DrLLPS - Data resource of LLPS

LLPS-Hos-0972
CACYBP

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Calcyclin-binding protein
Gene Name:	CACYBP, S100A6BP, SIP, PNAS-107
Ensembl Gene:	ENSG00000116161.17
Ensembl Protein:	ENSP00000479414.1
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Client

PDB: 2A25 (A, B) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Nucleolus	"...SILAC-based approaches identified 351 proteins with 24 proteins showing at least a 2-fold change after infection."	HeLa cells	19812395
Postsynaptic density	"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."	Human cortex	23071613

▼ FUNCTION

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000613570.4	ENSP00000479414.1
Ensembl	ENST00000426793.1	ENSP00000403674.1
Ensembl	ENST00000405362.1	ENSP00000385771.1
Ensembl	ENST00000406752.1	ENSP00000384139.1
Ensembl	ENST00000367679.6	ENSP00000356652.2
UniProt		Q9HB71, CYBP_HUMAN, B2ZWH2, B3KSF1, O60666, Q5R370, Q5R371
GeneBank	BC022352, Z99127, AF275803, AK313278, AL035305, BC078151, BC005975, CH471067, AF057356, AF314752, AY423723, AK093425	BAG52713.1, AAH05975.1, AAG23817.1, AAG34170.1, AAC21458.1, BAG36086.1, EAW90982.1, AAH22352.1, AAH78151.1, AAS00486.1, CAA22910.1
RefSeq	NM_001007214.1, NM_014412.2, XM_017001046.1	NP_001007215.1, NP_055227.1, XP_016856535.1
Entrez	27101

▼ SEQUENCE

Protein Sequence (FASTA)
1 MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK KAELLDNEKP 60 61 AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP TENVQVHFTE RSFDLLVKNL 120 121 NGKSYSMIVN NLLKPISVEG SSKKVKTDTV LILCRKKVEN TRWDYLTQVE KECKEKEKPS 180 181 YDTETDPSEG LMNVLKKIYE DGDDDMKRTI NKAWVESREK QAKGDTEF 228
Nucleotide CDS Sequence (FASTA)
1 ATGGCTTCAG AAGAGCTACA GAAAGATCTA GAAGAGGTAA AGGTGTTGCT GGAAAAGGCT 60 61 ACTAGGAAAA GAGTACGTGA TGCCCTTACA GCTGAAAAAT CCAAGATTGA GACAGAAATC 120 121 AAGAACAAGA TGCAACAGAA ATCACAGAAG AAAGCAGAAC TTCTTGATAA TGAAAAACCA 180 181 GCTGCTGTGG TTGCTCCCAT TACAACGGGC TATACGGTGA AAATCAGTAA TTATGGATGG 240 241 GATCAGTCAG ATAAGTTTGT GAAAATCTAC ATTACCTTAA CTGGAGTTCA TCAAGTTCCC 300 301 ACTGAGAATG TGCAGGTGCA TTTCACAGAG AGGTCATTTG ATCTTTTGGT AAAGAATCTA 360 361 AATGGGAAGA GTTACTCCAT GATTGTGAAC AATCTCTTGA AACCCATCTC TGTGGAAGGC 420 421 AGTTCAAAAA AAGTCAAGAC TGATACAGTT CTTATATTGT GTAGAAAGAA AGTGGAAAAC 480 481 ACAAGGTGGG ATTACCTGAC CCAGGTTGAA AAGGAGTGCA AAGAAAAAGA GAAGCCCTCC 540 541 TATGACACTG AAACAGATCC TAGTGAGGGA TTGATGAATG TTCTAAAGAA AATTTATGAA 600 601 GATGGAGACG ATGATATGAA GCGAACCATT AATAAAGCCT GGGTGGAATC AAGAGAGAAG 660 661 CAAGCCAAAG GAGACACGGA ATTTTGA 687

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0025	Alternative splicing
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0833	Ubl conjugation pathway

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0030877	Cellular Component	Beta-catenin destruction complex
GO:0044297	Cellular Component	Cell body
GO:0005829	Cellular Component	Cytosol
GO:0070062	Cellular Component	Extracellular exosome
GO:0043005	Cellular Component	Neuron projection
GO:0005641	Cellular Component	Nuclear envelope lumen
GO:0005654	Cellular Component	Nucleoplasm
GO:0005634	Cellular Component	Nucleus
GO:0019005	Cellular Component	SCF ubiquitin ligase complex
GO:0019904	Molecular Function	Protein domain specific binding
GO:0042803	Molecular Function	Protein homodimerization activity
GO:0044548	Molecular Function	S100 protein binding
GO:0015631	Molecular Function	Tubulin binding
GO:0031625	Molecular Function	Ubiquitin protein ligase binding
GO:0007568	Biological Process	Aging
GO:0055007	Biological Process	Cardiac muscle cell differentiation
GO:0071277	Biological Process	Cellular response to calcium ion
GO:1990830	Biological Process	Cellular response to leukemia inhibitory factor
GO:0007507	Biological Process	Heart development
GO:0060548	Biological Process	Negative regulation of cell death
GO:0045740	Biological Process	Positive regulation of DNA replication
GO:0060416	Biological Process	Response to growth hormone

▼ KEGG

hsa:27101

▼ ANNOTATION

Disorder
D²P²	IUPred2A	MobiDB

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
PROSITE	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	mUbiSiDa	PTMcode

Variation
dbSNP	VarCards	rSNPBase

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	RAIN	Mentha
PINA	IID	MIST	DifferentialNET	RNAct

Disease
PTMD	OMIM	DisGeNET	ActiveDriverDB

Drug
CTD

Physicochemical
Compute pI/Mw	AAindex

Function
iEKPD	CORUM	CellMarker	RaftProt

Proteomics
THPA	HPM

Structure
PDB	MMDB

Localization
COMPARTMENTS	NLSdb

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	circBase	CircNet	miRTarBase	miRWalk
miRcode	RAID	microRNA.org	m6AVar

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Gog-0797	Gorilla gorilla	100.0	1e-165	464
LLPS-Poa-0064	Pongo abelii	100.0	1e-165	464
LLPS-Pat-2069	Pan troglodytes	100.0	1e-165	464
LLPS-Paa-0374	Papio anubis	99.56	4e-165	462
LLPS-Chs-1155	Chlorocebus sabaeus	99.56	4e-165	462
LLPS-Maf-0337	Macaca fascicularis	99.56	4e-165	462
LLPS-Mam-0332	Macaca mulatta	99.56	4e-165	462
LLPS-Man-2973	Macaca nemestrina	99.56	4e-165	462
LLPS-Aon-0181	Aotus nancymaae	99.55	2e-161	453
LLPS-Nol-0478	Nomascus leucogenys	99.55	7e-161	451
LLPS-Pap-1487	Pan paniscus	99.12	6e-163	457
LLPS-Cea-3258	Cercocebus atys	98.68	6e-164	459
LLPS-Caj-1800	Callithrix jacchus	98.65	6e-160	449
LLPS-Caf-0602	Canis familiaris	97.8	8e-151	432
LLPS-Aim-0860	Ailuropoda melanoleuca	97.77	5e-152	429
LLPS-Mup-3365	Mustela putorius furo	97.77	3e-152	430
LLPS-Urm-0638	Ursus maritimus	97.77	5e-152	429
LLPS-Rhb-3515	Rhinopithecus bieti	96.93	7e-159	446
LLPS-Sus-0842	Sus scrofa	96.92	4e-152	429
LLPS-Otg-0527	Otolemur garnettii	96.88	1e-149	423
LLPS-Ict-1667	Ictidomys tridecemlineatus	96.86	1e-148	420
LLPS-Fec-1535	Felis catus	96.48	8e-152	429
LLPS-Tut-0670	Tursiops truncatus	95.65	5e-150	424
LLPS-Cas-2050	Carlito syrichta	95.56	5e-147	417
LLPS-Fud-2658	Fukomys damarensis	95.52	1e-146	415
LLPS-Mal-2302	Mandrillus leucophaeus	95.18	1e-148	421
LLPS-Bot-1095	Bos taurus	95.15	1e-148	421
LLPS-Loa-0199	Loxodonta africana	94.27	4e-144	409
LLPS-Myl-0505	Myotis lucifugus	94.2	4e-144	409
LLPS-Ova-2463	Ovis aries	94.2	3e-145	412
LLPS-Cap-0828	Cavia porcellus	93.04	4e-145	412
LLPS-Dio-1291	Dipodomys ordii	92.86	3e-142	404
LLPS-Mum-0373	Mus musculus	92.61	2e-144	410
LLPS-Eqc-0977	Equus caballus	91.77	2e-157	443
LLPS-Orc-1251	Oryctolagus cuniculus	91.67	2e-142	405
LLPS-Ran-0188	Rattus norvegicus	91.63	2e-142	405
LLPS-Ora-1778	Ornithorhynchus anatinus	83.11	8e-128	368
LLPS-Mea-0684	Mesocricetus auratus	82.24	2e-110	323
LLPS-Mod-0669	Monodelphis domestica	80.18	2e-118	348
LLPS-Sah-0009	Sarcophilus harrisii	80.0	4e-120	348
LLPS-Pes-0347	Pelodiscus sinensis	71.49	7e-97	289
LLPS-Xet-0305	Xenopus tropicalis	71.24	6e-113	330
LLPS-Tag-0604	Taeniopygia guttata	70.22	1e-96	288
LLPS-Fia-0642	Ficedula albicollis	69.78	6e-96	286
LLPS-Gaga-1845	Gallus gallus	69.2	6e-96	286
LLPS-Meg-1892	Meleagris gallopavo	68.78	5e-94	281
LLPS-Anp-0331	Anas platyrhynchos	68.61	5e-93	279
LLPS-Lac-1751	Latimeria chalumnae	67.95	3e-105	311
LLPS-Anc-0039	Anolis carolinensis	67.87	1e-72	227
LLPS-Scf-1276	Scleropages formosus	61.78	1e-90	273
LLPS-Dar-0865	Danio rerio	60.91	8e-81	248
LLPS-Leo-0646	Lepisosteus oculatus	60.18	1e-89	270
LLPS-Asm-0515	Astyanax mexicanus	60.0	2e-81	249
LLPS-Icp-2157	Ictalurus punctatus	59.64	9e-84	256
LLPS-Orn-2260	Oreochromis niloticus	56.11	7e-79	243
LLPS-Orl-1249	Oryzias latipes	55.2	2e-76	237
LLPS-Pof-0788	Poecilia formosa	54.3	7e-76	236
LLPS-Xim-3091	Xiphophorus maculatus	53.85	1e-74	232
LLPS-Ten-0288	Tetraodon nigroviridis	53.33	4e-63	203
LLPS-Gaa-0175	Gasterosteus aculeatus	52.49	3e-72	226
LLPS-Tar-0341	Takifugu rubripes	52.04	4e-65	208
LLPS-Scm-1127	Scophthalmus maximus	52.04	8e-73	228
LLPS-Cii-1779	Ciona intestinalis	41.89	3e-42	149
LLPS-Drm-0909	Drosophila melanogaster	40.89	3e-46	159
LLPS-Cis-1145	Ciona savignyi	40.17	1e-38	140
LLPS-Gor-0989	Gossypium raimondii	39.51	8e-24	100
LLPS-Php-2213	Physcomitrella patens	36.56	6e-30	117
LLPS-Thc-0497	Theobroma cacao	36.55	5e-25	103
LLPS-Sem-1668	Selaginella moellendorffii	36.28	6e-30	116
LLPS-Tru-0231	Triticum urartu	36.15	4e-14	72.0
LLPS-Nia-0395	Nicotiana attenuata	36.12	3e-28	112
LLPS-Mae-1824	Manihot esculenta	35.87	4e-28	112
LLPS-Sol-0943	Solanum lycopersicum	35.68	1e-28	112
LLPS-Amt-0414	Amborella trichopoda	35.45	5e-22	95.1
LLPS-Coc-1650	Corchorus capsularis	35.32	1e-27	110
LLPS-Mua-0785	Musa acuminata	35.16	5e-27	110
LLPS-Sei-0934	Setaria italica	34.83	5e-22	95.1
LLPS-Sot-0428	Solanum tuberosum	34.8	1e-26	107
LLPS-Met-0242	Medicago truncatula	34.67	8e-29	113
LLPS-Prp-1113	Prunus persica	34.03	2e-20	90.9
LLPS-Cus-1147	Cucumis sativus	33.94	1e-24	102
LLPS-Hea-0297	Helianthus annuus	33.62	9e-25	102
LLPS-Lep-0326	Leersia perrieri	33.48	2e-21	94.4
LLPS-Dac-0901	Daucus carota	33.33	1e-25	104
LLPS-Via-1391	Vigna angularis	33.08	4e-14	73.2
LLPS-Orp-0080	Oryza punctata	32.91	2e-24	102
LLPS-Viv-0236	Vitis vinifera	32.58	2e-23	99.4
LLPS-Sob-0794	Sorghum bicolor	32.57	5e-23	97.8
LLPS-Arl-0702	Arabidopsis lyrata	32.46	1e-23	99.8
LLPS-Orbr-0112	Oryza brachyantha	32.11	8e-25	102
LLPS-Orm-1369	Oryza meridionalis	32.05	1e-22	97.4
LLPS-Brd-1100	Brachypodium distachyon	31.96	1e-18	85.5
LLPS-Orgl-1255	Oryza glumaepatula	31.76	6e-23	97.8
LLPS-Ori-1306	Oryza indica	31.76	6e-23	97.8
LLPS-Orb-0225	Oryza barthii	31.76	6e-23	97.8
LLPS-Orni-0315	Oryza nivara	31.76	6e-23	97.8
LLPS-Orr-0034	Oryza rufipogon	31.76	2e-22	96.3
LLPS-Org-0258	Oryza glaberrima	31.76	6e-23	97.8
LLPS-Ors-1348	Oryza sativa	31.76	2e-22	96.3
LLPS-Art-0765	Arabidopsis thaliana	31.62	1e-25	105
LLPS-Glm-2623	Glycine max	31.56	1e-24	102
LLPS-Tra-2223	Triticum aestivum	31.51	2e-21	93.6
LLPS-Zem-0142	Zea mays	31.06	1e-19	88.6
LLPS-Bro-2138	Brassica oleracea	31.06	1e-22	100
LLPS-Brn-1881	Brassica napus	30.67	7e-24	100
LLPS-Pot-0602	Populus trichocarpa	30.57	1e-23	99.8
LLPS-Phv-0860	Phaseolus vulgaris	30.56	2e-23	99.4
LLPS-Brr-0112	Brassica rapa	30.53	9e-21	91.7
LLPS-Hov-1571	Hordeum vulgare	30.17	4e-21	92.8

LLPS-Hos-0972CACYBP

Protein Sequence

Nucleotide Sequence

LLPS-Hos-0972
CACYBP