LLPS-Hos-0915
RPL7

▼ OVERVIEW

Status: Reviewed
Protein Name: 60S ribosomal protein L7; Large ribosomal subunit protein uL30
Gene Name: RPL7
Ensembl Gene: ENSG00000147604.13
Ensembl Protein: ENSP00000339795.2
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...SILAC-based approaches identified 351 proteins with 24 proteins showing at least a 2-fold change after infection."
HeLa cells19812395
Nucleolus
"...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli."
HeLa cells15635413
Nucleolus
"...As a first step in elucidating these mechanisms we have carried out a proteomic analysis to draw up a list of proteins present within nucleoli of HeLa cells. This analysis allowed the identification of 213 different nucleolar proteins."
HeLa cells12429849

▼ FUNCTION

Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEGVEEKKKE  VPAVPETLKK  KRRNFAELKI  KRLRKKFAQK  MLRKARRKLI  YEKAKHYHKE  60
61    YRQMYRTEIR  MARMARKAGN  FYVPAEPKLA  FVIRIRGING  VSPKVRKVLQ  LLRLRQIFNG  120
121   TFVKLNKASI  NMLRIVEPYI  AWGYPNLKSV  NELIYKRGYG  KINKKRIALT  DNALIARSLG  180
181   KYGIICMEDL  IHEIYTVGKR  FKEANNFLWP  FKLSSPRGGM  KKKTTHFVEG  GDAGNREDQI  240
241   NRLIRRMN  248
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGGTG  TAGAAGAGAA  GAAGAAGGAG  GTTCCTGCTG  TGCCAGAAAC  CCTTAAGAAA  60
61    AAGCGAAGGA  ATTTCGCAGA  GCTGAAGATC  AAGCGCCTGA  GAAAGAAGTT  TGCCCAAAAG  120
121   ATGCTTCGAA  AGGCAAGGAG  GAAGCTTATC  TATGAAAAAG  CAAAGCACTA  TCACAAGGAA  180
181   TATAGGCAGA  TGTACAGAAC  TGAAATTCGA  ATGGCGAGGA  TGGCAAGAAA  AGCTGGCAAC  240
241   TTCTATGTAC  CTGCAGAACC  CAAATTGGCG  TTTGTCATCA  GAATCAGAGG  TATCAATGGA  300
301   GTGAGCCCAA  AGGTTCGAAA  GGTGTTGCAG  CTTCTTCGCC  TTCGTCAAAT  CTTCAATGGA  360
361   ACCTTTGTGA  AGCTCAACAA  GGCTTCGATT  AACATGCTGA  GGATTGTAGA  GCCATATATT  420
421   GCATGGGGGT  ACCCCAATCT  GAAGTCAGTA  AATGAACTAA  TCTACAAGCG  TGGTTATGGC  480
481   AAAATCAATA  AGAAGCGAAT  TGCTTTGACA  GATAACGCTT  TGATTGCTCG  ATCTCTTGGT  540
541   AAATACGGCA  TCATCTGCAT  GGAGGATTTG  ATTCATGAGA  TCTATACTGT  TGGAAAACGC  600
601   TTCAAAGAGG  CAAATAACTT  CCTGTGGCCC  TTCAAATTGT  CTTCTCCACG  AGGTGGAATG  660
661   AAGAAAAAGA  CCACCCATTT  TGTAGAAGGT  GGAGATGCTG  GCAACAGGGA  GGACCAGATC  720
721   AACAGGCTTA  TTAGAAGAAT  GAACTAA  747

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Phosphoprotein
Reference proteome
Repeat
Ribonucleoprotein
Ribosomal protein
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Cytosolic large ribosomal subunit
Cellular Component
Focal adhesion
Cellular Component
Membrane
Cellular Component
Nucleolus
Cellular Component
Nucleus
Cellular Component
Postsynaptic density
Cellular Component
Ribonucleoprotein complex
Molecular Function
DNA binding
Molecular Function
MRNA binding
Molecular Function
Protein homodimerization activity
Molecular Function
RNA binding
Molecular Function
Structural constituent of ribosome
Biological Process
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process
Ribosomal large subunit biogenesis
Biological Process
RRNA processing
Biological Process
SRP-dependent cotranslational protein targeting to membrane
Biological Process
Translation
Biological Process
Translational initiation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-1593Dipodomys ordii100.03e-138 394
LLPS-Paa-3207Papio anubis100.06e-156 441
LLPS-Maf-4618Macaca fascicularis100.01e-155 441
LLPS-Gog-1829Gorilla gorilla100.07e-156 441
LLPS-Poa-1386Pongo abelii100.06e-156 441
LLPS-Ict-2589Ictidomys tridecemlineatus100.03e-138 394
LLPS-Man-1823Macaca nemestrina100.06e-156 441
LLPS-Pap-0258Pan paniscus100.07e-156 441
LLPS-Pat-4139Pan troglodytes100.07e-156 441
LLPS-Bot-0003Bos taurus99.572e-155 439
LLPS-Ova-2969Ovis aries99.572e-155 440
LLPS-Caj-1487Callithrix jacchus99.575e-155 438
LLPS-Nol-3556Nomascus leucogenys99.571e-155 440
LLPS-Loa-0089Loxodonta africana99.577e-155 439
LLPS-Rhb-2396Rhinopithecus bieti99.571e-155 440
LLPS-Sus-1883Sus scrofa99.146e-155 438
LLPS-Caf-0299Canis familiaris99.143e-155 439
LLPS-Cas-1388Carlito syrichta99.145e-155 439
LLPS-Fec-0374Felis catus99.142e-154 437
LLPS-Urm-0623Ursus maritimus99.143e-155 439
LLPS-Mup-4418Mustela putorius furo99.042e-138 395
LLPS-Tut-0823Tursiops truncatus98.713e-154 437
LLPS-Aim-1852Ailuropoda melanoleuca98.711e-153 435
LLPS-Mal-3633Mandrillus leucophaeus98.712e-153 434
LLPS-Aon-0701Aotus nancymaae98.712e-153 434
LLPS-Mam-0537Macaca mulatta98.715e-154 436
LLPS-Eqc-0532Equus caballus98.717e-154 436
LLPS-Orc-2762Oryctolagus cuniculus98.712e-153 434
LLPS-Cap-2605Cavia porcellus98.535e-135 386
LLPS-Fud-0727Fukomys damarensis98.281e-153 435
LLPS-Otg-0359Otolemur garnettii98.283e-153 434
LLPS-Ere-0674Erinaceus europaeus97.416e-152 431
LLPS-Cea-1985Cercocebus atys97.417e-148 420
LLPS-Ran-1101Rattus norvegicus96.982e-152 432
LLPS-Chs-3125Chlorocebus sabaeus90.528e-141 402
LLPS-Mod-2737Monodelphis domestica90.522e-138 397
LLPS-Sah-1283Sarcophilus harrisii90.091e-137 394
LLPS-Ora-1196Ornithorhynchus anatinus89.741e-71 221
LLPS-Anp-2000Anas platyrhynchos88.894e-127 367
LLPS-Pes-2293Pelodiscus sinensis87.83e-91 274
LLPS-Anc-0253Anolis carolinensis87.074e-133 384
LLPS-Gaga-0811Gallus gallus85.342e-130 376
LLPS-Meg-1062Meleagris gallopavo85.342e-130 376
LLPS-Tag-1160Taeniopygia guttata84.916e-128 370
LLPS-Fia-1632Ficedula albicollis84.482e-127 369
LLPS-Xim-1212Xiphophorus maculatus83.196e-126 365
LLPS-Leo-1764Lepisosteus oculatus83.194e-128 370
LLPS-Orn-2051Oreochromis niloticus82.761e-127 369
LLPS-Scf-1146Scleropages formosus81.94e-127 368
LLPS-Pof-3958Poecilia formosa81.92e-124 360
LLPS-Orl-1349Oryzias latipes81.039e-125 361
LLPS-Icp-1075Ictalurus punctatus81.032e-121 353
LLPS-Mea-1979Mesocricetus auratus80.172e-116 340
LLPS-Dar-3488Danio rerio80.175e-120 349
LLPS-Tar-3216Takifugu rubripes79.742e-118 345
LLPS-Asm-1028Astyanax mexicanus79.742e-121 353
LLPS-Ten-2234Tetraodon nigroviridis79.741e-124 361
LLPS-Xet-2468Xenopus tropicalis79.743e-123 358
LLPS-Gaa-1934Gasterosteus aculeatus79.311e-123 358
LLPS-Scm-0740Scophthalmus maximus78.881e-121 353
LLPS-Myl-2813Myotis lucifugus76.299e-103 305
LLPS-Lac-3008Latimeria chalumnae72.227e-98 293
LLPS-Cii-1722Ciona intestinalis71.03e-90 274
LLPS-Aso-1441Aspergillus oryzae68.55e-88 268
LLPS-Asf-0870Aspergillus flavus68.55e-88 268
LLPS-Orbr-0582Oryza brachyantha68.327e-87 265
LLPS-Lep-1004Leersia perrieri67.822e-85 261
LLPS-Orgl-1518Oryza glumaepatula67.821e-85 262
LLPS-Ori-0642Oryza indica67.825e-86 263
LLPS-Orb-0906Oryza barthii67.821e-85 262
LLPS-Orni-0758Oryza nivara67.821e-85 262
LLPS-Prp-2547Prunus persica67.826e-89 270
LLPS-Orr-2316Oryza rufipogon67.825e-86 263
LLPS-Orm-0022Oryza meridionalis67.821e-85 262
LLPS-Org-1546Oryza glaberrima67.825e-86 263
LLPS-Orp-0900Oryza punctata67.821e-85 263
LLPS-Ors-1834Oryza sativa67.825e-86 263
LLPS-Amt-1815Amborella trichopoda67.825e-86 263
LLPS-Pytr-1091Pyrenophora triticirepentis67.763e-62 199
LLPS-Sei-2170Setaria italica67.338e-85 260
LLPS-Arl-0520Arabidopsis lyrata66.831e-87 267
LLPS-Brd-1027Brachypodium distachyon66.832e-85 261
LLPS-Art-1659Arabidopsis thaliana66.832e-87 266
LLPS-Tra-1145Triticum aestivum66.673e-85 261
LLPS-Tru-1740Triticum urartu66.673e-85 261
LLPS-Tum-0168Tuber melanosporum66.53e-85 261
LLPS-Hov-0671Hordeum vulgare66.346e-86 263
LLPS-Brn-3167Brassica napus66.342e-86 265
LLPS-Zem-0413Zea mays66.344e-84 258
LLPS-Bro-1828Brassica oleracea66.342e-85 261
LLPS-Brr-2400Brassica rapa66.342e-85 261
LLPS-Sem-1628Selaginella moellendorffii65.959e-94 283
LLPS-Php-1349Physcomitrella patens65.845e-85 260
LLPS-Dac-0415Daucus carota65.528e-85 259
LLPS-Scj-1030Schizosaccharomyces japonicus65.353e-82 253
LLPS-Drm-1477Drosophila melanogaster65.313e-78 243
LLPS-Osl-1342Ostreococcus lucimarinus64.857e-82 252
LLPS-Mae-0424Manihot esculenta64.532e-91 277
LLPS-Cis-1226Ciona savignyi64.229e-92 278
LLPS-Vir-0807Vigna radiata64.197e-90 273
LLPS-Via-1890Vigna angularis63.798e-90 272
LLPS-Glm-1864Glycine max63.792e-91 278
LLPS-Phv-0817Phaseolus vulgaris63.797e-90 273
LLPS-Pyt-0408Pyrenophora teres63.114e-86 263
LLPS-Cus-0199Cucumis sativus62.935e-90 273
LLPS-Met-0577Medicago truncatula62.933e-89 271
LLPS-Mua-0855Musa acuminata62.938e-90 274
LLPS-Pot-2460Populus trichocarpa62.931e-86 266
LLPS-Gor-0863Gossypium raimondii62.773e-90 274
LLPS-Coc-1477Corchorus capsularis62.344e-87 265
LLPS-Asfu-0185Aspergillus fumigatus62.235e-91 278
LLPS-Ast-1150Aspergillus terreus62.239e-87 265
LLPS-Sot-0739Solanum tuberosum62.073e-89 271
LLPS-Sol-0244Solanum lycopersicum62.072e-84 274
LLPS-Hea-1371Helianthus annuus62.071e-88 270
LLPS-Viv-1097Vitis vinifera62.072e-88 269
LLPS-Thc-1275Theobroma cacao61.91e-88 269
LLPS-Nia-1811Nicotiana attenuata61.646e-89 272
LLPS-Asni-0401Aspergillus niger61.373e-85 262
LLPS-Nef-0451Neosartorya fischeri61.372e-89 273
LLPS-Abg-1794Absidia glauca61.279e-78 242
LLPS-Chr-0254Chlamydomonas reinhardtii60.982e-79 246
LLPS-Asn-0070Aspergillus nidulans60.942e-87 266
LLPS-Asc-0120Aspergillus clavatus60.522e-87 266
LLPS-Scp-1303Schizosaccharomyces pombe60.08e-79 244
LLPS-Nec-1266Neurospora crassa59.664e-85 261
LLPS-Scs-0527Sclerotinia sclerotiorum59.669e-88 267
LLPS-Cogr-1075Colletotrichum graminicola59.664e-86 263
LLPS-Beb-0315Beauveria bassiana59.661e-84 259
LLPS-Zyt-0277Zymoseptoria tritici59.48e-86 263
LLPS-Gag-0832Gaeumannomyces graminis59.231e-85 262
LLPS-Mao-1468Magnaporthe oryzae59.233e-88 269
LLPS-Yal-0737Yarrowia lipolytica58.979e-84 257
LLPS-Chc-0497Chondrus crispus58.821e-79 247
LLPS-Lem-0003Leptosphaeria maculans58.742e-77 241
LLPS-Coo-1150Colletotrichum orbiculare58.371e-83 258
LLPS-Trv-0749Trichoderma virens58.374e-81 251
LLPS-Phn-1518Phaeosphaeria nodorum58.372e-84 259
LLPS-Fus-1570Fusarium solani58.371e-84 260
LLPS-Trr-1228Trichoderma reesei58.371e-81 252
LLPS-Gas-0723Galdieria sulphuraria58.231e-78 244
LLPS-Map-1120Magnaporthe poae57.943e-85 261
LLPS-Ved-0957Verticillium dahliae57.942e-85 261
LLPS-Blg-0251Blumeria graminis57.513e-86 263
LLPS-Fuv-1302Fusarium verticillioides57.511e-81 251
LLPS-Fuo-0510Fusarium oxysporum57.511e-81 251
LLPS-Asg-0786Ashbya gossypii57.07e-73 229
LLPS-Cog-0274Colletotrichum gloeosporioides56.221e-81 252
LLPS-Scc-0196Schizosaccharomyces cryophilus56.034e-83 256
LLPS-Cae-1472Caenorhabditis elegans55.844e-83 255
LLPS-Sob-0034Sorghum bicolor55.452e-69 221
LLPS-Usm-0250Ustilago maydis55.129e-72 226
LLPS-Sac-1020Saccharomyces cerevisiae55.073e-71 225
LLPS-Mel-0321Melampsora laricipopulina55.058e-74 232
LLPS-Pug-0867Puccinia graminis54.513e-76 238
LLPS-Put-0235Puccinia triticina54.082e-74 233
LLPS-Kop-0311Komagataella pastoris53.112e-68 218
LLPS-Crn-1476Cryptococcus neoformans51.292e-68 218
LLPS-Miv-0089Microbotryum violaceum50.02e-60 197