LLPS-Hos-1664
TEX10

▼ OVERVIEW

Status: Reviewed
Protein Name: Testis-expressed protein 10
Gene Name: TEX10, L18, Nbla10363
Ensembl Gene: ENSG00000136891.13
Ensembl Protein: ENSP00000399872.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...As a first step in elucidating these mechanisms we have carried out a proteomic analysis to draw up a list of proteins present within nucleoli of HeLa cells. This analysis allowed the identification of 213 different nucleolar proteins."
HeLa cells12429849
Nucleolus
"...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli."
HeLa cells15635413
Nucleolus
"...Finally, 221 proteins were found as nucleolar with No/Cyto > 1 and No/Nuc > 1."
HCT116 cells20026476

▼ FUNCTION

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTKKRKRQHD  FQKVKLKVGK  KKPKLQNATP  TNFKTKTIHL  PEQLKEDGTL  PTNNRKLNIK  60
61    DLLSQMHHYN  AGVKQSALLG  LKDLLSQYPF  IIDAHLSNIL  SEVTAVFTDK  DANVRLAAVQ  120
121   LLQFLAPKIR  AEQISPFFPL  VSAHLSSAMT  HITEGIQEDS  LKVLDILLEQ  YPALITGRSS  180
181   ILLKNFVELI  SHQQLSKGLI  NRDRSQSWIL  SVNPNRRLTS  QQWRLKVLVR  LSKFLQALAD  240
241   GSSRLRESEG  LQEQKENPHA  TSNSIFINWK  EHANDQQHIQ  VYENGGSQPN  VSSQFRLRYL  300
301   VGGLSGVDEG  LSSTENLKGF  IEIIIPLLIE  CWVEAVPPQL  ATPVGNGIER  EPLQVMQQVL  360
361   NIISLLWKLS  KQQDETHKLE  SWLRKNYLID  FKHHFMSRFP  YVLKEITKHK  RKEPNKSIKH  420
421   CTVLSNNIDH  LLLNLTLSDI  MVSLANASTL  QKDCSWIEMI  RKFVTETLED  GSRLNSKQLN  480
481   RLLGVSWRLM  QIQPNREDTE  TLIKAVYTLY  QQRGLILPVR  TLLLKFFSKI  YQTEELRSCR  540
541   FRYRSKVLSR  WLAGLPLQLA  HLGSRNPELS  TQLIDIIHTA  AARANKELLK  SLQATALRIY  600
601   DPQEGAVVVL  PADSQQRLVQ  LVYFLPSLPA  DLLSRLSRCC  IMGRLSSSLA  AMLIGILHMR  660
661   SSFSGWKYSA  KDWLMSDVDY  FSFLFSTLTG  FSKEELTWLQ  SLRGVPHVIQ  TQLSPVLLYL  720
721   TDLDQFLHHW  DVTEAVFHSL  LVIPARSQNF  DILQSAISKH  LVGLTVIPDS  TAGCVFGVIC  780
781   KLLDHTCVVS  ETLLPFLASC  CYSLLYFLLT  IEKGEAEHLR  KRDKLWGVCV  SILALLPRVL  840
841   RLMLQSLRVN  RVGPEELPVV  GQLLRLLLQH  APLRTHMLTN  AILVQQIIKN  ITTLKSGSVQ  900
901   EQWLTDLHYC  FNVYITGHPQ  GPSALATVY  929
Nucleotide CDS Sequence (FASTA)
1     ATGACTAAAA  AAAGAAAACG  CCAACATGAT  TTTCAAAAAG  TAAAATTGAA  AGTTGGTAAA  60
61    AAGAAGCCCA  AGTTACAAAA  TGCTACTCCT  ACAAACTTTA  AAACAAAGAC  TATACATCTG  120
121   CCTGAGCAAC  TCAAAGAGGA  TGGAACACTT  CCAACAAACA  ATAGAAAACT  TAACATAAAG  180
181   GATTTGCTGT  CACAGATGCA  TCACTACAAT  GCTGGGGTTA  AACAAAGTGC  TCTTCTTGGA  240
241   CTTAAAGACC  TTTTGTCTCA  ATACCCATTT  ATAATTGATG  CACACCTTTC  AAACATATTA  300
301   AGTGAAGTGA  CTGCTGTGTT  TACAGATAAA  GATGCTAATG  TACGATTAGC  AGCAGTTCAA  360
361   CTTCTTCAAT  TCCTGGCCCC  CAAAATACGA  GCTGAACAAA  TTTCTCCATT  TTTTCCTTTG  420
421   GTAAGTGCCC  ATCTCTCTAG  TGCCATGACT  CACATTACTG  AAGGAATTCA  GGAGGACTCT  480
481   TTAAAAGTTT  TGGACATTCT  GCTGGAACAG  TACCCAGCTC  TAATTACTGG  CCGTAGCAGC  540
541   ATATTGCTTA  AGAATTTTGT  AGAACTTATT  TCTCATCAGC  AGCTGTCCAA  AGGACTGATA  600
601   AATAGAGACA  GATCCCAGTC  CTGGATACTT  TCTGTAAATC  CTAATCGGAG  ACTCACTTCT  660
661   CAGCAATGGA  GGCTGAAAGT  CTTAGTGAGA  CTCAGTAAAT  TCCTTCAGGC  CTTGGCAGAT  720
721   GGATCCAGTA  GGTTGAGAGA  AAGTGAAGGA  CTTCAGGAAC  AGAAAGAAAA  TCCCCATGCC  780
781   ACTAGCAACT  CCATTTTTAT  CAACTGGAAG  GAACATGCCA  ACGACCAGCA  ACACATCCAG  840
841   GTTTATGAAA  ATGGGGGTTC  ACAGCCAAAT  GTCAGTTCAC  AGTTCAGGCT  ACGGTATCTG  900
901   GTTGGAGGAC  TGAGTGGTGT  GGATGAAGGC  CTGTCATCTA  CTGAAAACCT  GAAAGGATTT  960
961   ATTGAGATAA  TAATTCCATT  GCTAATTGAA  TGCTGGGTTG  AAGCTGTACC  TCCACAACTA  1020
1021  GCTACTCCTG  TTGGGAATGG  TATAGAACGA  GAACCTCTAC  AGGTTATGCA  GCAAGTTCTT  1080
1081  AATATTATTT  CCCTTCTGTG  GAAACTCTCT  AAACAACAGG  ATGAAACCCA  TAAATTGGAG  1140
1141  TCATGGCTTC  GAAAGAACTA  CCTTATTGAT  TTTAAACACC  ATTTTATGAG  TCGTTTTCCA  1200
1201  TATGTCTTAA  AAGAAATAAC  CAAGCACAAA  AGGAAAGAGC  CAAATAAAAG  CATCAAGCAT  1260
1261  TGCACAGTTC  TCTCCAATAA  CATAGATCAT  CTCTTACTGA  ATTTAACACT  GTCTGATATC  1320
1321  ATGGTCTCCC  TGGCAAATGC  GTCAACTTTG  CAGAAGGATT  GCAGTTGGAT  AGAAATGATA  1380
1381  AGGAAATTTG  TAACAGAGAC  CCTTGAAGAT  GGCTCTAGGC  TAAATAGTAA  GCAACTGAAC  1440
1441  AGATTGCTGG  GAGTATCCTG  GAGGTTAATG  CAAATACAGC  CAAACAGAGA  GGACACAGAG  1500
1501  ACTCTTATTA  AGGCAGTTTA  TACATTATAT  CAGCAGAGGG  GCCTTATCCT  TCCAGTTCGG  1560
1561  ACTTTGTTAT  TGAAGTTTTT  CAGTAAAATC  TATCAGACAG  AAGAACTGAG  ATCTTGTAGA  1620
1621  TTCAGATATC  GTAGTAAAGT  GTTATCCCGT  TGGCTGGCTG  GCTTACCATT  GCAACTTGCT  1680
1681  CATCTTGGCT  CCCGAAATCC  TGAGCTCTCT  ACACAGCTTA  TCGATATCAT  TCATACCGCT  1740
1741  GCAGCACGAG  CAAATAAAGA  ATTACTAAAA  AGTTTACAAG  CTACTGCCCT  CCGAATTTAT  1800
1801  GATCCACAAG  AAGGTGCTGT  GGTGGTTCTC  CCTGCAGACT  CTCAGCAGCG  TTTGGTTCAG  1860
1861  CTTGTATATT  TCCTACCCAG  TCTGCCGGCT  GATTTGCTTT  CTCGGTTAAG  TCGTTGCTGT  1920
1921  ATTATGGGAA  GACTCAGTTC  AAGTTTGGCT  GCCATGCTTA  TCGGGATACT  GCACATGAGA  1980
1981  TCATCATTTT  CTGGGTGGAA  GTATTCAGCT  AAAGACTGGT  TGATGAGTGA  TGTAGACTAT  2040
2041  TTCAGCTTCT  TATTTTCCAC  ACTTACAGGG  TTTTCGAAAG  AGGAGTTGAC  TTGGCTTCAG  2100
2101  AGCCTTCGAG  GAGTTCCTCA  TGTCATCCAG  ACACAGCTTT  CCCCTGTGCT  TCTCTACCTT  2160
2161  ACAGATTTGG  ATCAATTTTT  ACACCACTGG  GATGTAACAG  AGGCAGTTTT  TCACAGTTTA  2220
2221  TTGGTTATTC  CTGCCCGAAG  TCAGAACTTT  GACATCTTGC  AAAGTGCCAT  CAGTAAGCAT  2280
2281  TTGGTTGGGT  TGACTGTAAT  TCCTGACAGC  ACGGCTGGCT  GTGTTTTTGG  TGTTATCTGT  2340
2341  AAGCTCCTGG  ATCATACTTG  TGTAGTTAGT  GAGACTCTAC  TGCCATTTCT  GGCTTCTTGT  2400
2401  TGCTACAGTC  TTCTTTATTT  TCTGCTCACT  ATAGAGAAAG  GGGAAGCAGA  ACATCTAAGA  2460
2461  AAGAGGGACA  AGCTGTGGGG  GGTCTGTGTC  TCCATCCTGG  CTCTCTTGCC  TCGAGTCCTC  2520
2521  AGGTTGATGC  TGCAGAGCCT  GCGGGTGAAC  AGAGTTGGGC  CTGAGGAGCT  GCCTGTTGTG  2580
2581  GGCCAGCTGC  TTCGACTGCT  GCTTCAGCAT  GCACCCCTCA  GGACTCATAT  GTTGACCAAT  2640
2641  GCGATCTTGG  TGCAGCAGAT  CATCAAGAAT  ATCACGACAT  TGAAGAGTGG  AAGTGTTCAG  2700
2701  GAACAGTGGC  TCACAGACTT  ACATTACTGC  TTCAACGTGT  ATATCACTGG  GCATCCCCAA  2760
2761  GGGCCCAGTG  CACTGGCTAC  AGTGTATTGA  2790

▼ KEYWORD

ID
Family
Alternative splicing
Complete proteome
Cytoplasm
Nucleus
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
MLL1 complex
Cellular Component
Nucleolus
Cellular Component
Nucleoplasm
Cellular Component
Rix1 complex
Biological Process
RRNA processing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-3197Pan paniscus99.890.01737
LLPS-Pat-4204Pan troglodytes99.890.01737
LLPS-Gog-2377Gorilla gorilla99.890.01737
LLPS-Mam-0089Macaca mulatta99.780.01735
LLPS-Maf-2250Macaca fascicularis99.780.01735
LLPS-Paa-4307Papio anubis99.780.01735
LLPS-Man-2832Macaca nemestrina99.570.01735
LLPS-Cea-0171Cercocebus atys99.570.01734
LLPS-Mal-1227Mandrillus leucophaeus99.570.01733
LLPS-Poa-2688Pongo abelii99.460.01734
LLPS-Rhb-0688Rhinopithecus bieti99.350.01728
LLPS-Nol-4394Nomascus leucogenys99.250.01717
LLPS-Aon-2765Aotus nancymaae98.390.01715
LLPS-Urm-1867Ursus maritimus95.690.01643
LLPS-Caj-3178Callithrix jacchus95.690.01686
LLPS-Caf-2007Canis familiaris95.590.01642
LLPS-Cas-3650Carlito syrichta95.480.01641
LLPS-Aim-2605Ailuropoda melanoleuca95.480.01637
LLPS-Fec-1358Felis catus94.730.01619
LLPS-Loa-3485Loxodonta africana94.730.01626
LLPS-Ict-1827Ictidomys tridecemlineatus94.620.01625
LLPS-Orc-3521Oryctolagus cuniculus94.40.01646
LLPS-Sus-0699Sus scrofa94.40.01641
LLPS-Otg-0304Otolemur garnettii93.970.01623
LLPS-Eqc-0244Equus caballus93.520.01520
LLPS-Fud-0175Fukomys damarensis92.790.01580
LLPS-Cap-4168Cavia porcellus92.570.01570
LLPS-Bot-0843Bos taurus92.510.01610
LLPS-Myl-3954Myotis lucifugus92.420.01607
LLPS-Chs-4407Chlorocebus sabaeus92.415e-72 260
LLPS-Ova-1068Ovis aries92.370.01593
LLPS-Mup-0519Mustela putorius furo90.511e-69 253
LLPS-Dio-2187Dipodomys ordii90.20.01583
LLPS-Mea-3461Mesocricetus auratus89.770.01545
LLPS-Mum-4497Mus musculus88.810.01545
LLPS-Ran-4258Rattus norvegicus88.590.01525
LLPS-Ora-1936Ornithorhynchus anatinus78.920.01329
LLPS-Mod-3609Monodelphis domestica78.490.01345
LLPS-Sah-3545Sarcophilus harrisii76.530.01311
LLPS-Pes-3802Pelodiscus sinensis74.30.01273
LLPS-Anp-3169Anas platyrhynchos74.240.0 915
LLPS-Gaga-1978Gallus gallus73.090.01245
LLPS-Tag-1991Taeniopygia guttata72.980.01231
LLPS-Meg-2568Meleagris gallopavo72.550.01239
LLPS-Fia-0979Ficedula albicollis72.440.01231
LLPS-Lac-2322Latimeria chalumnae61.330.01025
LLPS-Anc-2468Anolis carolinensis57.620.0 883
LLPS-Xet-1322Xenopus tropicalis51.710.0 795
LLPS-Scf-2874Scleropages formosus49.310.0 753
LLPS-Xim-1684Xiphophorus maculatus48.660.0 712
LLPS-Dar-2157Danio rerio47.910.0 739
LLPS-Asm-2571Astyanax mexicanus47.780.0 703
LLPS-Pof-2026Poecilia formosa47.680.0 686
LLPS-Gaa-2537Gasterosteus aculeatus47.510.0 707
LLPS-Tar-3361Takifugu rubripes47.360.0 699
LLPS-Icp-0597Ictalurus punctatus47.330.0 710
LLPS-Scm-2264Scophthalmus maximus46.870.0 738
LLPS-Orn-1089Oreochromis niloticus46.50.0 707
LLPS-Ten-1366Tetraodon nigroviridis45.860.0 696
LLPS-Leo-3907Lepisosteus oculatus45.830.0 640
LLPS-Orl-1821Oryzias latipes45.640.0 702
LLPS-Cis-1606Ciona savignyi38.088e-32 130
LLPS-Usm-0404Ustilago maydis37.32e-1895.1
LLPS-Chr-1047Chlamydomonas reinhardtii36.143e-20 101
LLPS-Spr-0483Sporisorium reilianum36.076e-1996.3
LLPS-Miv-1545Microbotryum violaceum34.55e-0861.2
LLPS-Amt-0422Amborella trichopoda34.322e-1480.5
LLPS-Asg-1546Ashbya gossypii33.145e-0860.1
LLPS-Via-2187Vigna angularis33.143e-1477.8
LLPS-Vir-1186Vigna radiata32.784e-1377.8
LLPS-Mae-1992Manihot esculenta32.651e-1999.0
LLPS-Prp-0768Prunus persica32.164e-1481.3
LLPS-Met-2520Medicago truncatula32.141e-1792.4
LLPS-Mel-1225Melampsora laricipopulina31.82e-1997.8
LLPS-Viv-1685Vitis vinifera31.639e-2095.1
LLPS-Cus-0912Cucumis sativus31.219e-1995.5
LLPS-Arl-0246Arabidopsis lyrata31.144e-1584.3
LLPS-Nia-0258Nicotiana attenuata31.124e-1791.3
LLPS-Sol-1292Solanum lycopersicum31.129e-1892.8
LLPS-Ors-1149Oryza sativa31.072e-1689.0
LLPS-Org-1073Oryza glaberrima31.072e-1688.6
LLPS-Orr-2206Oryza rufipogon31.071e-1689.0
LLPS-Orm-1880Oryza meridionalis31.072e-1688.2
LLPS-Orni-1281Oryza nivara31.072e-1689.0
LLPS-Orb-2129Oryza barthii31.072e-1688.6
LLPS-Orgl-0198Oryza glumaepatula31.072e-1688.6
LLPS-Lep-0571Leersia perrieri31.079e-1686.3
LLPS-Scp-1593Schizosaccharomyces pombe31.062e-0655.5
LLPS-Kop-0431Komagataella pastoris30.987e-1271.6
LLPS-Sob-1058Sorghum bicolor30.857e-1583.6
LLPS-Zem-1602Zea mays30.853e-1481.6
LLPS-Pot-0665Populus trichocarpa30.615e-1687.4
LLPS-Art-2740Arabidopsis thaliana30.361e-1379.7
LLPS-Hea-1778Helianthus annuus30.157e-1893.2
LLPS-Gor-1692Gossypium raimondii30.19e-1479.7
LLPS-Coc-1252Corchorus capsularis29.953e-1585.1
LLPS-Thc-2482Theobroma cacao29.954e-1481.3
LLPS-Orbr-0666Oryza brachyantha29.942e-1585.5
LLPS-Orp-0251Oryza punctata29.941e-1483.2
LLPS-Scc-1232Schizosaccharomyces cryophilus29.934e-0654.7
LLPS-Sei-1674Setaria italica29.783e-1584.7
LLPS-Glm-2288Glycine max29.743e-1378.6
LLPS-Tra-1521Triticum aestivum29.555e-1480.9
LLPS-Cii-1760Ciona intestinalis28.571e-1999.0
LLPS-Ori-0640Oryza indica28.51e-1482.8
LLPS-Drm-1754Drosophila melanogaster28.132e-25 116
LLPS-Mua-2486Musa acuminata27.817e-1683.6
LLPS-Brr-2820Brassica rapa27.753e-0965.1
LLPS-Bro-1484Brassica oleracea27.752e-0965.9
LLPS-Brn-0741Brassica napus27.753e-0965.5
LLPS-Dac-0646Daucus carota27.642e-1585.5
LLPS-Brd-2160Brachypodium distachyon26.485e-1377.4
LLPS-Php-2317Physcomitrella patens25.935e-26 119
LLPS-Abg-0732Absidia glauca25.891e-22 108
LLPS-Sem-2062Selaginella moellendorffii23.41e-1379.7
LLPS-Pug-1439Puccinia graminis20.983e-20 100
LLPS-Crn-1128Cryptococcus neoformans20.783e-1068.6