LLPS-Hos-1024
CAMSAP1
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Stress granule | "...Together, our APEX and IF screening approaches identified 260 SG proteins, including ~150 candidates that had not previously been associated with SGs." | Neural progenitor cells | 29373831 |
| Postsynaptic density | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24486153, PubMed:24706919, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000409386.3 | ENSP00000386420.3 |
| Ensembl | ENST00000312405.10 | ENSP00000312463.6 |
| Ensembl | ENST00000389532.8 | ENSP00000374183.4 |
| UniProt | Q5T5Y3, CAMP1_HUMAN, A1L4L2, B2REB2, B2REB3, Q70W33, Q8NCY0, Q96E80, Q96FM3, Q9UFJ5 | |
| GeneBank | BC012778, AL353636, BC130580, AL834528, AJ519841, AL355574, BC010646, AL117634, AL158822 | AAI30581.1, AAH10646.1, CAB56024.2, CAD58627.1, CAD39184.1, AAH12778.2 |
| RefSeq | NM_015447.3, XM_005263396.3, XM_005263397.1 | NP_056262.3, XP_005263453.1, XP_005263454.1 |
| Entrez | 157922 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVDASGRAAA EGWRKMEAPP DGAADLVPLD RYDAARAKIA ANLQWICAKA YGRDNIPEDL 60 61 RDPFYVDQYE QEHIKPPVIK LLLSSELYCR VCSLILKGDQ VAALQGHQSV IQALSRKGIY 120 121 VMESDDTPVT ESDLSRAPIK MSAHMAMVDA LMMAYTVEMI SIEKVVASVK RFSTFSASKE 180 181 LPYDLEDAMV FWINKVNLKM REITEKEVKL KQQLLESPAH QKSPSKWYWK LVPVRYRREH 240 241 LSARQSPYFP LLEDLMRDGS DGAALLAVIH YYCPEQMKLD DICLKEVTSM ADSLYNIRLL 300 301 REFSNEYLNK CFYLTLEDML YAPLVLKPNV MVFIAELFWW FENVKPDFVQ PRDVQELKDA 360 361 KTVLHQKSSR PPVPISNATK RSFLGSPAAG TLAELQPPVQ LPAEGCHRHY LHPEEPEYLG 420 421 KGTAAFSPSH PLLPLRQKQQ KSIQGEDIPD QRHRSNSLTR VDGQPRGAAI AWPEKKTRPA 480 481 SQPTPFALHH AASCEVDPSS GDSISLARSI SKDSLASNIV NLTPQNQPHP TATKSHGKSL 540 541 LSNVSIEDEE EELVAIVRAD VVPQQADPEF PRASPRALGL TANARSPQGQ LDTSESKPDS 600 601 FFLEPLMPAV LKPAKEKQVI TKEDERGEGR PRSIVSRRPS EGPQPLVRRK MTGSRDLNRT 660 661 FTPIPCSEFP MGIDPTETGP LSVETAGEVC GGPLALGGFD PFPQGPSTDG FFLHVGRADE 720 721 DTEGRLYVSC SKSPNSHDSE PWTLLRQDSD SDVVDIEEAE HDFMGEAHPV VFSRYIGEEE 780 781 SAKLQEDMKV KEHEDKDDAS GRSSPCLSTA SQMSSVSMAS GSVKMTSFAE RKLQRLNSCE 840 841 TKSSTSSSQK TTPDASESCP APLTTWRQKR EQSPSQHGKD PASLLASELV QLHMQLEEKR 900 901 RAIEAQKKKM EALSARQRLK LGKAAFLHVV KKGKAEAAPP LRPEHFAKEY SQHNGEDCGD 960 961 AVSKTEDFLV KEEQREELLH EPQDVDKESL AFAQQHKAKD PVALHELERN KVISAALLED 1020 1021 TVGEVVDVNE CDLSIEKLNE TISTLQQAIL KISQQQEQLL MKSPTVPVPG SKNNSQDHKV 1080 1081 KAPVHFVEPL SPTGVAGHRK APRLGQGRNS RSGRPAELKV PKDRPQGSSR SKTPTPSVET 1140 1141 LPHLRPFPAS SHPRTPTDPG LDSALEPSGD PHGKCLFDSY RLHDESNQRT LTLSSSKDAN 1200 1201 ILSEQMSLKE VLDASVKEVG SSSSDVSGKE SVPVEEPLRS RASLIEVDLS DLKAPDEDGE 1260 1261 LVSLDGSADL VSEGDQKPGV GFFFKDEQKA EDELAKKRAA FLLKQQRKAE EARVRKQQLE 1320 1321 AEVELKRDEA RRKAEEDRVR KEEEKARREL IKQEYLRRKQ QQILEEQGLG KPKSKPKKPR 1380 1381 PKSVHREESC SDSGTKCSST PDNLSRTQSG SSLSLASAAT TEPESVHSGG TPSQRVESME 1440 1441 ALPILSRNPS RSTDRDWETA SAASSLASVA EYTGPKLFKE PSSKSNKPII HNAISHCCLA 1500 1501 GKVNEPHKNS ILEELEKCDA NHYIILFRDA GCQFRALYCY YPDTEEIYKL TGTGPKNITK 1560 1561 KMIDKLYKYS SDRKQFNLIP AKTMSVSVDA LTIHNHLWQP KRPAVPKKAQ TRK 1613 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGACA GTCTGTATAA TATTCGGCTT CTGAGAGAAT TCTCCAATGA ATATCTTAAT 60 61 AAATGTTTTT ATCTCACCTT GGAAGATATG CTGTATGCGC CATTAGTGTT GAAGCCGAAT 120 121 GTTATGGTTT TTATTGCGGA GCTTTTTTGG TGGTTCGAGA ATGTCAAGCC AGATTTTGTT 180 181 CAGCCCAGGG ATGTTCAGGA GCTGAAAGAC GCGAAAACAG TGTTACACCA GAAGAGCAGC 240 241 CGGCCTCCTG TACCGATCTC CAACGCGACC AAACGCAGTT TCCTAGGCAG CCCTGCTGCA 300 301 GGGACCCTGG CTGAGCTGCA GCCCCCCGTG CAGCTGCCGG CGGAAGGCTG TCACAGGCAC 360 361 TACCTGCACC CGGAAGAACC TGAATACCTC GGGAAAGGAA CTGCTGCCTT CAGCCCATCC 420 421 CATCCTTTAT TGCCACTGAG ACAGAAACAG CAGAAATCCA TACAGGGAGA GGACATCCCT 480 481 GATCAGCGAC ATCGATCGAA TTCTTTGACC CGAGTTGATG GTCAGCCTCG AGGAGCAGCA 540 541 ATAGCCTGGC CAGAAAAAAA AACCAGGCCT GCGTCCCAGC CAACACCTTT TGCTCTACAT 600 601 CACGCTGCGA GTTGTGAAGT GGATCCCAGC TCTGGCGACA GCATCAGCTT GGCCCGCTCC 660 661 ATCAGCAAAG ACAGTTTGGC ATCCAACATT GTTAATCTGA CCCCACAGAA CCAGCCACAC 720 721 CCCACGGCCA CGAAGAGCCA CGGGAAGAGC CTCCTGAGCA ATGTCAGTAT TGAGGATGAG 780 781 GAAGAGGAGC TTGTGGCTAT TGTTAGAGCA GACGTGGTTC CCCAGCAGGC TGACCCGGAG 840 841 TTCCCCAGGG CCTCACCCCG GGCCTTAGGC CTTACAGCAA ATGCCCGGTC TCCCCAAGGA 900 901 CAGCTGGACA CCTCGGAAAG TAAGCCTGAC AGTTTTTTCT TGGAGCCTTT GATGCCAGCA 960 961 GTTCTTAAGC CAGCGAAAGA GAAGCAGGTG ATCACCAAGG AGGATGAACG GGGGGAAGGG 1020 1021 AGACCGAGGA GCATCGTGTC TAGGAGGCCC AGCGAGGGCC CCCAGCCTTT GGTACGAAGG 1080 1081 AAAATGACTG GCAGTCGCGA CTTGAATAGG ACTTTTACCC CGATTCCATG CTCAGAATTC 1140 1141 CCCATGGGCA TCGACCCCAC CGAGACAGGA CCACTGTCAG TGGAAACCGC AGGAGAGGTC 1200 1201 TGTGGTGGGC CTCTGGCCCT TGGCGGATTC GATCCGTTCC CCCAGGGACC ATCCACGGAT 1260 1261 GGCTTCTTCC TTCATGTAGG CAGGGCCGAT GAAGACACCG AGGGAAGGTT ATATGTTAGT 1320 1321 TGTTCAAAAA GCCCCAACTC CCACGATTCA GAGCCGTGGA CTCTCCTCAG GCAGGATTCT 1380 1381 GACTCGGATG TGGTGGACAT AGAGGAAGCC GAGCACGATT TCATGGGTGA GGCCCATCCT 1440 1441 GTGGTTTTCA GCAGATACAT TGGGGAGGAA GAGTCGGCCA AACTGCAGGA GGACATGAAG 1500 1501 GTGAAGGAAC ATGAAGACAA AGATGACGCC AGCGGCCGCT CGAGCCCCTG CCTGAGCACA 1560 1561 GCCTCTCAGA TGAGCAGTGT CTCCATGGCG AGTGGGAGCG TGAAGATGAC CAGCTTTGCG 1620 1621 GAGAGGAAGC TCCAGAGACT CAACAGCTGT GAGACCAAGT CCAGCACCAG CAGCTCCCAG 1680 1681 AAGACCACGC CAGATGCGTC TGAGAGCTGC CCAGCCCCTC TGACGACGTG GAGGCAGAAG 1740 1741 AGGGAGCAGA GTCCGAGCCA GCATGGCAAG GATCCCGCCA GCCTCCTGGC ATCTGAGCTG 1800 1801 GTACAGCTGC ACATGCAGCT GGAGGAGAAG CGCAGGGCCA TCGAGGCCCA GAAGAAGAAG 1860 1861 ATGGAGGCGC TGTCGGCAAG GCAGCGCCTG AAGCTCGGCA AGGCTGCATT CCTGCATGTG 1920 1921 GTGAAGAAGG GCAAGGCCGA GGCTGCCCCA CCCCTCAGGC CGGAGCACTT TGCAAAGGAG 1980 1981 TACTCTCAGC ACAACGGGGA GGACTGTGGG GACGCTGTTT CCAAAACCGA AGACTTTCTC 2040 2041 GTGAAGGAGG AGCAGAGAGA GGAGCTCCTT CACGAGCCAC AGGATGTGGA CAAAGAGAGC 2100 2101 CTGGCCTTTG CTCAGCAACA TAAAGCAAAA GACCCTGTGG CTCTGCACGA GCTGGAGAGA 2160 2161 AATAAGGTGA TCTCCGCTGC CCTCCTGGAG GACACTGTTG GGGAGGTTGT CGACGTGAAT 2220 2221 GAATGTGACC TTTCCATCGA GAAGCTTAAC GAAACCATCA GTACGCTGCA GCAGGCCATC 2280 2281 CTGAAAATCT CTCAGCAGCA AGAGCAGCTT CTGATGAAGT CCCCCACAGT CCCAGTGCCA 2340 2341 GGCTCTAAGA ATAACTCGCA GGACCACAAA GTGAAGGCAC CAGTCCACTT CGTGGAGCCA 2400 2401 CTCTCTCCCA CGGGCGTGGC TGGCCACCGC AAAGCCCCCC GGCTGGGTCA AGGCCGGAAT 2460 2461 TCCCGTTCCG GAAGGCCGGC GGAGCTGAAG GTCCCAAAAG ACAGGCCACA GGGCTCCTCC 2520 2521 CGAAGTAAAA CCCCAACGCC CAGTGTAGAG ACGCTCCCGC ACTTGAGACC CTTCCCTGCC 2580 2581 AGCAGCCACC CTCGGACGCC CACGGACCCT GGCCTGGACA GTGCCCTGGA GCCCAGTGGT 2640 2641 GACCCACATG GGAAGTGTCT CTTCGACAGT TACAGGCTCC ATGATGAAAG CAATCAGCGG 2700 2701 ACACTTACTC TGTCCTCTTC CAAAGATGCC AACATTCTTT CGGAGCAGAT GAGCCTCAAA 2760 2761 GAAGTTCTGG ATGCGAGTGT GAAGGAGGTG GGGTCCAGCT CCTCAGATGT CTCGGGAAAA 2820 2821 GAGAGCGTCC CCGTGGAGGA GCCTCTGAGG AGCAGGGCCA GCCTCATTGA AGTGGACCTC 2880 2881 TCCGACCTGA AGGCCCCCGA CGAGGATGGG GAGCTGGTAA GCCTCGATGG CTCGGCGGAC 2940 2941 CTTGTCAGCG AAGGCGACCA GAAGCCGGGG GTCGGCTTCT TCTTCAAGGA TGAACAGAAA 3000 3001 GCGGAAGATG AGCTCGCCAA GAAGCGGGCG GCCTTCCTCC TGAAGCAGCA GCGCAAGGCC 3060 3061 GAGGAGGCCC GCGTGCGCAA GCAGCAGCTG GAAGCGGAGG TGGAGCTCAA GCGTGACGAA 3120 3121 GCCCGGCGCA AAGCTGAGGA AGACCGGGTG CGGAAGGAGG AGGAGAAGGC GCGGCGCGAG 3180 3181 CTCATCAAGC AGGAGTACCT GCGGAGGAAG CAGCAGCAGA TCCTAGAGGA GCAGGGGCTC 3240 3241 GGCAAGCCCA AGTCAAAGCC GAAGAAGCCG CGGCCGAAGT CGGTGCACCG GGAAGAGTCG 3300 3301 TGCAGCGACT CCGGCACCAA GTGCTCCTCC ACCCCTGATA ACTTGAGCCG GACTCAGTCA 3360 3361 GGCTCCAGCC TGTCCTTGGC CTCTGCGGCG ACGACAGAAC CCGAGAGCGT TCATTCCGGG 3420 3421 GGCACACCCT CTCAGCGAGT GGAATCGATG GAAGCCCTGC CCATACTGAG CCGTAACCCA 3480 3481 AGCAGGAGCA CAGACCGAGA CTGGGAGACC GCGTCGGCGG CATCTTCCCT GGCCTCAGTG 3540 3541 GCCGAGTACA CAGGTCCCAA GCTCTTTAAG GAGCCCAGTA GTAAATCAAA CAAGCCGATT 3600 3601 ATTCACAATG CCATATCCCA TTGCTGCCTG GCTGGAAAAG TGAACGAACC CCACAAGAAT 3660 3661 TCCATATTGG AGGAGCTGGA GAAGTGTGAT GCCAATCACT ACATCATACT GTTTCGTGAT 3720 3721 GCTGGCTGCC AGTTCAGGGC GCTTTACTGC TACTATCCTG ATACTGAGGA AATCTACAAA 3780 3781 CTCACTGGCA CGGGGCCAAA GAACATCACC AAGAAAATGA TCGACAAACT GTATAAATAC 3840 3841 AGCTCAGACC GAAAACAGTT TAACTTGATC CCAGCCAAAA CCATGTCTGT CAGTGTGGAC 3900 3901 GCACTCACAA TCCACAACCA CCTGTGGCAG CCCAAGCGGC CTGCAGTGCC AAAGAAGGCC 3960 3961 CAGACTCGTA AATGA 3975 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Microtubule | |
Molecular Function | Calmodulin binding | |
Molecular Function | Microtubule binding | |
Molecular Function | Microtubule minus-end binding | |
Molecular Function | Spectrin binding | |
Biological Process | Cytoplasmic microtubule organization | |
Biological Process | Cytoskeleton organization | |
Biological Process | Microtubule cytoskeleton organization | |
Biological Process | Negative regulation of microtubule depolymerization | |
Biological Process | Neuron projection development | |
Biological Process | Regulation of cell morphogenesis | |
Biological Process | Regulation of microtubule polymerization |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Structure | ||||
| PDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-0923 | Pan troglodytes | 99.5 | 0.0 | 3043 |
| LLPS-Poa-1047 | Pongo abelii | 98.31 | 0.0 | 2980 |
| LLPS-Pap-4312 | Pan paniscus | 97.84 | 0.0 | 2887 |
| LLPS-Cea-0031 | Cercocebus atys | 97.58 | 0.0 | 2992 |
| LLPS-Paa-2367 | Papio anubis | 97.52 | 0.0 | 2992 |
| LLPS-Maf-1518 | Macaca fascicularis | 97.37 | 0.0 | 2871 |
| LLPS-Chs-3024 | Chlorocebus sabaeus | 97.25 | 0.0 | 2736 |
| LLPS-Mal-0489 | Mandrillus leucophaeus | 96.92 | 0.0 | 2846 |
| LLPS-Rhb-1428 | Rhinopithecus bieti | 96.81 | 0.0 | 2233 |
| LLPS-Urm-3927 | Ursus maritimus | 96.65 | 5e-97 | 348 |
| LLPS-Man-2709 | Macaca nemestrina | 96.28 | 0.0 | 2826 |
| LLPS-Caj-4630 | Callithrix jacchus | 96.28 | 0.0 | 2947 |
| LLPS-Aon-4416 | Aotus nancymaae | 96.02 | 0.0 | 2912 |
| LLPS-Gog-4657 | Gorilla gorilla | 95.89 | 0.0 | 2856 |
| LLPS-Mam-2126 | Macaca mulatta | 95.74 | 0.0 | 2870 |
| LLPS-Otg-3388 | Otolemur garnettii | 88.24 | 0.0 | 2685 |
| LLPS-Orc-1602 | Oryctolagus cuniculus | 85.48 | 0.0 | 620 |
| LLPS-Eqc-4490 | Equus caballus | 85.3 | 0.0 | 2580 |
| LLPS-Ran-0617 | Rattus norvegicus | 84.94 | 0.0 | 2538 |
| LLPS-Mum-4688 | Mus musculus | 84.42 | 0.0 | 2507 |
| LLPS-Cas-2233 | Carlito syrichta | 84.38 | 0.0 | 2498 |
| LLPS-Ict-2806 | Ictidomys tridecemlineatus | 83.85 | 0.0 | 2453 |
| LLPS-Caf-1856 | Canis familiaris | 83.62 | 0.0 | 2477 |
| LLPS-Cap-3644 | Cavia porcellus | 83.02 | 0.0 | 2461 |
| LLPS-Loa-2908 | Loxodonta africana | 82.82 | 0.0 | 2360 |
| LLPS-Dio-3811 | Dipodomys ordii | 82.8 | 0.0 | 2284 |
| LLPS-Mup-3276 | Mustela putorius furo | 82.36 | 0.0 | 1190 |
| LLPS-Fud-4044 | Fukomys damarensis | 81.87 | 0.0 | 2314 |
| LLPS-Fec-4316 | Felis catus | 81.47 | 0.0 | 2401 |
| LLPS-Mod-2777 | Monodelphis domestica | 80.84 | 0.0 | 2447 |
| LLPS-Sah-3248 | Sarcophilus harrisii | 80.1 | 0.0 | 2412 |
| LLPS-Ora-2821 | Ornithorhynchus anatinus | 79.07 | 0.0 | 2364 |
| LLPS-Bot-1122 | Bos taurus | 78.57 | 0.0 | 2311 |
| LLPS-Tag-1805 | Taeniopygia guttata | 78.25 | 0.0 | 2305 |
| LLPS-Fia-2955 | Ficedula albicollis | 78.24 | 0.0 | 2326 |
| LLPS-Anp-2730 | Anas platyrhynchos | 77.71 | 0.0 | 2271 |
| LLPS-Gaga-3524 | Gallus gallus | 77.69 | 0.0 | 2296 |
| LLPS-Sus-3302 | Sus scrofa | 77.59 | 0.0 | 2265 |
| LLPS-Meg-3330 | Meleagris gallopavo | 77.1 | 0.0 | 2264 |
| LLPS-Pes-2122 | Pelodiscus sinensis | 76.43 | 0.0 | 2237 |
| LLPS-Anc-1224 | Anolis carolinensis | 73.46 | 0.0 | 2123 |
| LLPS-Myl-2465 | Myotis lucifugus | 73.36 | 0.0 | 1781 |
| LLPS-Lac-2402 | Latimeria chalumnae | 67.11 | 0.0 | 1911 |
| LLPS-Leo-1548 | Lepisosteus oculatus | 65.18 | 0.0 | 1795 |
| LLPS-Scf-0686 | Scleropages formosus | 61.1 | 0.0 | 1609 |
| LLPS-Dar-1438 | Danio rerio | 57.52 | 0.0 | 1481 |
| LLPS-Xim-1804 | Xiphophorus maculatus | 56.3 | 0.0 | 1436 |
| LLPS-Asm-2507 | Astyanax mexicanus | 55.83 | 0.0 | 1409 |
| LLPS-Icp-3372 | Ictalurus punctatus | 55.13 | 0.0 | 1381 |
| LLPS-Tar-3245 | Takifugu rubripes | 53.6 | 0.0 | 1333 |
| LLPS-Orn-3694 | Oreochromis niloticus | 50.43 | 0.0 | 1198 |
| LLPS-Scm-3834 | Scophthalmus maximus | 49.55 | 0.0 | 1171 |
| LLPS-Gaa-1221 | Gasterosteus aculeatus | 49.15 | 0.0 | 1206 |
| LLPS-Ten-3495 | Tetraodon nigroviridis | 47.33 | 0.0 | 1065 |
| LLPS-Pof-3763 | Poecilia formosa | 46.76 | 0.0 | 1153 |
| LLPS-Orl-1255 | Oryzias latipes | 46.61 | 0.0 | 1095 |
| LLPS-Cii-0729 | Ciona intestinalis | 29.08 | 2e-21 | 100 |