LLPS-Hos-1479
ALDH1B1

▼ OVERVIEW

Status: Reviewed
Protein Name: Aldehyde dehydrogenase X, mitochondrial; Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1
Gene Name: ALDH1B1, ALDH5, ALDHX
Ensembl Gene: ENSG00000137124.7
Ensembl Protein: ENSP00000366927.3
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."
N/A26980300

▼ FUNCTION

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLRFLAPRLL  SLQGRTARYS  SAAALPSPIL  NPDIPYNQLF  INNEWQDAVS  KKTFPTVNPT  60
61    TGEVIGHVAE  GDRADVDRAV  KAAREAFRLG  SPWRRMDASE  RGRLLNRLAD  LVERDRVYLA  120
121   SLETLDNGKP  FQESYALDLD  EVIKVYRYFA  GWADKWHGKT  IPMDGQHFCF  TRHEPVGVCG  180
181   QIIPWNFPLV  MQGWKLAPAL  ATGNTVVMKV  AEQTPLSALY  LASLIKEAGF  PPGVVNIITG  240
241   YGPTAGAAIA  QHVDVDKVAF  TGSTEVGHLI  QKAAGDSNLK  RVTLELGGKS  PSIVLADADM  300
301   EHAVEQCHEA  LFFNMGQCCC  AGSRTFVEES  IYNEFLERTV  EKAKQRKVGN  PFELDTQQGP  360
361   QVDKEQFERV  LGYIQLGQKE  GAKLLCGGER  FGERGFFIKP  TVFGGVQDDM  RIAKEEIFGP  420
421   VQPLFKFKKI  EEVVERANNT  RYGLAAAVFT  RDLDKAMYFT  QALQAGTVWV  NTYNIVTCHT  480
481   PFGGFKESGN  GRELGEDGLK  AYTEVKTVTI  KVPQKNS  517
Nucleotide CDS Sequence (FASTA)
1     ATGCTGCGCT  TCCTGGCACC  CCGGCTGCTT  AGCCTCCAGG  GCAGGACCGC  CCGCTACTCC  60
61    TCGGCAGCAG  CCCTCCCAAG  CCCCATTCTG  AACCCAGACA  TCCCCTACAA  CCAGCTGTTC  120
121   ATCAACAATG  AATGGCAAGA  TGCAGTCAGC  AAGAAGACCT  TCCCGACGGT  CAACCCTACC  180
181   ACCGGGGAGG  TCATTGGGCA  CGTGGCTGAA  GGTGACCGGG  CTGATGTGGA  TCGGGCCGTG  240
241   AAAGCAGCCC  GGGAAGCCTT  CCGCCTGGGG  TCCCCATGGC  GCCGGATGGA  TGCCTCTGAG  300
301   CGGGGCCGGC  TGCTGAACCG  CCTGGCAGAC  CTAGTGGAGC  GGGATCGAGT  CTACTTGGCC  360
361   TCACTCGAGA  CCTTGGACAA  TGGGAAGCCT  TTCCAAGAGT  CTTACGCCTT  GGACTTGGAT  420
421   GAGGTCATCA  AGGTGTATCG  GTACTTTGCT  GGCTGGGCTG  ACAAGTGGCA  TGGCAAGACC  480
481   ATCCCCATGG  ATGGCCAGCA  TTTCTGCTTC  ACCCGGCATG  AGCCCGTTGG  TGTCTGTGGC  540
541   CAGATCATCC  CGTGGAACTT  CCCCTTGGTC  ATGCAGGGTT  GGAAACTTGC  CCCGGCACTC  600
601   GCCACAGGCA  ACACTGTGGT  TATGAAGGTG  GCAGAGCAGA  CCCCCCTCTC  TGCCCTGTAT  660
661   TTGGCCTCCC  TCATCAAGGA  GGCAGGCTTT  CCCCCTGGGG  TGGTGAACAT  CATCACGGGG  720
721   TATGGCCCAA  CAGCAGGTGC  GGCCATCGCC  CAGCACGTGG  ATGTTGACAA  AGTTGCCTTC  780
781   ACCGGTTCCA  CCGAGGTGGG  CCACCTGATC  CAGAAAGCAG  CTGGCGATTC  CAACCTCAAG  840
841   AGAGTCACCC  TGGAGCTGGG  TGGTAAGAGC  CCCAGCATCG  TGCTGGCCGA  TGCTGACATG  900
901   GAGCATGCCG  TGGAGCAGTG  CCACGAAGCC  CTGTTCTTCA  ACATGGGCCA  GTGCTGCTGT  960
961   GCTGGCTCCC  GGACCTTCGT  GGAAGAATCC  ATCTACAATG  AGTTTCTCGA  GAGAACCGTG  1020
1021  GAGAAAGCAA  AGCAGAGGAA  AGTGGGGAAC  CCCTTTGAGC  TGGACACCCA  GCAGGGGCCT  1080
1081  CAGGTGGACA  AGGAGCAGTT  TGAACGAGTC  CTAGGCTACA  TCCAGCTTGG  CCAGAAGGAG  1140
1141  GGCGCAAAAC  TCCTCTGTGG  CGGAGAGCGT  TTCGGGGAGC  GTGGTTTCTT  CATCAAGCCT  1200
1201  ACTGTCTTTG  GTGGCGTGCA  GGATGACATG  AGAATTGCCA  AAGAGGAGAT  CTTTGGGCCT  1260
1261  GTGCAGCCCC  TGTTCAAGTT  CAAGAAGATT  GAGGAGGTGG  TTGAGAGGGC  CAACAACACC  1320
1321  AGGTATGGCC  TGGCTGCGGC  TGTGTTCACC  CGGGATCTGG  ACAAGGCCAT  GTACTTCACC  1380
1381  CAGGCACTCC  AGGCCGGGAC  CGTGTGGGTA  AACACCTACA  ACATCGTCAC  CTGCCACACG  1440
1441  CCATTTGGAG  GGTTTAAGGA  ATCTGGAAAC  GGGAGGGAGC  TGGGTGAGGA  TGGGCTTAAG  1500
1501  GCCTACACAG  AGGTAAAGAC  GGTCACCATC  AAGGTTCCTC  AGAAGAACTC  GTAA  1554

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Intracellular membrane-bounded organelle
Cellular Component
Mitochondrial matrix
Cellular Component
Mitochondrion
Cellular Component
Nucleoplasm
Molecular Function
Aldehyde dehydrogenase (NAD) activity
Molecular Function
Glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
Molecular Function
NAD binding
Biological Process
Carbohydrate metabolic process
Biological Process
Ethanol catabolic process
Biological Process
Ethanol oxidation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-3887Pan paniscus99.420.01006
LLPS-Pat-0745Pan troglodytes99.420.01006
LLPS-Poa-0377Pongo abelii99.030.01003
LLPS-Rhb-4279Rhinopithecus bieti98.650.01001
LLPS-Gog-0293Gorilla gorilla98.650.01000
LLPS-Paa-0698Papio anubis98.450.0 999
LLPS-Mal-1217Mandrillus leucophaeus98.420.0 977
LLPS-Maf-0955Macaca fascicularis98.260.0 996
LLPS-Chs-2058Chlorocebus sabaeus98.260.0 996
LLPS-Mam-0603Macaca mulatta98.070.0 993
LLPS-Man-2209Macaca nemestrina98.070.0 995
LLPS-Cea-0858Cercocebus atys98.070.0 993
LLPS-Caj-0313Callithrix jacchus97.490.0 986
LLPS-Ict-1226Ictidomys tridecemlineatus97.10.0 984
LLPS-Otg-1997Otolemur garnettii96.130.0 976
LLPS-Cas-2889Carlito syrichta95.360.0 974
LLPS-Fec-4647Felis catus95.180.0 969
LLPS-Mup-3085Mustela putorius furo95.160.0 968
LLPS-Mum-4113Mus musculus94.850.0 945
LLPS-Sus-0080Sus scrofa94.390.0 957
LLPS-Ran-2606Rattus norvegicus94.170.0 961
LLPS-Mea-0595Mesocricetus auratus93.990.0 956
LLPS-Caf-4171Canis familiaris93.920.0 814
LLPS-Aim-0066Ailuropoda melanoleuca93.810.0 951
LLPS-Urm-1262Ursus maritimus90.120.0 883
LLPS-Sah-2702Sarcophilus harrisii89.560.0 924
LLPS-Ora-3387Ornithorhynchus anatinus89.110.0 905
LLPS-Mod-4159Monodelphis domestica88.390.0 917
LLPS-Aon-0969Aotus nancymaae87.980.0 855
LLPS-Bot-1230Bos taurus87.170.0 862
LLPS-Nol-1846Nomascus leucogenys81.820.0 808
LLPS-Loa-0755Loxodonta africana80.00.0 729
LLPS-Xet-2548Xenopus tropicalis79.040.0 808
LLPS-Myl-3714Myotis lucifugus76.830.0 738
LLPS-Anp-0295Anas platyrhynchos75.920.0 754
LLPS-Fia-1023Ficedula albicollis75.720.0 698
LLPS-Ova-4203Ovis aries75.450.0 763
LLPS-Cap-2099Cavia porcellus74.710.0 766
LLPS-Tag-1097Taeniopygia guttata74.490.0 744
LLPS-Dio-0896Dipodomys ordii73.760.0 754
LLPS-Gaga-1805Gallus gallus73.60.0 766
LLPS-Eqc-0225Equus caballus73.490.0 752
LLPS-Fud-1035Fukomys damarensis72.880.0 756
LLPS-Asm-1518Astyanax mexicanus72.420.0 733
LLPS-Orl-1010Oryzias latipes71.520.0 717
LLPS-Ten-0943Tetraodon nigroviridis71.40.0 713
LLPS-Anc-1139Anolis carolinensis70.970.0 730
LLPS-Orn-1806Oreochromis niloticus70.850.0 746
LLPS-Orc-0968Oryctolagus cuniculus70.820.0 726
LLPS-Lac-3883Latimeria chalumnae70.710.0 733
LLPS-Pes-2180Pelodiscus sinensis70.690.0 679
LLPS-Icp-0718Ictalurus punctatus70.660.0 748
LLPS-Scm-0639Scophthalmus maximus70.330.0 743
LLPS-Tar-2028Takifugu rubripes70.330.0 734
LLPS-Leo-3032Lepisosteus oculatus70.320.0 671
LLPS-Gaa-0735Gasterosteus aculeatus70.210.0 736
LLPS-Dar-2072Danio rerio69.940.0 739
LLPS-Xim-1332Xiphophorus maculatus69.50.0 725
LLPS-Cii-0998Ciona intestinalis69.430.0 687
LLPS-Scf-1590Scleropages formosus69.310.0 715
LLPS-Pof-0622Poecilia formosa68.920.0 718
LLPS-Cis-2091Ciona savignyi68.710.0 678
LLPS-Meg-1121Meleagris gallopavo67.50.0 632
LLPS-Ere-0303Erinaceus europaeus67.470.0 621
LLPS-Drm-1545Drosophila melanogaster66.480.0 685
LLPS-Cae-1728Caenorhabditis elegans64.340.0 646
LLPS-Glm-1808Glycine max58.470.0 561
LLPS-Prp-0797Prunus persica58.450.0 562
LLPS-Mae-1799Manihot esculenta57.910.0 553
LLPS-Nia-1903Nicotiana attenuata57.910.0 561
LLPS-Vir-0584Vigna radiata57.910.0 564
LLPS-Pot-1779Populus trichocarpa57.630.0 562
LLPS-Sol-0065Solanum lycopersicum57.40.0 556
LLPS-Phv-2328Phaseolus vulgaris57.20.0 566
LLPS-Met-0514Medicago truncatula57.170.0 555
LLPS-Coc-1204Corchorus capsularis57.140.0 555
LLPS-Sob-2532Sorghum bicolor57.00.0 558
LLPS-Sei-0217Setaria italica57.00.0 562
LLPS-Sot-0286Solanum tuberosum57.00.0 555
LLPS-Art-1050Arabidopsis thaliana56.050.0 555
LLPS-Mua-2121Musa acuminata55.250.0 555