LLPS-Hos-1804
KIFC1

▼ OVERVIEW

Status: Reviewed
Protein Name: Kinesin-like protein KIFC1; Kinesin-like protein 2; Kinesin-related protein HSET
Gene Name: KIFC1, HSET, KNSL2
Ensembl Gene: ENSG00000204197.9
Ensembl Protein: ENSP00000363647.4
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 5WDH (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A7744954, 23895133; 22946058

▼ FUNCTION

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDPQRSPLLE  VKGNIELKRP  LIKAPSQLPL  SGSRLKRRPD  QMEDGLEPEK  KRTRGLGATT  60
61    KITTSHPRVP  SLTTVPQTQG  QTTAQKVSKK  TGPRCSTAIA  TGLKNQKPVP  AVPVQKSGTS  120
121   GVPPMAGGKK  PSKRPAWDLK  GQLCDLNAEL  KRCRERTQTL  DQENQQLQDQ  LRDAQQQVKA  180
181   LGTERTTLEG  HLAKVQAQAE  QGQQELKNLR  ACVLELEERL  STQEGLVQEL  QKKQVELQEE  240
241   RRGLMSQLEE  KERRLQTSEA  ALSSSQAEVA  SLRQETVAQA  ALLTEREERL  HGLEMERRRL  300
301   HNQLQELKGN  IRVFCRVRPV  LPGEPTPPPG  LLLFPSGPGG  PSDPPTRLSL  SRSDERRGTL  360
361   SGAPAPPTRH  DFSFDRVFPP  GSGQDEVFEE  IAMLVQSALD  GYPVCIFAYG  QTGSGKTFTM  420
421   EGGPGGDPQL  EGLIPRALRH  LFSVAQELSG  QGWTYSFVAS  YVEIYNETVR  DLLATGTRKG  480
481   QGGECEIRRA  GPGSEELTVT  NARYVPVSCE  KEVDALLHLA  RQNRAVARTA  QNERSSRSHS  540
541   VFQLQISGEH  SSRGLQCGAP  LSLVDLAGSE  RLDPGLALGP  GERERLRETQ  AINSSLSTLG  600
601   LVIMALSNKE  SHVPYRNSKL  TYLLQNSLGG  SAKMLMFVNI  SPLEENVSES  LNSLRFASKV  660
661   NQCVIGTAQA  NRK  673
Nucleotide CDS Sequence (FASTA)
1     ATGGATCCGC  AGAGGTCCCC  CCTATTGGAA  GTAAAGGGGA  ACATAGAACT  GAAGAGACCT  60
61    CTGATTAAGG  CCCCTTCCCA  GCTGCCTCTC  TCAGGAAGCA  GACTCAAGAG  GAGGCCTGAC  120
121   CAGATGGAAG  ATGGCCTGGA  GCCTGAGAAG  AAACGGACAA  GAGGCCTGGG  TGCAACGACC  180
181   AAAATTACCA  CATCCCACCC  AAGAGTTCCA  TCCCTCACTA  CAGTGCCACA  GACACAAGGC  240
241   CAGACCACAG  GCCCTTCCAG  TCACCCGTTG  CCTTGGCAAT  GTCATCACCA  ACCTTTTTTG  300
301   GTGACAGACC  CAGGGGGCCG  ATCTTGGGGG  CCAGGGCAGA  AGTGGCACCG  ACTTCACCTC  360
361   TGGTGCACCT  CAGCTCAAAA  AGTTTCCAAG  AAGACAGGAC  CCCGGTGTTC  CACAGCTATT  420
421   GCCACAGGGT  TGAAGAACCA  GAAGCCAGTT  CCTGCTGTTC  CTGTCCAGAA  GTCTGGCACA  480
481   TCAGGTGTTC  CTCCCATGGC  AGGAGGGAAG  AAACCCAGCA  AACGTCCAGC  CTGGGACTTA  540
541   AAGGGTCAGT  TATGTGACCT  AAATGCAGAA  CTAAAACGGT  GCCGTGAGAG  GACTCAAACG  600
601   TTGGACCAA  609

▼ KEYWORD

ID
Family
3D-structure
ATP-binding
Cell cycle
Cell division
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Endosome
Microtubule
Mitosis
Motor protein
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Early endosome
Cellular Component
Kinesin complex
Cellular Component
Membrane
Cellular Component
Microtubule
Cellular Component
Microtubule organizing center
Cellular Component
Mitotic spindle
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
ATPase activity
Molecular Function
Microtubule binding
Molecular Function
Microtubule motor activity
Biological Process
Cell division
Biological Process
Microtubule-based movement
Biological Process
Mitotic metaphase plate congression
Biological Process
Mitotic sister chromatid segregation
Biological Process
Mitotic spindle assembly
Biological Process
Spermatogenesis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-1845Gorilla gorilla98.810.01166
LLPS-Pap-0796Pan paniscus98.660.01155
LLPS-Pat-0868Pan troglodytes98.660.01155
LLPS-Paa-1917Papio anubis98.220.01156
LLPS-Man-0029Macaca nemestrina98.180.0 909
LLPS-Maf-2874Macaca fascicularis97.920.01154
LLPS-Chs-1214Chlorocebus sabaeus97.920.01156
LLPS-Mal-2377Mandrillus leucophaeus97.770.01152
LLPS-Poa-0168Pongo abelii97.770.01151
LLPS-Mam-0129Macaca mulatta97.770.01155
LLPS-Cea-1563Cercocebus atys97.620.01146
LLPS-Rhb-0224Rhinopithecus bieti97.470.01148
LLPS-Nol-0600Nomascus leucogenys97.330.01145
LLPS-Caj-2339Callithrix jacchus94.80.01141
LLPS-Aon-0469Aotus nancymaae94.70.01082
LLPS-Eqc-2838Equus caballus89.550.0 995
LLPS-Fec-2743Felis catus89.150.01042
LLPS-Otg-2356Otolemur garnettii88.940.01019
LLPS-Cas-1145Carlito syrichta88.330.01064
LLPS-Myl-0006Myotis lucifugus88.210.01039
LLPS-Urm-1046Ursus maritimus88.110.01034
LLPS-Aim-1862Ailuropoda melanoleuca87.910.01026
LLPS-Caf-0615Canis familiaris87.160.01011
LLPS-Mup-1787Mustela putorius furo86.970.01000
LLPS-Ict-0742Ictidomys tridecemlineatus86.780.01060
LLPS-Orc-1220Oryctolagus cuniculus86.70.01002
LLPS-Bot-1504Bos taurus86.180.01033
LLPS-Ova-0595Ovis aries85.820.01023
LLPS-Sus-3033Sus scrofa85.260.0 996
LLPS-Dio-1945Dipodomys ordii84.70.0 998
LLPS-Cap-2790Cavia porcellus80.980.0 951
LLPS-Mea-1477Mesocricetus auratus80.120.0 929
LLPS-Mum-3911Mus musculus80.00.0 959
LLPS-Ran-0523Rattus norvegicus79.20.0 926
LLPS-Fud-1604Fukomys damarensis78.480.0 844
LLPS-Mod-3422Monodelphis domestica67.610.0 798
LLPS-Sah-1445Sarcophilus harrisii64.390.0 726
LLPS-Xim-2841Xiphophorus maculatus59.219e-116 366
LLPS-Gas-0868Galdieria sulphuraria52.981e-93 315
LLPS-Scj-1114Schizosaccharomyces japonicus50.263e-94 314
LLPS-Pot-0252Populus trichocarpa49.746e-96 320
LLPS-Pes-1444Pelodiscus sinensis49.561e-174 521
LLPS-Lep-0097Leersia perrieri48.581e-97 323
LLPS-Orp-0106Oryza punctata48.582e-96 321
LLPS-Via-1783Vigna angularis48.551e-95 318
LLPS-Org-0108Oryza glaberrima48.326e-97 322
LLPS-Viv-1593Vitis vinifera48.325e-100 331
LLPS-Ast-0354Aspergillus terreus48.327e-91 307
LLPS-Nef-1373Neosartorya fischeri48.321e-90 305
LLPS-Scp-0151Schizosaccharomyces pombe48.232e-81 281
LLPS-Tag-3634Taeniopygia guttata48.174e-94 301
LLPS-Amt-1468Amborella trichopoda48.141e-106 348
LLPS-Php-1604Physcomitrella patens48.129e-107 348
LLPS-Orni-0183Oryza nivara48.121e-99 330
LLPS-Ori-1509Oryza indica48.061e-96 321
LLPS-Cym-0049Cyanidioschyzon merolae48.068e-100 332
LLPS-Ors-0235Oryza sativa48.066e-99 317
LLPS-Art-1296Arabidopsis thaliana47.971e-96 321
LLPS-Dar-0583Danio rerio47.886e-134 414
LLPS-Orb-0921Oryza barthii47.879e-99 328
LLPS-Orr-1023Oryza rufipogon47.878e-99 328
LLPS-Orm-0273Oryza meridionalis47.874e-99 327
LLPS-Orbr-1775Oryza brachyantha47.872e-98 327
LLPS-Sei-0607Setaria italica47.867e-94 314
LLPS-Anc-0352Anolis carolinensis47.837e-159 479
LLPS-Asfu-0422Aspergillus fumigatus47.818e-91 305
LLPS-Asc-0873Aspergillus clavatus47.722e-91 307
LLPS-Tra-0260Triticum aestivum47.682e-97 323
LLPS-Tru-0942Triticum urartu47.682e-98 323
LLPS-Orgl-0682Oryza glumaepatula47.623e-98 327
LLPS-Sob-0227Sorghum bicolor47.593e-93 312
LLPS-Phv-1044Phaseolus vulgaris47.591e-94 316
LLPS-Brn-1695Brassica napus47.532e-99 328
LLPS-Brr-1956Brassica rapa47.531e-99 328
LLPS-Lac-2191Latimeria chalumnae47.515e-150 457
LLPS-Cis-1850Ciona savignyi47.472e-93 301
LLPS-Hov-0552Hordeum vulgare47.421e-97 323
LLPS-Gor-1400Gossypium raimondii47.385e-98 325
LLPS-Mua-1110Musa acuminata47.378e-94 314
LLPS-Blg-1045Blumeria graminis47.283e-93 313
LLPS-Thc-0388Theobroma cacao47.261e-101 335
LLPS-Bro-0460Brassica oleracea47.137e-100 329
LLPS-Met-1476Medicago truncatula47.076e-97 322
LLPS-Nec-0460Neurospora crassa47.039e-94 315
LLPS-Vir-0544Vigna radiata47.022e-95 319
LLPS-Sem-0345Selaginella moellendorffii46.973e-100 332
LLPS-Xet-1941Xenopus tropicalis46.962e-158 478
LLPS-Map-0240Magnaporthe poae46.889e-98 325
LLPS-Mao-0117Magnaporthe oryzae46.84e-92 311
LLPS-Aso-0708Aspergillus oryzae46.757e-92 302
LLPS-Asf-0053Aspergillus flavus46.751e-91 302
LLPS-Cus-2087Cucumis sativus46.722e-96 321
LLPS-Scf-1416Scleropages formosus46.569e-140 430
LLPS-Osl-0314Ostreococcus lucimarinus46.462e-99 317
LLPS-Asni-1158Aspergillus niger46.271e-88 300
LLPS-Asn-0697Aspergillus nidulans46.253e-92 309
LLPS-Hea-1462Helianthus annuus46.226e-96 320
LLPS-Scm-1000Scophthalmus maximus46.118e-142 436
LLPS-Glm-0783Glycine max46.01e-96 321
LLPS-Coc-0676Corchorus capsularis46.07e-101 333
LLPS-Orl-3584Oryzias latipes45.882e-77 272
LLPS-Arl-0618Arabidopsis lyrata45.862e-98 326
LLPS-Gag-0232Gaeumannomyces graminis45.857e-97 323
LLPS-Chr-0630Chlamydomonas reinhardtii45.784e-99 329
LLPS-Usm-0128Ustilago maydis45.773e-94 313
LLPS-Scc-1302Schizosaccharomyces cryophilus45.643e-87 294
LLPS-Nia-0417Nicotiana attenuata45.545e-98 325
LLPS-Brd-0860Brachypodium distachyon45.432e-98 326
LLPS-Cog-1251Colletotrichum gloeosporioides45.356e-92 315
LLPS-Dac-1894Daucus carota45.095e-100 330
LLPS-Pof-3955Poecilia formosa45.092e-79 278
LLPS-Gaa-1251Gasterosteus aculeatus45.022e-136 421
LLPS-Orn-0005Oreochromis niloticus45.015e-133 414
LLPS-Tum-0506Tuber melanosporum44.995e-94 310
LLPS-Sol-0610Solanum lycopersicum44.991e-95 319
LLPS-Sot-0987Solanum tuberosum44.782e-98 327
LLPS-Mae-1983Manihot esculenta44.733e-98 326
LLPS-Fuo-0982Fusarium oxysporum44.412e-74 254
LLPS-Prp-2213Prunus persica44.394e-95 318
LLPS-Spr-1125Sporisorium reilianum44.198e-93 309
LLPS-Tar-0863Takifugu rubripes44.111e-139 429
LLPS-Fuv-0673Fusarium verticillioides44.117e-93 313
LLPS-Coo-1219Colletotrichum orbiculare44.021e-85 298
LLPS-Beb-0436Beauveria bassiana43.881e-91 308
LLPS-Crn-1074Cryptococcus neoformans43.838e-93 311
LLPS-Yal-0678Yarrowia lipolytica43.621e-88 300
LLPS-Ten-1351Tetraodon nigroviridis43.565e-134 415
LLPS-Lem-0405Leptosphaeria maculans43.291e-81 285
LLPS-Phn-0477Phaeosphaeria nodorum43.052e-88 302
LLPS-Chc-0536Chondrus crispus43.014e-72 256
LLPS-Asm-0268Astyanax mexicanus42.896e-81 283
LLPS-Trv-0808Trichoderma virens42.793e-92 311
LLPS-Trr-0848Trichoderma reesei42.596e-88 299
LLPS-Sac-0070Saccharomyces cerevisiae42.564e-85 289
LLPS-Asg-0772Ashbya gossypii42.341e-86 293
LLPS-Icp-0710Ictalurus punctatus42.234e-78 275
LLPS-Meg-0681Meleagris gallopavo42.162e-70 249
LLPS-Pytr-0888Pyrenophora triticirepentis41.913e-87 292
LLPS-Gaga-1139Gallus gallus41.897e-70 249
LLPS-Drm-0076Drosophila melanogaster41.462e-89 300
LLPS-Pyt-0093Pyrenophora teres41.241e-85 292
LLPS-Leo-3214Lepisosteus oculatus41.224e-78 275
LLPS-Cogr-0153Colletotrichum graminicola40.933e-92 316
LLPS-Abg-0504Absidia glauca40.531e-110 356
LLPS-Zyt-0884Zymoseptoria tritici40.353e-70 248
LLPS-Cii-2043Ciona intestinalis38.246e-93 306