LLPS-Hos-1007
WDR55
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | WD repeat-containing protein 55 |
| Gene Name: | WDR55 |
| Ensembl Gene: | ENSG00000120314.18 |
| Ensembl Protein: | ENSP00000426304.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli." | HeLa cells | 15635413 |
| Nucleolus | "...Finally, 221 proteins were found as nucleolar with No/Cyto > 1 and No/Nuc > 1." | HCT116 cells | 20026476 |
| Nucleolus | "...Finally, 221 proteins were found as nucleolar with No/Cyto > 1 and No/Nuc > 1." | HCT116 cells | 20026476 |
| P-body | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000506393.5 | ENSP00000426304.1 |
| Ensembl | ENST00000358337.9 | ENSP00000351100.5 |
| Ensembl | ENST00000504897.2 | ENSP00000439719.1 |
| UniProt | Q9H6Y2, WDR55_HUMAN, Q9NXK4 | |
| GeneBank | AK025355, BC068485, AC116353, AK000202 | BAB15118.1, AAH68485.1, BAA91006.1 |
| RefSeq | NM_017706.4, XM_005268469.2 | NP_060176.2, XP_005268526.1 |
| Entrez | 54853 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDRTCEERPA EDGSDEEDPD SMEAPTRIRD TPEDIVLEAP ASGLAFHPAR DLLAAGDVDG 60 61 DVFVFSYSCQ EGETKELWSS GHHLKACRAV AFSEDGQKLI TVSKDKAIHV LDVEQGQLER 120 121 RVSKAHGAPI NSLLLVDENV LATGDDTGGI CLWDQRKEGP LMDMRQHEEY IADMALDPAK 180 181 KLLLTASGDG CLGIFNIKRR RFELLSEPQS GDLTSVTLMK WGKKVACGSS EGTIYLFNWN 240 241 GFGATSDRFA LRAESIDCMV PVTESLLCTG STDGVIRAVN ILPNRVVGSV GQHTGEPVEE 300 301 LALSHCGRFL ASSGHDQRLK FWDMAQLRAV VVDDYRRRKK KGGPLRALSS KTWSTDDFFA 360 361 GLREEGEDSM AQEEKEETGD DSD 383 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGACCGCA CTTGTGAGGA GAGGCCCGCT GAGGATGGGA GCGACGAGGA GGACCCAGAC 60 61 TCCATGGAAG CCCCAACCCG GATCCGGGAC ACTCCGGAAG ACATCGTGCT GGAAGCTCCG 120 121 GCTAGTGGGC TGGCGTTCCA TCCGGCCCGT GACCTACTGG CTGCAGGGGA CGTGGACGGG 180 181 GACGTGTTCG TCTTTTCCTA CTCTTGCCAA GAGGGAGAAA CCAAGGAGCT CTGGTCATCA 240 241 GGTCACCATC TCAAGGCCTG CCGAGCTGTG GCCTTCTCTG AAGATGGGCA GAAGCTCATT 300 301 ACTGTCTCCA AGGACAAAGC CATCCATGTT CTAGATGTGG AGCAGGGCCA ACTGGAAAGA 360 361 CGTGTTTCCA AGGCTCATGG TGCCCCCATC AATAGTCTTC TGCTGGTGGA TGAGAATGTT 420 421 CTGGCCACTG GGGATGACAC AGGTGGTATC TGTCTCTGGG ACCAGCGGAA GGAGGGCCCC 480 481 TTAATGGATA TGAGGCAACA TGAAGAGTAC ATCGCAGACA TGGCTCTGGA TCCAGCCAAA 540 541 AAGCTGCTGC TGACAGCCAG CGGGGATGGC TGCCTTGGCA TCTTCAACAT TAAGAGGCGT 600 601 CGGTTTGAGC TGCTCTCAGA ACCTCAGTCT GGGGACCTGA CCTCTGTCAC TCTCATGAAA 660 661 TGGGGGAAGA AGGTAGCCTG TGGCTCCAGT GAAGGTACCA TCTACCTCTT CAATTGGAAT 720 721 GGCTTTGGGG CCACAAGTGA CCGCTTTGCC CTGAGAGCTG AATCTATCGA CTGCATGGTT 780 781 CCAGTCACCG AGAGTCTGCT GTGTACTGGC TCCACTGATG GAGTCATCAG GGCTGTGAAC 840 841 ATCCTACCGA ACCGAGTGGT GGGCAGTGTG GGCCAGCACA CTGGGGAGCC TGTGGAGGAG 900 901 CTGGCCCTCT CCCACTGTGG CCGCTTCCTG GCCAGTAGTG GCCATGACCA GCGCCTCAAG 960 961 TTTTGGGACA TGGCCCAGCT GCGAGCTGTG GTGGTGGATG ACTACCGTCG GCGCAAAAAA 1020 1021 AAGGGAGGAC CACTGCGGGC TCTGAGCAGC AAGACTTGGA GCACCGATGA CTTCTTCGCA 1080 1081 GGACTGAGGG AAGAGGGAGA AGACTCCATG GCTCAGGAAG AAAAGGAGGA GACTGGGGAT 1140 1141 GACAGTGACT GA 1152 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleolus | |
Biological Process | RRNA processing |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| iEKPD | PIRSF | CellMarker | ||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-0677 | Pan paniscus | 99.48 | 0.0 | 780 |
| LLPS-Pat-0638 | Pan troglodytes | 99.22 | 0.0 | 778 |
| LLPS-Gog-2361 | Gorilla gorilla | 98.96 | 0.0 | 776 |
| LLPS-Nol-2632 | Nomascus leucogenys | 98.17 | 0.0 | 766 |
| LLPS-Poa-0223 | Pongo abelii | 97.91 | 0.0 | 769 |
| LLPS-Man-1976 | Macaca nemestrina | 97.65 | 0.0 | 766 |
| LLPS-Paa-1958 | Papio anubis | 97.65 | 0.0 | 766 |
| LLPS-Maf-1750 | Macaca fascicularis | 97.39 | 0.0 | 764 |
| LLPS-Mam-2431 | Macaca mulatta | 97.3 | 8e-126 | 367 |
| LLPS-Cea-0567 | Cercocebus atys | 97.13 | 0.0 | 763 |
| LLPS-Chs-1129 | Chlorocebus sabaeus | 97.13 | 0.0 | 763 |
| LLPS-Mal-1408 | Mandrillus leucophaeus | 97.13 | 0.0 | 763 |
| LLPS-Caj-2284 | Callithrix jacchus | 94.79 | 0.0 | 740 |
| LLPS-Urm-0382 | Ursus maritimus | 94.64 | 0.0 | 732 |
| LLPS-Aon-2832 | Aotus nancymaae | 94.52 | 0.0 | 743 |
| LLPS-Eqc-2154 | Equus caballus | 94.35 | 0.0 | 735 |
| LLPS-Rhb-3389 | Rhinopithecus bieti | 93.99 | 0.0 | 733 |
| LLPS-Aim-4000 | Ailuropoda melanoleuca | 93.47 | 0.0 | 743 |
| LLPS-Ere-0116 | Erinaceus europaeus | 93.1 | 0.0 | 619 |
| LLPS-Orc-0797 | Oryctolagus cuniculus | 92.95 | 0.0 | 733 |
| LLPS-Bot-3326 | Bos taurus | 92.95 | 0.0 | 708 |
| LLPS-Mup-1374 | Mustela putorius furo | 92.95 | 0.0 | 728 |
| LLPS-Sus-3157 | Sus scrofa | 92.45 | 0.0 | 710 |
| LLPS-Myl-1750 | Myotis lucifugus | 92.27 | 0.0 | 694 |
| LLPS-Otg-0629 | Otolemur garnettii | 92.18 | 0.0 | 709 |
| LLPS-Caf-0508 | Canis familiaris | 92.16 | 0.0 | 722 |
| LLPS-Cap-0501 | Cavia porcellus | 91.91 | 0.0 | 719 |
| LLPS-Cas-1702 | Carlito syrichta | 91.64 | 0.0 | 720 |
| LLPS-Loa-1427 | Loxodonta africana | 91.13 | 0.0 | 696 |
| LLPS-Fud-0940 | Fukomys damarensis | 91.11 | 0.0 | 692 |
| LLPS-Fec-3234 | Felis catus | 90.62 | 0.0 | 704 |
| LLPS-Dio-0570 | Dipodomys ordii | 90.57 | 0.0 | 688 |
| LLPS-Ict-2186 | Ictidomys tridecemlineatus | 90.08 | 0.0 | 712 |
| LLPS-Mum-1148 | Mus musculus | 89.07 | 0.0 | 692 |
| LLPS-Ran-3199 | Rattus norvegicus | 89.06 | 0.0 | 712 |
| LLPS-Mea-1504 | Mesocricetus auratus | 86.45 | 0.0 | 687 |
| LLPS-Ora-1469 | Ornithorhynchus anatinus | 82.55 | 2e-86 | 266 |
| LLPS-Mod-1425 | Monodelphis domestica | 82.35 | 0.0 | 622 |
| LLPS-Sah-1946 | Sarcophilus harrisii | 79.51 | 0.0 | 616 |
| LLPS-Gaga-0556 | Gallus gallus | 74.87 | 2e-100 | 303 |
| LLPS-Xet-2735 | Xenopus tropicalis | 67.57 | 3e-29 | 114 |
| LLPS-Orn-0578 | Oreochromis niloticus | 66.67 | 3e-169 | 487 |
| LLPS-Anc-3217 | Anolis carolinensis | 66.58 | 6e-178 | 525 |
| LLPS-Ten-0224 | Tetraodon nigroviridis | 66.03 | 5e-167 | 480 |
| LLPS-Pof-1176 | Poecilia formosa | 65.18 | 2e-159 | 462 |
| LLPS-Meg-0802 | Meleagris gallopavo | 65.04 | 4e-110 | 348 |
| LLPS-Scf-0929 | Scleropages formosus | 64.91 | 2e-171 | 491 |
| LLPS-Xim-1117 | Xiphophorus maculatus | 64.88 | 3e-158 | 459 |
| LLPS-Scm-0113 | Scophthalmus maximus | 64.72 | 2e-168 | 485 |
| LLPS-Gaa-2451 | Gasterosteus aculeatus | 63.99 | 1e-163 | 471 |
| LLPS-Icp-1947 | Ictalurus punctatus | 63.61 | 2e-167 | 481 |
| LLPS-Tar-0232 | Takifugu rubripes | 63.41 | 6e-170 | 489 |
| LLPS-Dar-0651 | Danio rerio | 63.33 | 8e-165 | 474 |
| LLPS-Asm-0871 | Astyanax mexicanus | 62.26 | 5e-168 | 483 |
| LLPS-Orl-0129 | Oryzias latipes | 62.25 | 2e-166 | 479 |
| LLPS-Lac-1838 | Latimeria chalumnae | 59.72 | 1e-144 | 422 |
| LLPS-Tag-0918 | Taeniopygia guttata | 58.09 | 3e-101 | 323 |
| LLPS-Phv-2059 | Phaseolus vulgaris | 42.12 | 9e-69 | 227 |
| LLPS-Php-0756 | Physcomitrella patens | 41.47 | 4e-75 | 244 |
| LLPS-Via-1120 | Vigna angularis | 41.44 | 7e-68 | 224 |
| LLPS-Thc-1084 | Theobroma cacao | 40.64 | 2e-66 | 221 |
| LLPS-Gor-0884 | Gossypium raimondii | 40.21 | 1e-66 | 221 |
| LLPS-Glm-0030 | Glycine max | 40.0 | 6e-65 | 217 |
| LLPS-Sem-0807 | Selaginella moellendorffii | 39.65 | 1e-64 | 216 |
| LLPS-Cis-0050 | Ciona savignyi | 39.59 | 2e-69 | 230 |
| LLPS-Abg-1149 | Absidia glauca | 39.39 | 1e-68 | 228 |
| LLPS-Ors-0019 | Oryza sativa | 39.12 | 8e-66 | 219 |
| LLPS-Org-1365 | Oryza glaberrima | 39.12 | 6e-66 | 219 |
| LLPS-Ori-1537 | Oryza indica | 39.12 | 6e-66 | 219 |
| LLPS-Orni-2185 | Oryza nivara | 39.12 | 6e-66 | 219 |
| LLPS-Orbr-0176 | Oryza brachyantha | 39.08 | 4e-64 | 215 |
| LLPS-Orm-1338 | Oryza meridionalis | 38.85 | 1e-54 | 190 |
| LLPS-Viv-1803 | Vitis vinifera | 38.83 | 2e-56 | 205 |
| LLPS-Lep-0648 | Leersia perrieri | 38.8 | 2e-66 | 221 |
| LLPS-Orr-1357 | Oryza rufipogon | 38.78 | 5e-63 | 212 |
| LLPS-Orgl-0910 | Oryza glumaepatula | 38.78 | 5e-63 | 212 |
| LLPS-Mua-1673 | Musa acuminata | 38.73 | 2e-64 | 216 |
| LLPS-Met-1292 | Medicago truncatula | 38.72 | 2e-64 | 218 |
| LLPS-Orb-0452 | Oryza barthii | 38.44 | 2e-62 | 210 |
| LLPS-Sei-0684 | Setaria italica | 38.38 | 5e-63 | 212 |
| LLPS-Cii-0142 | Ciona intestinalis | 38.36 | 2e-70 | 232 |
| LLPS-Brr-2012 | Brassica rapa | 38.31 | 5e-67 | 222 |
| LLPS-Bro-1763 | Brassica oleracea | 38.31 | 8e-67 | 222 |
| LLPS-Brn-2015 | Brassica napus | 38.31 | 5e-67 | 222 |
| LLPS-Pot-0151 | Populus trichocarpa | 38.16 | 5e-61 | 206 |
| LLPS-Brd-2029 | Brachypodium distachyon | 38.11 | 1e-62 | 211 |
| LLPS-Sob-2461 | Sorghum bicolor | 38.03 | 2e-63 | 213 |
| LLPS-Art-2118 | Arabidopsis thaliana | 37.97 | 2e-64 | 216 |
| LLPS-Vir-1507 | Vigna radiata | 37.97 | 2e-60 | 206 |
| LLPS-Mae-1662 | Manihot esculenta | 37.89 | 9e-62 | 208 |
| LLPS-Nia-0557 | Nicotiana attenuata | 37.81 | 1e-62 | 211 |
| LLPS-Coc-1965 | Corchorus capsularis | 37.65 | 6e-68 | 225 |
| LLPS-Chr-0397 | Chlamydomonas reinhardtii | 37.5 | 4e-44 | 166 |
| LLPS-Sot-0837 | Solanum tuberosum | 37.46 | 8e-63 | 211 |
| LLPS-Dac-0190 | Daucus carota | 37.33 | 3e-58 | 199 |
| LLPS-Sol-0327 | Solanum lycopersicum | 37.1 | 1e-61 | 208 |
| LLPS-Tra-1644 | Triticum aestivum | 36.71 | 4e-60 | 206 |
| LLPS-Hea-0231 | Helianthus annuus | 36.27 | 5e-61 | 207 |
| LLPS-Arl-0456 | Arabidopsis lyrata | 36.15 | 4e-54 | 188 |
| LLPS-Amt-0826 | Amborella trichopoda | 35.53 | 4e-22 | 96.3 |
| LLPS-Prp-0119 | Prunus persica | 35.49 | 4e-64 | 215 |
| LLPS-Drm-2165 | Drosophila melanogaster | 34.67 | 4e-66 | 224 |
| LLPS-Hov-1696 | Hordeum vulgare | 33.97 | 3e-54 | 191 |
| LLPS-Crn-1060 | Cryptococcus neoformans | 33.67 | 1e-46 | 169 |
| LLPS-Spr-1270 | Sporisorium reilianum | 33.56 | 1e-14 | 79.3 |
| LLPS-Orp-0705 | Oryza punctata | 32.65 | 5e-42 | 155 |
| LLPS-Usm-0962 | Ustilago maydis | 32.52 | 1e-11 | 70.1 |
| LLPS-Osl-0741 | Ostreococcus lucimarinus | 31.93 | 3e-49 | 176 |
| LLPS-Zem-2271 | Zea mays | 31.65 | 3e-36 | 141 |
| LLPS-Scp-0225 | Schizosaccharomyces pombe | 29.82 | 8e-28 | 116 |
| LLPS-Gas-1160 | Galdieria sulphuraria | 29.74 | 3e-21 | 97.8 |
| LLPS-Scj-0724 | Schizosaccharomyces japonicus | 28.97 | 5e-26 | 111 |
| LLPS-Scc-0574 | Schizosaccharomyces cryophilus | 28.47 | 2e-28 | 119 |
| LLPS-Cym-0686 | Cyanidioschyzon merolae | 25.89 | 1e-19 | 93.2 |
| LLPS-Ova-0559 | Ovis aries | 25.61 | 1e-11 | 69.7 |
| LLPS-Anp-1883 | Anas platyrhynchos | 25.23 | 1e-11 | 70.1 |
| LLPS-Fia-3029 | Ficedula albicollis | 25.23 | 1e-11 | 70.1 |
| LLPS-Pes-0673 | Pelodiscus sinensis | 25.23 | 2e-11 | 69.3 |
| LLPS-Cae-0291 | Caenorhabditis elegans | 25.0 | 1e-15 | 81.6 |
| LLPS-Leo-0699 | Lepisosteus oculatus | 24.92 | 3e-11 | 68.6 |
| LLPS-Tut-1738 | Tursiops truncatus | 24.92 | 2e-11 | 68.9 |
| LLPS-Sac-0069 | Saccharomyces cerevisiae | 23.88 | 2e-12 | 72.0 |
| LLPS-Yal-0802 | Yarrowia lipolytica | 23.66 | 1e-11 | 69.7 |