LLPS-Hos-1801
CLIC2

▼ OVERVIEW

Status: Reviewed
Protein Name: Chloride intracellular channel protein 2; XAP121
Gene Name: CLIC2
Ensembl Gene: ENSG00000155962.12
Ensembl Protein: ENSP00000358460.2
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 2PER (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."
N/A26980300

▼ FUNCTION

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSGLRPGTQV  DPEIELFVKA  GSDGESIGNC  PFCQRLFMIL  WLKGVKFNVT  TVDMTRKPEE  60
61    LKDLAPGTNP  PFLVYNKELK  TDFIKIEEFL  EQTLAPPRYP  HLSPKYKESF  DVGCNLFAKF  120
121   SAYIKNTQKE  ANKNFEKSLL  KEFKRLDDYL  NTPLLDEIDP  DSAEEPPVSR  RLFLDGDQLT  180
181   LADCSLLPKL  NIIKVAAKKY  RDFDIPAEFS  GVWRYLHNAY  AREEFTHTCP  EDKEIENTYA  240
241   NVAKQKS  247
Nucleotide CDS Sequence (FASTA)
1     ATGTCAGGCC  TGCGGCCCGG  CACTCAAGTG  GACCCTGAGA  TTGAGCTTTT  TGTAAAGGCT  60
61    GGAAGTGATG  GAGAGAGTAT  TGGAAACTGT  CCCTTTTGCC  AACGCCTTTT  CATGATCCTC  120
121   TGGCTTAAAG  GAGTTAAATT  TAATGTGACA  ACTGTTGACA  TGACCAGGTA  CCCTCACCTG  180
181   AGTCCCAAGT  ACAAGGAGTC  TTTTGATGTG  GGCTGTAACC  TCTTTGCCAA  GTTTTCTGCA  240
241   TACATTAAGA  ATACACAAAA  GGAGGCAAAT  AAGAATTTTG  AAAAATCTCT  GCTCAAAGAA  300
301   TTCAAGCGTC  TGGATGACTA  CTTAAACACC  CCACTTCTGG  ATGAAATTGA  TCCAGACAGT  360
361   GCTGAGGAAC  CCCCAGTTTC  CAGAAGACTA  TTCTTGGAT  399

▼ KEYWORD

ID
Family
3D-structure
Chloride
Chloride channel
Complete proteome
Cytoplasm
Disease mutation
Disulfide bond
Ion channel
Ion transport
Membrane
Mental retardation
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chloride channel complex
Cellular Component
Cytoplasm
Cellular Component
Intracellular
Cellular Component
Nucleus
Molecular Function
Chloride channel activity
Molecular Function
Glutathione peroxidase activity
Molecular Function
Voltage-gated ion channel activity
Biological Process
Negative regulation of ryanodine-sensitive calcium-release channel activity
Biological Process
Positive regulation of binding
Biological Process
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process
Signal transduction

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-2714Gorilla gorilla100.00.0 509
LLPS-Pap-2576Pan paniscus100.00.0 509
LLPS-Pat-0928Pan troglodytes100.00.0 509
LLPS-Cea-2177Cercocebus atys99.190.0 504
LLPS-Poa-0796Pongo abelii99.190.0 504
LLPS-Paa-2293Papio anubis98.792e-180 503
LLPS-Mal-1818Mandrillus leucophaeus98.792e-180 503
LLPS-Maf-1785Macaca fascicularis98.792e-180 503
LLPS-Chs-3853Chlorocebus sabaeus98.792e-180 503
LLPS-Man-4322Macaca nemestrina98.792e-180 503
LLPS-Rhb-0298Rhinopithecus bieti98.474e-138 394
LLPS-Caj-4676Callithrix jacchus98.381e-179 501
LLPS-Mam-0855Macaca mulatta98.382e-179 500
LLPS-Caf-4589Canis familiaris97.486e-170 476
LLPS-Urm-3701Ursus maritimus97.486e-170 476
LLPS-Fec-4463Felis catus97.064e-169 474
LLPS-Mup-2129Mustela putorius furo96.223e-167 469
LLPS-Cas-1623Carlito syrichta95.554e-174 487
LLPS-Orc-0641Oryctolagus cuniculus95.186e-159 447
LLPS-Loa-0365Loxodonta africana95.13e-172 482
LLPS-Ict-2486Ictidomys tridecemlineatus94.742e-173 485
LLPS-Tut-0368Tursiops truncatus94.332e-171 480
LLPS-Aim-3383Ailuropoda melanoleuca94.318e-170 476
LLPS-Nol-3949Nomascus leucogenys94.316e-168 471
LLPS-Cap-1762Cavia porcellus94.292e-169 475
LLPS-Ova-1708Ovis aries93.939e-171 478
LLPS-Eqc-1818Equus caballus93.931e-170 478
LLPS-Sus-2671Sus scrofa93.525e-170 476
LLPS-Fud-3472Fukomys damarensis93.477e-168 471
LLPS-Bot-4383Bos taurus93.124e-169 474
LLPS-Ran-1161Rattus norvegicus92.651e-168 473
LLPS-Myl-4239Myotis lucifugus91.841e-165 465
LLPS-Ora-0479Ornithorhynchus anatinus86.643e-158 446
LLPS-Sah-0078Sarcophilus harrisii83.263e-138 395
LLPS-Mod-1796Monodelphis domestica81.631e-143 409
LLPS-Tag-0171Taeniopygia guttata78.79e-132 379
LLPS-Meg-0792Meleagris gallopavo78.483e-138 395
LLPS-Fia-2759Ficedula albicollis78.141e-141 404
LLPS-Gaga-3339Gallus gallus78.064e-138 395
LLPS-Lac-0310Latimeria chalumnae75.922e-136 392
LLPS-Leo-1407Lepisosteus oculatus74.794e-130 375
LLPS-Xim-3251Xiphophorus maculatus72.542e-126 365
LLPS-Pof-2641Poecilia formosa72.362e-124 361
LLPS-Scm-0677Scophthalmus maximus72.172e-118 347
LLPS-Scf-3908Scleropages formosus71.951e-126 366
LLPS-Tar-3053Takifugu rubripes71.132e-121 353
LLPS-Gaa-0195Gasterosteus aculeatus71.022e-124 361
LLPS-Dar-3880Danio rerio70.785e-124 359
LLPS-Orl-1723Oryzias latipes70.491e-121 353
LLPS-Orn-3991Oreochromis niloticus70.082e-121 353
LLPS-Icp-4145Ictalurus punctatus69.24e-117 342
LLPS-Asm-3234Astyanax mexicanus68.983e-118 345
LLPS-Anc-3121Anolis carolinensis67.251e-108 335
LLPS-Xet-0475Xenopus tropicalis66.81e-117 343
LLPS-Anp-0217Anas platyrhynchos66.245e-112 330
LLPS-Pes-2596Pelodiscus sinensis66.081e-108 320
LLPS-Aon-1912Aotus nancymaae66.071e-105 313
LLPS-Mum-3192Mus musculus65.963e-112 330
LLPS-Otg-2266Otolemur garnettii64.969e-109 320
LLPS-Dio-4220Dipodomys ordii64.372e-112 331
LLPS-Ere-0512Erinaceus europaeus64.024e-107 323
LLPS-Ten-1148Tetraodon nigroviridis63.522e-103 307
LLPS-Cis-0835Ciona savignyi51.081e-75 238