LLPS-Hos-1616
ZGPAT

▼ OVERVIEW

Status: Reviewed
Protein Name: Zinc finger CCCH-type with G patch domain-containing protein; G patch domain-containing protein 6; Zinc finger CCCH domain-containing protein 9; Zinc finger and G patch domain-containing protein
Gene Name: ZGPAT, GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP
Ensembl Gene: ENSG00000197114.11
Ensembl Protein: ENSP00000391176.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 4II1 (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Cajal body
"...In total, we identified 325 proteins localized to distinct nuclear bodies, including nucleoli, promyelocytic leukemia nuclear bodies, nuclear speckles, paraspeckles, Cajal bodies, Sam68 nuclear bodies, Polycomb bodies, and uncharacterized nuclear bodies."
HeLa cells24127217

▼ FUNCTION

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDEESLESAL  QTYRAQLQQV  ELALGAGLDS  SEQADLRQLQ  GDLKELIELT  EASLVSVRKS  60
61    SLLAALDEER  PGRQEDAEYQ  AFREAITEAV  EAPAAARGSG  SETVPKAEAG  PESAAGGQEE  120
121   EEGEDEEELS  GTKVSAPYYS  SWGTLEYHNA  MVVGTEEAED  GSAGVRVLYL  YPTHKSLKPC  180
181   PFFLEGKCRF  KENCRFSHGQ  VVSLDELRPF  QDPDLSSLQA  GSACLAKHQD  GLWHAARITD  240
241   VDNGYYTVKF  DSLLLREAVV  EGDGILPPLR  TEATESDSDS  DGTGDSSYAR  VVGSDAVDSA  300
301   QSSALCPSLA  VVGSDAVDSG  TCSSAFAGWE  VHTRGIGSRL  LTKMGYEFGK  GLGRHAEGRV  360
361   EPIHAVVLPR  GKSLDQCVET  LQKQTRVGKA  GTNKPPRCRG  RGARPGGRPA  PRNVFDFLNE  420
421   KLQGQAPGAL  EAGAAPAGRR  SKDMYHASKS  AKRALSLRLF  QTEEKIERTQ  RDIRSIQEAL  480
481   ARNAGRHSVA  SAQLQEKLAG  AQRQLGQLRA  QEAGLQQEQR  KADTHKKMTE  F  531
Nucleotide CDS Sequence (FASTA)
1     ATGGACGAGG  AGAGCCTGGA  GTCGGCCTTG  CAGACCTACC  GTGCGCAGCT  GCAGCAGGTG  60
61    GAGCTGGCCT  TGGGCGCCGG  CCTGGATTCG  TCTGAGCAGG  CTGACCTGCG  CCAGCTGCAG  120
121   GGGGACCTGA  AGGAGCTCAT  CGAGCTCACC  GAGGCCAGCC  TGGTGTCTGT  CAGGAAGAGC  180
181   AGCTTGTTGG  CCGCGCTGGA  CGAAGAGCGC  CCGGGCCGCC  AGGAAGATGC  TGAGTACCAG  240
241   GCTTTCCGGG  AGGCCATCAC  TGAGGCGGTG  GAGGCACCAG  CAGCGGCCCG  TGGGTCCGGA  300
301   TCAGAGACCG  TTCCTAAAGC  AGAGGCGGGG  CCAGAATCTG  CGGCAGGTGG  GCAGGAGGAG  360
361   GAAGAGGGAG  AGGACGAGGA  AGAGCTGAGT  GGGACAAAGG  TGAGCGCGCC  CTACTACAGC  420
421   TCCTGGGGCA  CTCTGGAGTA  TCACAACGCC  ATGGTGGTGG  GAACGGAAGA  GGCGGAGGAT  480
481   GGCTCGGCGG  GTGTCCGTGT  GCTTTACCTG  TACCCCACTC  ACAAGTCTCT  GAAGCCGTGC  540
541   CCGTTCTTCC  TGGAGGGAAA  GTGCCGCTTT  AAGGAGAACT  GCAGGTTCTC  CCATGGGCAG  600
601   GTGGTCTCTC  TGGATGAGCT  GCGCCCCTTC  CAGGACCCAG  ACCTGAGCTC  CCTGCAGGCC  660
661   GGCTCTGCGT  GTCTGGCCAA  GCACCAGGAT  GGCCTCTGGC  ACGCAGCACG  CATCACCGAT  720
721   GTGGACAACG  GCTACTACAC  AGTCAAGTTT  GACTCGCTGC  TGCTGAGGGA  GGCCGTGGTG  780
781   GAGGGGGACG  GCATCCTGCC  CCCACTGCGC  ACAGAGGCCA  CAGAGTCCGA  CTCAGACAGC  840
841   GACGTGGTGG  GGTCAGATGC  TGTGGACTCT  GGGACCTGCA  GCTCTGCCTT  TGCTGGCTGG  900
901   GAGGTGCACA  CGCGAGGTAT  AGGCTCCAGA  CTCCTCACCA  AGATGGGCTA  TGAGTTTGGC  960
961   AAGGGTTTGG  GCCGACACGC  GGAAGGCCGG  GTGGAGCCCA  TCCATGCTGT  GGTGTTGCCT  1020
1021  CGAGGGAAGT  CGCTGGACCA  GTGTGTGGAG  ACCCTGCAGA  AGCAGACCAG  GGTTGGCAAG  1080
1081  GCTGGCACCA  ACAAGCCCCC  CAGGTGCCGG  GGAAGAGGGG  CCAGGCCTGG  GGGCCGCCCA  1140
1141  GCTCCTCGGA  ATGTGTTTGA  CTTCCTCAAT  GAAAAGCTGC  AAGGTCAGGC  TCCTGGGGCC  1200
1201  CTAGAAGCCG  GGGCGGCCCC  AGCGGGGAGG  AGGAGCAAGG  ACATGTACCA  TGCCAGCAAG  1260
1261  AGTGCCAAGC  GGGCCCTGAG  CCTGCGGCTC  TTCCAGACTG  AGGAGAAGAT  CGAGCGAACC  1320
1321  CAGCGGGACA  TCAGGAGCAT  CCAGGAGGCT  CTCGCCCGCA  ACGCTGGCCG  GCATAGCGTG  1380
1381  GCGTCAGCCC  AGCTGCAGGA  GAAGCTGGCA  GGAGCCCAGC  GCCAGCTGGG  GCAGCTCCGG  1440
1441  GCTCAGGAAG  CCGGCCTGCA  GCAGGAGCAG  AGGAAGGCAG  ACACCCACAA  GAAGATGACT  1500
1501  GAGTTCTAG  1509

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Alternative splicing
Complete proteome
DNA-binding
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Molecular Function
DNA-binding transcription factor activity
Molecular Function
DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function
DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function
Metal ion binding
Molecular Function
RNA polymerase II proximal promoter sequence-specific DNA binding
Molecular Function
Sequence-specific DNA binding
Biological Process
Negative regulation of epidermal growth factor-activated receptor activity
Biological Process
Negative regulation of transcription by RNA polymerase II
Biological Process
Negative regulation of transcription, DNA-templated

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-1075Pan troglodytes99.440.0 884
LLPS-Pap-4098Pan paniscus99.440.0 885
LLPS-Gog-3101Gorilla gorilla99.250.0 881
LLPS-Chs-4038Chlorocebus sabaeus95.670.0 837
LLPS-Paa-2194Papio anubis94.920.0 827
LLPS-Poa-2693Pongo abelii94.160.0 820
LLPS-Mal-2220Mandrillus leucophaeus94.160.0 812
LLPS-Nol-2319Nomascus leucogenys93.970.0 838
LLPS-Maf-3414Macaca fascicularis93.970.0 813
LLPS-Mam-3134Macaca mulatta93.790.0 809
LLPS-Man-4241Macaca nemestrina93.790.0 808
LLPS-Rhb-4530Rhinopithecus bieti93.410.0 808
LLPS-Cea-2187Cercocebus atys93.410.0 808
LLPS-Aon-1339Aotus nancymaae87.780.0 768
LLPS-Caj-3105Callithrix jacchus86.060.0 776
LLPS-Urm-1864Ursus maritimus77.110.0 680
LLPS-Otg-1980Otolemur garnettii76.990.0 703
LLPS-Mea-4251Mesocricetus auratus76.740.0 706
LLPS-Myl-3898Myotis lucifugus76.520.0 684
LLPS-Aim-3129Ailuropoda melanoleuca76.020.0 689
LLPS-Mum-3255Mus musculus75.560.0 711
LLPS-Bot-4203Bos taurus75.140.0 681
LLPS-Fud-1669Fukomys damarensis74.720.0 689
LLPS-Fec-2489Felis catus74.580.0 668
LLPS-Dio-1365Dipodomys ordii74.460.0 618
LLPS-Cap-4177Cavia porcellus74.350.0 699
LLPS-Ran-1467Rattus norvegicus74.250.0 704
LLPS-Sus-0813Sus scrofa73.830.0 667
LLPS-Ict-3766Ictidomys tridecemlineatus73.430.0 627
LLPS-Orc-0519Oryctolagus cuniculus72.573e-150 441
LLPS-Ova-1819Ovis aries72.530.0 671
LLPS-Eqc-1615Equus caballus69.350.0 587
LLPS-Ora-1228Ornithorhynchus anatinus66.730.0 637
LLPS-Orn-0130Oreochromis niloticus66.671e-0758.9
LLPS-Scf-0820Scleropages formosus66.674e-0757.4
LLPS-Mod-0849Monodelphis domestica64.650.0 553
LLPS-Sah-0119Sarcophilus harrisii64.620.0 618
LLPS-Orl-0700Oryzias latipes64.12e-0758.2
LLPS-Pes-0234Pelodiscus sinensis63.410.0 602
LLPS-Tag-0618Taeniopygia guttata62.780.0 597
LLPS-Loa-0489Loxodonta africana62.554e-158 468
LLPS-Dar-2264Danio rerio62.54e-0757.4
LLPS-Asm-1881Astyanax mexicanus61.93e-0757.8
LLPS-Meg-2387Meleagris gallopavo61.80.0 604
LLPS-Gaga-0050Gallus gallus61.470.0 604
LLPS-Fia-1683Ficedula albicollis61.110.0 597
LLPS-Ten-0692Tetraodon nigroviridis59.522e-0758.5
LLPS-Scm-0669Scophthalmus maximus59.461e-0655.8
LLPS-Leo-2511Lepisosteus oculatus58.492e-0757.8
LLPS-Ere-0024Erinaceus europaeus57.892e-0655.1
LLPS-Cii-1420Ciona intestinalis57.781e-0758.9
LLPS-Cas-2959Carlito syrichta57.56e-0756.6
LLPS-Caf-0676Canis familiaris57.56e-0756.6
LLPS-Mup-1921Mustela putorius furo57.57e-0756.2
LLPS-Lac-0475Latimeria chalumnae55.811e-0655.8
LLPS-Xet-3919Xenopus tropicalis54.468e-56 192
LLPS-Cis-1661Ciona savignyi53.491e-0655.8
LLPS-Icp-1306Ictalurus punctatus52.632e-0757.8
LLPS-Pof-1623Poecilia formosa51.721e-0758.5
LLPS-Xim-0236Xiphophorus maculatus51.721e-0758.5
LLPS-Gaa-2122Gasterosteus aculeatus50.02e-0757.8
LLPS-Tar-0715Takifugu rubripes50.03e-0757.4
LLPS-Sol-1781Solanum lycopersicum46.159e-0653.1
LLPS-Chr-0649Chlamydomonas reinhardtii43.281e-0655.8
LLPS-Cae-1907Caenorhabditis elegans36.892e-1892.0
LLPS-Tru-1743Triticum urartu34.31e-2099.8
LLPS-Org-1730Oryza glaberrima33.865e-26 115
LLPS-Orr-1461Oryza rufipogon33.862e-26 116
LLPS-Ors-2041Oryza sativa33.862e-26 116
LLPS-Orb-2199Oryza barthii33.865e-26 115
LLPS-Tra-1905Triticum aestivum33.751e-26 117
LLPS-Orbr-2259Oryza brachyantha33.69e-26 114
LLPS-Hov-0517Hordeum vulgare32.645e-25 112
LLPS-Nia-0740Nicotiana attenuata32.59e-25 111
LLPS-Coc-0842Corchorus capsularis32.348e-2199.8
LLPS-Orp-1249Oryza punctata32.06e-26 115
LLPS-Lep-2094Leersia perrieri31.925e-27 118
LLPS-Pot-1814Populus trichocarpa31.71e-1892.8
LLPS-Sei-1567Setaria italica31.335e-23 106
LLPS-Cus-0100Cucumis sativus31.276e-26 115
LLPS-Sot-2034Solanum tuberosum31.099e-23 105
LLPS-Sem-1511Selaginella moellendorffii30.834e-22 103
LLPS-Php-0668Physcomitrella patens30.82e-24 110
LLPS-Met-1034Medicago truncatula30.591e-1996.3
LLPS-Dac-2078Daucus carota30.253e-24 109
LLPS-Viv-1143Vitis vinifera30.173e-25 112
LLPS-Mae-0955Manihot esculenta29.831e-23 108
LLPS-Prp-1525Prunus persica29.762e-23 107
LLPS-Gor-1250Gossypium raimondii29.619e-2199.8
LLPS-Zem-1622Zea mays29.462e-23 107
LLPS-Thc-1672Theobroma cacao29.417e-2096.7
LLPS-Glm-2991Glycine max29.413e-2097.8
LLPS-Drm-1304Drosophila melanogaster29.355e-45 171
LLPS-Mua-1317Musa acuminata28.971e-2099.4
LLPS-Orgl-2337Oryza glumaepatula28.753e-28 121
LLPS-Vir-0512Vigna radiata28.72e-1273.2
LLPS-Brr-2665Brassica rapa28.632e-21 101
LLPS-Phv-0941Phaseolus vulgaris28.573e-1788.6
LLPS-Via-2203Vigna angularis28.514e-2097.8
LLPS-Amt-1785Amborella trichopoda28.467e-25 112
LLPS-Orni-2003Oryza nivara28.439e-27 117
LLPS-Ori-2323Oryza indica28.439e-27 117
LLPS-Brd-2401Brachypodium distachyon28.293e-27 119
LLPS-Art-2541Arabidopsis thaliana27.879e-1993.6
LLPS-Hea-1059Helianthus annuus27.342e-1995.5
LLPS-Arl-2547Arabidopsis lyrata27.053e-1892.0
LLPS-Sob-1773Sorghum bicolor27.05e-24 109
LLPS-Brn-0365Brassica napus24.84e-24 109
LLPS-Bro-1234Brassica oleracea24.485e-24 108