LLPS-Hos-1844
NVL

▼ OVERVIEW

Status: Reviewed
Protein Name: Nuclear valosin-containing protein-like
Gene Name: NVL, NVL2
Ensembl Gene: ENSG00000143748.17
Ensembl Protein: ENSP00000418380.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 2X8A (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli."
HeLa cells15635413
Nucleolus
"...As a first step in elucidating these mechanisms we have carried out a proteomic analysis to draw up a list of proteins present within nucleoli of HeLa cells. This analysis allowed the identification of 213 different nucleolar proteins."
HeLa cells12429849

▼ FUNCTION

Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKPRPAGFVD  NKLKQRVIQY  LTSNKCGKYV  DIGVLASDLQ  RVYSIDYGRR  KRNAFRIQVE  60
61    KVFSIISSEK  ELKNLTELED  EHLAKRARQG  EEDNEYTESY  SDDDSSMEDY  PDPQSANHMN  120
121   SSLLSLYRKG  NPDSVSNTPE  MEQRETTSST  PRISSKTGSI  PLKTPAKDSE  GGWFIDKTPS  180
181   VKKDSFFLDL  SCEKSNPKKP  ITEIQDSKDS  SLLESDMKRK  GKLKNKGSKR  KKEDLQEVDG  240
241   EIEAVLQKKA  KARGLEFQIS  NVKFEDVGGN  DMTLKEVCKM  LIHMRHPEVY  HHLGVVPPRG  300
301   VLLHGPPGCG  KTLLAHAIAG  ELDLPILKVA  APEIVSGVSG  ESEQKLRELF  EQAVSNAPCI  360
361   IFIDEIDAIT  PKREVASKDM  ERRIVAQLLT  CMDDLNNVAA  TARVLVIGAT  NRPDSLDPAL  420
421   RRAGRFDREI  CLGIPDEASR  ERILQTLCRK  LRLPQAFDFC  HLAHLTPGFV  GADLMALCRE  480
481   AAMCAVNRVL  MKLQEQQKKN  PEMEDLPSKG  VQEERLGTEP  TSETQDELQR  LLGLLRDQDP  540
541   LSEEQMQGLC  IELNDFIVAL  SSVQPSAKRE  GFVTVPNVTW  ADIGALEDIR  EELTMAILAP  600
601   VRNPDQFKAL  GLVTPAGVLL  AGPPGCGKTL  LAKAVANESG  LNFISVKGPE  LLNMYVGESE  660
661   RAVRQVFQRA  KNSAPCVIFF  DEVDALCPRR  SDRETGASVR  VVNQLLTEMD  GLEARQQVFI  720
721   MAATNRPDII  DPAILRPGRL  DKTLFVGLPP  PADRLAILKT  ITKNGTKPPL  DADVNLEAIA  780
781   GDLRCDCYTG  ADLSALVREA  SICALRQEMA  RQKSGNEKGE  LKVSHKHFEE  AFKKVRSSIS  840
841   KKDQIMYERL  QESLSR  856
Nucleotide CDS Sequence (FASTA)
1     ATGAAGCCCA  GACCTGCAGG  GTTCGTGGAT  AATAAACTCA  AGCAGCGAGT  CATCCAGTAC  60
61    CTTACCAGTA  ACAAATGTGG  CAAATATGTG  GACATTGGAG  TCTTAGCGTC  TGATTTACAA  120
121   AGAGTGTACA  GTATAGACTA  TGGTCGAAGA  AAAAGAAATG  CTTTTAGGAT  TCAGGTAGAA  180
181   AAAGTATTTA  GCATAATTAG  TAGTGAGAAG  GAACTTAAGA  ATTTAACAGA  ATTAGAAGAT  240
241   GAACATTTGG  CAAAAAGGGC  AAGACAAGGT  GAAGAGGATA  ATGAGTATAC  TGAAAGCTAT  300
301   TCTGATGATG  ATTCAAGTAT  GGAAGACTAC  CCAGATCCAC  AGTCAGCAAA  TCACATGAAC  360
361   AGTTCCCTGC  TGTCTTTATA  TCGGAAAGGA  AATCCTGATT  CTGTTTCAAA  TACTCCTGAG  420
421   ATGGAGCAAA  GAGAAACCAC  CTCTTCAACA  CCACGGATAA  GTTCCAAAAC  AGGCTCCATT  480
481   CCCTTGAAGA  CCCCTGCCAA  AGATTCTGAA  GGAGGATGGT  TTATTGACAA  AACCCCAAGT  540
541   GTAAAGAAAG  ACAGTTTTTT  CTTGGACCTG  TCATGTGAGA  AAAGTAATCC  TAAGAAGCCA  600
601   ATAACTGAGA  TACAGGATTC  AAAAGATTCT  TCTCTTTTGG  AGAGTGATAT  GAAACGGAAA  660
661   GGCAAGCTAA  AGAATAAAGG  AAGCAAAAGG  AAGAAAGAAG  ATCTTCAGGA  AGTAGATGGA  720
721   GAAATTGAAG  CTGTCCTGCA  AAAGAAAGCT  AAAGCCAGGG  GGTTAGAATT  CCAGATCTCC  780
781   AACGTGAAGT  TTGAAGATGT  GGGAGGCAAT  GATATGACAT  TAAAAGAGGT  CTGCAAGATG  840
841   CTCATACACA  TGCGTCACCC  GGAGGTGTAC  CACCACCTGG  GCGTCGTGCC  CCCTCGTGGA  900
901   GTTCTCCTTC  ATGGACCACC  AGGCTGTGGG  AAGACATTAC  TTGCACATGC  AATTGCTGGG  960
961   GAACTTGACC  TGCCAATTTT  GAAAGTGGCT  GCTCCAGAGA  TTGTGTCTGG  AGTATCCGGA  1020
1021  GAGTCTGAGC  AGAAGCTGAG  AGAACTATTT  GAGCAAGCTG  TGTCAAATGC  ACCATGTATC  1080
1081  ATTTTCATTG  ATGAAATTGA  TGCTATTACC  CCCAAAAGAG  AAGTGGCTTC  AAAAGATATG  1140
1141  GAACGAAGAA  TTGTAGCCCA  ACTCCTAACC  TGCATGGATG  ATCTGAATAA  TGTGGCTGCT  1200
1201  ACAGCCCGGG  TCCTAGTTAT  TGGAGCTACT  AATCGACCAG  ACTCGTTAGA  CCCTGCTTTG  1260
1261  AGACGTGCGG  GAAGGTTCGA  CCGAGAAATA  TGCCTAGGTA  TCCCAGATGA  AGCATCCAGG  1320
1321  GAAAGAATAC  TTCAAACATT  GTGCAGAAAA  CTGAGGCTTC  CTCAAGCTTT  TGATTTCTGT  1380
1381  CACTTAGCAC  ACCTAACTCC  AGGCTTTGTT  GGTGCTGATC  TCATGGCACT  GTGCCGAGAG  1440
1441  GCAGCAATGT  GTGCAGTCAA  TAGAGTCTTA  ATGAAGCTAC  AGGAACAGCA  GAAGAAAAAT  1500
1501  CCTGAAATGG  AAGATTTGCC  ATCTAAAGGA  GTCCAGGAGG  AAAGGCTGGG  AACTGAGCCC  1560
1561  ACTTCTGAAA  CACAGGATGA  ATTACAAAGG  CTGCTGGGGT  TGCTAAGAGA  CCAAGATCCC  1620
1621  CTCTCAGAGG  AGCAGATGCA  AGGACTGTGC  ATTGAACTGA  ATGATTTCAT  TGTTGCTCTA  1680
1681  TCCTCAGTCC  AACCCTCTGC  CAAAAGGGAA  GGCTTTGTCA  CTGTCCCTAA  TGTGACATGG  1740
1741  GCAGATATTG  GTGCCCTGGA  AGACATTAGA  GAGGAGCTCA  CCATGGCAAT  ATTGGCACCA  1800
1801  GTACGCAACC  CAGACCAGTT  CAAAGCTCTT  GGATTGGTGA  CTCCAGCTGG  GGTCCTCCTT  1860
1861  GCTGGTCCTC  CTGGCTGTGG  GAAGACTCTG  CTGGCGAAGG  CTGTTGCAAA  TGAGTCCGGA  1920
1921  CTAAATTTTA  TATCTGTCAA  GGGCCCCGAA  TTACTAAACA  TGTATGTTGG  TGAGAGTGAA  1980
1981  CGTGCTGTGC  GACAAGTTTT  TCAACGAGCC  AAGAACTCAG  CACCCTGTGT  GATATTCTTT  2040
2041  GATGAAGTGG  ATGCTTTATG  TCCTCGAAGA  TCAGACCGAG  AGACAGGGGC  AAGTGTCCGA  2100
2101  GTGGTGAATC  AGCTACTTAC  AGAGATGGAT  GGTCTGGAAG  CACGCCAGCA  GGTTTTTATT  2160
2161  ATGGCAGCCA  CTAACAGGCC  AGATATAATT  GACCCTGCAA  TCCTGCGCCC  GGGCCGCCTG  2220
2221  GACAAAACAC  TGTTTGTGGG  TTTACCGCCC  CCTGCAGATC  GCCTTGCCAT  CTTAAAAACT  2280
2281  ATCACAAAAA  ATGGTACCAA  ACCACCACTG  GATGCAGATG  TAAATTTGGA  AGCAATTGCT  2340
2341  GGTGACCTTC  GCTGTGATTG  CTATACGGGC  GCAGATCTCT  CTGCTTTGGT  ACGAGAAGCT  2400
2401  TCTATCTGTG  CCCTGAGACA  GGAAATGGCA  AGACAGAAGA  GTGGAAATGA  AAAAGGTGAA  2460
2461  CTCAAGGTTA  GTCATAAGCA  TTTTGAAGAA  GCTTTCAAGA  AAGTAAGATC  ATCTATATCA  2520
2521  AAAAAGGATC  AAATCATGTA  TGAACGTTTG  CAGGAGTCCC  TCAGCCGGTG  A  2571

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Alternative splicing
ATP-binding
Complete proteome
Isopeptide bond
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Ribosome biogenesis
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Membrane
Cellular Component
Nucleolus
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Cellular Component
Telomerase holoenzyme complex
Molecular Function
ATP binding
Molecular Function
ATPase activity
Molecular Function
Preribosome binding
Molecular Function
RNA binding
Biological Process
Positive regulation of protein binding
Biological Process
Positive regulation of telomerase activity
Biological Process
Regulation of protein localization to nucleolus
Biological Process
Ribosomal large subunit biogenesis
Biological Process
Ribosome biogenesis
Biological Process
RRNA processing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-0612Pan troglodytes99.770.01623
LLPS-Gog-2761Gorilla gorilla99.420.01618
LLPS-Pap-0736Pan paniscus98.830.01601
LLPS-Maf-0428Macaca fascicularis97.780.01590
LLPS-Nol-0450Nomascus leucogenys97.780.01586
LLPS-Mam-3586Macaca mulatta97.660.01588
LLPS-Cea-3537Cercocebus atys97.620.01558
LLPS-Aon-0528Aotus nancymaae97.550.01597
LLPS-Chs-1458Chlorocebus sabaeus97.550.01585
LLPS-Paa-0140Papio anubis97.550.01587
LLPS-Rhb-1863Rhinopithecus bieti96.260.01559
LLPS-Caj-1463Callithrix jacchus96.030.01576
LLPS-Man-1870Macaca nemestrina95.330.01527
LLPS-Mal-2257Mandrillus leucophaeus94.280.01515
LLPS-Cas-0383Carlito syrichta93.930.01516
LLPS-Poa-1014Pongo abelii92.990.01483
LLPS-Sus-1591Sus scrofa91.760.01494
LLPS-Tut-0408Tursiops truncatus91.590.01500
LLPS-Ict-0533Ictidomys tridecemlineatus91.240.01495
LLPS-Eqc-1812Equus caballus90.190.01473
LLPS-Myl-2642Myotis lucifugus90.00.0 731
LLPS-Ova-3562Ovis aries89.850.01462
LLPS-Otg-0394Otolemur garnettii88.280.01203
LLPS-Bot-0022Bos taurus87.840.01432
LLPS-Orc-0684Oryctolagus cuniculus87.730.01414
LLPS-Mum-0343Mus musculus87.620.01417
LLPS-Loa-1056Loxodonta africana86.450.01407
LLPS-Cap-2641Cavia porcellus86.450.01417
LLPS-Fud-1841Fukomys damarensis86.330.01410
LLPS-Ran-1789Rattus norvegicus85.630.01392
LLPS-Caf-2061Canis familiaris84.050.01387
LLPS-Dio-0986Dipodomys ordii84.010.01328
LLPS-Mup-0752Mustela putorius furo83.970.01357
LLPS-Mea-0888Mesocricetus auratus83.160.01354
LLPS-Urm-0854Ursus maritimus82.090.01322
LLPS-Tag-1218Taeniopygia guttata81.780.0 810
LLPS-Fec-0020Felis catus81.710.01368
LLPS-Aim-3141Ailuropoda melanoleuca81.650.01353
LLPS-Ora-1556Ornithorhynchus anatinus80.660.01045
LLPS-Sah-2022Sarcophilus harrisii73.930.01230
LLPS-Meg-0036Meleagris gallopavo73.310.01199
LLPS-Gaga-0448Gallus gallus72.410.01201
LLPS-Pes-0164Pelodiscus sinensis72.380.01217
LLPS-Mod-0914Monodelphis domestica72.190.01178
LLPS-Anp-0329Anas platyrhynchos71.910.01177
LLPS-Fia-1894Ficedula albicollis71.530.01154
LLPS-Xet-0040Xenopus tropicalis71.230.01147
LLPS-Leo-0494Lepisosteus oculatus70.810.0 776
LLPS-Lac-0989Latimeria chalumnae70.030.01097
LLPS-Anc-1486Anolis carolinensis68.560.01167
LLPS-Scm-1007Scophthalmus maximus63.130.0 972
LLPS-Icp-0037Ictalurus punctatus63.050.01014
LLPS-Asm-1514Astyanax mexicanus62.840.01044
LLPS-Gaa-0171Gasterosteus aculeatus62.260.0 987
LLPS-Dar-0101Danio rerio62.240.01009
LLPS-Scf-0056Scleropages formosus61.490.01014
LLPS-Pof-0837Poecilia formosa60.980.0 969
LLPS-Orn-1478Oreochromis niloticus60.950.0 999
LLPS-Ten-1269Tetraodon nigroviridis60.610.0 941
LLPS-Xim-2471Xiphophorus maculatus60.160.0 961
LLPS-Orl-2512Oryzias latipes59.810.0 935
LLPS-Cii-0812Ciona intestinalis57.380.0 708
LLPS-Cis-0052Ciona savignyi56.740.0 685
LLPS-Tum-0076Tuber melanosporum56.190.0 650
LLPS-Scj-0304Schizosaccharomyces japonicus55.370.0 652
LLPS-Tar-0105Takifugu rubripes55.022e-160 486
LLPS-Scc-0251Schizosaccharomyces cryophilus54.930.0 659
LLPS-Osl-0743Ostreococcus lucimarinus54.640.0 612
LLPS-Gas-0587Galdieria sulphuraria53.450.0 605
LLPS-Scp-0813Schizosaccharomyces pombe53.380.0 638
LLPS-Asn-0125Aspergillus nidulans53.350.0 561
LLPS-Aso-0537Aspergillus oryzae51.830.0 577
LLPS-Asf-0541Aspergillus flavus51.830.0 577
LLPS-Asg-0044Ashbya gossypii51.480.0 613
LLPS-Kop-0225Komagataella pastoris51.470.0 607
LLPS-Crn-0029Cryptococcus neoformans51.410.0 587
LLPS-Asc-0624Aspergillus clavatus50.990.0 570
LLPS-Cae-0835Caenorhabditis elegans50.320.0 605
LLPS-Cym-0390Cyanidioschyzon merolae50.250.0 582
LLPS-Asni-0747Aspergillus niger50.160.0 567
LLPS-Sac-0307Saccharomyces cerevisiae49.840.0 608
LLPS-Asfu-0499Aspergillus fumigatus49.60.0 563
LLPS-Nef-0009Neosartorya fischeri49.280.0 558
LLPS-Yal-0165Yarrowia lipolytica49.070.0 605
LLPS-Mel-0172Melampsora laricipopulina49.040.0 587
LLPS-Php-0246Physcomitrella patens48.50.0 566
LLPS-Blg-0512Blumeria graminis48.410.0 577
LLPS-Put-0402Puccinia triticina48.330.0 575
LLPS-Pug-0563Puccinia graminis48.170.0 573
LLPS-Phn-0282Phaeosphaeria nodorum48.123e-166 508
LLPS-Met-0880Medicago truncatula47.473e-175 534
LLPS-Scs-0393Sclerotinia sclerotiorum47.340.0 580
LLPS-Pyt-0421Pyrenophora teres47.331e-168 514
LLPS-Zyt-0140Zymoseptoria tritici47.313e-160 491
LLPS-Mua-2302Musa acuminata46.991e-175 534
LLPS-Pytr-0557Pyrenophora triticirepentis46.922e-165 506
LLPS-Sem-0219Selaginella moellendorffii46.912e-164 498
LLPS-Dos-0283Dothistroma septosporum46.887e-167 509
LLPS-Lem-0884Leptosphaeria maculans46.792e-168 514
LLPS-Amt-0582Amborella trichopoda46.732e-169 519
LLPS-Thc-0261Theobroma cacao46.712e-175 535
LLPS-Mae-0482Manihot esculenta46.623e-171 525
LLPS-Brr-0712Brassica rapa46.552e-169 520
LLPS-Bro-0470Brassica oleracea46.532e-169 520
LLPS-Viv-0518Vitis vinifera46.462e-174 532
LLPS-Brn-0361Brassica napus46.385e-170 517
LLPS-Glm-0001Glycine max46.312e-170 521
LLPS-Cus-0621Cucumis sativus46.279e-175 533
LLPS-Hea-0084Helianthus annuus45.821e-178 543
LLPS-Phv-2091Phaseolus vulgaris45.825e-169 517
LLPS-Tra-0406Triticum aestivum45.773e-167 513
LLPS-Prp-1253Prunus persica45.561e-168 517
LLPS-Arl-1167Arabidopsis lyrata45.458e-165 505
LLPS-Gor-0406Gossypium raimondii45.061e-170 523
LLPS-Sot-1493Solanum tuberosum44.992e-174 532
LLPS-Nia-0628Nicotiana attenuata44.934e-174 531
LLPS-Sei-0646Setaria italica44.929e-168 513
LLPS-Sob-1181Sorghum bicolor44.924e-171 522
LLPS-Zem-0020Zea mays44.755e-168 514
LLPS-Orgl-1416Oryza glumaepatula44.724e-160 496
LLPS-Pot-1310Populus trichocarpa44.679e-166 509
LLPS-Dac-0768Daucus carota44.577e-158 488
LLPS-Art-2052Arabidopsis thaliana44.55e-157 487
LLPS-Brd-0135Brachypodium distachyon44.461e-165 508
LLPS-Tru-0438Triticum urartu44.468e-158 480
LLPS-Lep-0280Leersia perrieri44.171e-163 503
LLPS-Orb-1799Oryza barthii44.012e-164 500
LLPS-Ori-0346Oryza indica44.016e-163 501
LLPS-Orp-0511Oryza punctata44.012e-163 502
LLPS-Ors-0738Oryza sativa44.011e-162 500
LLPS-Orr-0041Oryza rufipogon44.011e-162 500
LLPS-Org-0548Oryza glaberrima44.014e-163 501
LLPS-Orm-0595Oryza meridionalis43.845e-163 501
LLPS-Sol-0115Solanum lycopersicum43.724e-167 514
LLPS-Orbr-1023Oryza brachyantha43.684e-166 504
LLPS-Hov-1048Hordeum vulgare43.511e-161 499
LLPS-Via-1117Vigna angularis43.481e-156 486
LLPS-Orni-0085Oryza nivara43.392e-160 495
LLPS-Vir-0466Vigna radiata43.323e-155 482