LLPS-Hos-1244
SAMD4A

▼ OVERVIEW

Status: Reviewed
Protein Name: Protein Smaug homolog 1
Gene Name: SAMD4A, KIAA1053, SAMD4, SMAUG1
Ensembl Gene: ENSG00000020577.13
Ensembl Protein: ENSP00000450808.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granule
"...283 proteins identified as APEX hits in HEK293T cells or previously shown to associate with SGs."
N/A29373831
Stress granule
"...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell."
U2OS cells26777405

▼ FUNCTION

Acts as a translational repressor of SRE-containing messengers.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MMFRDQVGVL  AGWFKGWNEC  EQTVALLSLL  KRVSQTQARF  LQLCLEHSLA  DCAELHVLER  60
61    EANSPGIINQ  WQQESKDKVI  SLLLTHLPLL  KPGNLDAKVE  YMKLLPKILA  HSIEHNQHIE  120
121   ESRQLLSYAL  IHPATSLEDR  SALAMWLNHL  EDRTSTSFGG  QNRGRSDSVD  YGQTHYYHQR  180
181   QNSDDKLNGW  QNSRDSGICI  NASNWQDKSM  GCENGHVPLY  SSSSVPTTIN  TIGTSTSTIL  240
241   SGQAHHSPLK  RSVSLTPPMN  VPNQPLGHGW  MSHEDLRARG  PQCLPSDHAP  LSPQSSVASS  300
301   GSGGSEHLED  QTTARNTFQE  EGSGMKDVPA  WLKSLRLHKY  AALFSQMTYE  EMMALTECQL  360
361   EAQNVTKGAR  HKIVISIQKL  KERQNLLKSL  ERDIIEGGSL  RIPLQELHQM  ILTPIKAYSS  420
421   PSTTPEARRR  EPQAPRQPSL  MGPESQSPDC  KDGAAATGAT  ATPSAGASGG  LQPHQLSSCD  480
481   GELAVAPLPE  GDLPGQFTRV  MGKVCTQLLV  SRPDEENISS  YLQLIDKCLI  HEAFTETQKK  540
541   RLLSWKQQVQ  KLFRSFPRKT  LLDISGYRQQ  RNRGFGQSNS  LPTAGSVGGG  MGRRNPRQYQ  600
601   IPSRNVPSAR  LGLLGTSGFV  SSNQRNTTAT  PTIMKQGRQN  LWFANPGGSN  SMPSRTHSSV  660
661   QRTRSLPVHT  SPQNMLMFQQ  PEFQLPVTEP  DINNRLESLC  LSMTEHALGD  GVDRTSTI  718
Nucleotide CDS Sequence (FASTA)
1     ATGATGTTTC  GCGACCAGGT  CGGGGTGCTG  GCGGGCTGGT  TTAAGGGCTG  GAACGAGTGC  60
61    GAGCAGACTG  TTGCGCTGCT  GTCGCTGCTC  AAGCGCGTGA  GCCAGACCCA  GGCCCGCTTC  120
121   CTCCAGCTCT  GCCTGGAGCA  CTCGCTGGCC  GACTGCGCCG  AGCTGCACGT  CCTCGAACGC  180
181   GAGGCCAACA  GCCCCGGAAT  CATTAACCAA  TGGCAACAGG  AATCCAAGGA  TAAAGTGATT  240
241   TCCCTCCTGT  TAACTCATCT  GCCTTTGCTG  AAGCCAGGAA  ACCTCGACGC  GAAAGTAGAA  300
301   TATATGAAAC  TGCTGCCCAA  AATCCTGGCT  CACTCTATTG  AACACAACCA  GCACATTGAG  360
361   GAGAGCAGGC  AGCTGCTGTC  CTATGCTTTG  ATACATCCAG  CCACTTCGTT  AGAAGACCGT  420
421   AGTGCTTTAG  CCATGTGGCT  GAATCACTTG  GAGGACCGCA  CGTCGACCAG  CTTTGGTGGC  480
481   CAGAACCGAG  GCCGCTCAGA  CTCTGTGGAT  TATGGACAGA  CACACTACTA  TCACCAAAGA  540
541   CAGAACTCTG  ATGACAAGCT  CAATGGGTGG  CAGAACTCTC  GGGATTCTGG  GATTTGCATC  600
601   AATGCCTCCA  ACTGGCAGGA  CAAAAGCATG  GGGTGTGAGA  ATGGCCATGT  GCCCCTCTAC  660
661   TCCTCCTCAT  CTGTCCCCAC  CACAATCAAT  ACGATTGGAA  CCAGCACAAG  TACAAATGTT  720
721   CCAGCCTGGC  TGAAAAGCCT  CCGCCTGCAC  AAATATGCCG  CGCTTTTCTC  CCAGATGACC  780
781   TATGAGGAGA  TGATGGCCCT  CACCGAGTGC  CAGCTGGAGG  CGCAGAATGT  TACCAAAGGT  840
841   GCAAGACACA  AAATTGTCAT  CAGTATTCAG  AAGCTCAAAG  AAAGACAAAA  TCTCCTGAAG  900
901   TCTTTGGAAA  GGGACATCAT  CGAGGGGGGC  AGCCTGCGCA  TCCCGCTCCA  GGAACTGCAC  960
961   CAGATGATCC  TGACTCCGAT  CAAGGCCTAC  AGCTCCCCGA  GCACCACCCC  CGAGGCTCGC  1020
1021  CGCCGGGAGC  CCCAGGCCCC  GCGTCAGCCC  TCACTGATGG  GCCCCGAGAG  CCAGAGCCCC  1080
1081  GACTGCAAAG  ATGGGGCCGC  AGCCACTGGC  GCCACGGCCA  CCCCCTCGGC  CGGGGCCAGC  1140
1141  GGGGGGCTCC  AGCCGCACCA  GCTGAGCAGC  TGCGATGGGG  AGCTGGCCGT  CGCCCCCCTG  1200
1201  CCAGAGGGGG  ACCTCCCCGG  GCAGTTCACA  CGCGTCATGG  GGAAAGTGTG  CACACAGCTC  1260
1261  TTGGTCTCCA  GACCTGATGA  GGAAAATATA  AGTTCCTATT  TACAGCTCAT  AGACAAGTGT  1320
1321  CTAATTCATG  AGGCATTTAC  AGAGACACAG  AAAAAAAGAT  TGTTGTCATG  GAAACAGCAG  1380
1381  GTGCAGAAGC  TCTTTCGGTC  TTTCCCTCGG  AAAACCCTTC  TAGACATATC  AGGATATCGA  1440
1441  CAGCAAAGAA  ATCGAGGCTT  TGGGCAATCC  AACTCCCTCC  CGACGGCTGG  CTCTGTGGGC  1500
1501  GGTGGCATGG  GCAGACGGAA  CCCGCGCCAG  TACCAGATCC  CCTCTCGGAA  CGTCCCTTCC  1560
1561  GCCCGCCTGG  GCCTCTTGGG  CACCAGTGGA  TTCGTCAGCT  CCAACCAGCG  CAACACCACA  1620
1621  GCTACCCCCA  CCATCATGAA  ACAAGGAAGA  CAGAACCTGT  GGTTTGCCAA  CCCCGGGGGC  1680
1681  AGCAATAGCA  TGCCAAGCCG  CACCCACAGC  TCAGTCCAGA  GGACCCGCTC  GCTGCCCGTG  1740
1741  CACACTTCCC  CACAGAACAT  GCTGATGTTC  CAGCAGCCAG  AATTCCAGCT  TCCCGTGACC  1800
1801  GAACCTGACA  TCAACAACAG  GCTGGAGTCG  TTGTGCCTCA  GTATGACCGA  ACACGCCCTG  1860
1861  GGAGACGGGG  TTGACCGGAC  CTCCACCATC  TAG  1893

▼ KEYWORD

ID
Family
Alternative splicing
Cell junction
Cell projection
Complete proteome
Cytoplasm
Methylation
Phosphoprotein
Reference proteome
Repressor
Synapse
Synaptosome
Translation regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell junction
Cellular Component
Cytosol
Cellular Component
Dendrite
Cellular Component
Fibrillar center
Cellular Component
P-body
Cellular Component
Synapse
Molecular Function
MRNA binding
Molecular Function
RNA binding
Molecular Function
Translation repressor activity
Biological Process
Negative regulation of translation
Biological Process
Nuclear-transcribed mRNA poly(A) tail shortening
Biological Process
Positive regulation of translation
Biological Process
Regulation of mRNA stability

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-4786Gorilla gorilla99.860.01309
LLPS-Pat-1293Pan troglodytes99.860.01309
LLPS-Nol-4558Nomascus leucogenys99.690.0 580
LLPS-Poa-4068Pongo abelii99.350.01128
LLPS-Maf-3006Macaca fascicularis99.030.01301
LLPS-Chs-0373Chlorocebus sabaeus99.030.01301
LLPS-Cea-1849Cercocebus atys99.030.01301
LLPS-Mal-0656Mandrillus leucophaeus99.030.01301
LLPS-Paa-4086Papio anubis99.030.01301
LLPS-Rhb-4545Rhinopithecus bieti99.030.01301
LLPS-Man-2651Macaca nemestrina99.030.01301
LLPS-Caj-0656Callithrix jacchus98.890.01301
LLPS-Mam-0063Macaca mulatta98.890.01305
LLPS-Aon-3715Aotus nancymaae98.470.01295
LLPS-Myl-0340Myotis lucifugus98.280.01138
LLPS-Fec-2781Felis catus97.60.01264
LLPS-Caf-4374Canis familiaris97.490.01288
LLPS-Sus-3425Sus scrofa97.350.01285
LLPS-Mup-2154Mustela putorius furo97.350.01288
LLPS-Tut-1665Tursiops truncatus97.210.01283
LLPS-Loa-3474Loxodonta africana97.080.01283
LLPS-Ova-4337Ovis aries96.320.01145
LLPS-Urm-2870Ursus maritimus95.980.01139
LLPS-Ict-4137Ictidomys tridecemlineatus95.960.01285
LLPS-Ran-4860Rattus norvegicus94.930.01234
LLPS-Dio-2276Dipodomys ordii94.850.01280
LLPS-Cas-2629Carlito syrichta94.490.01122
LLPS-Mum-4777Mus musculus94.440.01254
LLPS-Orc-3545Oryctolagus cuniculus94.280.01225
LLPS-Mea-1355Mesocricetus auratus93.880.01257
LLPS-Eqc-2349Equus caballus93.530.01196
LLPS-Cap-0833Cavia porcellus93.470.01267
LLPS-Otg-4520Otolemur garnettii91.980.01204
LLPS-Pap-4037Pan paniscus91.510.01040
LLPS-Mod-4103Monodelphis domestica88.530.01085
LLPS-Gaga-1159Gallus gallus86.350.01152
LLPS-Tag-1619Taeniopygia guttata85.30.01128
LLPS-Fia-3295Ficedula albicollis85.260.01130
LLPS-Sah-2462Sarcophilus harrisii85.150.01085
LLPS-Anc-1215Anolis carolinensis84.040.01150
LLPS-Pes-2669Pelodiscus sinensis83.00.01040
LLPS-Lac-1532Latimeria chalumnae82.890.01112
LLPS-Meg-0487Meleagris gallopavo81.460.0 949
LLPS-Anp-3284Anas platyrhynchos78.290.0 689
LLPS-Ora-1653Ornithorhynchus anatinus77.782e-0858.9
LLPS-Fud-1437Fukomys damarensis75.950.0 867
LLPS-Leo-1596Lepisosteus oculatus71.140.0 929
LLPS-Scf-3735Scleropages formosus68.60.0 888
LLPS-Ten-2734Tetraodon nigroviridis66.210.0 835
LLPS-Orn-2862Oreochromis niloticus66.050.0 840
LLPS-Dar-1402Danio rerio65.240.0 821
LLPS-Tar-0039Takifugu rubripes64.840.0 843
LLPS-Xim-1818Xiphophorus maculatus62.990.0 822
LLPS-Xet-2646Xenopus tropicalis62.770.0 721
LLPS-Orl-2933Oryzias latipes62.50.0 798
LLPS-Pof-3819Poecilia formosa60.960.0 735
LLPS-Scm-2875Scophthalmus maximus59.390.0 782
LLPS-Cii-0365Ciona intestinalis48.731e-38 154
LLPS-Put-0811Puccinia triticina43.13e-0758.2
LLPS-Asm-0914Astyanax mexicanus42.863e-0654.7
LLPS-Abg-0643Absidia glauca41.389e-0859.7
LLPS-Zyt-0736Zymoseptoria tritici40.984e-0757.4
LLPS-Gaa-3379Gasterosteus aculeatus40.06e-0653.9