LLPS-Hos-1458
NOL8

▼ OVERVIEW

Status: Reviewed
Protein Name: Nucleolar protein 8; Nucleolar protein Nop132
Gene Name: NOL8, C9orf34, NOP132
Ensembl Gene: ENSG00000198000.11
Ensembl Protein: ENSP00000439751.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli."
HeLa cells15635413
Nucleolus
"...SILAC-based approaches identified 351 proteins with 24 proteins showing at least a 2-fold change after infection."
HeLa cells19812395
Nucleolus
"...Finally, 221 proteins were found as nucleolar with No/Cyto > 1 and No/Nuc > 1."
HCT116 cells20026476

▼ FUNCTION

Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENST00000544867.5ENSP00000439751.1
EnsemblENST00000433029.6ENSP00000412471.2
EnsemblENST00000535807.5ENSP00000442666.1
EnsemblENST00000411621.6ENSP00000388335.2
EnsemblENST00000543260.5ENSP00000437615.1
EnsemblENST00000535387.5ENSP00000441300.1
EnsemblENST00000542613.5ENSP00000442596.1
EnsemblENST00000442668.6ENSP00000401177.2
EnsemblENST00000542573.5ENSP00000440342.1
EnsemblENST00000432670.6ENSP00000414112.2
EnsemblENST00000421075.6ENSP00000390143.2
EnsemblENST00000360868.7ENSP00000354115.3
EnsemblENST00000542053.5ENSP00000440709.1
EnsemblENST00000536593.5ENSP00000446265.1
EnsemblENST00000536624.5ENSP00000442037.1
EnsemblENST00000358855.8ENSP00000351723.4
EnsemblENST00000544321.5ENSP00000444790.1
EnsemblENST00000545558.5ENSP00000441140.1
EnsemblENST00000545444.5ENSP00000439829.1
EnsemblENST00000445919.6ENSP00000390791.2
EnsemblENST00000434228.5ENSP00000415750.1
UniProtQ76FK4, NOL8_HUMAN, Q5TCC7, Q5TCC8, Q5TCD3, Q5TCD5, Q5TCD6, Q5TCD7, Q76D35, Q7L3E2, Q9H586, Q9H795, Q9H7W7, Q9H9J6, Q9NWA4, Q9NWM4
GeneBankAL136097, AK024786, AK024245, AB109030, AB105104, AK022755, AK000743, BC013788, AK001049BAD12268.1, BAA91356.1, BAB14857.1, BAB15003.1, BAB14229.1, AAH13788.2, BAC99315.1, BAA91479.1
RefSeqNM_001256394.1, NM_001330722.1, NM_017948.5, XM_006717166.3, XM_006717167.3, XM_006717169.3, XM_006717170.3, XM_011518824.2, XM_017014876.1NP_001243323.1, NP_001317651.1, NP_060418.4, XP_006717229.1, XP_006717230.1, XP_006717232.1, XP_006717233.1, XP_011517126.1, XP_016870365.1
Entrez55035

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKVNRETKRL  YVGGLSQDIS  EADLQNQFSR  FGEVSDVEII  TRKDDQGNPQ  KVFAYINISV  60
61    AEADLKKCMS  VLNKTKWKGG  TLQIQLAKES  FLHRLAQERE  AAKAKKEEST  TGNANLLEKT  120
121   GGVDFHMKAV  PGTEVPGHKN  WVVSKFGRVL  PVLHLKNQHK  RKIIKYDPSK  YCHNLKKIGE  180
181   DFSNTIPISS  LTWELEGGND  PMSKKRRGEF  SDFHGPPKKI  IKVQKDESST  GSLAMSTRPR  240
241   RVIERPPLTQ  QQAAQKRTCD  SITPSKSSPV  PVSDTQKLKN  LPFKTSGLET  AKKRNSISDD  300
301   DTDSEDELRM  MIAKEENLQR  TTQPSINESE  SDPFEVVRDD  FKSGVHKLHS  LIGLGIKNRV  360
361   SCHDSDDDIM  RNDREYDSGD  TDEIIAMKKN  VAKVKNSTEF  SQMEKSTKKT  SFKNRENCEL  420
421   SDHCIKLQKR  KSNVESALSH  GLKSLNRKSP  SHSSSSEDAD  SASELADSEG  GEEYNAMMKN  480
481   CLRVNLTLAD  LEQLAGSDLK  VPNEDTKSDG  PETTTQCKFD  RGSKSPKTPT  GLRRGRQCIR  540
541   PAEIVASLLE  GEENTCGKQK  PKENNLKPKF  QAFKGVGCLY  EKESMKKSLK  DSVASNNKDQ  600
601   NSMKHEDPSI  ISMEDGSPYV  NGSLGEVTPC  QHAKKANGPN  YIQPQKRQTT  FESQDRKAVS  660
661   PSSSEKRSKN  PISRPLEGKK  SLSLSAKTHN  IGFDKDSCHS  TTKTEASQEE  RSDSSGLTSL  720
721   KKSPKVSSKD  TREIKTDFSL  SISNSSDVSA  KDKHAEDNEK  RLAALEARQK  AKEVQKKLVH  780
781   NALANLDGHP  EDKPTHIIFG  SDSECETEET  STQEQSHPGE  EWVKESMGKT  SGKLFDSSDD  840
841   DESDSEDDSN  RFKIKPQFEG  RAGQKLMDLQ  SHFGTDDRFR  MDSRFLETDS  EEEQEEVNEK  900
901   KTAEEEELAE  EKKKALNVVQ  SVLQINLSNS  TNRGSVAAKK  FKDIIHYDPT  KQDHATYERK  960
961   RDDKPKESKA  KRKKKREEAE  KLPEVSKEMY  YNIAMDLKEI  FQTTKYTSEK  EEGTPWNEDC  1020
1021  GKEKPEEIQD  PAALTSDAEQ  PSGFTFSFFD  SDTKDIKEET  YRVETVKPGK  IVWQEDPRLQ  1080
1081  DSSSEEEDVT  EETDHRNSSP  GEASLLEKET  TRFFFFSKND  ERLQGSDLFW  RGVGSNMSRN  1140
1141  SWEARTTNLR  MDCRKKHKDA  KRKMKPK  1167
Nucleotide CDS Sequence (FASTA)
1     ATGTCTGTTT  TAAATAAAAC  AAAATGGAAA  GGTGGAACAT  TACAAATTCA  ACTAGCAAAA  60
61    GAAAGCTTTC  TGCACAGATT  GGCCCAAGAG  AGAGAAGCAG  CAAAAGCTAA  GAAAGAAGAA  120
121   TCAACAACAG  GTAACGCCAA  CTTGTTAGAA  AAGACAGGAG  GAGTGGATTT  CCATATGAAA  180
181   GCTGTGCCAG  GGACAGAAGT  GCCAGGGCAT  AAGAATTGGG  TTGTGAGCAA  ATTTGGAAGA  240
241   GTCTTACCTG  TTCTTCACCT  TAAAAATCAA  CATAAACGTA  AAATCATCAA  ATATGATCCC  300
301   TCAAAATACT  GCCACAACCT  GAAGAAGATA  GGGGAGGATT  TCTCAAACAC  CATTCCTATA  360
361   TCCAGCCTGA  CTTGGGAATT  AGAAGGAGGG  AATGACCCTA  TGAGTAAGAA  ACGGCGAGGA  420
421   GAGTTCTCTG  ACTTTCATGG  CCCTCCCAAG  AAGATAATAA  AAGTGCAGAA  GGATGAGAGT  480
481   TCCACTGGGT  CTCTGGCCAT  GAGTACAAGG  CCCAGGAGGG  TAATAGAGAG  ACCACCCTTA  540
541   ACACAGCAAC  AGGCTGCACA  AAAAAGAACT  TGTGATTCCA  TTACTCCTTC  TAAATCATCT  600
601   CCTGTACCTG  TTTCTGATAC  TCAGAAACTT  AAAAATCTAC  CTTTTAAGAC  TTCTGGCTTG  660
661   GAAACTGCCA  AGAAGAGAAA  CAGCATTTCT  GATGATGATA  CTGATTCTGA  AGATGAATTG  720
721   AGAATGATGA  TTGCGAAAGA  GGAAAACTTA  CAGAGAACTA  CACAACCCTC  AATAAATGAA  780
781   TCTGAAAGTG  ATCCTTTTGA  AGTTGTAAGG  GATGATTTCA  AATCAGGCGT  TCACAAACTG  840
841   CATTCTTTAA  TAGGTTTAGG  TATCAAAAAT  CGTGTCTCTT  GCCATGATAG  TGATGATGAT  900
901   ATTATGAGAA  ATGATCGTGA  GTATGACTCA  GGAGATACAG  ATGAAATTAT  TGCGATGAAA  960
961   AAAAATGTTG  CTAAGGTCAA  AAACAGTACA  GAATTTTCAC  AAATGGAAAA  ATCTACGAAG  1020
1021  AAAACTTCTT  TCAAAAATAG  AGAAAACTGT  GAGCTTTCTG  ATCACTGTAT  TAAACTACAA  1080
1081  AAAAGAAAAA  GCAATGTAGA  GTCAGCCCTC  AGTCATGGAT  TAAAGTCTCT  TAATCGTAAA  1140
1141  TCTCCCTCTC  ACTCCAGTAG  CAGTGAAGAT  GCTGATTCTG  CATCAGAATT  AGCTGACTCT  1200
1201  GAAGGAGGTG  AGGAGTATAA  TGCCATGATG  AAAAACTGCC  TTCGTGTGAA  TCTCACTTTA  1260
1261  GCTGATTTGG  AACAATTGGC  TGGCAGTGAT  CTGAAGGTTC  CAAATGAAGA  TACTAAGAGT  1320
1321  GATGGACCAG  AAACCACCAC  CCAATGCAAG  TTTGACAGAG  GCTCCAAGAG  CCCCAAGACT  1380
1381  CCCACTGGCC  TCCGCAGAGG  CCGACAGTGT  ATTCGTCCTG  CGGAGATTGT  GGCTTCCCTG  1440
1441  TTAGAAGGAG  AGGAGAACAC  CTGTGGCAAA  CAGAAACCAA  AGGAAAACAA  TTTAAAGCCA  1500
1501  AAATTTCAGG  CTTTCAAGGG  AGTAGGCTGT  CTATATGAAA  AGGAGTCAAT  GAAAAAATCC  1560
1561  TTGAAAGACA  GTGTTGCCTC  TAACAATAAA  GATCAGAATT  CCATGAAACA  TGAGGATCCC  1620
1621  AGTATCATAT  CCATGGAAGA  TGGGTCCCCA  TATGTTAATG  GCTCATTAGG  TGAAGTGACT  1680
1681  CCATGCCAAC  ATGCAAAGAA  GGCGAATGGC  CCAAACTATA  TTCAGCCTCA  AAAAAGACAG  1740
1741  ACCACTTTTG  AAAGCCAGGA  TCGCAAGGCA  GTGTCCCCTA  GCAGTTCTGA  AAAGAGAAGT  1800
1801  AAGAATCCTA  TTTCTAGGCC  ATTAGAAGGT  AAGAAGTCCT  TAAGTCTTAG  TGCAAAGACT  1860
1861  CACAACATAG  GCTTTGACAA  AGACAGCTGC  CATAGTACCA  CAAAGACAGA  AGCTTCACAG  1920
1921  GAAGAGCGGT  CTGATTCAAG  CGGCCTCACA  TCTCTCAAGA  AATCACCAAA  GGTCTCATCC  1980
1981  AAGGACACTC  GGGAAATCAA  AACTGATTTC  TCACTTTCTA  TTAGTAATTC  GTCAGATGTG  2040
2041  AGTGCTAAAG  ATAAGCATGC  TGAAGACAAT  GAGAAGCGTT  TGGCAGCCTT  GGAAGCGAGG  2100
2101  CAAAAAGCAA  AAGAAGTGCA  GAAGAAGCTG  GTGCATAATG  CTCTGGCAAA  TTTGGATGGT  2160
2161  CATCCAGAGG  ATAAGCCAAC  GCACATCATC  TTCGGTTCTG  ACAGTGAATG  TGAAACAGAG  2220
2221  GAGACATCGA  CTCAGGAGCA  GAGCCATCCA  GGAGAGGAAT  GGGTGAAAGA  GTCTATGGGT  2280
2281  AAAACATCAG  GGAAGCTGTT  TGATAGCAGT  GATGATGACG  AATCTGATTC  TGAAGATGAC  2340
2341  AGTAATAGGT  TCAAAATTAA  ACCTCAGTTT  GAGGGCAGAG  CTGGACAGAA  GCTCATGGAT  2400
2401  TTACAGTCGC  ACTTTGGCAC  CGATGACAGA  TTCCGCATGG  ACTCTCGATT  TCTAGAAACT  2460
2461  GACAGTGAAG  AGGAACAGGA  AGAGGTAAAT  GAAAAGAAAA  CTGCTGAGGA  AGAAGAGCTT  2520
2521  GCTGAAGAAA  AAAAGAAAGC  CCTGAATGTT  GTACAAAGTG  TTTTGCAAAT  CAACTTAAGC  2580
2581  AATTCTACAA  ACAGAGGATC  AGTAGCTGCT  AAGAAATTTA  AGGACATCAT  ACATTATGAT  2640
2641  CCAACGAAGC  AAGACCATGC  CACTTACGAA  AGAAAAAGAG  ATGATAAGCC  AAAAGAAAGT  2700
2701  AAAGCAAAAC  GAAAAAAGAA  AAGGGAGGAA  GCTGAGAAAC  TACCTGAGGT  GTCTAAAGAA  2760
2761  ATGTATTATA  ATATTGCTAT  GGATCTGAAA  GAAATATTCC  AAACTACAAA  ATATACCAGT  2820
2821  GAAAAGGAAG  AGGGCACACC  CTGGAATGAG  GACTGTGGTA  AAGAGAAACC  TGAGGAAATC  2880
2881  CAGGACCCTG  CAGCTCTGAC  CAGTGACGCT  GAGCAGCCCA  GCGGGTTCAC  GTTCTCTTTT  2940
2941  TTTGATTCAG  ACACTAAAGA  CATAAAGGAA  GAGACCTACA  GAGTTGAAAC  AGTGAAACCT  3000
3001  GGAAAGATTG  TCTGGCAGGA  AGACCCTCGT  TTACAAGACA  GCAGTTCAGA  AGAGGAAGAT  3060
3061  GTTACTGAAG  AAACAGATCA  CAGAAACTCC  AGTCCTGGAG  AAGCATCATT  ACTTGAGAAA  3120
3121  GAGACCACTA  GATTTTTCTT  TTTCTCTAAG  AATGATGAAC  GACTTCAAGG  TTCTGACTTA  3180
3181  TTCTGGAGAG  GAGTAGGAAG  TAATATGAGC  AGGAACTCTT  GGGAGGCCAG  AACAACCAAC  3240
3241  CTGCGTATGG  ATTGTCGAAA  GAAACATAAA  GACGCAAAAA  GGAAAATGAA  ACCAAAATAA  3300

▼ KEYWORD

ID
Family
Alternative splicing
Coiled coil
Complete proteome
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
RNA-binding
rRNA processing
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleolus
Cellular Component
Ribonucleoprotein complex
Molecular Function
RNA binding
Biological Process
Protein localization to nucleolus
Biological Process
RRNA processing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-3776Pan troglodytes98.440.02003
LLPS-Pap-0821Pan paniscus97.680.01984
LLPS-Poa-0636Pongo abelii96.110.01933
LLPS-Nol-0574Nomascus leucogenys95.160.01905
LLPS-Gog-0983Gorilla gorilla95.010.01697
LLPS-Maf-0087Macaca fascicularis94.060.01870
LLPS-Chs-2621Chlorocebus sabaeus94.030.01505
LLPS-Man-1384Macaca nemestrina93.720.01888
LLPS-Mam-1244Macaca mulatta93.630.01863
LLPS-Mal-0593Mandrillus leucophaeus93.250.01873
LLPS-Paa-2424Papio anubis92.530.01848
LLPS-Rhb-1306Rhinopithecus bieti90.970.01787
LLPS-Caj-1216Callithrix jacchus90.770.01818
LLPS-Cea-1600Cercocebus atys90.280.01760
LLPS-Aon-2615Aotus nancymaae89.910.01752
LLPS-Dio-0812Dipodomys ordii87.234e-50 178
LLPS-Mea-3564Mesocricetus auratus86.178e-49 174
LLPS-Fud-0911Fukomys damarensis85.864e-51 182
LLPS-Cas-1510Carlito syrichta78.980.01490
LLPS-Otg-0082Otolemur garnettii75.060.01029
LLPS-Eqc-2189Equus caballus74.810.01405
LLPS-Sus-2539Sus scrofa73.280.01398
LLPS-Bot-0169Bos taurus73.170.01382
LLPS-Ict-2122Ictidomys tridecemlineatus73.130.01362
LLPS-Ova-0779Ovis aries72.890.01359
LLPS-Myl-1785Myotis lucifugus71.820.01340
LLPS-Loa-1080Loxodonta africana69.430.01307
LLPS-Asm-1799Astyanax mexicanus67.022e-37 142
LLPS-Fec-0774Felis catus66.950.01260
LLPS-Mup-1549Mustela putorius furo66.240.01228
LLPS-Orc-0289Oryctolagus cuniculus65.490.0 920
LLPS-Aim-1041Ailuropoda melanoleuca65.430.01217
LLPS-Caf-1887Canis familiaris65.090.01204
LLPS-Urm-0489Ursus maritimus64.490.01191
LLPS-Cap-3061Cavia porcellus63.840.0 905
LLPS-Scm-1957Scophthalmus maximus62.772e-32 128
LLPS-Xim-0278Xiphophorus maculatus62.55e-31 124
LLPS-Mum-1570Mus musculus62.40.01156
LLPS-Ran-1604Rattus norvegicus61.770.01132
LLPS-Pof-0302Poecilia formosa55.984e-70 259
LLPS-Orl-1371Oryzias latipes55.562e-67 251
LLPS-Ten-1263Tetraodon nigroviridis54.173e-68 234
LLPS-Tar-1152Takifugu rubripes52.055e-63 238
LLPS-Orn-1685Oreochromis niloticus47.393e-28 127
LLPS-Anc-2243Anolis carolinensis46.482e-88 315
LLPS-Gaa-1211Gasterosteus aculeatus45.833e-33 144
LLPS-Ora-0308Ornithorhynchus anatinus44.50.0 655
LLPS-Dar-3902Danio rerio44.392e-76 280
LLPS-Tag-1522Taeniopygia guttata43.01e-49 187
LLPS-Mod-1938Monodelphis domestica42.990.0 630
LLPS-Pes-0106Pelodiscus sinensis42.420.0 610
LLPS-Anp-1367Anas platyrhynchos41.930.0 586
LLPS-Brr-1457Brassica rapa41.762e-0965.9
LLPS-Bro-0526Brassica oleracea41.761e-0966.6
LLPS-Brn-1347Brassica napus41.761e-0966.6
LLPS-Php-0204Physcomitrella patens41.499e-1377.0
LLPS-Meg-0514Meleagris gallopavo41.162e-177 560
LLPS-Gaga-0201Gallus gallus41.011e-176 559
LLPS-Leo-1035Lepisosteus oculatus40.86e-49 194
LLPS-Sem-0437Selaginella moellendorffii40.431e-1172.8
LLPS-Tra-1273Triticum aestivum39.785e-1171.2
LLPS-Xet-1629Xenopus tropicalis39.391e-154 499
LLPS-Fia-0790Ficedula albicollis39.090.0 572
LLPS-Gor-1759Gossypium raimondii38.641e-0863.5
LLPS-Orp-0150Oryza punctata38.462e-1068.9
LLPS-Thc-1056Theobroma cacao38.462e-0863.2
LLPS-Orgl-0912Oryza glumaepatula38.462e-1068.9
LLPS-Phv-0208Phaseolus vulgaris37.786e-0964.3
LLPS-Via-0262Vigna angularis37.781e-0863.2
LLPS-Lac-2216Latimeria chalumnae37.772e-146 478
LLPS-Crn-0429Cryptococcus neoformans37.651e-1070.1
LLPS-Mae-1413Manihot esculenta37.54e-0964.7
LLPS-Coc-0035Corchorus capsularis37.51e-0760.5
LLPS-Sah-0316Sarcophilus harrisii37.458e-87 303
LLPS-Sot-1023Solanum tuberosum37.113e-0862.4
LLPS-Nia-0521Nicotiana attenuata36.842e-0862.8
LLPS-Glm-0603Glycine max36.672e-0863.2
LLPS-Sob-0664Sorghum bicolor36.369e-0963.9
LLPS-Spr-0337Sporisorium reilianum36.363e-1068.9
LLPS-Scf-0536Scleropages formosus36.353e-146 477
LLPS-Ors-0563Oryza sativa36.261e-0966.6
LLPS-Org-0194Oryza glaberrima36.262e-0966.2
LLPS-Orm-1252Oryza meridionalis36.261e-0966.6
LLPS-Orni-0853Oryza nivara36.261e-0966.6
LLPS-Ori-1937Oryza indica36.261e-0966.6
LLPS-Sei-0265Setaria italica36.263e-0965.5
LLPS-Hea-0869Helianthus annuus36.086e-1067.8
LLPS-Icp-1407Ictalurus punctatus35.633e-135 447
LLPS-Brd-0415Brachypodium distachyon35.231e-0863.2
LLPS-Pug-0749Puccinia graminis35.162e-1275.1
LLPS-Zem-0999Zea mays35.169e-0963.9
LLPS-Lep-0942Leersia perrieri35.162e-0965.9
LLPS-Miv-0194Microbotryum violaceum34.418e-0860.8
LLPS-Sol-0639Solanum lycopersicum34.411e-0657.0
LLPS-Scp-0515Schizosaccharomyces pombe33.713e-1790.5
LLPS-Chc-0827Chondrus crispus32.981e-0965.9
LLPS-Mua-0872Musa acuminata32.979e-0860.5
LLPS-Usm-0502Ustilago maydis32.638e-0964.3
LLPS-Scj-0165Schizosaccharomyces japonicus32.612e-0965.5
LLPS-Met-1196Medicago truncatula31.915e-0758.2
LLPS-Mel-0031Melampsora laricipopulina31.871e-0966.6
LLPS-Scc-0053Schizosaccharomyces cryophilus31.641e-1585.5
LLPS-Cus-0190Cucumis sativus30.261e-0760.5
LLPS-Abg-0437Absidia glauca28.492e-1379.0