LLPS-Hos-1232
DZIP3
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | E3 ubiquitin-protein ligase DZIP3; DAZ-interacting protein 3; RING-type E3 ubiquitin transferase DZIP3; RNA-binding ubiquitin ligase of 138 kDa; hRUL138 |
| Gene Name: | DZIP3, KIAA0675 |
| Ensembl Gene: | ENSG00000198919.12 |
| Ensembl Protein: | ENSP00000417829.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body | "...Analysis of correlated patterns between endogenous preys uncovers the spatial organization of RNA regulatory structures and enables the definition of 144 core components of SGs and PBs." | N/A | 29395067 |
| Stress granule | "...Analysis of correlated patterns between endogenous preys uncovers the spatial organization of RNA regulatory structures and enables the definition of 144 core components of SGs and PBs." | N/A | 29395067 |
▼ FUNCTION
| E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000497905.5 | ENSP00000417829.1 |
| Ensembl | ENST00000463306.1 | ENSP00000419981.1 |
| Ensembl | ENST00000495008.5 | ENSP00000418871.1 |
| Ensembl | ENST00000479138.5 | ENSP00000418115.1 |
| Ensembl | ENST00000486815.5 | ENSP00000420030.1 |
| Ensembl | ENST00000361582.7 | ENSP00000355028.3 |
| UniProt | Q86Y13, DZIP3_HUMAN, B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9 | |
| GeneBank | AY227653, AB014575, AY227651, AY227652, AK023138, BC056674, BC063882, AY227654, BC039018, AF279370 | AAO72970.1, AAH63882.1, BAG51163.1, AAK69484.1, AAO72968.1, BAA31650.2, AAH56674.1, AAO72967.1, AAH39018.1, AAO72969.1 |
| RefSeq | NM_014648.3, XM_005247914.3, XM_005247915.3, XM_005247916.3, XM_005247917.3, XM_005247918.3, XM_017007540.1 | NP_055463.1, XP_005247971.1, XP_005247972.1, XP_005247973.1, XP_005247974.1, XP_005247975.1, XP_016863029.1 |
| Entrez | 9666 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDSLPDEFFV RHPAVEDQRK EETENKLEKS SGQLNKQEND IPTDLVPVNL LLEVKKLLNA 60 61 INTLPKGVVP HIKKFLQEDF SFQTMQREVA ANSQNGEEIV PALTLRFLIT QLEAALRNIQ 120 121 AGNYTAHQIN IGYYLTLLFL YGVALTERGK KEDYTEAENK FLVMKMMIQE NEICENFMSL 180 181 VYFGRGLLRC AQKRYNGGLL EFHKSLQEIG DKNDHWFDID PTEDEDLPTT FKDLLNNFIK 240 241 TTESNIMKQT ICSYLDCERS CEADILKNTS YKGFFQLMCS KSCCVYFHKI CWKKFKNLKY 300 301 PGENDQSFSG KKCLKEGCTG DMVRMLQCDV PGIVKILFEV VRKDEYITIE NLGASYRKLI 360 361 SLKITDTDIR PKISLKFNTK DEMPIFKLDY NYFYHLLHII IISGTDIVRQ IFDEAMPPPL 420 421 LKKELLIHKN VLESYYNHLW TNHPLGGSWH LLYPPNKELP QSKQFDLCLL LALIKHLNVF 480 481 PAPKKGWNME PPSSDISKSA DILRLCKYRD ILLSEILMNG LTESQFNSIW KKVSDILLRL 540 541 GMMQEDIDKV KENPIENISL DYHQLSVYLG IPVPEIIQRM LSCYQQGIAL QSITGSQRIE 600 601 IEELQNEEEE LSPPLMEYNI NVKSHPEIQF AEINKDGTSI PSESSTESLK DLQEVKSKQR 660 661 KKKKTKNKKN KDSKEDQVPY VVEKEEQLRK EQANPHSVSR LIKDDASDVQ EDSAMEDKFY 720 721 SLDELHILDM IEQGSAGKVT TDYGETEKER LARQRQLYKL HYQCEDFKRQ LRTVTFRWQE 780 781 NQMQIKKKDK IIASLNQQVA FGINKVSKLQ RQIHAKDNEI KNLKEQLSMK RSQWEMEKHN 840 841 LESTMKTYVS KLNAETSRAL TAEVYFLQCR RDFGLLHLEQ TEKECLNQLA RVTHMAASNL 900 901 ESLQLKAAVD SWNAIVADVR NKIAFLRTQY NEQINKVKQG FALSTLPPVQ LPPPPPSPEI 960 961 LMQQFLGRPL VKESFFRPIL TVPQMPAVCP GVVSATGQPR APLMTGIAWA LPAPVGDAVP 1020 1021 PSAGLRSDPS IMNWERITDR LKTAFPQQTR KELTDFLRKL KDAYGKSLSE LTFDEIVCKI 1080 1081 SQFIDPKKSQ SQGKSVSNVN CVSPSHSPSQ PDAAQPPKPA WRPLTSQGPA TWEGASNPDE 1140 1141 EEEEEEPCVI CHENLSPENL SVLPCAHKFH AQCIRPWLMQ QGTCPTCRLH VLLPEEFPGH 1200 1201 PSRQLPKI 1208 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGATTCTC TACCAGATGA ATTTTTTGTG AGGCATCCTG CTGTGGAGGA TCAGAGGAAG 60 61 GAAGAAACTG AGAATAAGCT AGAAAAATCA TCTGGTCAAC TGAACAAACA GGAAAATGAC 120 121 ATACCTACTG ATCTTGTCCC TGTTAACCTA CTATTAGAAG TGAAGAAGTT ATTAAATGCA 180 181 ATTAATACTC TACCAAAAGG TGTGGTTCCT CACATTAAGA AGTTCTTACA AGAAGATTTT 240 241 TCCTTCCAAA CTATGCAGAG AGAAGTTGCA GCTAACAGCC AGAATGGTGA GGAAATTGTT 300 301 CCTGCTTTGA CTTTACGTTT CTTGATTACA CAGCTAGAAG CAGCACTTAG GAACATTCAA 360 361 GCTGGCAATT ATACCGCACA CCAGATTAAT ATTGGTTATT ATTTGACATT ACTGTTTTTA 420 421 TATGGAGTAG CACTCACTGA AAGAGGAAAG AAAGAGGATT ATACAGAAGC TGAGAATAAA 480 481 TTTCTGGTGA TGAAGATGAT GATCCAAGAA AATGAAATTT GTGAAAACTT TATGTCTTTA 540 541 GTTTATTTTG GACGTGGTTT ACTGCGATGT GCTCAAAAGA GATATAATGG AGGACTGCTA 600 601 GAATTTCATA AAAGCTTACA AGAAATTGGA GACAAAAATG ACCATTGGTT TGACATAGAT 660 661 CCTACAGAAG ATGAAGATTT ACCTACAACT TTTAAAGATC TTCTTAATAA TTTTATCAAG 720 721 ACAACTGAAA GCAATATAAT GAAGCAGACG ATTTGTAGTT ACCTAGATTG TGAACGATCT 780 781 TGTGAAGCTG ACATTTTGAA GAACACCAGT TATAAGGGAT TTTTTCAGTT AATGTGCAGT 840 841 AAAAGTTGCT GTGTTTATTT CCATAAAATT TGCTGGAAAA AGTTCAAGAA TTTAAAGTAT 900 901 CCAGGTGAAA ATGATCAGAG TTTTAGTGGG AAAAAATGTT TGAAGGAAGG ATGTACAGGT 960 961 GACATGGTAA GGATGCTGCA ATGTGATGTA CCTGGAATTG TTAAAATTTT GTTTGAAGTT 1020 1021 GTGAGAAAGG ATGAATATAT CACCATTGAA AATTTAGGAG CAAGTTATAG AAAGTTGATA 1080 1081 TCTCTGAAAA TAACTGATAC TGATATAAGA CCGAAGATCA GTTTAAAATT TAATACAAAA 1140 1141 GATGAAATGC CTATCTTCAA GCTTGATTAT AATTATTTCT ATCATCTGCT TCATATAATT 1200 1201 ATTATTTCTG GTACTGACAT TGTTCGACAA ATATTTGATG AGGCTATGCC ACCTCCTCTT 1260 1261 TTGAAAAAAG AGCTTCTTAT ACACAAGAAT GTGCTGGAAT CCTACTACAA CCATCTTTGG 1320 1321 ACCAATCATC CTTTGGGTGG ATCATGGCAT CTGCTTTATC CTCCTAACAA GGAGTTACCG 1380 1381 CAATCCAAAC AGTTTGACTT ATGCCTCCTG TTAGCTCTTA TAAAACATTT AAATGTGTTC 1440 1441 CCTGCACCCA AAAAAGGATG GAATATGGAA CCGCCATCTT CTGACATCTC TAAATCTGCA 1500 1501 GACATCCTGA GACTGTGCAA ATACAGGGAT ATCCTCCTTA GTGAGATTTT GATGAATGGT 1560 1561 CTCACTGAGT CACAGTTCAA TTCAATTTGG AAAAAAGTTT CAGATATTCT TCTGCGCCTT 1620 1621 GGGATGATGC AAGAGGATAT TGACAAAGTG AAGGAGAATC CCATTGAGAA TATCTCCCTT 1680 1681 GATTACCATC AGCTATCTGT CTACCTAGGC ATACCAGTAC CAGAAATCAT ACAGAGGATG 1740 1741 TTATCCTGCT ATCAACAAGG AATTGCTCTA CAGTCAATAA CAGGCAGTCA GCGTATTGAA 1800 1801 ATAGAAGAGT TACAGAATGA GGAAGAAGAA CTAAGTCCAC CTCTCATGGA GTACAATATA 1860 1861 AATGTGAAAT CACACCCTGA GATACAGTTT GCAGAAATTA ATAAAGATGG GACCTCAATA 1920 1921 CCCAGTGAAT CTTCAACAGA ATCTCTTAAA GATCTCCAGG AAGTTAAGAG TAAACAAAGG 1980 1981 AAAAAGAAGA AGACTAAGAA TAAAAAGAAT AAAGACTCAA AAGAAGACCA AGTCCCATAT 2040 2041 GTGGTAGAAA AGGAAGAGCA GTTGAGGAAA GAACAAGCAA ATCCACACTC AGTCAGTAGA 2100 2101 CTTATAAAAG ATGATGCAAG TGATGTTCAA GAGGATTCTG CAATGGAAGA CAAGTTCTAT 2160 2161 AGCCTGGATG AATTGCATAT TCTGGACATG ATAGAGCAGG GCTCAGCTGG CAAAGTAACT 2220 2221 ACAGACTATG GAGAAACTGA AAAGGAAAGG CTTGCTCGTC AAAGGCAGCT TTATAAATTG 2280 2281 CACTATCAGT GTGAAGATTT CAAAAGACAG TTGAGAACAG TGACTTTTCG GTGGCAAGAA 2340 2341 AACCAAATGC AGATTAAAAA GAAAGACAAA ATTATCGCAT CTCTTAATCA ACAAGTTGCT 2400 2401 TTTGGAATCA ATAAGGTTTC CAAATTACAG CGTCAAATCC ATGCTAAAGA TAATGAAATC 2460 2461 AAGAACCTTA AAGAGCAACT TTCTATGAAA AGATCTCAGT GGGAAATGGA AAAACATAAT 2520 2521 CTGGAAAGCA CAATGAAAAC ATACGTAAGC AAACTGAACG CAGAAACTAG CAGAGCTTTA 2580 2581 ACAGCCGAGG TGTATTTCTT ACAGTGTCGT AGGGATTTTG GTTTGCTTCA TCTAGAGCAG 2640 2641 ACTGAAAAGG AATGTCTCAA TCAGCTTGCC AGGGTGACTC ACATGGCAGC AAGCAACCTA 2700 2701 GAATCACTTC AATTAAAGGC TGCGGTAGAC AGTTGGAATG CCATTGTGGC AGATGTTAGA 2760 2761 AACAAGATTG CATTCCTCAG GACACAGTAC AATGAACAAA TAAACAAAGT CAAGCAAGGA 2820 2821 TTTGCCTTGA GTACCTTGCC TCCAGTCCAG CTTCCTCCTC CACCACCCAG TCCTGAGATA 2880 2881 CTGATGCAGC AGTTCTTAGG AAGACCTCTT GTGAAAGAAT CTTTCTTTAG ACCCATACTT 2940 2941 ACTGTTCCTC AAATGCCTGC AGTTTGCCCG GGAGTCGTCT CTGCAACTGG CCAACCTAGA 3000 3001 GCCCCCCTGA TGACTGGCAT AGCCTGGGCT CTGCCAGCGC CTGTGGGAGA CGCTGTGCCT 3060 3061 CCCAGTGCAG GTCTGCGGAG TGATCCCTCC ATCATGAATT GGGAGAGAAT TACAGACAGG 3120 3121 CTGAAAACTG CCTTTCCACA GCAAACCAGA AAGGAACTTA CAGATTTCTT ACGGAAATTG 3180 3181 AAGGATGCTT ATGGAAAATC CTTGTCTGAA CTGACATTTG ATGAAATTGT TTGCAAGATT 3240 3241 TCCCAGTTTA TTGACCCCAA AAAGTCTCAG AGTCAAGGAA AATCAGTGTC AAATGTTAAT 3300 3301 TGTGTTTCAC CTAGTCATTC TCCATCACAG CCTGATGCTG CCCAGCCCCC AAAACCAGCC 3360 3361 TGGAGGCCAC TCACTTCACA GGGTCCTGCC ACATGGGAAG GAGCCAGTAA TCCAGATGAG 3420 3421 GAAGAGGAAG AAGAAGAGCC TTGTGTGATC TGTCATGAGA ATCTGTCTCC AGAAAATCTT 3480 3481 TCAGTTTTGC CTTGCGCTCA CAAATTCCAT GCTCAGTGCA TTAGACCATG GTTGATGCAA 3540 3541 CAGGGGACAT GTCCAACGTG CAGACTCCAC GTTTTGCTAC CAGAAGAATT CCCTGGTCAC 3600 3601 CCCAGCCGGC AGTTGCCCAA GATCTGA 3627 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Molecular Function | Metal ion binding | |
Molecular Function | Phosphatase binding | |
Molecular Function | Polyubiquitin modification-dependent protein binding | |
Molecular Function | RNA binding | |
Molecular Function | Ubiquitin protein ligase activity | |
Molecular Function | Ubiquitin-protein transferase activity | |
Biological Process | Protein polyubiquitination |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-4211 | Gorilla gorilla | 99.25 | 0.0 | 2335 |
| LLPS-Pap-2833 | Pan paniscus | 98.68 | 0.0 | 2327 |
| LLPS-Pat-3813 | Pan troglodytes | 98.51 | 0.0 | 2321 |
| LLPS-Nol-2155 | Nomascus leucogenys | 98.34 | 0.0 | 2310 |
| LLPS-Paa-2760 | Papio anubis | 97.27 | 0.0 | 2292 |
| LLPS-Man-4626 | Macaca nemestrina | 97.19 | 0.0 | 2291 |
| LLPS-Cea-3042 | Cercocebus atys | 97.1 | 0.0 | 2292 |
| LLPS-Mam-4133 | Macaca mulatta | 97.02 | 0.0 | 2286 |
| LLPS-Mal-4415 | Mandrillus leucophaeus | 97.02 | 0.0 | 2287 |
| LLPS-Maf-2078 | Macaca fascicularis | 97.02 | 0.0 | 2285 |
| LLPS-Chs-4167 | Chlorocebus sabaeus | 96.94 | 0.0 | 2283 |
| LLPS-Poa-4471 | Pongo abelii | 95.87 | 0.0 | 2227 |
| LLPS-Caj-0063 | Callithrix jacchus | 94.62 | 0.0 | 2243 |
| LLPS-Aon-1691 | Aotus nancymaae | 93.96 | 0.0 | 2211 |
| LLPS-Otg-2157 | Otolemur garnettii | 93.13 | 0.0 | 2179 |
| LLPS-Eqc-4098 | Equus caballus | 92.3 | 0.0 | 2172 |
| LLPS-Rhb-0101 | Rhinopithecus bieti | 92.23 | 0.0 | 2159 |
| LLPS-Urm-1641 | Ursus maritimus | 91.46 | 0.0 | 2115 |
| LLPS-Ict-4061 | Ictidomys tridecemlineatus | 91.15 | 0.0 | 2110 |
| LLPS-Aim-2709 | Ailuropoda melanoleuca | 91.07 | 0.0 | 2149 |
| LLPS-Caf-2208 | Canis familiaris | 90.9 | 0.0 | 2145 |
| LLPS-Fec-1733 | Felis catus | 90.9 | 0.0 | 2149 |
| LLPS-Cas-2028 | Carlito syrichta | 90.48 | 0.0 | 2146 |
| LLPS-Mup-2001 | Mustela putorius furo | 90.24 | 0.0 | 2132 |
| LLPS-Orc-1132 | Oryctolagus cuniculus | 88.75 | 0.0 | 2040 |
| LLPS-Dio-1692 | Dipodomys ordii | 88.07 | 0.0 | 1966 |
| LLPS-Fud-4323 | Fukomys damarensis | 87.66 | 0.0 | 2012 |
| LLPS-Sus-3137 | Sus scrofa | 86.78 | 0.0 | 2028 |
| LLPS-Bot-4626 | Bos taurus | 85.79 | 0.0 | 690 |
| LLPS-Cap-3932 | Cavia porcellus | 84.77 | 0.0 | 1875 |
| LLPS-Mea-2944 | Mesocricetus auratus | 84.62 | 0.0 | 1992 |
| LLPS-Myl-2849 | Myotis lucifugus | 84.6 | 0.0 | 1974 |
| LLPS-Mum-3500 | Mus musculus | 82.98 | 0.0 | 1968 |
| LLPS-Ran-0604 | Rattus norvegicus | 81.01 | 0.0 | 1866 |
| LLPS-Loa-0798 | Loxodonta africana | 79.27 | 4e-137 | 424 |
| LLPS-Zyt-0363 | Zymoseptoria tritici | 55.0 | 7e-07 | 53.1 |
| LLPS-Mod-2945 | Monodelphis domestica | 54.05 | 7e-175 | 549 |
| LLPS-Orr-1858 | Oryza rufipogon | 53.33 | 9e-08 | 58.5 |
| LLPS-Orgl-2294 | Oryza glumaepatula | 53.33 | 9e-08 | 58.5 |
| LLPS-Lep-1487 | Leersia perrieri | 53.33 | 2e-07 | 58.2 |
| LLPS-Ori-1645 | Oryza indica | 53.33 | 1e-07 | 58.9 |
| LLPS-Sah-1113 | Sarcophilus harrisii | 51.89 | 3e-100 | 348 |
| LLPS-Orp-1866 | Oryza punctata | 46.55 | 1e-07 | 58.9 |
| LLPS-Gaa-1116 | Gasterosteus aculeatus | 40.7 | 4e-13 | 73.9 |
| LLPS-Pof-1192 | Poecilia formosa | 35.67 | 1e-24 | 107 |
| LLPS-Tru-1228 | Triticum urartu | 33.68 | 5e-08 | 60.5 |
| LLPS-Pes-1468 | Pelodiscus sinensis | 26.75 | 8e-14 | 80.1 |
| LLPS-Xet-2834 | Xenopus tropicalis | 26.13 | 3e-21 | 102 |
| LLPS-Meg-2063 | Meleagris gallopavo | 25.47 | 2e-09 | 65.9 |
| LLPS-Tag-3057 | Taeniopygia guttata | 25.35 | 3e-09 | 65.1 |
| LLPS-Leo-0645 | Lepisosteus oculatus | 25.2 | 6e-07 | 57.0 |
| LLPS-Fia-2912 | Ficedula albicollis | 25.06 | 3e-08 | 62.0 |
| LLPS-Cii-2337 | Ciona intestinalis | 25.06 | 3e-20 | 98.6 |
| LLPS-Ora-3382 | Ornithorhynchus anatinus | 24.88 | 4e-06 | 55.5 |
| LLPS-Gaga-0681 | Gallus gallus | 24.83 | 7e-12 | 73.6 |
| LLPS-Orn-2573 | Oreochromis niloticus | 24.36 | 1e-06 | 56.6 |
| LLPS-Lac-4077 | Latimeria chalumnae | 24.35 | 1e-14 | 82.8 |
| LLPS-Ova-1888 | Ovis aries | 24.11 | 9e-07 | 57.8 |
| LLPS-Amt-1533 | Amborella trichopoda | 24.07 | 3e-09 | 63.5 |
| LLPS-Xim-3581 | Xiphophorus maculatus | 23.87 | 4e-06 | 55.5 |
| LLPS-Asm-2356 | Astyanax mexicanus | 22.67 | 7e-10 | 67.0 |
| LLPS-Icp-1039 | Ictalurus punctatus | 21.13 | 1e-09 | 66.6 |