissue/Cell | PMIDs |
---|---|---|---|
P-body | "...Comparing protein relative abundances between the sorted and pre-sorted fractions, we identified 125 proteins as significantly enriched in P-bodies." | HEK293 cells | 28965817 |
▼ FUNCTION
Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENST00000269491.5 | ENSP00000269491.1 |
Ensembl | ENST00000382768.1 | ENSP00000372218.1 |
UniProt | Q96P63, SPB12_HUMAN, Q3SYB4 | |
GeneBank | AC090307, BC103885, AF411191 | AAI03886.1, AAL05571.1 |
RefSeq | NM_001307928.1, NM_080474.2, XM_011526248.1, XM_011526249.1, XM_017026067.1 | NP_001294857.1, NP_536722.1, XP_011524550.1, XP_011524551.1, XP_016881556.1 |
Entrez | 89777 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MDSLVTANTK FCFDLFQEIG KDDRHKNIFF SPLSLSAALG MVRLGARSDS AHQIDEVLHF 60 61 NEFSQNESKE PDPCLKSNKQ KVLADSSLEG QKKTTEPLDQ QAGSLNNESG LVSCYFGQLL 120 121 SKLDRIKTDY TLSIANRLYG EQEFPICQEY LDGVIQFYHT TIESVDFQKN PEKSRQEINF 180 181 WVECQSQGKI KELFSKDAIN AETVLVLVNA VYFKAKWETY FDHENTVDAP FCLNANENKS 240 241 VKMMTQKGLY RIGFIEEVKA QILEMRYTKG KLSMFVLLPS HSKDNLKGLE ELERKITYEK 300 301 MVAWSSSENM SEESVVLSFP RFTLEDSYDL NSILQDMGIT DIFDETRADL TGISPSPNLY 360 361 LSKIIHKTFV EVDENGTQAA AATGAVVSER SLRSWVEFNA NHPFLFFIRH NKTQTILFYG 420 421 RVCSP 425 |
Nucleotide CDS Sequence (FASTA) |
1 ATGGACTCTC TTGTTACAGC AAACACCAAA TTTTGCTTTG ATCTTTTTCA AGAGATAGGC 60 61 AAAGATGATC GTCATAAAAA CATATTTTTC TCTCCCCTGA GCCTCTCAGC TGCCCTTGGT 120 121 ATGGTACGCT TGGGTGCTAG AAGTGACAGT GCACATCAGA TTGATGAGGT ACTACACTTC 180 181 AACGAATTTT CCCAGAATGA AAGCAAAGAA CCTGACCCTT GTCTGAAAAG CAACAAACAA 240 241 AAAGCTGGGT CCTTAAACAA TGAGAGCGGA CTGGTCAGCT GCTACTTTGG GCAGCTTCTC 300 301 TCCAAATTAG ACAGGATCAA GACTGATTAC ACACTGAGTA TTGCCAACAG GCTTTATGGA 360 361 GAGCAGGAAT TCCCAATCTG TCAGGAATAC TTAGATGGTG TGATTCAATT TTACCACACG 420 421 ACGATTGAAA GTGTTGATTT CCAAAAAAAC CCTGAAAAAT CCAGACAAGA GATTAACTTC 480 481 TGGGTTGAAT GTCAATCCCA AGGTAAAATC AAGGAACTCT TCAGCAAGGA CGCTATTAAT 540 541 GCTGAGACTG TGCTGGTACT GGTGAATGCT GTTTACTTCA AGGCCAAATG GGAAACATAC 600 601 TTTGACCATG AAAACACGGT GGATGCACCT TTCTGTCTAA ATGCGAATGA AAACAAGAGT 660 661 GTGAAGATGA TGACGCAAAA AGGCCTCTAC AGAATTGGCT TCATAGAGGA GGTGAAGGCA 720 721 CAGATCCTGG AAATGAGGTA CACCAAGGGG AAGCTCAGCA TGTTCGTGCT GCTGCCATCT 780 781 CACTCTAAAG ATAACCTGAA GGGTCTGGAA GAGCTTGAAA GGAAAATCAC CTATGAAAAA 840 841 ATGGTGGCCT GGAGCAGCTC AGAAAACATG TCAGAAGAAT CGGTGGTCCT GTCCTTCCCC 900 901 CGGTTCACCC TGGAAGACAG CTATGATCTC AATTCCATTT TACAAGACAT GGGCATTACG 960 961 GATATCTTTG ATGAAACGAG GGCTGATCTT ACTGGAATCT CTCCAAGTCC CAATTTGTAC 1020 1021 TTGTCAAAAA TTATCCACAA AACCTTTGTG GAGGTGGATG AAAACGGTAC CCAGGCAGCT 1080 1081 GCAGCCACTG GGGCTGTTGT CTCGGAAAGG TCACTACGAT CTTGGGTGGA GTTTAATGCC 1140 1141 AACCACCCTT TTCTCTTTTT CATTAGACAC AACAAAACCC AAACCATTCT CTTTTATGGC 1200 1201 AGGGTCTGCT CTCCTTAA 1218 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Collagen-containing extracellular matrix | |
Cellular Component | Cytoplasm | |
Cellular Component | Extracellular space | |
Cellular Component | Ficolin-1-rich granule membrane | |
Cellular Component | Plasma membrane | |
Molecular Function | Enzyme binding | |
Molecular Function | Serine-type endopeptidase inhibitor activity | |
Biological Process | Hematopoietic progenitor cell differentiation | |
Biological Process | Negative regulation of endopeptidase activity | |
Biological Process | Negative regulation of protein catabolic process | |
Biological Process | Neutrophil degranulation |
▼ ANNOTATION
Disease | ||||
OMIM | ActiveDriverDB |
Drug | ||||
CTD |
Physicochemical | ||||
Compute pI/Mw | AAindex |
Localization | ||||
COMPARTMENTS |
Methylation | ||||
TCGA | ICGC | MethyCancer |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Pat-2895 | Pan troglodytes | 99.53 | 0.0 | 825 |
LLPS-Pap-4558 | Pan paniscus | 99.29 | 0.0 | 822 |
LLPS-Gog-2062 | Gorilla gorilla | 99.29 | 0.0 | 822 |
LLPS-Poa-2491 | Pongo abelii | 97.65 | 0.0 | 810 |
LLPS-Man-4009 | Macaca nemestrina | 95.53 | 0.0 | 790 |
LLPS-Nol-3821 | Nomascus leucogenys | 95.53 | 0.0 | 785 |
LLPS-Maf-3719 | Macaca fascicularis | 95.29 | 0.0 | 787 |
LLPS-Mam-4259 | Macaca mulatta | 95.06 | 0.0 | 783 |
LLPS-Chs-4468 | Chlorocebus sabaeus | 95.06 | 0.0 | 792 |
LLPS-Cea-4471 | Cercocebus atys | 94.82 | 0.0 | 784 |
LLPS-Mal-4335 | Mandrillus leucophaeus | 94.59 | 0.0 | 781 |
LLPS-Paa-1525 | Papio anubis | 94.35 | 0.0 | 780 |
LLPS-Rhb-2088 | Rhinopithecus bieti | 94.12 | 0.0 | 781 |
LLPS-Aon-2153 | Aotus nancymaae | 91.53 | 0.0 | 757 |
LLPS-Caj-1479 | Callithrix jacchus | 90.35 | 0.0 | 747 |
LLPS-Aim-2490 | Ailuropoda melanoleuca | 82.82 | 0.0 | 689 |
LLPS-Fec-4168 | Felis catus | 81.65 | 0.0 | 686 |
LLPS-Mup-4455 | Mustela putorius furo | 81.65 | 0.0 | 682 |
LLPS-Cas-3219 | Carlito syrichta | 80.71 | 0.0 | 671 |
LLPS-Caf-4049 | Canis familiaris | 80.71 | 0.0 | 675 |
LLPS-Eqc-4093 | Equus caballus | 80.47 | 0.0 | 658 |
LLPS-Urm-1635 | Ursus maritimus | 79.76 | 0.0 | 658 |
LLPS-Bot-1999 | Bos taurus | 78.59 | 0.0 | 656 |
LLPS-Sus-1915 | Sus scrofa | 77.88 | 0.0 | 644 |
LLPS-Dio-3266 | Dipodomys ordii | 77.65 | 0.0 | 634 |
LLPS-Ova-3256 | Ovis aries | 76.94 | 0.0 | 636 |
LLPS-Fud-1813 | Fukomys damarensis | 76.24 | 0.0 | 621 |
LLPS-Cap-1377 | Cavia porcellus | 75.29 | 0.0 | 603 |
LLPS-Otg-1559 | Otolemur garnettii | 75.06 | 0.0 | 625 |
LLPS-Orc-1142 | Oryctolagus cuniculus | 75.06 | 0.0 | 625 |
LLPS-Myl-1464 | Myotis lucifugus | 74.59 | 0.0 | 606 |
LLPS-Ere-0884 | Erinaceus europaeus | 73.65 | 0.0 | 620 |
LLPS-Mea-0969 | Mesocricetus auratus | 72.94 | 0.0 | 575 |
LLPS-Loa-0104 | Loxodonta africana | 72.49 | 0.0 | 573 |
LLPS-Mum-3331 | Mus musculus | 71.83 | 0.0 | 591 |
LLPS-Ran-2540 | Rattus norvegicus | 71.53 | 0.0 | 575 |
LLPS-Mod-1525 | Monodelphis domestica | 64.4 | 1e-178 | 513 |
LLPS-Sah-1296 | Sarcophilus harrisii | 64.08 | 0.0 | 519 |
LLPS-Anp-2282 | Anas platyrhynchos | 36.71 | 4e-88 | 280 |
LLPS-Meg-1666 | Meleagris gallopavo | 36.24 | 1e-83 | 268 |
LLPS-Gaga-0002 | Gallus gallus | 36.0 | 5e-83 | 266 |
LLPS-Fia-2902 | Ficedula albicollis | 35.53 | 6e-83 | 266 |
LLPS-Lac-3902 | Latimeria chalumnae | 33.1 | 9e-55 | 193 |
LLPS-Tut-0438 | Tursiops truncatus | 31.84 | 3e-54 | 191 |
LLPS-Ict-1502 | Ictidomys tridecemlineatus | 31.76 | 2e-54 | 192 |
LLPS-Ora-1964 | Ornithorhynchus anatinus | 30.68 | 1e-42 | 159 |
LLPS-Xet-1170 | Xenopus tropicalis | 29.74 | 2e-38 | 148 |
LLPS-Pes-2851 | Pelodiscus sinensis | 29.47 | 5e-45 | 167 |
LLPS-Orn-0621 | Oreochromis niloticus | 29.15 | 3e-36 | 142 |
LLPS-Pof-1247 | Poecilia formosa | 27.93 | 9e-39 | 149 |
LLPS-Orl-0560 | Oryzias latipes | 27.76 | 4e-40 | 154 |
LLPS-Dar-0926 | Danio rerio | 27.46 | 2e-43 | 162 |
LLPS-Icp-2283 | Ictalurus punctatus | 27.46 | 9e-42 | 157 |
LLPS-Xim-1545 | Xiphophorus maculatus | 27.46 | 6e-37 | 144 |
LLPS-Scm-2114 | Scophthalmus maximus | 27.27 | 1e-40 | 155 |
LLPS-Anc-2941 | Anolis carolinensis | 27.19 | 2e-42 | 160 |
LLPS-Tag-0679 | Taeniopygia guttata | 27.12 | 1e-42 | 160 |
LLPS-Leo-1436 | Lepisosteus oculatus | 27.01 | 2e-41 | 157 |
LLPS-Asm-3246 | Astyanax mexicanus | 26.89 | 1e-41 | 157 |
LLPS-Tar-1956 | Takifugu rubripes | 26.82 | 9e-42 | 157 |
LLPS-Scf-3516 | Scleropages formosus | 26.71 | 2e-41 | 157 |
LLPS-Gaa-1434 | Gasterosteus aculeatus | 25.59 | 5e-39 | 150 |