LLPS-Hos-0962
SIK2
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Serine/threonine-protein kinase SIK2; Qin-induced kinase; Salt-inducible kinase 2; SIK-2; Serine/threonine-protein kinase SNF1-like kinase 2 |
| Gene Name: | SIK2, KIAA0781, QIK, SNF1LK2 |
| Ensembl Gene: | ENSG00000170145.4 |
| Ensembl Protein: | ENSP00000305976.3 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Centrosome/Spindle pole body | "...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle." | N/A | 20708153 |
▼ FUNCTION
| Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000304987.3 | ENSP00000305976.3 |
| UniProt | Q9H0K1, SIK2_HUMAN, A8K5B8, B0YJ94, O94878, Q17RV0, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8 | |
| GeneBank | BC113459, AL136764, AB084424, EF445030, AB018324, BC117183, BC013612, CH471065, BC078150, AK291233 | ACA06072.1, BAB91442.1, AAH13612.1, CAB66698.1, EAW67148.1, BAA34501.3, BAF83922.1, AAI13460.1, AAH78150.1, AAI17184.1 |
| RefSeq | NM_015191.2 | NP_056006.1 |
| Entrez | 23235 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60 61 LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK NGEIFDYLAN HGRLNESEAR 120 121 RKFWQILSAV DYCHGRKIVH RDLKAENLLL DNNMNIKIAD FGFGNFFKSG ELLATWCGSP 180 181 PYAAPEVFEG QQYEGPQLDI WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM 240 241 SEDCEHLIRR MLVLDPSKRL TIAQIKEHKW MLIEVPVQRP VLYPQEQENE PSIGEFNEQV 300 301 LRLMHSLGID QQKTIESLQN KSYNHFAAIY FLLVERLKSH RSSFPVEQRL DGRQRRPSTI 360 361 AEQTVAKAQT VGLPVTMHSP NMRLLRSALL PQASNVEAFS FPASGCQAEA AFMEEECVDT 420 421 PKVNGCLLDP VPPVLVRKGC QSLPSNMMET SIDEGLETEG EAEEDPAHAF EAFQSTRSGQ 480 481 RRHTLSEVTN QLVVMPGAGK IFSMNDSPSL DSVDSEYDMG SVQRDLNFLE DNPSLKDIML 540 541 ANQPSPRMTS PFISLRPTNP AMQALSSQKR EVHNRSPVSF REGRRASDTS LTQGIVAFRQ 600 601 HLQNLARTKG ILELNKVQLL YEQIGPEADP NLAPAAPQLQ DLASSCPQEE VSQQQESVST 660 661 LPASVHPQLS PRQSLETQYL QHRLQKPSLL SKAQNTCQLY CKEPPRSLEQ QLQEHRLQQK 720 721 RLFLQKQSQL QAYFNQMQIA ESSYPQPSQQ LPLPRQETPP PSQQAPPFSL TQPLSPVLEP 780 781 SSEQMQYSPF LSQYQEMQLQ PLPSTSGPRA APPLPTQLQQ QQPPPPPPPP PPRQPGAAPA 840 841 PLQFSYQTCE LPSAASPAPD YPTPCQYPVD GAQQSDLTGP DCPRSPGLQE APSSYDPLAL 900 901 SELPGLFDCE MLDAVDPQHN GYVLVN 926 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTCATGG CGGATGGCCC GAGGCACTTG CAGCGCGGGC CGGTCCGGGT GGGGTTCTAC 60 61 GACATCGAGG GCACGCTGGG CAAGGGCAAC TTCGCTGTGG TGAAGCTGGG GCGGCACCGG 120 121 ATCACCAAGA CGGAGGTGGC AATAAAAATA ATCGATAAGT CTCAGCTGGA TGCAGTGAAC 180 181 CTTGAGAAAA TCTACCGAGA AGTACAAATA ATGAAAATGT TAGACCACCC TCACATAATC 240 241 AAACTTTATC AGGTAATGGA GACCAAAAGT ATGTTGTACC TTGTGACAGA ATATGCCAAA 300 301 AATGGAGAAA TTTTTGACTA TCTTGCTAAT CATGGCCGGT TAAATGAGTC TGAAGCCAGG 360 361 CGAAAATTCT GGCAAATCCT GTCTGCTGTT GATTATTGTC ATGGTCGGAA GATTGTGCAC 420 421 CGTGACCTCA AAGCTGAAAA TCTCCTGCTG GATAACAACA TGAATATCAA AATAGCAGAT 480 481 TTCGGTTTTG GAAATTTCTT TAAAAGTGGT GAACTGCTGG CAACATGGTG TGGCAGCCCC 540 541 CCTTATGCAG CCCCAGAAGT CTTTGAAGGG CAGCAGTATG AAGGACCACA GCTGGACATC 600 601 TGGAGTATGG GAGTTGTTCT TTATGTCCTT GTCTGTGGAG CTCTGCCCTT TGATGGACCG 660 661 ACTCTTCCAA TTTTGAGGCA GAGGGTTCTG GAAGGAAGAT TCCGGATTCC GTATTTCATG 720 721 TCAGAAGATT GCGAGCACCT TATCCGAAGG ATGTTGGTCC TAGACCCATC CAAACGGCTA 780 781 ACCATAGCCC AAATCAAGGA GCATAAATGG ATGCTCATAG AAGTTCCTGT CCAGAGACCT 840 841 GTTCTCTATC CACAAGAGCA AGAAAATGAG CCATCCATCG GGGAGTTTAA TGAGCAGGTT 900 901 CTGCGACTGA TGCACAGCCT TGGAATAGAT CAGCAGAAAA CCATTGAGTC TTTGCAGAAC 960 961 AAGAGCTATA ACCACTTTGC TGCCATTTAT TTCTTGTTGG TGGAGCGCCT GAAATCACAT 1020 1021 CGGAGCAGTT TCCCAGTGGA GCAGAGACTT GATGGCCGCC AGCGTCGGCC TAGCACCATT 1080 1081 GCTGAGCAAA CAGTTGCCAA GGCACAGACT GTGGGGCTCC CAGTGACCAT GCATTCACCG 1140 1141 AACATGAGGC TGCTGCGATC TGCCCTCCTC CCCCAGGCAT CCAACGTGGA GGCCTTTTCA 1200 1201 TTTCCAGCAT CTGGCTGTCA GGCGGAAGCT GCATTCATGG AAGAAGAGTG TGTGGACACT 1260 1261 CCAAAGGTCA ATGGCTGTCT GCTTGACCCT GTGCCTCCTG TCCTGGTGCG GAAGGGATGC 1320 1321 CAGTCACTGC CCAGCAACAT GATGGAGACC TCCATTGACG AAGGGCTGGA GACAGAAGGA 1380 1381 GAGGCCGAGG AAGACCCCGC TCATGCCTTT GAGGCATTTC AGTCCACACG CAGCGGGCAG 1440 1441 AGACGGCACA CTCTGTCAGA AGTGACCAAT CAACTGGTCG TGATGCCTGG GGCAGGGAAA 1500 1501 ATTTTCTCCA TGAATGACAG CCCCTCCCTT GACAGTGTGG ACTCTGAGTA TGATATGGGG 1560 1561 TCTGTTCAGA GGGACCTGAA CTTTCTGGAA GACAACCCTT CCCTTAAGGA CATCATGTTA 1620 1621 GCCAATCAGC CTTCACCCCG CATGACATCT CCCTTCATAA GCCTGAGACC TACCAACCCA 1680 1681 GCCATGCAGG CTCTGAGCTC CCAGAAACGA GAGGTCCACA ACAGGTCTCC AGTGAGCTTC 1740 1741 AGAGAGGGCC GCAGAGCATC AGATACCTCC CTCACCCAGG GAATTGTAGC ATTTAGACAA 1800 1801 CATCTTCAGA ATCTGGCTAG AACCAAAGGA ATTCTAGAGT TGAACAAAGT GCAGTTGTTG 1860 1861 TATGAACAAA TAGGACCGGA GGCAGACCCT AACCTGGCGC CGGCGGCTCC TCAGCTCCAG 1920 1921 GACCTTGCTA GCAGCTGCCC TCAGGAAGAA GTTTCTCAGC AGCAGGAAAG CGTCTCCACT 1980 1981 CTCCCTGCCA GCGTGCATCC CCAGCTGTCC CCACGGCAGA GCCTGGAGAC CCAGTACCTG 2040 2041 CAGCACAGAC TCCAGAAGCC CAGCCTTCTG TCAAAGGCCC AGAACACCTG TCAGCTTTAT 2100 2101 TGCAAAGAAC CACCGCGGAG CCTTGAGCAG CAGCTGCAGG AACATAGGCT CCAGCAGAAG 2160 2161 CGACTCTTTC TTCAGAAGCA GTCTCAACTG CAGGCCTATT TTAATCAGAT GCAGATAGCA 2220 2221 GAGAGCTCCT ACCCACAGCC AAGTCAGCAG CTGCCCCTTC CCCGCCAGGA GACTCCACCG 2280 2281 CCTTCTCAGC AGGCCCCACC GTTCAGCCTG ACCCAGCCCC TGAGCCCCGT CCTGGAGCCT 2340 2341 TCCTCCGAGC AGATGCAATA CAGCCCTTTC CTCAGCCAGT ACCAAGAGAT GCAGCTTCAG 2400 2401 CCCCTGCCCT CCACTTCCGG TCCCCGGGCT GCTCCTCCTC TGCCCACGCA GCTACAGCAG 2460 2461 CAGCAGCCGC CACCGCCACC ACCCCCTCCA CCACCACGAC AGCCAGGAGC TGCCCCAGCC 2520 2521 CCCTTACAGT TCTCCTATCA GACTTGTGAG CTGCCAAGCG CTGCTTCCCC TGCGCCAGAC 2580 2581 TATCCCACTC CCTGTCAGTA TCCTGTGGAT GGAGCCCAGC AGAGCGACCT AACGGGGCCA 2640 2641 GACTGTCCCA GAAGCCCAGG ACTGCAAGAG GCCCCCTCCA GCTACGACCC ACTAGCCCTC 2700 2701 TCTGAGCTAC CTGGACTCTT TGATTGTGAA ATGCTAGACG CTGTGGATCC ACAACACAAC 2760 2761 GGGTATGTCC TGGTGAATTA G 2781 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleotide-activated protein kinase complex | |
Cellular Component | Nucleus | |
Molecular Function | ATP binding | |
Molecular Function | Magnesium ion binding | |
Molecular Function | Protein serine/threonine kinase activity | |
Biological Process | Cellular response to glucose starvation | |
Biological Process | Intracellular signal transduction | |
Biological Process | Negative regulation of TOR signaling | |
Biological Process | Protein autophosphorylation | |
Biological Process | Protein phosphorylation | |
Biological Process | Regulation of insulin receptor signaling pathway |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-1915 | Gorilla gorilla | 100.0 | 0.0 | 1640 |
| LLPS-Pat-4701 | Pan troglodytes | 99.89 | 0.0 | 1637 |
| LLPS-Pap-3762 | Pan paniscus | 99.89 | 0.0 | 1639 |
| LLPS-Nol-3700 | Nomascus leucogenys | 99.68 | 0.0 | 1636 |
| LLPS-Poa-4504 | Pongo abelii | 99.03 | 0.0 | 1628 |
| LLPS-Man-1674 | Macaca nemestrina | 98.81 | 0.0 | 1625 |
| LLPS-Rhb-2309 | Rhinopithecus bieti | 98.81 | 0.0 | 1624 |
| LLPS-Paa-4619 | Papio anubis | 98.81 | 0.0 | 1625 |
| LLPS-Mal-1727 | Mandrillus leucophaeus | 98.81 | 0.0 | 1625 |
| LLPS-Maf-4624 | Macaca fascicularis | 98.7 | 0.0 | 1623 |
| LLPS-Cea-2786 | Cercocebus atys | 98.6 | 0.0 | 1620 |
| LLPS-Chs-2248 | Chlorocebus sabaeus | 98.59 | 0.0 | 1618 |
| LLPS-Aon-3134 | Aotus nancymaae | 98.38 | 0.0 | 1612 |
| LLPS-Caj-3289 | Callithrix jacchus | 97.52 | 0.0 | 1603 |
| LLPS-Mam-0890 | Macaca mulatta | 96.92 | 0.0 | 1615 |
| LLPS-Fud-1560 | Fukomys damarensis | 93.81 | 0.0 | 1561 |
| LLPS-Ict-2590 | Ictidomys tridecemlineatus | 93.28 | 0.0 | 1560 |
| LLPS-Eqc-2442 | Equus caballus | 93.2 | 0.0 | 1520 |
| LLPS-Otg-4637 | Otolemur garnettii | 92.46 | 0.0 | 1350 |
| LLPS-Orc-4161 | Oryctolagus cuniculus | 92.4 | 0.0 | 1505 |
| LLPS-Mum-3369 | Mus musculus | 90.8 | 0.0 | 1513 |
| LLPS-Mup-2531 | Mustela putorius furo | 90.72 | 0.0 | 1488 |
| LLPS-Aim-4126 | Ailuropoda melanoleuca | 90.71 | 0.0 | 1131 |
| LLPS-Ova-4140 | Ovis aries | 90.01 | 0.0 | 1095 |
| LLPS-Fec-0039 | Felis catus | 89.75 | 0.0 | 1501 |
| LLPS-Cap-4636 | Cavia porcellus | 89.74 | 0.0 | 1384 |
| LLPS-Ran-2726 | Rattus norvegicus | 89.05 | 0.0 | 1457 |
| LLPS-Caf-3791 | Canis familiaris | 88.69 | 0.0 | 1471 |
| LLPS-Tut-1818 | Tursiops truncatus | 88.14 | 0.0 | 1458 |
| LLPS-Myl-3176 | Myotis lucifugus | 87.85 | 0.0 | 1481 |
| LLPS-Loa-2477 | Loxodonta africana | 87.74 | 0.0 | 1385 |
| LLPS-Mea-3661 | Mesocricetus auratus | 87.26 | 0.0 | 1403 |
| LLPS-Sus-0653 | Sus scrofa | 87.15 | 0.0 | 1435 |
| LLPS-Dio-2572 | Dipodomys ordii | 86.54 | 0.0 | 1451 |
| LLPS-Bot-0911 | Bos taurus | 85.35 | 0.0 | 1465 |
| LLPS-Mod-4089 | Monodelphis domestica | 82.84 | 0.0 | 1441 |
| LLPS-Sah-0887 | Sarcophilus harrisii | 82.84 | 0.0 | 1438 |
| LLPS-Lac-3533 | Latimeria chalumnae | 81.78 | 0.0 | 1098 |
| LLPS-Anp-0743 | Anas platyrhynchos | 76.8 | 0.0 | 1221 |
| LLPS-Pes-3465 | Pelodiscus sinensis | 75.95 | 0.0 | 1194 |
| LLPS-Gaga-3513 | Gallus gallus | 74.75 | 0.0 | 1229 |
| LLPS-Tag-1818 | Taeniopygia guttata | 73.84 | 0.0 | 1135 |
| LLPS-Fia-3244 | Ficedula albicollis | 72.9 | 0.0 | 1093 |
| LLPS-Meg-3201 | Meleagris gallopavo | 72.21 | 0.0 | 929 |
| LLPS-Xet-3588 | Xenopus tropicalis | 71.01 | 0.0 | 1205 |
| LLPS-Drm-0586 | Drosophila melanogaster | 69.7 | 3e-150 | 486 |
| LLPS-Asm-0084 | Astyanax mexicanus | 68.1 | 0.0 | 975 |
| LLPS-Tar-0035 | Takifugu rubripes | 67.93 | 0.0 | 978 |
| LLPS-Anc-2841 | Anolis carolinensis | 66.45 | 0.0 | 1022 |
| LLPS-Gaa-2733 | Gasterosteus aculeatus | 66.07 | 0.0 | 972 |
| LLPS-Dar-0584 | Danio rerio | 63.8 | 0.0 | 1066 |
| LLPS-Cii-0952 | Ciona intestinalis | 63.1 | 1e-157 | 495 |
| LLPS-Scm-1732 | Scophthalmus maximus | 62.55 | 0.0 | 1004 |
| LLPS-Scf-2139 | Scleropages formosus | 61.87 | 0.0 | 937 |
| LLPS-Pof-2417 | Poecilia formosa | 61.84 | 0.0 | 989 |
| LLPS-Xim-2800 | Xiphophorus maculatus | 61.84 | 0.0 | 993 |
| LLPS-Leo-2397 | Lepisosteus oculatus | 61.43 | 0.0 | 955 |
| LLPS-Orn-3320 | Oreochromis niloticus | 60.95 | 0.0 | 997 |
| LLPS-Orl-2458 | Oryzias latipes | 60.56 | 0.0 | 1002 |
| LLPS-Cis-1457 | Ciona savignyi | 58.99 | 3e-108 | 350 |
| LLPS-Icp-1528 | Ictalurus punctatus | 55.21 | 1e-113 | 374 |
| LLPS-Cas-4009 | Carlito syrichta | 55.0 | 1e-113 | 369 |
| LLPS-Ora-1247 | Ornithorhynchus anatinus | 54.89 | 1e-114 | 375 |
| LLPS-Urm-2924 | Ursus maritimus | 54.86 | 2e-114 | 375 |
| LLPS-Ten-3415 | Tetraodon nigroviridis | 53.89 | 3e-111 | 366 |
| LLPS-Cae-0220 | Caenorhabditis elegans | 53.85 | 7e-112 | 379 |
| LLPS-Ere-0560 | Erinaceus europaeus | 46.21 | 2e-117 | 374 |
| LLPS-Sob-2229 | Sorghum bicolor | 45.65 | 1e-90 | 303 |
| LLPS-Sei-0362 | Setaria italica | 45.65 | 3e-90 | 303 |
| LLPS-Zem-1597 | Zea mays | 45.54 | 1e-90 | 310 |
| LLPS-Art-2601 | Arabidopsis thaliana | 45.11 | 2e-90 | 303 |
| LLPS-Bro-1072 | Brassica oleracea | 45.11 | 7e-89 | 299 |
| LLPS-Arl-1065 | Arabidopsis lyrata | 44.79 | 5e-89 | 300 |
| LLPS-Ors-2364 | Oryza sativa | 44.62 | 2e-89 | 300 |
| LLPS-Orbr-0158 | Oryza brachyantha | 44.62 | 4e-89 | 299 |
| LLPS-Orr-1376 | Oryza rufipogon | 44.62 | 2e-89 | 300 |
| LLPS-Orb-2279 | Oryza barthii | 44.62 | 3e-89 | 301 |
| LLPS-Orni-0188 | Oryza nivara | 44.62 | 1e-88 | 302 |
| LLPS-Orgl-0300 | Oryza glumaepatula | 44.62 | 7e-89 | 302 |
| LLPS-Lep-2156 | Leersia perrieri | 44.62 | 1e-88 | 298 |
| LLPS-Brd-1892 | Brachypodium distachyon | 44.62 | 5e-89 | 299 |
| LLPS-Orm-0713 | Oryza meridionalis | 44.31 | 6e-89 | 299 |
| LLPS-Gas-1092 | Galdieria sulphuraria | 44.31 | 2e-89 | 300 |
| LLPS-Pot-2455 | Populus trichocarpa | 44.05 | 2e-88 | 298 |
| LLPS-Brn-1105 | Brassica napus | 40.63 | 3e-88 | 297 |