LLPS-Hos-0737
UBXN4

▼ OVERVIEW

Status: Reviewed
Protein Name: UBX domain-containing protein 4; Erasin; UBX domain-containing protein 2
Gene Name: UBXN4, KIAA0242, UBXD2, UBXDC1
Ensembl Gene: ENSG00000144224.16
Ensembl Protein: ENSP00000272638.9
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 2KXJ (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granule
"...Together, our APEX and IF screening approaches identified 260 SG proteins, including ~150 candidates that had not previously been associated with SGs."
HEK293T cells29373831

▼ FUNCTION

Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLWFQGAIPA  AIATAKRSGA  VFVVFVAGDD  EQSTQMAASW  EDDKVTEASS  NSFVAIKIDT  60
61    KSEACLQFSQ  IYPVVCVPSS  FFIGDSGIPL  EVIAGSVSAD  ELVTRIHKVR  QMHLLKSETS  120
121   VANGSQSESS  VSTPSASFEP  NNTCENSQSR  NAELCEIPPT  SDTKSDTATG  GESAGHATSS  180
181   QEPSGCSDQR  PAEDLNIRVE  RLTKKLEERR  EEKRKEEEQR  EIKKEIERRK  TGKEMLDYKR  240
241   KQEEELTKRM  LEERNREKAE  DRAARERIKQ  QIALDRAERA  ARFAKTKEEV  EAAKAAALLA  300
301   KQAEMEVKRE  SYARERSTVA  RIQFRLPDGS  SFTNQFPSDA  PLEEARQFAA  QTVGNTYGNF  360
361   SLATMFPRRE  FTKEDYKKKL  LDLELAPSAS  VVLLPAGRPT  ASIVHSSSGD  IWTLLGTVLY  420
421   PFLAIWRLIS  NFLFSNPPPT  QTSVRVTSSE  PPNPASSSKS  EKREPVRKRV  LEKRGDDFKK  480
481   EGKIYRLRTQ  DDGEDENNTW  NGNSTQQM  508
Nucleotide CDS Sequence (FASTA)
1     ATGCTGTGGT  TCCAGGGCGC  CATTCCGGCC  GCCATCGCGA  CGGCCAAAAG  GAGCGGCGCG  60
61    GTCTTCGTGG  TGTTCGTGGC  AGGTGATGAT  GAACAGTCTA  CACAGATGGC  TGCAAGTTGG  120
121   GAAGATGATA  AAGTTACAGA  AGCATCTTCA  AACAGTTTTG  TTGCTATTAA  AATCGATACC  180
181   AAAAGTGAAG  CCTGCCTACA  GTTTTCACAA  ATCTATCCTG  TAGTGTGTGT  TCCATCCAGT  240
241   TTCTTTATTG  GAGACAGTGG  AATTCCCTTG  GAAGTAATAG  CAGGAAGTGT  TTCTGCAGAT  300
301   GAACTTGTTA  CAAGAATTCA  CAAGGTCCGA  CAGATGCATT  TGCTAAAAAG  TGAAACATCA  360
361   GTAGCAAATG  GCAGTCAGTC  AGAAAGTTCA  GTGTCTACTC  CATCTGCGTC  ATTTGAACCT  420
421   AACAACACTT  GTGAAAACTC  TCAGTCCAGA  AATGCAGAGC  TTTGTGAGAT  ACCACCCACT  480
481   TCTGATACAA  AGTCAGATAC  TGCAACAGGA  GGAGAAAGTG  CAGGCCATGC  CACTTCCTCT  540
541   CAGGAGCCTA  GTGGATGCTC  AGATCAGAGA  CCTGCAGAGG  ACCTCAACAT  CCGAGTGGAA  600
601   AGACTAACAA  AAAAACTTGA  AGAAAGGAGA  GAAGAGAAAA  GAAAAGAGGA  AGAACAGAGA  660
661   GAAATTAAGA  AGGAAATTGA  GAGGAGAAAA  ACTGGAAAAG  AAATGTTGGA  TTATAAAAGA  720
721   AAACAAGAAG  AAGAATTAAC  AAAAAGAATG  CTGGAGGAAA  GAAACAGAGA  GAAAGCAGAA  780
781   GATAGGGCAG  CTCGAGAACG  TATAAAACAG  CAGATTGCAT  TGGACCGTGC  AGAGAGAGCT  840
841   GCTCGTTTTG  CAAAGACAAA  GGAAGAAGTA  GAGGCTGCCA  AAGCTGCTGC  CTTGCTAGCA  900
901   AAACAGGCAG  AAATGGAAGT  CAAGAGGGAA  TCTTATGCAA  GAGAAAGAAG  CACTGTTGCA  960
961   AGAATTCAAT  TCCGTCTTCC  TGATGGTTCT  TCCTTTACAA  ATCAGTTCCC  TTCTGATGCT  1020
1021  CCTCTAGAAG  AGGCAAGGCA  GTTTGCTGCA  CAGACTGTTG  GCAACACTTA  CGGTAATTTT  1080
1081  TCGTTAGCAA  CCATGTTTCC  CAGGAGGGAA  TTTACCAAAG  AAGATTATAA  AAAGAAGTTA  1140
1141  CTGGATTTGG  AACTTGCCCC  AAGCGCTTCG  GTGGTACTGT  TGCCAGCAGG  AAGACCAACT  1200
1201  GCATCCATTG  TACACTCTTC  CAGCGGAGAC  ATTTGGACCT  TGTTGGGAAC  AGTGCTTTAT  1260
1261  CCATTCCTTG  CCATCTGGAG  ATTAATTAGC  AATTTCTTGT  TTAGTAATCC  GCCTCCCACA  1320
1321  CAGACTTCAG  TGAGAGTAAC  ATCGTCAGAA  CCCCCAAACC  CTGCATCATC  TAGCAAATCA  1380
1381  GAAAAAAGGG  AACCAGTGAG  AAAAAGAGTG  CTGGAAAAAC  GTGGAGACGA  CTTTAAAAAG  1440
1441  GAGGGGAAAA  TTTATAGATT  AAGGACTCAA  GATGATGGTG  AAGATGAAAA  CAACACTTGG  1500
1501  AATGGAAATT  CCACTCAACA  GATGTAG  1527

▼ KEYWORD

ID
Family
3D-structure
Complete proteome
Endoplasmic reticulum
Membrane
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Unfolded protein response

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Endoplasmic reticulum
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Nuclear envelope
Biological Process
Response to unfolded protein
Biological Process
Ubiquitin-dependent ERAD pathway

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-3853Pan troglodytes100.00.0 840
LLPS-Pap-3135Pan paniscus100.00.0 840
LLPS-Gog-4453Gorilla gorilla99.410.0 817
LLPS-Mam-2522Macaca mulatta98.820.0 827
LLPS-Paa-4720Papio anubis98.820.0 828
LLPS-Mal-1809Mandrillus leucophaeus98.820.0 828
LLPS-Maf-2371Macaca fascicularis98.820.0 827
LLPS-Cea-4751Cercocebus atys98.820.0 828
LLPS-Nol-2147Nomascus leucogenys98.620.0 823
LLPS-Man-2401Macaca nemestrina98.620.0 825
LLPS-Chs-1084Chlorocebus sabaeus98.620.0 825
LLPS-Aon-1943Aotus nancymaae98.230.0 826
LLPS-Caj-2680Callithrix jacchus97.440.0 820
LLPS-Rhb-3492Rhinopithecus bieti97.050.0 804
LLPS-Ict-2483Ictidomys tridecemlineatus93.710.0 773
LLPS-Orc-3801Oryctolagus cuniculus93.70.0 769
LLPS-Aim-2546Ailuropoda melanoleuca93.452e-99 306
LLPS-Fec-3604Felis catus92.910.0 761
LLPS-Eqc-4769Equus caballus92.730.0 759
LLPS-Loa-2687Loxodonta africana92.530.0 720
LLPS-Bot-1759Bos taurus91.930.0 759
LLPS-Mup-4003Mustela putorius furo91.730.0 748
LLPS-Cap-3331Cavia porcellus91.680.0 699
LLPS-Caf-1781Canis familiaris91.540.0 733
LLPS-Urm-0418Ursus maritimus91.540.0 736
LLPS-Tut-2050Tursiops truncatus91.340.0 747
LLPS-Sus-2401Sus scrofa90.960.0 711
LLPS-Myl-0843Myotis lucifugus90.570.0 719
LLPS-Ran-4791Rattus norvegicus87.990.0 724
LLPS-Mum-4549Mus musculus87.80.0 729
LLPS-Cas-1561Carlito syrichta87.230.0 678
LLPS-Fud-3739Fukomys damarensis85.860.0 669
LLPS-Otg-2840Otolemur garnettii83.950.0 739
LLPS-Ova-3179Ovis aries83.370.0 656
LLPS-Mod-3374Monodelphis domestica83.270.0 661
LLPS-Mea-3903Mesocricetus auratus82.680.0 663
LLPS-Sah-1371Sarcophilus harrisii81.620.0 654
LLPS-Dio-0756Dipodomys ordii79.690.0 627
LLPS-Leo-3749Lepisosteus oculatus72.812e-48 180
LLPS-Meg-0281Meleagris gallopavo71.292e-177 516
LLPS-Pes-2561Pelodiscus sinensis71.120.0 562
LLPS-Fia-2206Ficedula albicollis71.111e-178 518
LLPS-Tag-0932Taeniopygia guttata70.310.0 547
LLPS-Anp-2380Anas platyrhynchos69.740.0 528
LLPS-Anc-1979Anolis carolinensis68.581e-165 486
LLPS-Scm-2443Scophthalmus maximus68.141e-46 175
LLPS-Ora-2109Ornithorhynchus anatinus67.137e-157 463
LLPS-Gaa-3429Gasterosteus aculeatus65.494e-44 167
LLPS-Xet-3748Xenopus tropicalis64.553e-168 493
LLPS-Lac-3691Latimeria chalumnae62.643e-165 486
LLPS-Ten-2829Tetraodon nigroviridis61.952e-42 163
LLPS-Scf-3644Scleropages formosus60.983e-160 473
LLPS-Icp-3498Ictalurus punctatus59.492e-130 397
LLPS-Orn-3452Oreochromis niloticus57.57e-151 449
LLPS-Xim-1466Xiphophorus maculatus54.265e-133 402
LLPS-Gaga-3389Gallus gallus54.242e-45 164
LLPS-Pof-3058Poecilia formosa53.923e-132 401
LLPS-Tar-3439Takifugu rubripes53.821e-131 399
LLPS-Dar-4109Danio rerio52.313e-26 108
LLPS-Drm-2209Drosophila melanogaster40.166e-1994.4
LLPS-Gor-1838Gossypium raimondii37.041e-1067.8
LLPS-Mae-2522Manihot esculenta36.116e-1168.9
LLPS-Hea-2019Helianthus annuus35.195e-0963.2
LLPS-Nia-0602Nicotiana attenuata34.862e-0963.9
LLPS-Cii-0889Ciona intestinalis34.559e-1784.7
LLPS-Cus-1813Cucumis sativus33.579e-1271.2
LLPS-Ors-0017Oryza sativa33.044e-1066.2
LLPS-Ori-1294Oryza indica33.044e-1066.2
LLPS-Thc-2333Theobroma cacao32.82e-0860.8
LLPS-Abg-0670Absidia glauca32.434e-1066.2
LLPS-Tra-0977Triticum aestivum32.413e-0860.1
LLPS-Mua-1814Musa acuminata32.385e-1168.9
LLPS-Org-0219Oryza glaberrima32.175e-1065.9
LLPS-Coc-2377Corchorus capsularis32.146e-1066.2
LLPS-Hov-0258Hordeum vulgare31.759e-0962.0
LLPS-Pot-0764Populus trichocarpa31.673e-1066.6
LLPS-Lep-0028Leersia perrieri31.32e-0860.5
LLPS-Orbr-2298Oryza brachyantha31.194e-0860.1
LLPS-Dac-1375Daucus carota31.158e-0962.0
LLPS-Brd-1318Brachypodium distachyon29.52e-0964.3
LLPS-Cae-1860Caenorhabditis elegans29.321e-0861.6
LLPS-Sob-2381Sorghum bicolor27.557e-0962.4
LLPS-Orm-2030Oryza meridionalis25.786e-0652.8