LLPS-Hos-0969
SLC4A4
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body | "...Using an RNA-mediated interference-based screen, we identify 101 human genes required for SG assembly, 39 genes required for PB assembly, and 31 genes required for coordinate SG and PB assembly." | U2OS cells | 18794846 |
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ FUNCTION
| Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000512686.5 | ENSP00000422400.1 |
| Ensembl | ENST00000264485.10 | ENSP00000264485.5 |
| Ensembl | ENST00000425175.5 | ENSP00000393557.1 |
| Ensembl | ENST00000639096.1 | ENSP00000491107.1 |
| Ensembl | ENST00000351898.10 | ENSP00000307349.7 |
| Ensembl | ENST00000340595.3 | ENSP00000344272.3 |
| Ensembl | ENST00000638464.1 | ENSP00000492496.1 |
| Ensembl | ENST00000649996.1 | ENSP00000497468.1 |
| UniProt | Q9Y6R1, S4A4_HUMAN, C4B714, O15153, Q8NEJ2, Q9H262, Q9NRZ1, Q9UIC0, Q9UIC1, Q9UP50 | |
| GeneBank | AC096713, AF310248, AF007216, AF053754, AC019089, AC079230, AF157492, AC110783, AF069510, AB470072, BC030977, AF011390, AF053753, AC112226 | AAD42020.1, AAC39840.1, AAC51645.1, BAH58226.1, AAF21719.1, AAH30977.1, AAG47773.1, AAF21718.1, AAF80343.1 |
| RefSeq | NM_001098484.2, NM_003759.3 | NP_001091954.1, NP_003750.1 |
| Entrez | 8671 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKTG HKEKKEKERI 60 61 SENYSDKSDI ENADESSSSI LKPLISPAAE RIRFILGEED DSPAPPQLFT ELDELLAVDG 120 121 QEMEWKETAR WIKFEEKVEQ GGERWSKPHV ATLSLHSLFE LRTCMEKGSI MLDREASSLP 180 181 QLVEMIVDHQ IETGLLKPEL KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASRMFTN 240 241 PDNGSPAMTH RNLTSSSLND ISDKPEKDQL KNKFMKKLPR DAEASNVLVG EVDFLDTPFI 300 301 AFVRLQQAVM LGALTEVPVP TRFLFILLGP KGKAKSYHEI GRAIATLMSD EVFHDIAYKA 360 361 KDRHDLIAGI DEFLDEVIVL PPGEWDPAIR IEPPKSLPSS DKRKNMYSGG ENVQMNGDTP 420 421 HDGGHGGGGH GDCEELQRTG RFCGGLIKDI KRKAPFFASD FYDALNIQAL SAILFIYLAT 480 481 VTNAITFGGL LGDATDNMQG VLESFLGTAV SGAIFCLFAG QPLTILSSTG PVLVFERLLF 540 541 NFSKDNNFDY LEFRLWIGLW SAFLCLILVA TDASFLVQYF TRFTEEGFSS LISFIFIYDA 600 601 FKKMIKLADY YPINSNFKVG YNTLFSCTCV PPDPANISIS NDTTLAPEYL PTMSSTDMYH 660 661 NTTFDWAFLS KKECSKYGGN LVGNNCNFVP DITLMSFILF LGTYTSSMAL KKFKTSPYFP 720 721 TTARKLISDF AIILSILIFC VIDALVGVDT PKLIVPSEFK PTSPNRGWFV PPFGENPWWV 780 781 CLAAAIPALL VTILIFMDQQ ITAVIVNRKE HKLKKGAGYH LDLFWVAILM VICSLMALPW 840 841 YVAATVISIA HIDSLKMETE TSAPGEQPKF LGVREQRVTG TLVFILTGLS VFMAPILKFI 900 901 PMPVLYGVFL YMGVASLNGV QFMDRLKLLL MPLKHQPDFI YLRHVPLRRV HLFTFLQVLC 960 961 LALLWILKST VAAIIFPVMI LALVAVRKGM DYLFSQHDLS FLDDVIPEKD KKKKEDEKKK 1020 1021 KKKKGSLDSD NDDEKDHQHS LNATHHADKI PFLQSLGMPS PPRTPVKVVP QIRIELEPED 1080 1081 NDYFWRSKGT ETTL 1094 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGGATG AAGCTGTCCT GGACAGAGGG GCTTCCTTCC TCAAGCATGT GTGTGATGAA 60 61 GAAGAAGTAG AAGGCCACCA TACCATTTAC ATCGGAGTCC ATGTGCCGAA GAGTTACAGG 120 121 AGAAGGAGAC GTCACAAGAG AAAGACAGGG CACAAAGAAA AGAAGGAAAA GGAGAGAATC 180 181 TCTGAGAACT ACTCTGACAA ATCAGATATT GAAAATGCTG ATGAATCCAG CAGCAGCATC 240 241 CTAAAACCTC TCATCTCTCC TGCTGCAGAA CGCATCCGAT TCATCTTGGG AGAGGAGGAT 300 301 GACAGCCCAG CTCCCCCTCA GCTCTTCACG GAACTGGATG AGCTGCTGGC CGTGGATGGG 360 361 CAGGAGATGG AGTGGAAGGA AACAGCCAGG TGGATCAAGT TTGAAGAAAA AGTGGAACAG 420 421 GGTGGGGAAA GATGGAGCAA GCCCCATGTG GCCACATTGT CCCTTCATAG TTTATTTGAG 480 481 CTGAGGACAT GTATGGAGAA AGGATCCATC ATGCTTGATC GGGAGGCTTC TTCTCTCCCA 540 541 CAGTTGGTGG AGATGATTGT TGACCATCAG ATTGAGACAG GCCTATTGAA ACCTGAACTT 600 601 AAGGATAAGG TGACCTATAC TTTGCTCCGG AAGCACCGGC ATCAAACCAA GAAATCCAAC 660 661 CTTCGGTCCC TGGCTGACAT TGGGAAGACA GTCTCCAGTG CAAGTAGGAT GTTTACCAAC 720 721 CCTGATAATG GTAGCCCAGC CATGACCCAT AGGAATCTGA CTTCCTCCAG TCTGAATGAC 780 781 ATTTCTGATA AACCGGAGAA GGACCAGCTG AAGAATAAGT TCATGAAAAA ATTGCCACGT 840 841 GATGCAGAAG CTTCCAACGT GCTTGTTGGG GAGGTTGACT TTTTGGATAC TCCTTTCATT 900 901 GCCTTTGTTA GGCTACAGCA GGCTGTCATG CTGGGTGCCC TGACTGAAGT TCCTGTGCCC 960 961 ACAAGGTTCT TGTTCATTCT CTTAGGTCCT AAGGGGAAAG CCAAGTCCTA CCACGAGATT 1020 1021 GGCAGAGCCA TTGCCACCCT GATGTCTGAT GAGGTGTTCC ATGACATTGC TTATAAAGCA 1080 1081 AAAGACAGGC ACGACCTGAT TGCTGGTATT GATGAGTTCC TAGATGAAGT CATCGTCCTT 1140 1141 CCACCTGGGG AATGGGATCC AGCAATTAGG ATAGAGCCTC CTAAGAGTCT TCCATCCTCT 1200 1201 GACAAAAGAA AGAATATGTA CTCAGGTGGA GAGAATGTTC AGATGAATGG GGATACGCCC 1260 1261 CATGATGGAG GTCACGGAGG AGGAGGACAT GGGGATTGTG AAGAATTGCA GCGAACTGGA 1320 1321 CGGTTCTGTG GTGGACTAAT TAAAGACATA AAGAGGAAAG CGCCATTTTT TGCCAGTGAT 1380 1381 TTTTATGATG CTTTAAATAT TCAAGCTCTT TCGGCAATTC TCTTCATTTA TCTGGCAACT 1440 1441 GTAACTAATG CTATCACTTT TGGAGGACTG CTTGGGGATG CCACTGACAA CATGCAGGGC 1500 1501 GTGTTGGAGA GTTTCCTGGG CACTGCTGTC TCTGGAGCCA TCTTTTGCCT TTTTGCTGGT 1560 1561 CAACCACTCA CTATTCTGAG CAGCACCGGA CCTGTCCTAG TTTTTGAGAG GCTTCTATTT 1620 1621 AATTTCAGCA AGGACAATAA TTTTGACTAT TTGGAGTTTC GCCTTTGGAT TGGCCTGTGG 1680 1681 TCCGCCTTCC TATGTCTCAT TTTGGTAGCC ACTGATGCCA GCTTCTTGGT TCAATACTTC 1740 1741 ACACGTTTCA CGGAGGAGGG CTTTTCCTCT CTGATTAGCT TCATCTTTAT CTATGATGCT 1800 1801 TTCAAGAAGA TGATCAAGCT TGCAGATTAC TACCCCATCA ACTCCAACTT CAAAGTGGGC 1860 1861 TACAACACTC TCTTTTCCTG TACCTGTGTG CCACCTGACC CAGCTAATAT CTCAATATCT 1920 1921 AATGACACCA CACTGGCCCC AGAGTATTTG CCAACTATGT CTTCTACTGA CATGTACCAT 1980 1981 AATACTACCT TTGACTGGGC ATTTTTGTCG AAGAAGGAGT GTTCAAAATA CGGAGGAAAC 2040 2041 CTCGTCGGGA ACAACTGTAA TTTTGTTCCT GATATCACAC TCATGTCTTT TATCCTCTTC 2100 2101 TTGGGAACCT ACACCTCTTC CATGGCTCTG AAAAAATTCA AAACTAGTCC TTATTTTCCA 2160 2161 ACCACAGCAA GAAAACTGAT CAGTGATTTT GCCATTATCT TGTCCATTCT CATCTTTTGT 2220 2221 GTAATAGATG CCCTAGTAGG CGTGGACACC CCAAAACTAA TTGTGCCAAG TGAGTTCAAG 2280 2281 CCAACAAGTC CAAACCGAGG TTGGTTCGTT CCACCGTTTG GAGAAAACCC CTGGTGGGTG 2340 2341 TGCCTTGCTG CTGCTATCCC GGCTTTGTTG GTCACTATAC TGATTTTCAT GGACCAACAA 2400 2401 ATTACAGCTG TGATTGTAAA CAGGAAAGAA CATAAACTCA AGAAAGGAGC AGGGTATCAC 2460 2461 TTGGATCTCT TTTGGGTGGC CATCCTCATG GTTATATGCT CCCTCATGGC TCTTCCGTGG 2520 2521 TATGTAGCTG CTACGGTCAT CTCCATTGCT CACATCGACA GTTTGAAGAT GGAGACAGAG 2580 2581 ACTTCTGCAC CTGGAGAACA ACCAAAGTTT CTAGGAGTGA GGGAACAAAG AGTCACTGGA 2640 2641 ACCCTTGTGT TTATTCTGAC TGGTCTGTCA GTCTTTATGG CTCCCATCTT GAAGTTTATA 2700 2701 CCCATGCCTG TACTCTATGG TGTGTTCCTG TATATGGGAG TAGCATCCCT TAATGGTGTG 2760 2761 CAGTTCATGG ATCGTCTGAA GCTGCTTCTG ATGCCTCTGA AGCATCAGCC TGACTTCATC 2820 2821 TACCTGCGTC ATGTTCCTCT GCGCAGAGTC CACCTGTTCA CTTTCCTGCA GGTGTTGTGT 2880 2881 CTGGCCCTGC TTTGGATCCT CAAGTCAACG GTGGCTGCTA TCATTTTTCC AGTAATGATC 2940 2941 TTGGCACTTG TAGCTGTCAG AAAAGGCATG GACTACCTCT TCTCCCAGCA CGACCTCAGC 3000 3001 TTCCTGGATG ATGTCATTCC AGAAAAGGAC AAGAAAAAGA AGGAGGATGA GAAGAAAAAG 3060 3061 AAAAAGAAGA AGGGAAGTCT GGACAGTGAC AATGATGATT CTGACTGCCC ATACTCAGAA 3120 3121 AAAGTTCCAA GTATTAAAAT TCCAATGGAC ATCATGGAAC AGCAACCTTT CCTAAGCGAT 3180 3181 AGCAAACCTT CTGACAGAGA AAGATCACCA ACATTCCTTG AACGCCACAC ATCATGCTGA 3240 |
▼ KEYWORD
ID | Family |
3D-structure | |
Alternative splicing | |
Cell membrane | |
Complete proteome | |
Disease mutation | |
Disulfide bond | |
Glycoprotein | |
Ion transport | |
Membrane | |
Phosphoprotein | |
Reference proteome | |
Retinitis pigmentosa | |
Sodium | |
Sodium transport | |
Symport | |
Transmembrane | |
Transmembrane helix | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Basolateral plasma membrane | |
Cellular Component | Extracellular exosome | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | Plasma membrane | |
Molecular Function | Identical protein binding | |
Molecular Function | Inorganic anion exchanger activity | |
Molecular Function | Sodium:bicarbonate symporter activity | |
Biological Process | Bicarbonate transport | |
Biological Process | Regulation of intracellular pH | |
Biological Process | Sodium ion transport |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | CellMarker | RaftProt | ||
| Structure | ||||
| PDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-4523 | Pan troglodytes | 99.91 | 0.0 | 2090 |
| LLPS-Pap-1473 | Pan paniscus | 99.82 | 0.0 | 2089 |
| LLPS-Gog-1460 | Gorilla gorilla | 99.82 | 0.0 | 2093 |
| LLPS-Man-2234 | Macaca nemestrina | 99.45 | 0.0 | 2087 |
| LLPS-Paa-4382 | Papio anubis | 99.45 | 0.0 | 2081 |
| LLPS-Cea-3981 | Cercocebus atys | 99.45 | 0.0 | 2081 |
| LLPS-Mam-2160 | Macaca mulatta | 99.36 | 0.0 | 2085 |
| LLPS-Mal-4239 | Mandrillus leucophaeus | 99.36 | 0.0 | 2077 |
| LLPS-Rhb-3923 | Rhinopithecus bieti | 99.3 | 0.0 | 1944 |
| LLPS-Maf-4281 | Macaca fascicularis | 99.27 | 0.0 | 2077 |
| LLPS-Chs-4211 | Chlorocebus sabaeus | 98.95 | 0.0 | 1434 |
| LLPS-Aon-2885 | Aotus nancymaae | 98.72 | 0.0 | 2066 |
| LLPS-Caj-2404 | Callithrix jacchus | 98.26 | 0.0 | 2046 |
| LLPS-Ict-0503 | Ictidomys tridecemlineatus | 97.71 | 0.0 | 2044 |
| LLPS-Ova-1012 | Ovis aries | 97.42 | 0.0 | 1908 |
| LLPS-Dio-4139 | Dipodomys ordii | 97.26 | 0.0 | 2039 |
| LLPS-Bot-4759 | Bos taurus | 97.26 | 0.0 | 2035 |
| LLPS-Aim-2416 | Ailuropoda melanoleuca | 97.08 | 0.0 | 2043 |
| LLPS-Poa-4469 | Pongo abelii | 97.02 | 0.0 | 1880 |
| LLPS-Mup-1754 | Mustela putorius furo | 96.93 | 0.0 | 1902 |
| LLPS-Nol-2291 | Nomascus leucogenys | 96.89 | 0.0 | 1993 |
| LLPS-Mum-4964 | Mus musculus | 96.89 | 0.0 | 2038 |
| LLPS-Orc-0771 | Oryctolagus cuniculus | 96.72 | 0.0 | 1896 |
| LLPS-Ran-2064 | Rattus norvegicus | 96.53 | 0.0 | 2028 |
| LLPS-Caf-0190 | Canis familiaris | 96.33 | 0.0 | 1893 |
| LLPS-Cas-0296 | Carlito syrichta | 96.17 | 0.0 | 1821 |
| LLPS-Cap-2172 | Cavia porcellus | 95.65 | 0.0 | 1778 |
| LLPS-Otg-0726 | Otolemur garnettii | 95.54 | 0.0 | 1766 |
| LLPS-Loa-0135 | Loxodonta africana | 95.03 | 0.0 | 1858 |
| LLPS-Eqc-4354 | Equus caballus | 94.58 | 0.0 | 2018 |
| LLPS-Myl-2080 | Myotis lucifugus | 94.37 | 0.0 | 1758 |
| LLPS-Mod-0036 | Monodelphis domestica | 93.97 | 0.0 | 1960 |
| LLPS-Fec-0534 | Felis catus | 93.85 | 0.0 | 1881 |
| LLPS-Sus-1198 | Sus scrofa | 93.55 | 0.0 | 1875 |
| LLPS-Ora-2105 | Ornithorhynchus anatinus | 93.42 | 0.0 | 1956 |
| LLPS-Fud-4177 | Fukomys damarensis | 92.69 | 0.0 | 1848 |
| LLPS-Gaga-2820 | Gallus gallus | 92.55 | 0.0 | 1812 |
| LLPS-Anp-1966 | Anas platyrhynchos | 92.21 | 0.0 | 1692 |
| LLPS-Urm-0640 | Ursus maritimus | 92.21 | 0.0 | 1833 |
| LLPS-Tag-2105 | Taeniopygia guttata | 91.67 | 0.0 | 1782 |
| LLPS-Anc-3517 | Anolis carolinensis | 91.15 | 0.0 | 1742 |
| LLPS-Pes-0764 | Pelodiscus sinensis | 90.47 | 0.0 | 1770 |
| LLPS-Fia-3735 | Ficedula albicollis | 89.61 | 0.0 | 1767 |
| LLPS-Xet-3635 | Xenopus tropicalis | 85.9 | 0.0 | 1765 |
| LLPS-Scf-0874 | Scleropages formosus | 85.6 | 0.0 | 1682 |
| LLPS-Icp-3620 | Ictalurus punctatus | 84.5 | 0.0 | 1647 |
| LLPS-Orn-3067 | Oreochromis niloticus | 83.9 | 0.0 | 1648 |
| LLPS-Leo-3695 | Lepisosteus oculatus | 83.84 | 0.0 | 1795 |
| LLPS-Ten-3802 | Tetraodon nigroviridis | 83.53 | 0.0 | 1634 |
| LLPS-Tar-2902 | Takifugu rubripes | 82.16 | 0.0 | 1626 |
| LLPS-Scm-2895 | Scophthalmus maximus | 81.95 | 0.0 | 1623 |
| LLPS-Pof-2550 | Poecilia formosa | 81.19 | 0.0 | 1586 |
| LLPS-Dar-0799 | Danio rerio | 80.86 | 0.0 | 1637 |
| LLPS-Orl-0308 | Oryzias latipes | 80.36 | 0.0 | 1687 |
| LLPS-Asm-0851 | Astyanax mexicanus | 79.86 | 0.0 | 1680 |
| LLPS-Gaa-2208 | Gasterosteus aculeatus | 79.77 | 0.0 | 1622 |
| LLPS-Mea-2569 | Mesocricetus auratus | 79.11 | 0.0 | 1365 |
| LLPS-Xim-2776 | Xiphophorus maculatus | 78.64 | 0.0 | 1667 |
| LLPS-Tut-0767 | Tursiops truncatus | 40.15 | 0.0 | 620 |
| LLPS-Sah-0574 | Sarcophilus harrisii | 39.57 | 0.0 | 646 |