LLPS-Hos-1572
PARP2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Poly [ADP-ribose] polymerase 2
Gene Name: PARP2, ADPRT2, ADPRTL2
Ensembl Gene: ENSG00000129484.13
Ensembl Protein: ENSP00000445524.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 6F5B (A, C) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:28190768, PubMed:25043379). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (PubMed:25043379). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (PubMed:27471034).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAARRRRSTG  GGRARALNES  KRVNNGNTAP  EDSSPAKKTR  RCQRQESKKM  PVAGGKANKD  60
61    RTEDKQDGMP  GRSWASKRVS  ESVKALLLKG  KAPVDPECTA  KVGKAHVYCE  GNDVYDVMLN  120
121   QTNLQFNNNK  YYLIQLLEDD  AQRNFSVWMR  WGRVGKMGQH  SLVACSGNLN  KAKEIFQKKF  180
181   LDKTKNNWED  REKFEKVPGK  YDMLQMDYAT  NTQDEEETKK  EESLKSPLKP  ESQLDLRVQE  240
241   LIKLICNVQA  MEEMMMEMKY  NTKKAPLGKL  TVAQIKAGYQ  SLKKIEDCIR  AGQHGRALME  300
301   ACNEFYTRIP  HDFGLRTPPL  IRTQKELSEK  IQLLEALGDI  EIAIKLVKTE  LQSPEHPLDQ  360
361   HYRNLHCALR  PLDHESYEFK  VISQYLQSTH  APTHSDYTMT  LLDLFEVEKD  GEKEAFREDL  420
421   HNRMLLWHGS  RMSNWVGILS  HGLRIAPPEA  PITGYMFGKG  IYFADMSSKS  ANYCFASRLK  480
481   NTGLLLLSEV  ALGQCNELLE  ANPKAEGLLQ  GKHSTKGLGK  MAPSSAHFVT  LNGSTVPLGP  540
541   ASDTGILNPD  GYTLNYNEYI  VYNPNQVRMR  YLLKVQFNFL  QLW  583
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCGC  GGCGGCGACG  GAGCACCGGC  GGCGGCAGGG  CGAGAGCATT  AAATGAAAGC  60
61    AAAAGAGTTA  ATAATGGCAA  CACGGCTCCA  GAAGACTCTT  CCCCTGCCAA  GAAAACTCGT  120
121   AGATGCCAGA  GACAGGAGTC  GAAAAAGATG  CCTGTGGCTG  GAGGAAAAGC  TAATAAGGAC  180
181   AGGACAGAAG  ACAAGCAAGA  TGGTATGCCA  GGAAGGTCAT  GGGCCAGCAA  AAGGGTCTCT  240
241   GAATCTGTGA  AGGCCTTGCT  GTTAAAGGGC  AAAGCTCCTG  TGGACCCAGA  GTGTACAGCC  300
301   AAGGTGGGGA  AGGCTCATGT  GTATTGTGAA  GGAAATGATG  TCTATGATGT  CATGCTAAAT  360
361   CAGACCAATC  TCCAGTTCAA  CAACAACAAG  TACTATCTGA  TTCAGCTATT  AGAAGATGAT  420
421   GCCCAGAGGA  ACTTCAGTGT  TTGGATGAGA  TGGGGCCGAG  TTGGGAAAAT  GGGACAGCAC  480
481   AGCCTGGTGG  CTTGTTCAGG  CAATCTCAAC  AAGGCCAAGG  AAATCTTTCA  GAAGAAATTC  540
541   CTTGACAAAA  CGAAAAACAA  TTGGGAAGAT  CGAGAAAAGT  TTGAGAAGGT  GCCTGGAAAA  600
601   TATGATATGC  TACAGATGGA  CTATGCCACC  AATACTCAGG  ATGAAGAGGA  AACAAAGAAA  660
661   GAGGAATCTC  TTAAATCTCC  CTTGAAGCCA  GAGTCACAGC  TAGATCTTCG  GGTACAGGAG  720
721   TTAATAAAGT  TGATCTGTAA  TGTTCAGGCC  ATGGAAGAAA  TGATGATGGA  AATGAAGTAT  780
781   AATACCAAGA  AAGCCCCACT  TGGGAAGCTG  ACAGTGGCAC  AAATCAAGGC  AGGTTACCAG  840
841   TCTCTTAAGA  AGATTGAGGA  TTGTATTCGG  GCTGGCCAGC  ATGGACGAGC  TCTCATGGAA  900
901   GCATGCAATG  AATTCTACAC  CAGGATTCCG  CATGACTTTG  GACTCCGTAC  TCCTCCACTA  960
961   ATCCGGACAC  AGAAGGAACT  GTCAGAAAAA  ATACAATTAC  TAGAGGCTTT  GGGAGACATT  1020
1021  GAAATTGCTA  TTAAGCTGGT  GAAAACAGAG  CTACAAAGCC  CAGAACACCC  ATTGGACCAA  1080
1081  CACTATAGAA  ACCTACATTG  TGCCTTGCGC  CCCCTTGACC  ATGAAAGTTA  TGAGTTCAAA  1140
1141  GTGATTTCCC  AGTACCTACA  ATCTACCCAT  GCTCCCACAC  ACAGCGACTA  TACCATGACC  1200
1201  TTGCTGGATT  TGTTTGAAGT  GGAGAAGGAT  GGTGAGAAAG  AAGCCTTCAG  AGAGGACCTT  1260
1261  CATAACAGGA  TGCTTCTATG  GCATGGTTCC  AGGATGAGTA  ACTGGGTGGG  AATCTTGAGC  1320
1321  CATGGGCTTC  GAATTGCCCC  ACCTGAAGCT  CCCATCACAG  GTTACATGTT  TGGGAAAGGA  1380
1381  ATCTACTTTG  CTGACATGTC  TTCCAAGAGT  GCCAATTACT  GCTTTGCCTC  TCGCCTAAAG  1440
1441  AATACAGGAC  TGCTGCTCTT  ATCAGAGGTA  GCTCTAGGTC  AGTGTAATGA  ACTACTAGAG  1500
1501  GCCAATCCTA  AGGCCGAAGG  ATTGCTTCAA  GGTAAACATA  GCACCAAGGG  GCTGGGCAAG  1560
1561  ATGGCTCCCA  GTTCTGCCCA  CTTCGTCACC  CTGAATGGGA  GTACAGTGCC  ATTAGGACCA  1620
1621  GCAAGTGACA  CAGGAATTCT  GAATCCAGAT  GGTTATACCC  TCAACTACAA  TGAATATATT  1680
1681  GTATATAACC  CCAACCAGGT  CCGTATGCGG  TACCTTTTAA  AGGTTCAGTT  TAATTTCCTT  1740
1741  CAGCTGTGGT  GA  1752

▼ KEYWORD

ID
Family
3D-structure
Acetylation
ADP-ribosylation
Alternative splicing
Complete proteome
DNA damage
DNA repair
DNA-binding
Glycosyltransferase
NAD
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleolus
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Molecular Function
DNA binding
Molecular Function
NAD DNA ADP-ribosyltransferase activity
Molecular Function
NAD+ ADP-ribosyltransferase activity
Molecular Function
Protein ADP-ribosylase activity
Biological Process
Base-excision repair
Biological Process
DNA ADP-ribosylation
Biological Process
DNA repair
Biological Process
Double-strand break repair
Biological Process
Extrinsic apoptotic signaling pathway
Biological Process
Negative regulation of neuron death
Biological Process
Peptidyl-serine ADP-ribosylation
Biological Process
Positive regulation of cell growth involved in cardiac muscle cell development
Biological Process
Protein ADP-ribosylation
Biological Process
Protein poly-ADP-ribosylation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nol-1745Nomascus leucogenys99.290.01119
LLPS-Pat-0073Pan troglodytes97.710.01091
LLPS-Gog-3544Gorilla gorilla97.350.01088
LLPS-Mal-1887Mandrillus leucophaeus97.180.01097
LLPS-Poa-0019Pongo abelii96.650.01080
LLPS-Mam-0560Macaca mulatta95.410.01066
LLPS-Pap-1375Pan paniscus95.410.01050
LLPS-Maf-0722Macaca fascicularis95.410.01066
LLPS-Cea-1156Cercocebus atys95.240.01058
LLPS-Chs-1412Chlorocebus sabaeus95.240.01045
LLPS-Rhb-0872Rhinopithecus bieti95.060.01063
LLPS-Man-1133Macaca nemestrina95.060.01064
LLPS-Caj-1512Callithrix jacchus94.70.01070
LLPS-Otg-0249Otolemur garnettii90.490.01035
LLPS-Loa-1048Loxodonta africana89.610.01017
LLPS-Cas-0294Carlito syrichta89.240.01020
LLPS-Ova-1536Ovis aries88.890.01008
LLPS-Bot-1874Bos taurus88.890.01010
LLPS-Eqc-2992Equus caballus88.710.01016
LLPS-Sus-0744Sus scrofa88.360.01002
LLPS-Aon-1445Aotus nancymaae88.030.0 968
LLPS-Aim-1885Ailuropoda melanoleuca87.630.01020
LLPS-Ere-0397Erinaceus europaeus87.540.01003
LLPS-Urm-1783Ursus maritimus87.460.01019
LLPS-Mup-3135Mustela putorius furo86.950.01016
LLPS-Ict-1577Ictidomys tridecemlineatus86.750.0 993
LLPS-Fec-1560Felis catus86.420.01010
LLPS-Orc-0083Oryctolagus cuniculus86.170.0 991
LLPS-Fud-0297Fukomys damarensis85.890.0 993
LLPS-Cap-0301Cavia porcellus85.590.0 967
LLPS-Caf-0144Canis familiaris85.190.0 992
LLPS-Dio-1600Dipodomys ordii85.110.0 976
LLPS-Mum-0575Mus musculus83.980.0 973
LLPS-Sah-2164Sarcophilus harrisii83.460.0 900
LLPS-Ran-1424Rattus norvegicus83.070.0 969
LLPS-Mod-2433Monodelphis domestica82.470.0 880
LLPS-Mea-0951Mesocricetus auratus80.950.0 940
LLPS-Myl-3043Myotis lucifugus79.320.0 729
LLPS-Lac-1072Latimeria chalumnae71.710.0 752
LLPS-Xet-1418Xenopus tropicalis68.570.0 732
LLPS-Anc-1219Anolis carolinensis68.240.0 754
LLPS-Xim-0633Xiphophorus maculatus64.210.0 691
LLPS-Icp-2820Ictalurus punctatus64.020.0 692
LLPS-Asm-0423Astyanax mexicanus63.580.0 715
LLPS-Scm-1139Scophthalmus maximus63.040.0 687
LLPS-Dar-1649Danio rerio62.850.0 684
LLPS-Tar-2176Takifugu rubripes62.230.0 545
LLPS-Scf-1095Scleropages formosus62.060.0 699
LLPS-Pof-0687Poecilia formosa61.730.0 704
LLPS-Gaa-0193Gasterosteus aculeatus60.630.0 698
LLPS-Orl-1475Oryzias latipes60.280.0 616
LLPS-Orn-0266Oreochromis niloticus59.780.0 654
LLPS-Ten-3163Tetraodon nigroviridis59.740.0 656
LLPS-Sol-0746Solanum lycopersicum52.919e-58 214
LLPS-Zem-0161Zea mays52.616e-87 278
LLPS-Coc-0897Corchorus capsularis52.03e-0654.7
LLPS-Leo-1975Lepisosteus oculatus51.940.0 533
LLPS-Cis-0156Ciona savignyi50.981e-174 512
LLPS-Tra-1496Triticum aestivum50.11e-147 451
LLPS-Cus-0060Cucumis sativus48.963e-139 427
LLPS-Amt-0791Amborella trichopoda48.861e-146 445
LLPS-Brn-3160Brassica napus48.855e-147 446
LLPS-Brr-0678Brassica rapa48.637e-146 442
LLPS-Phv-0221Phaseolus vulgaris48.544e-145 439
LLPS-Bro-1088Brassica oleracea48.338e-146 445
LLPS-Mae-1535Manihot esculenta48.331e-133 411
LLPS-Viv-0205Vitis vinifera48.236e-144 435
LLPS-Hov-0763Hordeum vulgare48.232e-138 429
LLPS-Glm-0196Glycine max48.122e-140 427
LLPS-Gor-2055Gossypium raimondii48.022e-143 438
LLPS-Thc-1222Theobroma cacao47.89e-145 440
LLPS-Sei-1591Setaria italica47.731e-136 417
LLPS-Brd-0095Brachypodium distachyon47.712e-133 414
LLPS-Tru-1270Triticum urartu47.675e-129 405
LLPS-Sem-0309Selaginella moellendorffii47.614e-145 441
LLPS-Pot-0052Populus trichocarpa47.592e-143 436
LLPS-Hea-2308Helianthus annuus47.41e-141 432
LLPS-Art-0542Arabidopsis thaliana47.392e-145 441
LLPS-Lep-1511Leersia perrieri47.085e-139 426
LLPS-Dac-0097Daucus carota47.07e-144 440
LLPS-Cii-1479Ciona intestinalis46.982e-158 472
LLPS-Ori-2039Oryza indica46.978e-0756.2
LLPS-Nia-0607Nicotiana attenuata46.913e-136 418
LLPS-Orbr-2008Oryza brachyantha46.762e-140 429
LLPS-Sot-1210Solanum tuberosum46.641e-132 412
LLPS-Orm-0778Oryza meridionalis46.259e-138 422
LLPS-Orr-1724Oryza rufipogon46.234e-135 420
LLPS-Met-1811Medicago truncatula45.931e-135 417
LLPS-Prp-2051Prunus persica45.751e-144 439
LLPS-Mua-1430Musa acuminata45.271e-129 397
LLPS-Ors-0056Oryza sativa45.067e-138 422
LLPS-Arl-2051Arabidopsis lyrata44.913e-146 444
LLPS-Sob-0951Sorghum bicolor44.063e-118 367
LLPS-Orp-1976Oryza punctata44.051e-138 425
LLPS-Org-1189Oryza glaberrima43.635e-137 421
LLPS-Orb-1681Oryza barthii43.637e-131 419
LLPS-Php-0916Physcomitrella patens43.331e-138 428
LLPS-Orgl-0958Oryza glumaepatula42.882e-128 398
LLPS-Orni-1874Oryza nivara41.852e-130 402
LLPS-Tag-1555Taeniopygia guttata41.142e-115 371
LLPS-Gaga-3404Gallus gallus41.142e-115 374
LLPS-Meg-1238Meleagris gallopavo41.144e-115 372
LLPS-Anp-0454Anas platyrhynchos40.941e-118 379
LLPS-Paa-0580Papio anubis40.941e-117 380
LLPS-Fia-1185Ficedula albicollis40.753e-113 367
LLPS-Pes-0866Pelodiscus sinensis40.477e-117 377
LLPS-Via-0824Vigna angularis40.085e-99 317
LLPS-Drm-0204Drosophila melanogaster40.02e-114 371
LLPS-Pyt-1075Pyrenophora teres39.882e-91 302
LLPS-Map-0755Magnaporthe poae39.812e-85 290
LLPS-Ora-0714Ornithorhynchus anatinus39.743e-116 375
LLPS-Fus-0229Fusarium solani39.465e-86 289
LLPS-Cog-0505Colletotrichum gloeosporioides39.114e-78 267
LLPS-Zyt-0954Zymoseptoria tritici38.996e-81 272
LLPS-Fuo-0590Fusarium oxysporum38.921e-95 315
LLPS-Trv-1319Trichoderma virens38.883e-87 291
LLPS-Fuv-1273Fusarium verticillioides38.881e-88 296
LLPS-Ved-0826Verticillium dahliae38.813e-79 271
LLPS-Phn-0556Phaeosphaeria nodorum38.637e-83 279
LLPS-Trr-1190Trichoderma reesei38.611e-92 306
LLPS-Beb-0252Beauveria bassiana38.618e-93 308
LLPS-Pytr-1032Pyrenophora triticirepentis38.511e-88 294
LLPS-Mao-1004Magnaporthe oryzae38.482e-84 285
LLPS-Gag-0349Gaeumannomyces graminis38.13e-84 287
LLPS-Dos-0339Dothistroma septosporum37.991e-91 301
LLPS-Aso-1146Aspergillus oryzae37.793e-94 310
LLPS-Asni-0241Aspergillus niger37.622e-88 293
LLPS-Asf-0875Aspergillus flavus37.69e-94 308
LLPS-Lem-0868Leptosphaeria maculans37.222e-82 288
LLPS-Cogr-0969Colletotrichum graminicola36.821e-79 272
LLPS-Asn-0677Aspergillus nidulans36.133e-95 312
LLPS-Asc-0626Aspergillus clavatus36.11e-82 279
LLPS-Asfu-1606Aspergillus fumigatus36.018e-95 311
LLPS-Ast-1421Aspergillus terreus35.881e-92 305
LLPS-Cae-0773Caenorhabditis elegans35.763e-85 291
LLPS-Nef-1280Neosartorya fischeri35.471e-91 303