LLPS-Hos-1150
PWP2

▼ OVERVIEW

Status: Reviewed
Protein Name: Periodic tryptophan protein 2 homolog
Gene Name: PWP2, PWP2H
Ensembl Gene: ENSG00000241945.7
Ensembl Protein: ENSP00000411749.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli."
HeLa cells15635413
Nucleolus
"...Finally, 221 proteins were found as nucleolar with No/Cyto > 1 and No/Nuc > 1."
HCT116 cells20026476
Nucleolus
"...SILAC-based approaches identified 351 proteins with 24 proteins showing at least a 2-fold change after infection."
HeLa cells19812395
Nucleolus
"...As a first step in elucidating these mechanisms we have carried out a proteomic analysis to draw up a list of proteins present within nucleoli of HeLa cells. This analysis allowed the identification of 213 different nucleolar proteins."
HeLa cells12429849

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKFAYRFSNL  LGTVYRRGNL  NFTCDGNSVI  SPVGNRVTVF  DLKNNKSDTL  PLATRYNVKC  60
61    VGLSPDGRLA  IIVDEGGDAL  LVSLVCRSVL  HHFHFKGSVH  SVSFSPDGRK  FVVTKGNIAQ  120
121   MYHAPGKKRE  FNAFVLDKTY  FGPYDETTCI  DWTDDSRCFV  VGSKDMSTWV  FGAERWDNLI  180
181   YYALGGHKDA  IVACFFESNS  LDLYSLSQDG  VLCMWQCDTP  PEGLRLKPPA  GWKADLLQRE  240
241   EEEEEEEDQE  GDRETTIRGK  ATPAEEEKTG  KVKYSRLAKY  FFNKEGDFNN  LTAAAFHKKS  300
301   HLLVTGFASG  IFHLHELPEF  NLIHSLSISD  QSIASVAINS  SGDWIAFGCS  GLGQLLVWEW  360
361   QSESYVLKQQ  GHFNSMVALA  YSPDGQYIVT  GGDDGKVKVW  NTLSGFCFVT  FTEHSSGVTG  420
421   VTFTATGYVV  VTSSMDGTVR  AFDLHRYRNF  RTFTSPRPTQ  FSCVAVDASG  EIVSAGAQDS  480
481   FEIFVWSMQT  GRLLDVLSGH  EGPISGLCFN  PMKSVLASAS  WDKTVRLWDM  FDSWRTKETL  540
541   ALTSDALAVT  FRPDGAELAV  ATLNSQITFW  DPENAVQTGS  IEGRHDLKTG  RKELDKITAK  600
601   HAAKGKAFTA  LCYSADGHSI  LAGGMSKFVC  IYHVREQILM  KRFEISCNLS  LDAMEEFLNR  660
661   RKMTEFGNLA  LIDQDAGQED  GVAIPLPGVR  KGDMSSRHFK  PEIRVTSLRF  SPTGRCWAAT  720
721   TTEGLLIYSL  DTRVLFDPFE  LDTSVTPGRV  REALRQQDFT  RAILMALRLN  ESKLVQEALE  780
781   AVPRGEIEVV  TSSLPELYVE  KVLEFLASSF  EVSRHLEFYL  LWTHKLLMLH  GQKLKSRAGT  840
841   LLPVIQFLQK  SIQRHLDDLS  KLCSWNHYNM  QYALAVSKQR  GTKRSLDPLG  SEEEAEASED  900
901   DSLHLLGGGG  RDSEEEMLA  919
Nucleotide CDS Sequence (FASTA)
1     ATGAAGTTCG  CTTACCGGTT  TTCAAATTTG  CTGGGTACGG  TGTACCGGCG  TGGGAACCTA  60
61    AATTTTACCT  GCGATGGAAA  TTCAGTTATC  AGTCCCGTGG  GCAATAGAGT  CACTGTATTT  120
121   GACCTTAAAA  ACAACAAATC  TGACACGCTG  CCCCTGGCCA  CTCGGTACAA  CGTCAAGTGC  180
181   GTGGGGCTGT  CCCCGGATGG  CCGCCTCGCT  ATCATCGTCG  ATGAAGGGGG  CGATGCGCTG  240
241   CTGGTCAGCC  TGGTCTGCAG  GTCTGTGCTG  CACCACTTCC  ACTTCAAGGG  CTCTGTGCAC  300
301   AGTGTGTCCT  TCTCCCCTGA  TGGCAGGAAG  TTTGTTGTCA  CAAAGGGTAA  CATTGCCCAG  360
361   ATGTATCATG  CCCCTGGGAA  GAAGCGGGAG  TTCAACGCCT  TCGTTCTGGA  CAAGACCTAT  420
421   TTTGGGCCCT  ACGATGAGAC  CACCTGCATC  GACTGGACGG  ATGACTCCAG  GTGCTTTGTG  480
481   GTTGGGAGCA  AAGACATGTC  CACCTGGGTG  TTCGGAGCCG  AGCGCTGGGA  CAACCTCATC  540
541   TACTATGCAC  TGGGGGGACA  TAAGGATGCC  ATCGTGGCCT  GCTTCTTTGA  ATCCAACAGC  600
601   CTGGACCTGT  ACTCACTCAG  CCAGGACGGA  GTGCTGTGCA  TGTGGCAGTG  TGACACGCCC  660
661   CCCGAGGGCT  TGCGGCTGAA  GCCCCCTGCG  GGCTGGAAAG  CAGACCTGTT  GCAGCGGGAG  720
721   GAGGAAGAGG  AGGAGGAGGA  GGACCAGGAG  GGCGACAGAG  AGACCACCAT  CCGGGGAAAA  780
781   GCCACTCCGG  CCGAGGAGGA  GAAGACAGGA  AAAGTGAAGT  ACTCACGGCT  GGCCAAGTAC  840
841   TTCTTCAATA  AAGAAGGGGA  TTTTAACAAC  CTGACAGCTG  CAGCATTTCA  TAAGAAGTCT  900
901   CACCTCTTGG  TCACTGGCTT  TGCTTCTGGA  ATCTTCCATC  TTCATGAGCT  GCCAGAGTTT  960
961   AACCTCATCC  ACTCCCTGAG  CATTTCAGAT  CAGAGCATCG  CCTCAGTGGC  CATCAATAGC  1020
1021  TCGGGGGACT  GGATTGCTTT  TGGCTGTTCA  GGCCTGGGCC  AGCTGCTGGT  GTGGGAGTGG  1080
1081  CAGAGTGAGT  CCTACGTGCT  CAAGCAGCAG  GGCCACTTCA  ACAGCATGGT  GGCCCTGGCC  1140
1141  TACTCGCCCG  ACGGACAGTA  CATCGTGACT  GGCGGGGACG  ACGGCAAGGT  CAAGGTGTGG  1200
1201  AACACCCTCA  GCGGCTTCTG  CTTCGTCACT  TTTACGGAGC  ACTCCAGCGG  GGTGACCGGT  1260
1261  GTGACCTTTA  CTGCCACCGG  CTACGTTGTG  GTGACCTCAT  CCATGGACGG  GACCGTGCGA  1320
1321  GCCTTTGACC  TTCACAGGTA  CCGAAACTTC  CGCACCTTCA  CCTCTCCACG  CCCCACCCAG  1380
1381  TTCTCCTGTG  TGGCGGTGGA  TGCGAGCGGT  GAGATCGTCT  CTGCAGGGGC  GCAGGACTCC  1440
1441  TTTGAGATTT  TCGTGTGGTC  CATGCAGACA  GGCAGGCTCC  TTGATGTTTT  GTCTGGACAC  1500
1501  GAAGGGCCCA  TCAGTGGTCT  GTGTTTTAAC  CCAATGAAGT  CCGTCCTGGC  CAGTGCCTCC  1560
1561  TGGGACAAGA  CAGTGCGCCT  ATGGGACATG  TTTGACAGCT  GGAGGACCAA  GGAGACGCTG  1620
1621  GCCCTGACCT  CTGATGCTCT  GGCTGTGACT  TTTCGCCCTG  ATGGTGCGGA  GCTGGCTGTG  1680
1681  GCCACACTGA  ACTCACAGAT  CACCTTCTGG  GACCCTGAGA  ACGCGGTGCA  GACGGGCTCC  1740
1741  ATTGAGGGCA  GGCATGACCT  CAAGACTGGC  AGGAAGGAGC  TGGACAAGAT  TACAGCCAAG  1800
1801  CACGCGGCCA  AGGGGAAGGC  CTTCACCGCC  CTGTGCTACT  CTGCAGACGG  CCACAGCATC  1860
1861  CTGGCGGGAG  GCATGTCCAA  GTTCGTGTGC  ATCTACCACG  TCCGTGAGCA  GATTCTCATG  1920
1921  AAGAGGTTCG  AGATCTCTTG  CAACCTGTCT  TTGGACGCCA  TGGAGGAATT  TTTGAACCGA  1980
1981  AGAAAAATGA  CAGAGTTTGG  CAACCTGGCA  CTAATTGATC  AGGATGCTGG  GCAGGAGGAT  2040
2041  GGAGTCGCGA  TACCACTGCC  AGGCGTCAGG  AAAGGTGACA  TGAGTTCTCG  GCACTTCAAA  2100
2101  CCTGAGATCA  GGGTGACCTC  ACTCCGCTTC  TCTCCCACTG  GGCGCTGCTG  GGCGGCCACC  2160
2161  ACCACGGAGG  GACTCCTCAT  CTACTCCCTG  GACACCCGCG  TGCTCTTTGA  CCCGTTTGAG  2220
2221  CTGGACACCA  GCGTCACCCC  CGGGAGGGTG  CGCGAGGCAC  TGCGCCAGCA  GGACTTCACC  2280
2281  AGGGCCATCC  TCATGGCCCT  CCGGCTCAAC  GAGAGCAAAC  TGGTGCAGGA  GGCCCTGGAG  2340
2341  GCGGTGCCCA  GGGGCGAGAT  TGAAGTGGTC  ACCTCCTCCC  TTCCTGAACT  GTATGTGGAG  2400
2401  AAAGTGCTGG  AGTTTTTAGC  TTCCTCCTTT  GAAGTGTCTC  GCCACCTGGA  ATTCTACCTC  2460
2461  CTCTGGACTC  ACAAACTGCT  CATGTTGCAC  GGACAGAAGC  TGAAGTCCAG  AGCCGGGACG  2520
2521  CTGCTGCCTG  TCATTCAGTT  CCTCCAGAAG  AGCATCCAGC  GGCACCTGGA  CGACCTGTCG  2580
2581  AAACTCTGTA  GCTGGAACCA  CTATAACATG  CAGTACGCAC  TAGCAGTTTC  CAAGCAGCGG  2640
2641  GGCACAAAAC  GCTCCCTAGA  CCCGCTGGGA  AGTGAGGAGG  AGGCAGAAGC  ATCTGAAGAT  2700
2701  GACAGCCTGC  ATCTGCTTGG  AGGAGGAGGC  AGAGACTCAG  AAGAAGAGAT  GCTGGCCTAG  2760

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-0891Pan troglodytes99.780.01833
LLPS-Pap-1670Pan paniscus99.670.01813
LLPS-Cea-2199Cercocebus atys98.910.01820
LLPS-Mal-0332Mandrillus leucophaeus98.80.01816
LLPS-Mam-1090Macaca mulatta98.690.01818
LLPS-Man-0422Macaca nemestrina98.690.01817
LLPS-Maf-0740Macaca fascicularis98.690.01818
LLPS-Nol-1253Nomascus leucogenys98.490.01716
LLPS-Paa-0968Papio anubis98.480.01813
LLPS-Gog-2819Gorilla gorilla98.480.01822
LLPS-Chs-1515Chlorocebus sabaeus98.260.01813
LLPS-Poa-0931Pongo abelii97.820.01806
LLPS-Rhb-0844Rhinopithecus bieti97.610.01808
LLPS-Aon-0205Aotus nancymaae96.080.01753
LLPS-Caj-0580Callithrix jacchus94.460.01748
LLPS-Cas-2937Carlito syrichta92.70.01741
LLPS-Otg-0189Otolemur garnettii92.540.01676
LLPS-Eqc-1838Equus caballus91.430.01637
LLPS-Loa-0057Loxodonta africana90.370.01622
LLPS-Ict-3539Ictidomys tridecemlineatus90.330.01694
LLPS-Bot-1248Bos taurus90.190.01638
LLPS-Fud-1276Fukomys damarensis89.80.01650
LLPS-Ran-2259Rattus norvegicus89.650.01676
LLPS-Mum-0769Mus musculus89.430.01662
LLPS-Caf-0840Canis familiaris88.720.01661
LLPS-Tut-0238Tursiops truncatus88.50.01587
LLPS-Cap-2236Cavia porcellus88.420.01691
LLPS-Aim-0400Ailuropoda melanoleuca88.40.01650
LLPS-Fec-0562Felis catus87.210.01639
LLPS-Ova-2823Ovis aries86.980.01582
LLPS-Sus-1495Sus scrofa86.90.01642
LLPS-Mup-1760Mustela putorius furo86.530.01414
LLPS-Myl-0054Myotis lucifugus84.510.01523
LLPS-Dio-1093Dipodomys ordii84.210.01488
LLPS-Urm-0330Ursus maritimus82.950.01535
LLPS-Mod-0771Monodelphis domestica82.90.01554
LLPS-Ora-0092Ornithorhynchus anatinus79.010.01490
LLPS-Pes-1451Pelodiscus sinensis77.60.01466
LLPS-Sah-2308Sarcophilus harrisii77.450.0 662
LLPS-Anp-0983Anas platyrhynchos77.210.01443
LLPS-Gaga-1336Gallus gallus77.150.01461
LLPS-Fia-0622Ficedula albicollis76.920.01433
LLPS-Tag-1651Taeniopygia guttata76.360.01428
LLPS-Anc-0736Anolis carolinensis75.820.01436
LLPS-Scm-0362Scophthalmus maximus72.960.01362
LLPS-Xim-1689Xiphophorus maculatus72.750.01367
LLPS-Pof-0966Poecilia formosa72.620.01363
LLPS-Orn-2617Oreochromis niloticus72.470.01363
LLPS-Scf-0785Scleropages formosus72.460.01357
LLPS-Orl-0023Oryzias latipes72.430.01362
LLPS-Lac-0459Latimeria chalumnae71.950.01280
LLPS-Leo-0614Lepisosteus oculatus71.380.01345
LLPS-Tar-0329Takifugu rubripes70.960.01343
LLPS-Gaa-2136Gasterosteus aculeatus70.850.01332
LLPS-Ten-2365Tetraodon nigroviridis70.060.01300
LLPS-Asm-0353Astyanax mexicanus69.380.01310
LLPS-Meg-1672Meleagris gallopavo69.290.01258
LLPS-Icp-0657Ictalurus punctatus69.220.01329
LLPS-Dar-1245Danio rerio67.670.01284
LLPS-Mea-1732Mesocricetus auratus64.021e-156 483
LLPS-Xet-2928Xenopus tropicalis60.01e-54 206
LLPS-Orc-3848Oryctolagus cuniculus59.062e-31 125
LLPS-Cii-0708Ciona intestinalis57.60.0 890
LLPS-Cis-1557Ciona savignyi50.490.0 923
LLPS-Dos-0329Dothistroma septosporum49.560.0 573
LLPS-Cog-0579Colletotrichum gloeosporioides49.150.0 601
LLPS-Vir-0694Vigna radiata47.870.0 581
LLPS-Abg-0512Absidia glauca47.270.0 853
LLPS-Miv-0358Microbotryum violaceum46.750.0 805
LLPS-Tum-0106Tuber melanosporum46.50.0 779
LLPS-Asfu-0189Aspergillus fumigatus46.140.0 791
LLPS-Drm-1351Drosophila melanogaster46.130.0 840
LLPS-Nef-0169Neosartorya fischeri45.940.0 795
LLPS-Ast-0008Aspergillus terreus45.940.0 794
LLPS-Asc-0599Aspergillus clavatus45.830.0 793
LLPS-Phn-0016Phaeosphaeria nodorum45.80.0 775
LLPS-Pytr-0267Pyrenophora triticirepentis45.480.0 778
LLPS-Asf-0146Aspergillus flavus45.480.0 787
LLPS-Aso-0138Aspergillus oryzae45.480.0 787
LLPS-Crn-0643Cryptococcus neoformans45.390.0 805
LLPS-Pyt-0517Pyrenophora teres45.370.0 780
LLPS-Lem-0432Leptosphaeria maculans45.310.0 781
LLPS-Pug-0166Puccinia graminis45.190.0 769
LLPS-Zyt-0740Zymoseptoria tritici44.870.0 777
LLPS-Scp-0319Schizosaccharomyces pombe44.710.0 751
LLPS-Mel-0472Melampsora laricipopulina44.630.0 761
LLPS-Yal-0674Yarrowia lipolytica44.610.0 766
LLPS-Asni-0918Aspergillus niger44.430.0 780
LLPS-Scc-0025Schizosaccharomyces cryophilus44.430.0 767
LLPS-Blg-0009Blumeria graminis44.310.0 769
LLPS-Beb-0664Beauveria bassiana44.210.0 762
LLPS-Kop-0106Komagataella pastoris43.850.0 753
LLPS-Map-1257Magnaporthe poae43.850.0 751
LLPS-Fuv-0379Fusarium verticillioides43.840.0 757
LLPS-Gag-0048Gaeumannomyces graminis43.770.0 754
LLPS-Sac-0399Saccharomyces cerevisiae43.710.0 753
LLPS-Sem-2140Selaginella moellendorffii43.620.0 720
LLPS-Coo-0256Colletotrichum orbiculare43.510.0 757
LLPS-Trr-0436Trichoderma reesei43.50.0 759
LLPS-Mao-0010Magnaporthe oryzae43.50.0 749
LLPS-Mae-0557Manihot esculenta43.490.0 743
LLPS-Fuo-0073Fusarium oxysporum43.380.0 767
LLPS-Fus-0070Fusarium solani43.370.0 759
LLPS-Chr-0888Chlamydomonas reinhardtii43.322e-172 535
LLPS-Asg-0071Ashbya gossypii43.260.0 744
LLPS-Nec-0288Neurospora crassa43.110.0 770
LLPS-Pot-1595Populus trichocarpa43.030.0 720
LLPS-Cogr-0323Colletotrichum graminicola42.940.0 747
LLPS-Zem-1211Zea mays42.890.0 726
LLPS-Php-1071Physcomitrella patens42.890.0 707
LLPS-Scj-1093Schizosaccharomyces japonicus42.810.0 748
LLPS-Viv-0238Vitis vinifera42.780.0 697
LLPS-Trv-0135Trichoderma virens42.710.0 748
LLPS-Thc-0149Theobroma cacao42.670.0 726
LLPS-Sot-0797Solanum tuberosum42.510.0 729
LLPS-Sol-1427Solanum lycopersicum42.510.0 727
LLPS-Asn-0723Aspergillus nidulans42.480.0 710
LLPS-Orp-1566Oryza punctata42.470.0 721
LLPS-Lep-0878Leersia perrieri42.440.0 717
LLPS-Usm-0278Ustilago maydis42.410.0 738
LLPS-Nia-0775Nicotiana attenuata42.370.0 728
LLPS-Sob-1200Sorghum bicolor42.360.0 723
LLPS-Sei-0488Setaria italica42.330.0 722
LLPS-Hov-0577Hordeum vulgare42.290.0 712
LLPS-Org-1622Oryza glaberrima42.260.0 715
LLPS-Tra-0421Triticum aestivum42.180.0 707
LLPS-Orm-0021Oryza meridionalis42.130.0 711
LLPS-Ors-0751Oryza sativa42.130.0 712
LLPS-Bro-0122Brassica oleracea42.090.0 711
LLPS-Brn-0751Brassica napus42.040.0 721
LLPS-Ori-0961Oryza indica42.020.0 712
LLPS-Via-1772Vigna angularis41.990.0 699
LLPS-Hea-1128Helianthus annuus41.990.0 726
LLPS-Cus-1045Cucumis sativus41.940.0 714
LLPS-Met-1593Medicago truncatula41.940.0 712
LLPS-Coc-0732Corchorus capsularis41.930.0 720
LLPS-Gor-1843Gossypium raimondii41.930.0 721
LLPS-Brr-2034Brassica rapa41.930.0 718
LLPS-Ved-0568Verticillium dahliae41.820.0 707
LLPS-Prp-0599Prunus persica41.810.0 715
LLPS-Orbr-0587Oryza brachyantha41.750.0 710
LLPS-Mua-0431Musa acuminata41.690.0 703
LLPS-Glm-0535Glycine max41.630.0 702
LLPS-Tru-0672Triticum urartu41.570.0 639
LLPS-Phv-1277Phaseolus vulgaris41.420.0 696
LLPS-Amt-0487Amborella trichopoda41.20.0 714
LLPS-Spr-0415Sporisorium reilianum41.140.0 727
LLPS-Orb-0286Oryza barthii41.040.0 678
LLPS-Brd-0064Brachypodium distachyon40.970.0 701
LLPS-Arl-0703Arabidopsis lyrata40.530.0 699
LLPS-Art-0318Arabidopsis thaliana39.850.0 692
LLPS-Chc-0288Chondrus crispus39.154e-130 422
LLPS-Cae-0852Caenorhabditis elegans38.130.0 651
LLPS-Put-0660Puccinia triticina38.010.0 582
LLPS-Dac-0809Daucus carota36.724e-2196.7
LLPS-Gas-0089Galdieria sulphuraria35.512e-179 550
LLPS-Orni-0064Oryza nivara34.422e-161 500
LLPS-Orgl-0666Oryza glumaepatula34.36e-161 499
LLPS-Orr-0324Oryza rufipogon34.192e-160 497
LLPS-Cym-0135Cyanidioschyzon merolae30.972e-121 399