LLPS-Hos-0755
RPL4
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | 60S ribosomal protein L4; 60S ribosomal protein L1; Large ribosomal subunit protein uL4 |
| Gene Name: | RPL4, RPL1 |
| Ensembl Gene: | ENSG00000174444.14 |
| Ensembl Protein: | ENSP00000311430.6 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...SILAC-based approaches identified 351 proteins with 24 proteins showing at least a 2-fold change after infection." | HeLa cells | 19812395 |
| Nucleolus | "...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli." | HeLa cells | 15635413 |
| Nucleolus | "...As a first step in elucidating these mechanisms we have carried out a proteomic analysis to draw up a list of proteins present within nucleoli of HeLa cells. This analysis allowed the identification of 213 different nucleolar proteins." | HeLa cells | 12429849 |
| Postsynaptic density | "...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461." | Human cortex | 23071613 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000307961.10 | ENSP00000311430.6 |
| Ensembl | ENST00000569438.2 | ENSP00000457268.1 |
| Ensembl | ENST00000569696.5 | ENSP00000457442.1 |
| Ensembl | ENST00000568588.5 | ENSP00000454281.1 |
| UniProt | P36578, RL4_HUMAN, A8K502, P39029, Q4VBR0, Q969Z9 | |
| GeneBank | BC066925, AK291859, CH471082, AB061820, BC010151, AK291117, BC007748, BC009888, BC014653, D23660, BC007996, L20868, BC005817, BC001365, BC095427 | AAH66925.1, BAF84548.1, AAH10151.1, AAH01365.1, AAH07996.1, EAW77776.1, AAH07748.1, BAF83806.1, AAH14653.1, AAH95427.1, AAH05817.1, BAB79458.1, BAA04887.1, AAA60281.2, AAH09888.1 |
| RefSeq | NM_000968.3 | NP_000959.2 |
| Entrez | 6124 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH 60 61 QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR MFAPTKTWRR WHRRVNTTQK 120 121 RYAICSALAA SALPALVMSK GHRIEEVPEL PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI 180 181 KKVYASQRMR AGKGKMRNRR RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL 240 241 APGGHVGRFC IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMINTDLS RILKSPEIQR 300 301 ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKLR VDKAAAAAAA 360 361 LQAKSDEKAA VAGKKPVVGK KGKKAAVGVK KQKKPLVGKK AAATKKPAPE KKPAEKKPTT 420 421 EEKKPAA 427 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGTGTG CTCGCCCACT GATATCGGTG TACTCCGAAA AGGGGGAGTC ATCTGGCAAA 60 61 AATGTCACTT TGCCTGCTGT ATTCAAGGCT CCTATTCGAC CAGATATTGT GAACTTTGTT 120 121 CACACCAACT TGCGCAAAAA CAACAGACAG CCCTATGCTG TCAGTGAATT AGCAGGTCAT 180 181 CAGACTAGTG CTGAGTCTTG GGGTACTGGC AGAGCTGTGG CTCGAATTCC CAGAGTTCGA 240 241 GGTGGTGGGA CTCACCGCTC TGGCCAGGGT GCTTTTGGAA ACATGTGTCG TGGAGGCCGA 300 301 ATGTTTGCAC CAACCAAAAC CTGGCGCCGT TGGCATCGTA GAGTGAACAC AACCCAAAAA 360 361 CGATACGCCA TCTGTTCTGC CCTGGCTGCC TCAGCCCTAC CAGCACTGGT CATGTCTAAA 420 421 GGTCATCGTA TTGAGGAAGT TCCTGAACTT CCTTTGGTAG TTGAAGATAA AGTTGAAGGC 480 481 TACAAGAAGA CCAAGGAAGC TGTTTTGCTC CTTAAGAAAC TTAAAGCCTG GAATGATATC 540 541 AAAAAGGTCT ATGCCTCTCA GCGAATGAGA GCTGGCAAAG GCAAAATGAG AAACCGTCGC 600 601 CGTATCCAGC GCAGGGGCCC GTGCATCATC TATAATGAGG ATAATGGTAT CATCAAGGCC 660 661 TTCAGAAACA TCCCTGGAAT TACTCTGCTT AATGTAAGCA AGCTGAACAT TTTGAAGCTT 720 721 GCTCCTGGTG GGCATGTGGG ACGTTTCTGC ATTTGGACTG AAAGTGCTTT CCGGAAGTTA 780 781 GATGAATTGT ACGGCACTTG GCGTAAAGCC GCTTCCCTCA AGAGTAACTA CAATCTTCCC 840 841 ATGCACAAGA TGATTAATAC AGATCTTAGC AGAATCTTGA AAAGCCCAGA GATCCAAAGA 900 901 GCCCTTCGAG CACCACGCAA GAAGATCCAT CGCAGAGTCC TAAAGAAGAA CCCACTGAAA 960 961 AACTTGAGAA TCATGTTGAA GCTAAACCCA TATGCAAAGA CCATGCGCCG GAACACCATT 1020 1021 CTTCGCCAGG CCAGGAATCA CAAGCTCCGG GTGGATAAGG CAGCTGCTGC AGCAGCGGCA 1080 1081 CTACAAGCCA AATCAGATGA GAAGGCGGCG GTTGCAGGCA AGAAGCCTGT GGTAGGTAAG 1140 1141 AAAGGAAAGA AGGCTGCTGT TGGTGTTAAG AAGCAGAAGA AGCCTCTGGT GGGAAAAAAG 1200 1201 GCAGCAGCTA CCAAGAAACC AGCCCCTGAA AAGAAGCCTG CAGAGAAGAA ACCTACTACA 1260 1261 GAGGAGAAGA AGCCTGCTGC ATAA 1284 |
▼ ANNOTATION
| Disease | ||||
| OMIM | DisGeNET | ActiveDriverDB | ||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ENPD | CORUM | CellMarker | RaftProt |
| Structure | ||||
| PDB | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| ICGC | COSMIC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mal-0750 | Mandrillus leucophaeus | 100.0 | 0.0 | 624 |
| LLPS-Paa-0571 | Papio anubis | 100.0 | 0.0 | 624 |
| LLPS-Gog-0219 | Gorilla gorilla | 100.0 | 0.0 | 625 |
| LLPS-Chs-0361 | Chlorocebus sabaeus | 100.0 | 9e-98 | 298 |
| LLPS-Maf-2137 | Macaca fascicularis | 100.0 | 0.0 | 624 |
| LLPS-Aon-0359 | Aotus nancymaae | 100.0 | 0.0 | 623 |
| LLPS-Mam-1580 | Macaca mulatta | 100.0 | 0.0 | 625 |
| LLPS-Pap-0055 | Pan paniscus | 100.0 | 0.0 | 624 |
| LLPS-Pat-1641 | Pan troglodytes | 100.0 | 0.0 | 624 |
| LLPS-Man-2580 | Macaca nemestrina | 100.0 | 0.0 | 624 |
| LLPS-Caj-2988 | Callithrix jacchus | 99.72 | 0.0 | 620 |
| LLPS-Ict-1166 | Ictidomys tridecemlineatus | 99.72 | 0.0 | 621 |
| LLPS-Mum-0465 | Mus musculus | 99.43 | 0.0 | 620 |
| LLPS-Nol-1714 | Nomascus leucogenys | 99.43 | 0.0 | 614 |
| LLPS-Mea-0658 | Mesocricetus auratus | 99.28 | 5e-164 | 472 |
| LLPS-Otg-1762 | Otolemur garnettii | 99.21 | 1e-80 | 259 |
| LLPS-Ova-0788 | Ovis aries | 99.15 | 0.0 | 620 |
| LLPS-Bot-0037 | Bos taurus | 99.15 | 0.0 | 622 |
| LLPS-Cas-0137 | Carlito syrichta | 99.15 | 0.0 | 613 |
| LLPS-Poa-0033 | Pongo abelii | 99.15 | 0.0 | 619 |
| LLPS-Fud-1585 | Fukomys damarensis | 99.14 | 0.0 | 615 |
| LLPS-Mup-0917 | Mustela putorius furo | 98.86 | 0.0 | 617 |
| LLPS-Tut-0666 | Tursiops truncatus | 98.86 | 0.0 | 619 |
| LLPS-Dio-1388 | Dipodomys ordii | 98.86 | 0.0 | 634 |
| LLPS-Eqc-0878 | Equus caballus | 98.86 | 0.0 | 617 |
| LLPS-Cap-0689 | Cavia porcellus | 98.86 | 0.0 | 634 |
| LLPS-Caf-3675 | Canis familiaris | 98.86 | 0.0 | 616 |
| LLPS-Fec-1138 | Felis catus | 98.86 | 0.0 | 620 |
| LLPS-Ran-1381 | Rattus norvegicus | 98.58 | 0.0 | 614 |
| LLPS-Myl-3483 | Myotis lucifugus | 98.58 | 0.0 | 613 |
| LLPS-Sus-0670 | Sus scrofa | 98.58 | 0.0 | 618 |
| LLPS-Urm-2051 | Ursus maritimus | 98.58 | 0.0 | 618 |
| LLPS-Loa-0247 | Loxodonta africana | 98.58 | 0.0 | 608 |
| LLPS-Orc-0775 | Oryctolagus cuniculus | 98.3 | 0.0 | 613 |
| LLPS-Ora-2407 | Ornithorhynchus anatinus | 97.25 | 5e-95 | 290 |
| LLPS-Anp-0149 | Anas platyrhynchos | 97.14 | 4e-84 | 261 |
| LLPS-Sah-0844 | Sarcophilus harrisii | 95.44 | 0.0 | 596 |
| LLPS-Anc-0566 | Anolis carolinensis | 95.31 | 5e-165 | 473 |
| LLPS-Mod-3306 | Monodelphis domestica | 95.14 | 0.0 | 592 |
| LLPS-Meg-1068 | Meleagris gallopavo | 94.93 | 1e-156 | 451 |
| LLPS-Pes-0066 | Pelodiscus sinensis | 94.83 | 0.0 | 564 |
| LLPS-Rhb-0943 | Rhinopithecus bieti | 94.22 | 0.0 | 558 |
| LLPS-Fia-0287 | Ficedula albicollis | 93.08 | 0.0 | 553 |
| LLPS-Tag-0468 | Taeniopygia guttata | 92.88 | 0.0 | 561 |
| LLPS-Scm-1999 | Scophthalmus maximus | 90.67 | 0.0 | 574 |
| LLPS-Leo-0133 | Lepisosteus oculatus | 90.09 | 0.0 | 576 |
| LLPS-Orn-0442 | Oreochromis niloticus | 90.09 | 0.0 | 533 |
| LLPS-Xet-0231 | Xenopus tropicalis | 90.0 | 0.0 | 568 |
| LLPS-Gaa-3052 | Gasterosteus aculeatus | 89.71 | 0.0 | 549 |
| LLPS-Orl-0102 | Oryzias latipes | 89.21 | 0.0 | 569 |
| LLPS-Lac-0927 | Latimeria chalumnae | 89.2 | 0.0 | 557 |
| LLPS-Tar-0242 | Takifugu rubripes | 88.92 | 0.0 | 550 |
| LLPS-Xim-2913 | Xiphophorus maculatus | 88.92 | 0.0 | 567 |
| LLPS-Pof-1294 | Poecilia formosa | 88.92 | 0.0 | 568 |
| LLPS-Ten-0181 | Tetraodon nigroviridis | 88.3 | 0.0 | 540 |
| LLPS-Scf-1916 | Scleropages formosus | 87.72 | 0.0 | 558 |
| LLPS-Icp-0947 | Ictalurus punctatus | 86.88 | 0.0 | 561 |
| LLPS-Asm-2099 | Astyanax mexicanus | 86.88 | 0.0 | 556 |
| LLPS-Cea-1973 | Cercocebus atys | 85.51 | 0.0 | 544 |
| LLPS-Dar-0090 | Danio rerio | 85.34 | 0.0 | 548 |
| LLPS-Gaga-1373 | Gallus gallus | 85.01 | 5e-177 | 507 |
| LLPS-Cii-2030 | Ciona intestinalis | 81.33 | 2e-34 | 128 |
| LLPS-Aim-2142 | Ailuropoda melanoleuca | 80.88 | 4e-29 | 114 |
| LLPS-Cis-0939 | Ciona savignyi | 72.83 | 1e-158 | 461 |
| LLPS-Drm-0799 | Drosophila melanogaster | 68.71 | 2e-145 | 427 |
| LLPS-Orbr-1331 | Oryza brachyantha | 68.29 | 8e-47 | 174 |
| LLPS-Php-1521 | Physcomitrella patens | 63.64 | 1e-135 | 402 |
| LLPS-Abg-0267 | Absidia glauca | 62.9 | 3e-127 | 380 |
| LLPS-Cus-0964 | Cucumis sativus | 62.72 | 3e-132 | 394 |
| LLPS-Via-2437 | Vigna angularis | 62.68 | 4e-131 | 391 |
| LLPS-Scj-0333 | Schizosaccharomyces japonicus | 62.57 | 1e-136 | 404 |
| LLPS-Mua-2245 | Musa acuminata | 62.36 | 5e-132 | 393 |
| LLPS-Glm-0599 | Glycine max | 62.36 | 2e-131 | 392 |
| LLPS-Phv-0062 | Phaseolus vulgaris | 62.36 | 3e-132 | 394 |
| LLPS-Osl-0996 | Ostreococcus lucimarinus | 61.83 | 5e-124 | 372 |
| LLPS-Gor-0391 | Gossypium raimondii | 61.78 | 1e-130 | 390 |
| LLPS-Sem-0860 | Selaginella moellendorffii | 61.76 | 1e-120 | 364 |
| LLPS-Pug-0136 | Puccinia graminis | 61.58 | 6e-121 | 366 |
| LLPS-Pot-0423 | Populus trichocarpa | 61.54 | 6e-133 | 395 |
| LLPS-Vir-0012 | Vigna radiata | 61.49 | 5e-133 | 397 |
| LLPS-Prp-1423 | Prunus persica | 61.45 | 9e-123 | 370 |
| LLPS-Mae-0057 | Manihot esculenta | 61.43 | 1e-133 | 397 |
| LLPS-Met-0184 | Medicago truncatula | 61.21 | 6e-130 | 388 |
| LLPS-Sot-0813 | Solanum tuberosum | 61.21 | 7e-120 | 362 |
| LLPS-Sol-1140 | Solanum lycopersicum | 61.21 | 1e-119 | 362 |
| LLPS-Viv-0646 | Vitis vinifera | 61.19 | 5e-131 | 390 |
| LLPS-Hea-1563 | Helianthus annuus | 61.14 | 3e-129 | 386 |
| LLPS-Nia-0277 | Nicotiana attenuata | 61.1 | 2e-119 | 361 |
| LLPS-Put-0125 | Puccinia triticina | 61.03 | 9e-127 | 379 |
| LLPS-Scp-0381 | Schizosaccharomyces pombe | 60.86 | 3e-133 | 395 |
| LLPS-Amt-0113 | Amborella trichopoda | 60.85 | 7e-129 | 385 |
| LLPS-Chr-0507 | Chlamydomonas reinhardtii | 60.81 | 9e-125 | 375 |
| LLPS-Asg-0369 | Ashbya gossypii | 60.78 | 2e-121 | 365 |
| LLPS-Arl-0892 | Arabidopsis lyrata | 60.34 | 2e-129 | 386 |
| LLPS-Art-0199 | Arabidopsis thaliana | 60.34 | 2e-130 | 389 |
| LLPS-Sac-1139 | Saccharomyces cerevisiae | 60.18 | 6e-110 | 335 |
| LLPS-Chc-0102 | Chondrus crispus | 60.18 | 2e-122 | 367 |
| LLPS-Mel-0482 | Melampsora laricipopulina | 60.06 | 3e-124 | 372 |
| LLPS-Thc-0653 | Theobroma cacao | 60.06 | 1e-130 | 390 |
| LLPS-Kop-0044 | Komagataella pastoris | 60.0 | 7e-122 | 365 |
| LLPS-Miv-0289 | Microbotryum violaceum | 60.0 | 2e-123 | 370 |
| LLPS-Dac-0571 | Daucus carota | 59.89 | 5e-128 | 383 |
| LLPS-Coc-0908 | Corchorus capsularis | 59.49 | 9e-132 | 392 |
| LLPS-Brn-0602 | Brassica napus | 59.48 | 2e-128 | 384 |
| LLPS-Bro-0009 | Brassica oleracea | 59.48 | 2e-128 | 384 |
| LLPS-Brr-2339 | Brassica rapa | 59.48 | 1e-127 | 382 |
| LLPS-Scc-0259 | Schizosaccharomyces cryophilus | 59.43 | 5e-131 | 389 |
| LLPS-Usm-0050 | Ustilago maydis | 59.01 | 1e-118 | 358 |
| LLPS-Spr-0604 | Sporisorium reilianum | 58.84 | 3e-118 | 356 |
| LLPS-Sei-0485 | Setaria italica | 58.81 | 4e-119 | 360 |
| LLPS-Tra-0076 | Triticum aestivum | 58.64 | 4e-120 | 363 |
| LLPS-Yal-0535 | Yarrowia lipolytica | 58.38 | 2e-116 | 352 |
| LLPS-Gas-0230 | Galdieria sulphuraria | 58.33 | 4e-118 | 357 |
| LLPS-Crn-0262 | Cryptococcus neoformans | 58.33 | 5e-114 | 345 |
| LLPS-Sob-0676 | Sorghum bicolor | 58.09 | 4e-120 | 363 |
| LLPS-Cae-1313 | Caenorhabditis elegans | 58.02 | 2e-121 | 364 |
| LLPS-Orr-1662 | Oryza rufipogon | 58.0 | 1e-116 | 354 |
| LLPS-Zem-0018 | Zea mays | 57.95 | 6e-120 | 362 |
| LLPS-Hov-0011 | Hordeum vulgare | 57.79 | 3e-119 | 361 |
| LLPS-Orgl-0182 | Oryza glumaepatula | 57.71 | 3e-119 | 360 |
| LLPS-Ori-0746 | Oryza indica | 57.71 | 4e-119 | 360 |
| LLPS-Org-0230 | Oryza glaberrima | 57.71 | 3e-119 | 360 |
| LLPS-Orm-0607 | Oryza meridionalis | 57.71 | 2e-119 | 361 |
| LLPS-Ors-0606 | Oryza sativa | 57.71 | 2e-119 | 361 |
| LLPS-Orp-1571 | Oryza punctata | 57.71 | 2e-119 | 361 |
| LLPS-Brd-0276 | Brachypodium distachyon | 57.59 | 4e-118 | 357 |
| LLPS-Lep-0754 | Leersia perrieri | 57.39 | 4e-117 | 355 |
| LLPS-Asfu-0684 | Aspergillus fumigatus | 57.06 | 6e-110 | 335 |
| LLPS-Tru-0146 | Triticum urartu | 56.73 | 5e-114 | 347 |
| LLPS-Orni-0405 | Oryza nivara | 56.5 | 3e-117 | 355 |
| LLPS-Asf-0352 | Aspergillus flavus | 56.48 | 1e-107 | 330 |
| LLPS-Aso-0497 | Aspergillus oryzae | 56.48 | 1e-107 | 330 |
| LLPS-Nef-0173 | Neosartorya fischeri | 56.48 | 3e-108 | 331 |
| LLPS-Asn-0607 | Aspergillus nidulans | 56.2 | 7e-107 | 328 |
| LLPS-Tum-0603 | Tuber melanosporum | 56.1 | 3e-105 | 325 |
| LLPS-Lem-0921 | Leptosphaeria maculans | 56.07 | 4e-115 | 349 |
| LLPS-Asc-0108 | Aspergillus clavatus | 56.06 | 9e-113 | 343 |
| LLPS-Pytr-0712 | Pyrenophora triticirepentis | 55.78 | 2e-114 | 347 |
| LLPS-Fuv-0610 | Fusarium verticillioides | 55.71 | 3e-105 | 323 |
| LLPS-Dos-0343 | Dothistroma septosporum | 55.46 | 1e-108 | 332 |
| LLPS-Zyt-0012 | Zymoseptoria tritici | 55.43 | 1e-107 | 330 |
| LLPS-Fuo-0447 | Fusarium oxysporum | 55.43 | 9e-105 | 322 |
| LLPS-Fus-0017 | Fusarium solani | 55.43 | 3e-109 | 333 |
| LLPS-Trr-0035 | Trichoderma reesei | 55.27 | 5e-110 | 335 |
| LLPS-Cog-0063 | Colletotrichum gloeosporioides | 55.23 | 3e-107 | 328 |
| LLPS-Pyt-0127 | Pyrenophora teres | 55.08 | 2e-114 | 347 |
| LLPS-Phn-0402 | Phaeosphaeria nodorum | 55.04 | 9e-110 | 335 |
| LLPS-Trv-0416 | Trichoderma virens | 54.99 | 7e-110 | 335 |
| LLPS-Cym-0155 | Cyanidioschyzon merolae | 54.73 | 1e-94 | 296 |
| LLPS-Beb-0420 | Beauveria bassiana | 54.57 | 4e-111 | 338 |
| LLPS-Orb-1578 | Oryza barthii | 54.52 | 5e-109 | 334 |
| LLPS-Ast-0486 | Aspergillus terreus | 54.47 | 1e-109 | 335 |
| LLPS-Asni-0282 | Aspergillus niger | 54.29 | 3e-106 | 326 |
| LLPS-Nec-1109 | Neurospora crassa | 53.62 | 1e-100 | 311 |
| LLPS-Ved-1010 | Verticillium dahliae | 53.62 | 2e-96 | 300 |
| LLPS-Mao-1064 | Magnaporthe oryzae | 53.6 | 3e-102 | 315 |
| LLPS-Blg-0005 | Blumeria graminis | 53.39 | 1e-103 | 319 |
| LLPS-Map-0193 | Magnaporthe poae | 53.31 | 6e-102 | 315 |
| LLPS-Gag-1350 | Gaeumannomyces graminis | 53.31 | 7e-103 | 317 |
| LLPS-Scs-0766 | Sclerotinia sclerotiorum | 53.03 | 7e-105 | 322 |
| LLPS-Coo-0498 | Colletotrichum orbiculare | 47.84 | 1e-95 | 299 |
| LLPS-Cogr-0178 | Colletotrichum graminicola | 46.84 | 4e-86 | 275 |