LLPS-Hos-1132
COPS6
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Centrosome/Spindle pole body | "...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle." | N/A | 17350042 |
▼ FUNCTION
| Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000419210.1 | ENSP00000388865.1 |
| Ensembl | ENST00000426712.1 | ENSP00000413702.1 |
| Ensembl | ENST00000418625.5 | ENSP00000400617.1 |
| Ensembl | ENST00000303904.7 | ENSP00000304102.3 |
| UniProt | Q7L5N1, CSN6_HUMAN, A4D2A3, O15387 | |
| GeneBank | CH236956, BC002520, CH471091, U70735 | EAW76601.1, AAD03469.1, EAL23857.1, AAH02520.2 |
| RefSeq | NM_006833.4 | NP_006824.2 |
| Entrez | 10980 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAAAAAAAA TNGTGGSSGM EVDAAVVPSV MACGVTGSVS VALHPLVILN ISDHWIRMRS 60 61 QEGRPVQVIG ALIGKQEGRN IEVMNSFELL SHTVEEKIII DKEYYYTKEE QFKQVFKELE 120 121 FLGWYTTGGP PDPSDIHVHK QVCEIIESPL FLKLNPMTKH TDLPVSVFES VIDIINGEAT 180 181 MLFAELTYTL ATEEAERIGV DHVARMTATG SGENSTVAEH LIAQHSAIKM LHSRVKLILE 240 241 YVKASEAGEV PFNHEILREA YALCHCLPVL STDKFKTDFY DQCNDVGLMA YLGTITKTCN 300 301 TMNQFVNKFN VLYDRQGIGR RMRGLFF 327 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGCGG CGGCGGCGGC GGCTGCAGCT ACGAACGGGA CCGGAGGAAG CAGCGGGATG 60 61 GAGGTGGATG CAGCAGTAGT CCCCAGCGTG ATGGCCTGCG GAGTGACTGG GAGTGTTTCC 120 121 GTCGCTCTCC ATCCCCTTGT CATTCTCAAC ATCTCAGACC ACTGGATCCG CATGCGCTCC 180 181 CAGGAGGGGC GGCCTGTGCA GGTGATTGGG GCTCTGATTG GCAAGCAGGA GGGCCGAAAT 240 241 ATCGAGGTGA TGAACTCCTT TGAGCTGCTG TCCCACACCG TGGAAGAGAA GATTATCATT 300 301 GACAAGGAAT ATTATTACAC CAAGGAGGAG CAGTTTAAAC AGGTGTTCAA GGAGCTGGAG 360 361 TTTCTGGGTT GGTATACCAC AGGGGGGCCA CCTGACCCCT CGGACATCCA CGTCCATAAG 420 421 CAGGTGTGTG AGATCATCGA GAGCCCCCTC TTTCTGAAGT TGAACCCTAT GACCAAGCAC 480 481 ACAGATCTTC CTGTCAGCGT TTTTGAGTCT GTCATTGATA TAATCAATGG AGAGGCCACA 540 541 ATGCTGTTTG CTGAGCTGAC CTACACTCTG GCCACAGAGG AAGCGGAACG CATTGGTGTA 600 601 GACCACGTAG CCCGAATGAC AGCAACAGGC AGTGGAGAGA ACTCCACTGT GGCTGAACAC 660 661 CTGATAGCAC AGCACAGCGC CATCAAGATG CTGCACAGCC GCGTCAAGCT CATCTTGGAG 720 721 TACGTCAAGG CCTCTGAAGC GGGAGAGGTC CCCTTTAATC ATGAGATCCT GCGGGAGGCC 780 781 TATGCTCTGT GTCACTGTCT CCCGGTGCTC AGCACAGACA AGTTCAAGAC AGATTTTTAT 840 841 GATCAATGCA ACGACGTGGG GCTCATGGCC TACCTCGGCA CCATCACCAA AACGTGCAAC 900 901 ACCATGAACC AGTTTGTGAA CAAGTTCAAT GTCCTCTACG ACCGACAAGG CATCGGCAGG 960 961 AGAATGCGCG GGCTCTTTTT CTGA 984 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | COP9 signalosome | |
Cellular Component | Cytosol | |
Cellular Component | Nucleoplasm | |
Biological Process | Nucleotide-excision repair, DNA damage recognition | |
Biological Process | Post-translational protein modification | |
Biological Process | Protein deneddylation | |
Biological Process | Transcription-coupled nucleotide-excision repair | |
Biological Process | Viral process |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CORUM | CellMarker | ||
| Structure | ||||
| PDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-1386 | Gorilla gorilla | 100.0 | 0.0 | 628 |
| LLPS-Pap-1606 | Pan paniscus | 100.0 | 0.0 | 628 |
| LLPS-Pat-4165 | Pan troglodytes | 100.0 | 0.0 | 628 |
| LLPS-Cas-0279 | Carlito syrichta | 100.0 | 0.0 | 530 |
| LLPS-Caj-3924 | Callithrix jacchus | 99.68 | 0.0 | 623 |
| LLPS-Aon-4546 | Aotus nancymaae | 99.68 | 0.0 | 623 |
| LLPS-Maf-4404 | Macaca fascicularis | 99.68 | 0.0 | 612 |
| LLPS-Myl-2724 | Myotis lucifugus | 99.68 | 0.0 | 623 |
| LLPS-Rhb-3852 | Rhinopithecus bieti | 99.68 | 0.0 | 624 |
| LLPS-Man-0671 | Macaca nemestrina | 99.68 | 0.0 | 612 |
| LLPS-Cap-4598 | Cavia porcellus | 99.68 | 0.0 | 624 |
| LLPS-Dio-1430 | Dipodomys ordii | 99.66 | 0.0 | 585 |
| LLPS-Ict-2410 | Ictidomys tridecemlineatus | 99.66 | 0.0 | 585 |
| LLPS-Fud-3693 | Fukomys damarensis | 99.37 | 0.0 | 621 |
| LLPS-Nol-2017 | Nomascus leucogenys | 99.37 | 0.0 | 618 |
| LLPS-Eqc-2121 | Equus caballus | 99.37 | 0.0 | 625 |
| LLPS-Poa-2806 | Pongo abelii | 99.37 | 0.0 | 624 |
| LLPS-Sus-4506 | Sus scrofa | 99.36 | 0.0 | 611 |
| LLPS-Mup-2213 | Mustela putorius furo | 99.36 | 0.0 | 617 |
| LLPS-Paa-3801 | Papio anubis | 99.36 | 0.0 | 605 |
| LLPS-Bot-3138 | Bos taurus | 99.36 | 0.0 | 611 |
| LLPS-Fec-1569 | Felis catus | 99.36 | 0.0 | 616 |
| LLPS-Mam-3319 | Macaca mulatta | 99.36 | 0.0 | 605 |
| LLPS-Caf-1812 | Canis familiaris | 99.36 | 0.0 | 615 |
| LLPS-Aim-3041 | Ailuropoda melanoleuca | 99.35 | 0.0 | 606 |
| LLPS-Ova-0065 | Ovis aries | 99.34 | 0.0 | 592 |
| LLPS-Urm-3512 | Ursus maritimus | 99.33 | 0.0 | 586 |
| LLPS-Chs-1246 | Chlorocebus sabaeus | 99.06 | 0.0 | 620 |
| LLPS-Mum-4188 | Mus musculus | 99.03 | 0.0 | 599 |
| LLPS-Mea-0917 | Mesocricetus auratus | 99.03 | 0.0 | 599 |
| LLPS-Sah-1920 | Sarcophilus harrisii | 98.73 | 0.0 | 620 |
| LLPS-Mod-1036 | Monodelphis domestica | 98.73 | 0.0 | 619 |
| LLPS-Ran-4069 | Rattus norvegicus | 98.7 | 0.0 | 596 |
| LLPS-Orc-2470 | Oryctolagus cuniculus | 98.7 | 0.0 | 602 |
| LLPS-Otg-1668 | Otolemur garnettii | 97.81 | 0.0 | 615 |
| LLPS-Loa-1497 | Loxodonta africana | 97.11 | 0.0 | 593 |
| LLPS-Tut-2020 | Tursiops truncatus | 95.68 | 0.0 | 560 |
| LLPS-Mal-3100 | Mandrillus leucophaeus | 94.01 | 0.0 | 577 |
| LLPS-Asm-1680 | Astyanax mexicanus | 93.27 | 0.0 | 548 |
| LLPS-Leo-1813 | Lepisosteus oculatus | 92.88 | 0.0 | 570 |
| LLPS-Pes-3185 | Pelodiscus sinensis | 92.72 | 0.0 | 552 |
| LLPS-Xet-2054 | Xenopus tropicalis | 91.94 | 0.0 | 574 |
| LLPS-Icp-0766 | Ictalurus punctatus | 91.59 | 0.0 | 561 |
| LLPS-Cea-3553 | Cercocebus atys | 91.46 | 0.0 | 573 |
| LLPS-Orn-2853 | Oreochromis niloticus | 90.48 | 0.0 | 568 |
| LLPS-Pof-0208 | Poecilia formosa | 90.48 | 0.0 | 569 |
| LLPS-Orl-3913 | Oryzias latipes | 90.16 | 0.0 | 568 |
| LLPS-Xim-3836 | Xiphophorus maculatus | 90.16 | 0.0 | 568 |
| LLPS-Scm-1311 | Scophthalmus maximus | 89.94 | 0.0 | 564 |
| LLPS-Tar-0111 | Takifugu rubripes | 89.84 | 0.0 | 568 |
| LLPS-Ten-3394 | Tetraodon nigroviridis | 89.84 | 0.0 | 568 |
| LLPS-Scf-0337 | Scleropages formosus | 89.68 | 0.0 | 549 |
| LLPS-Gaa-3447 | Gasterosteus aculeatus | 88.89 | 0.0 | 561 |
| LLPS-Lac-1417 | Latimeria chalumnae | 87.4 | 9e-148 | 423 |
| LLPS-Anc-1840 | Anolis carolinensis | 71.91 | 1e-100 | 303 |
| LLPS-Drm-1846 | Drosophila melanogaster | 61.95 | 4e-130 | 382 |
| LLPS-Cis-1964 | Ciona savignyi | 59.2 | 9e-121 | 357 |
| LLPS-Cii-0875 | Ciona intestinalis | 57.65 | 3e-121 | 358 |
| LLPS-Php-1215 | Physcomitrella patens | 43.06 | 3e-72 | 232 |
| LLPS-Sem-0769 | Selaginella moellendorffii | 42.32 | 1e-70 | 228 |
| LLPS-Dac-2388 | Daucus carota | 41.39 | 2e-67 | 220 |
| LLPS-Mua-1531 | Musa acuminata | 41.33 | 1e-68 | 224 |
| LLPS-Abg-0982 | Absidia glauca | 41.32 | 5e-24 | 100 |
| LLPS-Pot-2145 | Populus trichocarpa | 41.14 | 2e-68 | 223 |
| LLPS-Brd-2292 | Brachypodium distachyon | 40.73 | 5e-65 | 214 |
| LLPS-Glm-2664 | Glycine max | 40.32 | 8e-68 | 221 |
| LLPS-Orbr-2374 | Oryza brachyantha | 40.16 | 1e-55 | 187 |
| LLPS-Met-2589 | Medicago truncatula | 40.0 | 1e-66 | 218 |
| LLPS-Orm-1932 | Oryza meridionalis | 39.93 | 6e-67 | 219 |
| LLPS-Orni-1686 | Oryza nivara | 39.8 | 3e-66 | 218 |
| LLPS-Hea-2450 | Helianthus annuus | 39.8 | 3e-67 | 220 |
| LLPS-Orb-1951 | Oryza barthii | 39.8 | 8e-67 | 219 |
| LLPS-Sot-1952 | Solanum tuberosum | 39.8 | 5e-67 | 219 |
| LLPS-Orgl-1593 | Oryza glumaepatula | 39.8 | 8e-67 | 219 |
| LLPS-Ors-1300 | Oryza sativa | 39.8 | 1e-66 | 219 |
| LLPS-Org-0951 | Oryza glaberrima | 39.8 | 8e-67 | 219 |
| LLPS-Orr-0235 | Oryza rufipogon | 39.8 | 1e-66 | 219 |
| LLPS-Phv-0681 | Phaseolus vulgaris | 39.74 | 4e-67 | 220 |
| LLPS-Sei-2286 | Setaria italica | 39.67 | 6e-65 | 214 |
| LLPS-Lep-2126 | Leersia perrieri | 39.6 | 5e-65 | 214 |
| LLPS-Sol-0024 | Solanum lycopersicum | 39.54 | 5e-67 | 219 |
| LLPS-Tra-2767 | Triticum aestivum | 39.39 | 1e-67 | 222 |
| LLPS-Hov-1005 | Hordeum vulgare | 39.39 | 2e-67 | 221 |
| LLPS-Zem-2504 | Zea mays | 39.35 | 5e-65 | 214 |
| LLPS-Ori-1475 | Oryza indica | 39.34 | 2e-66 | 218 |
| LLPS-Orp-0860 | Oryza punctata | 39.34 | 1e-65 | 216 |
| LLPS-Nia-2367 | Nicotiana attenuata | 39.27 | 6e-67 | 219 |
| LLPS-Amt-0367 | Amborella trichopoda | 39.23 | 1e-54 | 186 |
| LLPS-Brn-2527 | Brassica napus | 39.22 | 3e-65 | 214 |
| LLPS-Viv-1471 | Vitis vinifera | 39.03 | 7e-66 | 216 |
| LLPS-Sob-1576 | Sorghum bicolor | 38.96 | 6e-64 | 212 |
| LLPS-Gor-2241 | Gossypium raimondii | 38.96 | 9e-65 | 214 |
| LLPS-Coc-2138 | Corchorus capsularis | 38.75 | 9e-63 | 219 |
| LLPS-Arl-0390 | Arabidopsis lyrata | 38.64 | 3e-66 | 218 |
| LLPS-Thc-1472 | Theobroma cacao | 38.54 | 1e-65 | 216 |
| LLPS-Chr-0348 | Chlamydomonas reinhardtii | 38.54 | 3e-53 | 183 |
| LLPS-Brr-1054 | Brassica rapa | 38.44 | 5e-64 | 211 |
| LLPS-Art-2850 | Arabidopsis thaliana | 38.31 | 2e-63 | 210 |
| LLPS-Bro-1851 | Brassica oleracea | 37.94 | 8e-64 | 211 |
| LLPS-Mae-0138 | Manihot esculenta | 37.93 | 4e-65 | 215 |
| LLPS-Cus-0769 | Cucumis sativus | 37.46 | 2e-53 | 183 |
| LLPS-Ast-1549 | Aspergillus terreus | 36.73 | 2e-16 | 83.6 |
| LLPS-Mel-1439 | Melampsora laricipopulina | 36.36 | 6e-43 | 157 |
| LLPS-Prp-0434 | Prunus persica | 36.31 | 4e-59 | 199 |
| LLPS-Miv-0047 | Microbotryum violaceum | 36.18 | 1e-53 | 186 |
| LLPS-Usm-0515 | Ustilago maydis | 36.01 | 4e-53 | 184 |
| LLPS-Spr-1427 | Sporisorium reilianum | 35.82 | 5e-52 | 181 |
| LLPS-Put-1253 | Puccinia triticina | 35.35 | 1e-41 | 153 |
| LLPS-Pug-1252 | Puccinia graminis | 34.67 | 3e-37 | 141 |
| LLPS-Pyt-1520 | Pyrenophora teres | 34.42 | 9e-17 | 84.3 |
| LLPS-Via-1614 | Vigna angularis | 34.38 | 1e-48 | 172 |
| LLPS-Cae-0962 | Caenorhabditis elegans | 34.1 | 1e-28 | 119 |
| LLPS-Lem-1287 | Leptosphaeria maculans | 33.78 | 7e-16 | 82.0 |
| LLPS-Crn-1195 | Cryptococcus neoformans | 33.55 | 4e-50 | 176 |
| LLPS-Beb-0717 | Beauveria bassiana | 33.33 | 6e-07 | 54.7 |
| LLPS-Tru-0987 | Triticum urartu | 32.44 | 5e-53 | 182 |
| LLPS-Fus-0551 | Fusarium solani | 32.3 | 2e-12 | 71.6 |
| LLPS-Trr-1439 | Trichoderma reesei | 32.18 | 4e-14 | 76.6 |
| LLPS-Trv-1317 | Trichoderma virens | 32.12 | 3e-14 | 76.6 |
| LLPS-Yal-1337 | Yarrowia lipolytica | 32.01 | 1e-34 | 134 |
| LLPS-Gas-1368 | Galdieria sulphuraria | 32.0 | 2e-40 | 150 |
| LLPS-Fuo-1553 | Fusarium oxysporum | 32.0 | 7e-13 | 72.8 |
| LLPS-Asni-0326 | Aspergillus niger | 31.96 | 5e-28 | 116 |
| LLPS-Tum-1504 | Tuber melanosporum | 31.82 | 1e-32 | 129 |
| LLPS-Gag-1316 | Gaeumannomyces graminis | 30.43 | 1e-06 | 53.9 |
| LLPS-Mao-1140 | Magnaporthe oryzae | 30.28 | 6e-15 | 79.0 |
| LLPS-Asfu-1325 | Aspergillus fumigatus | 30.0 | 1e-23 | 103 |
| LLPS-Asc-1586 | Aspergillus clavatus | 29.97 | 2e-20 | 94.4 |
| LLPS-Asn-0683 | Aspergillus nidulans | 29.49 | 2e-15 | 80.1 |
| LLPS-Vir-0550 | Vigna radiata | 29.17 | 1e-31 | 123 |
| LLPS-Cog-0696 | Colletotrichum gloeosporioides | 29.17 | 6e-06 | 51.2 |
| LLPS-Nef-0540 | Neosartorya fischeri | 28.69 | 2e-23 | 103 |
| LLPS-Aso-1027 | Aspergillus oryzae | 28.45 | 6e-18 | 87.4 |
| LLPS-Asf-0620 | Aspergillus flavus | 27.78 | 3e-14 | 76.6 |
| LLPS-Zyt-0797 | Zymoseptoria tritici | 27.7 | 4e-19 | 90.1 |
| LLPS-Cogr-0340 | Colletotrichum graminicola | 27.27 | 6e-22 | 99.0 |
| LLPS-Scs-0045 | Sclerotinia sclerotiorum | 27.22 | 3e-23 | 102 |
| LLPS-Blg-0052 | Blumeria graminis | 25.9 | 9e-18 | 87.0 |
| LLPS-Coo-1536 | Colletotrichum orbiculare | 25.65 | 2e-17 | 86.3 |
| LLPS-Chc-0384 | Chondrus crispus | 25.56 | 4e-11 | 66.6 |
| LLPS-Fia-3328 | Ficedula albicollis | 24.16 | 8e-15 | 77.0 |
| LLPS-Dar-3907 | Danio rerio | 22.26 | 9e-13 | 71.2 |
| LLPS-Meg-2899 | Meleagris gallopavo | 21.98 | 4e-08 | 57.4 |
| LLPS-Anp-1837 | Anas platyrhynchos | 21.8 | 6e-06 | 50.4 |
| LLPS-Tag-0380 | Taeniopygia guttata | 21.12 | 3e-07 | 54.7 |
| LLPS-Ora-1971 | Ornithorhynchus anatinus | 20.69 | 8e-07 | 53.5 |