LLPS-Hos-1680
ASCC1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Activating signal cointegrator 1 complex subunit 1; ASC-1 complex subunit p50; Trip4 complex subunit p50 |
| Gene Name: | ASCC1, CGI-18 |
| Ensembl Gene: | ENSG00000138303.17 |
| Ensembl Protein: | ENSP00000431573.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body | "...Analysis of correlated patterns between endogenous preys uncovers the spatial organization of RNA regulatory structures and enables the definition of 144 core components of SGs and PBs." | N/A | 29395067 |
| Stress granule | "...Analysis of correlated patterns between endogenous preys uncovers the spatial organization of RNA regulatory structures and enables the definition of 144 core components of SGs and PBs." | N/A | 29395067 |
▼ FUNCTION
| Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. |
▼ CROSS REFERENCE
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEVLRPQLIR IDGRNYRKNP VQEQTYQHEE DEEDFYQGSM ECADEPCDAY EVEQTPQGFR 60 61 STLRAPSLLY NLIHLNTSND CGFQKITLDC QNIYTWKSRH IVGKRGDTRK KIEMETKTSI 120 121 SIPKPGQDGE IVITGQHRNG VISARTRIDV LLDTFRRKQP FTHFLAFFLN EVEVQEGFLR 180 181 FQEEVLAKCS MDHGVDSSIF QNPKKLHLTI GMLVLLSEEE IQQTCEMLQQ CKEEFINDIS 240 241 GGKPLEVEMA GIEYMNDDPG MVDVLYAKVH MKDGSNRLQE LVDRVLERFQ ASGLIVKEWN 300 301 SVKLHATVMN TLFRKDPNAE GRYNLYTAEG KYIFKERESF DGRNILKSFA LLPRLEYNDA 360 361 ISAHCNLCLP GSSDSPASAS QVAGITGVSD AYSQSLPGKS 400 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAAGTTC TGCGTCCACA GCTTATAAGA ATTGATGGCC GGAATTACAG GAAGAATCCA 60 61 GTCCAAGAAC AGACCTATCA ACATGAAGAA GATGAAGAGG ACTTCTATCA AGGCTCCATG 120 121 GAGTGTGCTG ATGAGCCCTG TGATGCCTAC GAGGTGGAGC AGACCCCACA AGGATTCCGG 180 181 TCTACTTTGA GGGCCCCCAG CTTGCTCTAT AAGCATATAG TTGGAAAGAG AGGGGACACT 240 241 AGGAAGAAAA TAGAAATGGA GACCAAAACT TCTATTAGCA TTCCTAAACC TGGACAAGAC 300 301 GGGGAAATTG TAATCACTGG CCAGCATCGA AATGGTGTAA TTTCAGCCCG AACACGGATT 360 361 GATGTTCTTT TGGACACTTT TCGAAGAAAG CAGCCCTTCA CTCACTTCCT TGCCTTTTTC 420 421 CTCAATGAAG TTGAGGTTCA GGAAGGATTC CTGAGATTCC AGGAGGAAGT ACTGGCGAAG 480 481 TGCTCCATGG ATCATGGGGT TGACAGCAGC ATTTTCCAGA ATCCTAAAAA GCTTCATCTA 540 541 ACTATTGGGA TGTTGGTGCT TTTGAGTGAG GAAGAGATCC AGCAGACATG TGAGATGCTA 600 601 CAGCAGTGTA AAGAGGAATT CATTAATGAT ATTTCTGGGG GTAAACCCCT AGAAGTGGAG 660 661 ATGGCAGGGA TAGAATACAT GAATGATGAT CCTGGCATGG TGGATGTTCT TTACGCCAAA 720 721 GTCCATATGA AAGATGGCTC CAACAGGCTA CAAGAATTAG TTGATCGAGT GCTGGAACGT 780 781 TTTCAGGCAT CTGGACTAAT AGTGAAAGAG TGGAATAGTG TGAAACTGCA TGCTACAGTT 840 841 ATGAATACAC TATTCAGGAA AGACCCCAAT GCTGAAGGCA GGTACAATCT CTACACAGCG 900 901 GAAGGCAAAT ATATCTTCAA GGAAAGAGAA TCATTTGATG GCCGAAATAT TTTAAAGTTG 960 961 TTTGAGAACT TCTACTTTGG CTCCCTAAAG CTGAATTCAA TTCACATCTC TCAGAGGTTC 1020 1021 ACCGTAGACA GCTTTGGAAA CTACGCTTCC TGTGGACAAA TTGACTTCTC CTGA 1074 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Neuromuscular junction | |
Cellular Component | Nuclear speck | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Cellular Component | Transcription factor complex | |
Molecular Function | RNA binding | |
Biological Process | DNA dealkylation involved in DNA repair | |
Biological Process | Regulation of transcription, DNA-templated |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ENPD | CORUM | CellMarker | |
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-1096 | Pan troglodytes | 99.25 | 0.0 | 830 |
| LLPS-Gog-2985 | Gorilla gorilla | 98.75 | 0.0 | 825 |
| LLPS-Maf-3665 | Macaca fascicularis | 97.75 | 0.0 | 820 |
| LLPS-Paa-4689 | Papio anubis | 97.5 | 0.0 | 818 |
| LLPS-Mal-2949 | Mandrillus leucophaeus | 97.5 | 0.0 | 819 |
| LLPS-Man-3452 | Macaca nemestrina | 97.5 | 0.0 | 816 |
| LLPS-Nol-0914 | Nomascus leucogenys | 97.5 | 0.0 | 812 |
| LLPS-Rhb-1316 | Rhinopithecus bieti | 97.25 | 0.0 | 814 |
| LLPS-Mea-1574 | Mesocricetus auratus | 94.48 | 7e-94 | 286 |
| LLPS-Pap-2118 | Pan paniscus | 90.83 | 0.0 | 645 |
| LLPS-Mam-4006 | Macaca mulatta | 90.2 | 0.0 | 642 |
| LLPS-Chs-1476 | Chlorocebus sabaeus | 89.97 | 0.0 | 644 |
| LLPS-Poa-4481 | Pongo abelii | 89.97 | 0.0 | 642 |
| LLPS-Caj-2787 | Callithrix jacchus | 89.4 | 0.0 | 637 |
| LLPS-Aon-2258 | Aotus nancymaae | 89.4 | 0.0 | 639 |
| LLPS-Tut-1859 | Tursiops truncatus | 87.29 | 0.0 | 642 |
| LLPS-Otg-1204 | Otolemur garnettii | 85.96 | 0.0 | 618 |
| LLPS-Ict-1586 | Ictidomys tridecemlineatus | 85.96 | 0.0 | 615 |
| LLPS-Cap-2608 | Cavia porcellus | 85.01 | 0.0 | 609 |
| LLPS-Orc-0669 | Oryctolagus cuniculus | 84.81 | 0.0 | 610 |
| LLPS-Aim-1329 | Ailuropoda melanoleuca | 84.24 | 0.0 | 597 |
| LLPS-Fec-4345 | Felis catus | 83.95 | 0.0 | 601 |
| LLPS-Mup-4081 | Mustela putorius furo | 83.67 | 0.0 | 597 |
| LLPS-Caf-1743 | Canis familiaris | 83.67 | 0.0 | 599 |
| LLPS-Ova-2106 | Ovis aries | 83.38 | 0.0 | 599 |
| LLPS-Cas-0284 | Carlito syrichta | 83.37 | 0.0 | 679 |
| LLPS-Sus-2977 | Sus scrofa | 83.09 | 0.0 | 600 |
| LLPS-Cea-3223 | Cercocebus atys | 82.86 | 2e-09 | 59.7 |
| LLPS-Fud-1953 | Fukomys damarensis | 82.81 | 0.0 | 600 |
| LLPS-Dio-3526 | Dipodomys ordii | 82.81 | 0.0 | 593 |
| LLPS-Eqc-2010 | Equus caballus | 82.81 | 0.0 | 592 |
| LLPS-Bot-1789 | Bos taurus | 82.52 | 0.0 | 595 |
| LLPS-Loa-4245 | Loxodonta africana | 79.37 | 0.0 | 567 |
| LLPS-Urm-0102 | Ursus maritimus | 78.89 | 0.0 | 598 |
| LLPS-Mum-3538 | Mus musculus | 78.8 | 0.0 | 565 |
| LLPS-Ran-4380 | Rattus norvegicus | 78.8 | 0.0 | 563 |
| LLPS-Myl-3653 | Myotis lucifugus | 77.43 | 0.0 | 547 |
| LLPS-Sah-2745 | Sarcophilus harrisii | 63.32 | 5e-155 | 449 |
| LLPS-Gaga-3732 | Gallus gallus | 62.57 | 2e-147 | 429 |
| LLPS-Fia-0730 | Ficedula albicollis | 61.32 | 1e-148 | 433 |
| LLPS-Meg-3228 | Meleagris gallopavo | 61.14 | 6e-146 | 427 |
| LLPS-Ora-0183 | Ornithorhynchus anatinus | 60.91 | 3e-153 | 444 |
| LLPS-Anp-3219 | Anas platyrhynchos | 60.68 | 2e-148 | 432 |
| LLPS-Anc-1076 | Anolis carolinensis | 59.31 | 1e-136 | 402 |
| LLPS-Xet-2356 | Xenopus tropicalis | 59.08 | 4e-144 | 421 |
| LLPS-Pes-2701 | Pelodiscus sinensis | 58.84 | 2e-112 | 337 |
| LLPS-Dar-2538 | Danio rerio | 58.45 | 5e-84 | 263 |
| LLPS-Tag-0849 | Taeniopygia guttata | 56.32 | 1e-64 | 211 |
| LLPS-Leo-3101 | Lepisosteus oculatus | 55.71 | 4e-138 | 406 |
| LLPS-Lac-2874 | Latimeria chalumnae | 54.76 | 3e-134 | 396 |
| LLPS-Icp-3704 | Ictalurus punctatus | 54.42 | 5e-123 | 367 |
| LLPS-Asm-2349 | Astyanax mexicanus | 53.69 | 6e-124 | 370 |
| LLPS-Tar-3454 | Takifugu rubripes | 53.56 | 2e-120 | 360 |
| LLPS-Scf-2743 | Scleropages formosus | 52.84 | 8e-126 | 374 |
| LLPS-Scm-3686 | Scophthalmus maximus | 51.95 | 2e-108 | 332 |
| LLPS-Ten-2107 | Tetraodon nigroviridis | 51.9 | 7e-118 | 355 |
| LLPS-Orl-3557 | Oryzias latipes | 51.7 | 5e-118 | 355 |
| LLPS-Pof-3690 | Poecilia formosa | 51.69 | 2e-116 | 350 |
| LLPS-Xim-1417 | Xiphophorus maculatus | 51.41 | 3e-117 | 352 |
| LLPS-Gaa-0429 | Gasterosteus aculeatus | 51.4 | 9e-118 | 354 |
| LLPS-Orn-3598 | Oreochromis niloticus | 50.84 | 3e-117 | 352 |
| LLPS-Cis-0103 | Ciona savignyi | 38.16 | 1e-64 | 217 |
| LLPS-Cii-0900 | Ciona intestinalis | 37.89 | 7e-66 | 220 |
| LLPS-Drm-2285 | Drosophila melanogaster | 34.5 | 7e-36 | 140 |
| LLPS-Tru-2035 | Triticum urartu | 33.33 | 1e-06 | 53.9 |
| LLPS-Pot-2688 | Populus trichocarpa | 31.75 | 1e-10 | 67.0 |
| LLPS-Ori-2267 | Oryza indica | 30.63 | 4e-15 | 81.3 |
| LLPS-Zem-1501 | Zea mays | 30.63 | 4e-14 | 77.8 |
| LLPS-Org-1245 | Oryza glaberrima | 30.63 | 3e-15 | 81.3 |
| LLPS-Orni-2106 | Oryza nivara | 30.43 | 3e-12 | 72.8 |
| LLPS-Orb-1330 | Oryza barthii | 30.43 | 2e-14 | 79.3 |
| LLPS-Via-2090 | Vigna angularis | 30.22 | 8e-16 | 81.6 |
| LLPS-Ors-2190 | Oryza sativa | 30.0 | 1e-14 | 79.3 |
| LLPS-Nia-1657 | Nicotiana attenuata | 29.84 | 3e-16 | 84.3 |
| LLPS-Sem-0967 | Selaginella moellendorffii | 29.77 | 2e-20 | 93.2 |
| LLPS-Phv-0203 | Phaseolus vulgaris | 29.73 | 1e-15 | 82.4 |
| LLPS-Mae-2313 | Manihot esculenta | 29.69 | 8e-15 | 80.1 |
| LLPS-Glm-0945 | Glycine max | 29.67 | 3e-15 | 81.6 |
| LLPS-Cus-1445 | Cucumis sativus | 29.67 | 5e-11 | 68.6 |
| LLPS-Amt-1845 | Amborella trichopoda | 29.67 | 4e-17 | 85.9 |
| LLPS-Thc-1778 | Theobroma cacao | 29.44 | 9e-15 | 80.1 |
| LLPS-Gor-1352 | Gossypium raimondii | 29.44 | 2e-12 | 72.8 |
| LLPS-Php-2143 | Physcomitrella patens | 29.28 | 4e-23 | 103 |
| LLPS-Chr-0700 | Chlamydomonas reinhardtii | 29.02 | 2e-32 | 130 |
| LLPS-Dac-2243 | Daucus carota | 28.89 | 7e-14 | 77.0 |
| LLPS-Fuo-0896 | Fusarium oxysporum | 28.64 | 2e-11 | 67.4 |
| LLPS-Orp-1464 | Oryza punctata | 28.47 | 8e-12 | 71.2 |
| LLPS-Sol-0914 | Solanum lycopersicum | 28.42 | 2e-15 | 82.0 |
| LLPS-Met-1700 | Medicago truncatula | 28.34 | 1e-14 | 79.7 |
| LLPS-Sob-0440 | Sorghum bicolor | 28.32 | 2e-20 | 97.4 |
| LLPS-Sot-2206 | Solanum tuberosum | 28.21 | 4e-15 | 80.9 |
| LLPS-Brn-2000 | Brassica napus | 28.15 | 6e-14 | 77.0 |
| LLPS-Orgl-2189 | Oryza glumaepatula | 28.02 | 6e-14 | 77.8 |
| LLPS-Arl-1862 | Arabidopsis lyrata | 27.75 | 1e-13 | 74.3 |
| LLPS-Art-2471 | Arabidopsis thaliana | 27.75 | 1e-13 | 73.9 |
| LLPS-Mua-2574 | Musa acuminata | 27.23 | 8e-14 | 77.4 |
| LLPS-Bro-2272 | Brassica oleracea | 27.23 | 3e-11 | 67.4 |
| LLPS-Abg-1571 | Absidia glauca | 27.2 | 2e-17 | 86.7 |
| LLPS-Brr-3030 | Brassica rapa | 27.12 | 9e-08 | 58.2 |
| LLPS-Cae-1710 | Caenorhabditis elegans | 26.95 | 3e-19 | 92.4 |
| LLPS-Fuv-0922 | Fusarium verticillioides | 26.63 | 2e-09 | 61.2 |
| LLPS-Zyt-1207 | Zymoseptoria tritici | 26.6 | 9e-08 | 57.4 |
| LLPS-Mao-0038 | Magnaporthe oryzae | 26.52 | 2e-06 | 53.5 |
| LLPS-Orbr-0581 | Oryza brachyantha | 25.81 | 1e-16 | 85.9 |
| LLPS-Fus-0390 | Fusarium solani | 25.54 | 9e-08 | 56.6 |
| LLPS-Scc-0900 | Schizosaccharomyces cryophilus | 25.32 | 5e-08 | 57.0 |
| LLPS-Hea-2384 | Helianthus annuus | 24.69 | 9e-16 | 82.8 |
| LLPS-Brd-2301 | Brachypodium distachyon | 24.46 | 6e-18 | 89.4 |
| LLPS-Vir-1270 | Vigna radiata | 24.34 | 5e-08 | 59.3 |
| LLPS-Tra-2278 | Triticum aestivum | 24.16 | 2e-18 | 90.9 |
| LLPS-Lep-0608 | Leersia perrieri | 23.87 | 1e-13 | 77.0 |
| LLPS-Sei-1978 | Setaria italica | 23.14 | 2e-17 | 87.4 |