LLPS-Hos-1660
PTTG1

▼ OVERVIEW

Status: Reviewed
Protein Name: Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG
Gene Name: PTTG1, EAP1, PTTG, TUTR1
Ensembl Gene: ENSG00000164611.12
Ensembl Protein: ENSP00000377536.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A21937724

▼ FUNCTION

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATLIYVDKE  NGEPGTRVVA  KDGLKLGSGP  SIKALDGRSQ  VSTPRFGKTF  DAPPALPKAT  60
61    RKALGTVNRA  TEKSVKTKGP  LKQKQPSFSA  KKMTEKTVKA  KSSVPASDDA  YPEIEKFFPF  120
121   NPLDFESFDL  PEEHQIAHLP  LSGVPLMILD  EERELEKLFQ  LGPPSPVKMP  SPPWESNLLQ  180
181   SPSSILSTLD  VELPPVCCDI  DI  202
Nucleotide CDS Sequence (FASTA)
1     ATGGCTACTC  TGATCTATGT  TGATAAGGAA  AATGGAGAAC  CAGGCACCCG  TGTGGTTGCT  60
61    AAGGATGGGC  TGAAGCTGGG  GTCTGGACCT  TCAATCAAAG  CCTTAGATGG  GAGATCTCAA  120
121   GTTTCAACAC  CACGTTTTGG  CAAAACGTTC  GATGCCCCAC  CAGCCTTACC  TAAAGCTACT  180
181   AGAAAGGCTT  TGGGAACTGT  CAACAGAGCT  ACAGAAAAGT  CTGTAAAGAC  CAAGGGACCC  240
241   CTCAAACAAA  AACAGCCAAG  CTTTTCTGCC  AAAAAGATGA  CTGAGAAGAC  TGTTAAAGCA  300
301   AAAAGCTCTG  TTCCTGCCTC  AGATGATGCC  TATCCAGAAA  TAGAAAAATT  CTTTCCCTTC  360
361   AATCCTCTAG  ACTTTGAGAG  TTTTGACCTG  CCTGAAGAGC  ACCAGATTGC  GCACCTCCCC  420
421   TTGAGTGGAG  TGCCTCTCAT  GATCCTTGAC  GAGGAGAGAG  AGCTTGAAAA  GCTGTTTCAG  480
481   CTGGGCCCCC  CTTCACCTGT  GAAGATGCCC  TCTCCACCAT  GGGAATCCAA  TCTGTTGCAG  540
541   TCTCCTTCAA  GCATTCTGTC  GACCCTGGAT  GTTGAATTGC  CACCTGTTTG  CTGTGACATA  600
601   GATATTTAA  609

▼ KEYWORD

ID
Family
Acetylation
Cell cycle
Cell division
Chromosome partition
Complete proteome
Cytoplasm
DNA damage
DNA repair
Mitosis
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
Repeat
SH3-binding
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
Cysteine-type endopeptidase inhibitor activity
Molecular Function
DNA-binding transcription factor activity
Molecular Function
DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function
SH3 domain binding
Biological Process
Anaphase-promoting complex-dependent catabolic process
Biological Process
Cell division
Biological Process
Chromosome organization
Biological Process
DNA repair
Biological Process
Homologous chromosome segregation
Biological Process
Negative regulation of mitotic sister chromatid separation
Biological Process
Spermatogenesis
Biological Process
Transcription by RNA polymerase II

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-4253Pan troglodytes99.58e-133 378
LLPS-Nol-2968Nomascus leucogenys99.013e-132 377
LLPS-Gog-4467Gorilla gorilla99.013e-132 377
LLPS-Pap-2907Pan paniscus98.515e-132 376
LLPS-Man-3763Macaca nemestrina98.519e-132 375
LLPS-Mam-2786Macaca mulatta98.519e-132 375
LLPS-Maf-2827Macaca fascicularis98.519e-132 375
LLPS-Cea-3885Cercocebus atys98.519e-132 375
LLPS-Poa-2437Pongo abelii98.025e-130 371
LLPS-Chs-1238Chlorocebus sabaeus98.024e-131 374
LLPS-Paa-1489Papio anubis98.023e-131 374
LLPS-Mal-2097Mandrillus leucophaeus98.023e-131 374
LLPS-Aon-0742Aotus nancymaae95.545e-125 358
LLPS-Caj-3970Callithrix jacchus95.052e-125 360
LLPS-Rhb-1319Rhinopithecus bieti89.119e-114 329
LLPS-Eqc-4800Equus caballus87.621e-106 312
LLPS-Urm-3987Ursus maritimus86.637e-111 323
LLPS-Tut-1515Tursiops truncatus86.633e-117 338
LLPS-Aim-3936Ailuropoda melanoleuca86.637e-111 323
LLPS-Cas-0459Carlito syrichta86.146e-114 330
LLPS-Bot-4443Bos taurus86.143e-116 336
LLPS-Ova-1981Ovis aries86.142e-116 337
LLPS-Mup-4403Mustela putorius furo85.641e-111 324
LLPS-Loa-2883Loxodonta africana85.316e-92 274
LLPS-Fec-3922Felis catus84.162e-109 319
LLPS-Sus-3334Sus scrofa82.181e-108 317
LLPS-Otg-2422Otolemur garnettii81.599e-105 307
LLPS-Orc-0947Oryctolagus cuniculus80.697e-105 307
LLPS-Myl-0917Myotis lucifugus80.22e-103 304
LLPS-Caf-3522Canis familiaris79.72e-102 301
LLPS-Ict-4117Ictidomys tridecemlineatus74.87e-55 177
LLPS-Cap-0431Cavia porcellus74.262e-91 273
LLPS-Fud-2395Fukomys damarensis74.268e-100 294
LLPS-Mea-0093Mesocricetus auratus72.918e-88 264
LLPS-Mum-3561Mus musculus71.782e-90 270
LLPS-Ran-3321Rattus norvegicus71.292e-88 266
LLPS-Dio-3727Dipodomys ordii67.333e-83 252
LLPS-Mod-2188Monodelphis domestica60.591e-61 197
LLPS-Sah-3943Sarcophilus harrisii59.813e-62 199
LLPS-Ora-2457Ornithorhynchus anatinus56.657e-56 182
LLPS-Gaga-1083Gallus gallus46.466e-36 130
LLPS-Tag-3469Taeniopygia guttata43.659e-37 133
LLPS-Lac-2033Latimeria chalumnae42.314e-2396.7
LLPS-Fia-3096Ficedula albicollis41.922e-33 124
LLPS-Anp-0082Anas platyrhynchos41.584e-30 115
LLPS-Asm-1862Astyanax mexicanus40.911e-0958.5
LLPS-Anc-2949Anolis carolinensis37.931e-24 101
LLPS-Scf-2246Scleropages formosus32.721e-1678.6
LLPS-Icp-3798Ictalurus punctatus31.91e-0958.9
LLPS-Dar-3528Danio rerio31.085e-1368.6
LLPS-Scm-3975Scophthalmus maximus30.738e-0956.6