LLPS-Hos-1449
HMMR
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Hyaluronan mediated motility receptor; Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility |
| Gene Name: | HMMR, IHABP, RHAMM |
| Ensembl Gene: | ENSG00000072571.19 |
| Ensembl Protein: | ENSP00000377492.4 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
▼ FUNCTION
| Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000393915.8 | ENSP00000377492.4 |
| Ensembl | ENST00000353866.7 | ENSP00000185942.6 |
| Ensembl | ENST00000358715.3 | ENSP00000351554.3 |
| Ensembl | ENST00000522094.5 | ENSP00000428406.1 |
| Ensembl | ENST00000520345.5 | ENSP00000428481.1 |
| Ensembl | ENST00000432118.6 | ENSP00000402673.2 |
| UniProt | O75330, HMMR_HUMAN, A8K3G2, B4E114, D3DQK9, D3DQL0, E9PCS0, Q32N02, Q92767 | |
| GeneBank | AK303616, CH471062, U29343, AK290577, AC112205, AF032862, BC108904 | BAG64626.1, AAC52049.1, AAC32548.1, EAW61523.1, EAW61524.1, EAW61525.1, AAI08905.1, EAW61522.1, BAF83266.1 |
| RefSeq | NM_001142556.1, NM_001142557.1, NM_012484.2, NM_012485.2 | NP_001136028.1, NP_001136029.1, NP_036616.2, NP_036617.2 |
| Entrez | 3161 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES KQNLNVDKDT 60 61 TLPASARKVK SSESKKESQK NDKDLKILEK EIRVLLQERG AQDRRIQDLE TELEKMEARL 120 121 NAALREKTSL SANNATLEKQ LIELTRTNEL LKSKFSENGN QKNLRILSLE LMKLRNKRET 180 181 KMRGMMAKQE GMEMKLQVTQ RSLEESQGKI AQLEGKLVSI EKEKIDEKSE TEKLLEYIEE 240 241 ISCASDQVEK YKLDIAQLEE NLKEKNDEIL SLKQSLEENI VILSKQVEDL NVKCQLLEKE 300 301 KEDHVNRNRE HNENLNAEMQ NLKQKFILEQ QEREKLQQKE LQIDSLLQQE KELSSSLHQK 360 361 LCSFQEEMVK EKNLFEEELK QTLDELDKLQ QKEEQAERLV KQLEEEAKSR AEELKLLEEK 420 421 LKGKEAELEK SSAAHTQATL LLQEKYDSMV QSLEDVTAQF ESYKALTASE IEDLKLENSS 480 481 LQEKAAKAGK NAEDVQHQIL ATESSNQEYV RMLLDLQTKS ALKETEIKEI TVSFLQKITD 540 541 LQNQLKQQEE DFRKQLEDEE GRKAEKENTT AELTEEINKW RLLYEELYNK TKPFQLQLDA 600 601 FEVEKQALLN EHGAAQEQLN KIRDSYAKLL GHQNLKQKIK HVVKLKDENS QLKSEVSKLR 660 661 CQLAKKKQSE TKLQEELNKV LGIKHFDPSK AFHHESKENF ALKTPLKEGN TNCYRAPMEC 720 721 QESWK 725 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCCTTTC CTAAGGCGCC CTTGAAACGA TTCAATGACC CTTCTGGTTG TGCACCATCT 60 61 CCAGGTGCTT ATGATGTTAA AACTTTAGAA GTATTGAAAG GACCAGTATC CTTTCAGAAA 120 121 TCACAAAGAT TTAAACAACA AAAAGAATCT AAACAAAATC TTAATGTTGA CAAAGATACT 180 181 ACCTTGCCTG CTTCAGCTAG AAAAGTTAAG TCTTCGGAAT CAAAGATTCG TGTTCTTCTA 240 241 CAGGAACGTG GTGCCCAGGA CAGGCGGATC CAGGATCTGG AAACTGAGTT GGAAAAGATG 300 301 GAAGCAAGGC TAAATGCTGC ACTAAGGGAA AAAACATCTC TCTCTGCAAA TAATGCTACA 360 361 CTGGAAAAAC AACTTATTGA ATTGACCAGG ACTAATGAAC TACTAAAATC TAAGTTTTCT 420 421 GAAAATGGTA ACCAGAAGAA TTTGAGAATT CTAAGCTTGG AGTTGATGAA ACTTAGAAAC 480 481 AAAAGAGAAA CAAAGATGAG GGGTATGATG GCTAAGCAAG AAGGCATGGA GATGAAGCTG 540 541 CAGGTCACCC AAAGGAGTCT CGAAGAGTCT CAAGGGAAAA TAGCCCAACT GGAGGGAAAA 600 601 CTTGTTTCAA TAGAGAAAGA AAAGATTGAT GAAAAATCTG AAACAGAAAA ACTCTTGGAA 660 661 TACATCGAAG AAATTAGTTG TGCTTCAGAT CAAGTGGAAA AATACAAGCT AGATATTGCC 720 721 CAGTTAGAAG AAAATTTGAA AGAGAAGAAT GATGAAATTT TAAGCCTTAA GCAGTCTCTT 780 781 GAGGAGAATA TTGTTATATT ATCTAAACAA GTAGAAGATC TAAATGTGAA ATGTCAGCTG 840 841 CTTGAAAAAG AAAAAGAAGA CCATGTCAAC AGGAATAGAG AACACAACGA AAATCTAAAT 900 901 GCAGAGATGC AAAACTTAAA ACAGAAGTTT ATTCTTGAAC AACAGGAACG TGAAAAGCTT 960 961 CAACAAAAAG AATTACAAAT TGATTCACTT CTGCAACAAG AGAAAGAATT ATCTTCGAGT 1020 1021 CTTCATCAGA AGCTCTGTTC TTTTCAAGAG GAAATGGTTA AAGAGAAGAA TCTGTTTGAG 1080 1081 GAAGAATTAA AGCAAACACT GGATGAGCTT GATAAATTAC AGCAAAAGGA GGAACAAGCT 1140 1141 GAAAGGCTGG TCAAGCAATT GGAAGAGGAA GCAAAATCTA GAGCTGAAGA ATTAAAACTC 1200 1201 CTAGAAGAAA AGCTGAAAGG GAAGGAGGCT GAACTGGAGA AAAGTAGTGC TGCTCATACC 1260 1261 CAGGCCACCC TGCTTTTGCA GGAAAAGTAT GACAGTATGG TGCAAAGCCT TGAAGATGTT 1320 1321 ACTGCTCAAT TTGAAAGCTA TAAAGCGTTA ACAGCCAGTG AGATAGAAGA TCTTAAGCTG 1380 1381 GAGAACTCAT CATTACAGGA AAAAGCGGCC AAGGCTGGGA AAAATGCAGA GGATGTTCAG 1440 1441 CATCAGATTT TGGCAACTGA GAGCTCAAAT CAAGAATATG TAAGGATGCT TCTAGATCTG 1500 1501 CAGACCAAGT CAGCACTAAA GGAAACAGAA ATTAAAGAAA TCACAGTTTC TTTTCTTCAA 1560 1561 AAAATAACTG ATTTGCAGAA CCAACTCAAG CAACAGGAGG AAGACTTTAG AAAACAGCTG 1620 1621 GAAGATGAAG AAGGAAGAAA AGCTGAAAAA GAAAATACAA CAGCAGAATT AACTGAAGAA 1680 1681 ATTAACAAGT GGCGTCTCCT CTATGAAGAA CTATATAATA AAACAAAACC TTTTCAGCTA 1740 1741 CAACTAGATG CTTTTGAAGT AGAAAAACAG GCATTGTTGA ATGAACATGG TGCAGCTCAG 1800 1801 GAACAGCTAA ATAAAATAAG AGATTCATAT GCTAAATTAT TGGGTCATCA GAATTTGAAA 1860 1861 CAAAAAATCA AGCATGTTGT GAAGTTGAAA GATGAAAATA GCCAACTCAA ATCGGAAGTA 1920 1921 TCAAAACTCC GCTGTCAGCT TGCTAAAAAA AAACAAAGTG AGACAAAACT TCAAGAGGAA 1980 1981 TTGAATAAAG TTCTAGGTAT CAAACACTTT GATCCTTCAA AGGCTTTTCA TCATGAAAGT 2040 2041 AAAGAAAATT TTGCCCTGAA GACCCCATTA AAAGAAGGCA ATACAAACTG TTACCGAGCT 2100 2101 CCTATGGAGT GTCAAGAATC ATGGAAGTAA 2130 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell surface | |
Cellular Component | Centrosome | |
Cellular Component | Cytosol | |
Cellular Component | Membrane | |
Cellular Component | Microtubule cytoskeleton | |
Cellular Component | Plasma membrane | |
Molecular Function | Hyaluronic acid binding | |
Biological Process | Hyaluronan catabolic process | |
Biological Process | Regulation of G2/M transition of mitotic cell cycle |
▼ ANNOTATION
| Disease | ||||
| OMIM | DisGeNET | ActiveDriverDB | ||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CORUM | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| ICGC | MethyCancer | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-4643 | Pan paniscus | 98.9 | 0.0 | 1185 |
| LLPS-Pat-2461 | Pan troglodytes | 98.76 | 0.0 | 1182 |
| LLPS-Gog-4707 | Gorilla gorilla | 98.34 | 0.0 | 1176 |
| LLPS-Poa-1345 | Pongo abelii | 98.21 | 0.0 | 1179 |
| LLPS-Nol-1788 | Nomascus leucogenys | 97.1 | 0.0 | 1155 |
| LLPS-Chs-2925 | Chlorocebus sabaeus | 96.92 | 0.0 | 1139 |
| LLPS-Man-0449 | Macaca nemestrina | 96.64 | 0.0 | 1132 |
| LLPS-Cea-0137 | Cercocebus atys | 96.5 | 0.0 | 1131 |
| LLPS-Rhb-3924 | Rhinopithecus bieti | 96.46 | 0.0 | 621 |
| LLPS-Maf-3742 | Macaca fascicularis | 96.36 | 0.0 | 1133 |
| LLPS-Paa-3934 | Papio anubis | 95.45 | 0.0 | 615 |
| LLPS-Mam-0345 | Macaca mulatta | 94.76 | 0.0 | 1112 |
| LLPS-Mal-2778 | Mandrillus leucophaeus | 94.51 | 0.0 | 1093 |
| LLPS-Aon-1854 | Aotus nancymaae | 93.38 | 0.0 | 1102 |
| LLPS-Caj-0946 | Callithrix jacchus | 89.82 | 0.0 | 1029 |
| LLPS-Aim-1711 | Ailuropoda melanoleuca | 88.89 | 1e-140 | 441 |
| LLPS-Fec-0336 | Felis catus | 87.34 | 0.0 | 546 |
| LLPS-Caf-0155 | Canis familiaris | 86.96 | 3e-133 | 420 |
| LLPS-Mup-2832 | Mustela putorius furo | 86.6 | 0.0 | 998 |
| LLPS-Sus-0717 | Sus scrofa | 86.4 | 0.0 | 995 |
| LLPS-Eqc-3301 | Equus caballus | 85.99 | 0.0 | 1006 |
| LLPS-Tut-1720 | Tursiops truncatus | 85.1 | 0.0 | 1001 |
| LLPS-Myl-1095 | Myotis lucifugus | 84.36 | 0.0 | 985 |
| LLPS-Loa-4181 | Loxodonta africana | 84.19 | 6e-127 | 405 |
| LLPS-Bot-4882 | Bos taurus | 83.87 | 0.0 | 971 |
| LLPS-Ova-4039 | Ovis aries | 83.66 | 0.0 | 965 |
| LLPS-Orc-1099 | Oryctolagus cuniculus | 82.93 | 0.0 | 936 |
| LLPS-Ict-4292 | Ictidomys tridecemlineatus | 82.91 | 0.0 | 949 |
| LLPS-Cap-3766 | Cavia porcellus | 80.25 | 0.0 | 897 |
| LLPS-Otg-2231 | Otolemur garnettii | 80.07 | 5e-144 | 448 |
| LLPS-Cas-2140 | Carlito syrichta | 78.34 | 0.0 | 936 |
| LLPS-Urm-3634 | Ursus maritimus | 77.78 | 0.0 | 933 |
| LLPS-Ran-4592 | Rattus norvegicus | 74.19 | 0.0 | 863 |
| LLPS-Mea-0348 | Mesocricetus auratus | 72.93 | 0.0 | 835 |
| LLPS-Leo-3810 | Lepisosteus oculatus | 65.47 | 2e-44 | 175 |
| LLPS-Mum-3686 | Mus musculus | 64.12 | 0.0 | 742 |
| LLPS-Sah-4120 | Sarcophilus harrisii | 62.75 | 2e-122 | 393 |
| LLPS-Mod-4139 | Monodelphis domestica | 62.0 | 0.0 | 688 |
| LLPS-Orn-3491 | Oreochromis niloticus | 58.99 | 4e-36 | 150 |
| LLPS-Meg-3301 | Meleagris gallopavo | 58.82 | 3e-62 | 230 |
| LLPS-Anp-0570 | Anas platyrhynchos | 57.71 | 2e-76 | 267 |
| LLPS-Xet-1429 | Xenopus tropicalis | 53.42 | 2e-53 | 204 |
| LLPS-Tar-3467 | Takifugu rubripes | 53.33 | 3e-27 | 122 |
| LLPS-Scm-2611 | Scophthalmus maximus | 52.86 | 2e-33 | 142 |
| LLPS-Tag-2488 | Taeniopygia guttata | 52.33 | 1e-145 | 446 |
| LLPS-Ora-2185 | Ornithorhynchus anatinus | 52.11 | 7e-160 | 486 |
| LLPS-Pes-2205 | Pelodiscus sinensis | 51.82 | 3e-177 | 530 |
| LLPS-Gaa-3340 | Gasterosteus aculeatus | 50.57 | 8e-36 | 149 |
| LLPS-Icp-0149 | Ictalurus punctatus | 50.31 | 6e-34 | 143 |
| LLPS-Orl-3215 | Oryzias latipes | 49.72 | 2e-34 | 145 |
| LLPS-Gaga-3215 | Gallus gallus | 49.59 | 1e-163 | 497 |
| LLPS-Fia-1855 | Ficedula albicollis | 49.45 | 4e-166 | 503 |
| LLPS-Pof-2400 | Poecilia formosa | 48.6 | 2e-33 | 142 |
| LLPS-Dar-3307 | Danio rerio | 48.39 | 1e-36 | 152 |
| LLPS-Lac-3288 | Latimeria chalumnae | 47.7 | 3e-93 | 315 |
| LLPS-Asm-3630 | Astyanax mexicanus | 46.33 | 7e-33 | 140 |
| LLPS-Anc-3249 | Anolis carolinensis | 45.48 | 1e-158 | 484 |
| LLPS-Scf-0065 | Scleropages formosus | 44.19 | 1e-34 | 145 |
| LLPS-Xim-2676 | Xiphophorus maculatus | 40.16 | 1e-33 | 142 |
| LLPS-Cii-1595 | Ciona intestinalis | 37.26 | 8e-25 | 114 |
| LLPS-Dio-3466 | Dipodomys ordii | 26.42 | 7e-06 | 53.9 |