LLPS-Hos-0689
TRAF3IP2

▼ OVERVIEW

Status: Reviewed
Protein Name: Adapter protein CIKS; Connection to IKK and SAPK/JNK; Nuclear factor NF-kappa-B activator 1; ACT1; TRAF3-interacting protein 2
Gene Name: TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6
Ensembl Gene: ENSG00000056972.18
Ensembl Protein: ENSP00000357724.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...Act1 was co-localized with Dcp1 decapping enzyme, a component of P-bodies."
HeLa cells29563620
Others
"...IL-17A stimulation induced the assembly of Act1, the key adaptor of IL-17R, into microscopically visible cytoplasmic granules and nuclear localization."
HeLa cells29563620

▼ FUNCTION

Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPPQLQETRM  NRSIPVEVDE  SEPYPSQLLK  PIPEYSPEEE  SEPPAPNIRN  MAPNSLSAPT  60
61    MLHNSSGDFS  QAHSTLKLAN  HQRPVSRQVT  CLRTQVLEDS  EDSFCRRHPG  LGKAFPSGCS  120
121   AVSEPASESV  VGALPAEHQF  SFMEKRNQWL  VSQLSAASPD  TGHDSDKSDQ  SLPNASADSL  180
181   GGSQEMVQRP  QPHRNRAGLD  LPTIDTGYDS  QPQDVLGIRQ  LERPLPLTSV  CYPQDLPRPL  240
241   RSREFPQFEP  QRYPACAQML  PPNLSPHAPW  NYHYHCPGSP  DHQVPYGHDY  PRAAYQQVIQ  300
301   PALPGQPLPG  ASVRGLHPVQ  KVILNYPSPW  DHEERPAQRD  CSFPGLPRHQ  DQPHHQPPNR  360
361   AGAPGESLEC  PAELRPQVPQ  PPSPAAVPRP  PSNPPARGTL  KTSNLPEELR  KVFITYSMDT  420
421   AMEVVKFVNF  LLVNGFQTAI  DIFEDRIRGI  DIIKWMERYL  RDKTVMIIVA  ISPKYKQDVE  480
481   GAESQLDEDE  HGLHTKYIHR  MMQIEFIKQG  SMNFRFIPVL  FPNAKKEHVP  TWLQNTHVYS  540
541   WPKNKKNILL  RLLREEEYVA  PPRGPLPTLQ  VVPL  574
Nucleotide CDS Sequence (FASTA)
1     ATGCCTCCTC  AGCTTCAAGA  AACTAGAATG  AACCGAAGCA  TTCCTGTGGA  GGTTGATGAA  60
61    TCAGAACCAT  ACCCAAGTCA  GTTGCTGAAA  CCAATCCCAG  AATATTCCCC  GGAAGAGGAA  120
121   TCAGAACCAC  CTGCTCCAAA  TATAAGGAAC  ATGGCACCCA  ACAGCTTGTC  TGCACCCACA  180
181   ATGCTTCACA  ATTCCTCCGG  AGACTTTTCT  CAAGCTCACT  CAACCCTGAA  ACTTGCAAAT  240
241   CACCAGCGGC  CTGTATCCCG  GCAGGTCACC  TGCCTGCGCA  CTCAAGTTCT  GGAGGACAGT  300
301   GAAGACAGTT  TCTGCAGGAG  ACACCCAGGC  CTGGGCAAAG  CTTTCCCTTC  TGGGTGCTCT  360
361   GCAGTCAGCG  AGCCTGCGTC  TGAGTCTGTG  GTTGGAGCCC  TCCCTGCAGA  GCATCAGTTT  420
421   TCATTTATGG  AAAAACGTAA  TCAATGGCTG  GTATCTCAGC  TTTCAGCGGC  TTCTCCTGAC  480
481   ACTGGCCATG  ACTCAGACAA  ATCAGACCAA  AGTTTACCTA  ATGCCTCAGC  AGACTCCTTG  540
541   GGCGGTAGCC  AGGAGATGGT  GCAACGGCCC  CAGCCTCACA  GGAACCGAGC  AGGCCTGGAT  600
601   CTGCCAACCA  TAGACACGGG  ATATGATTCC  CAGCCCCAGG  ATGTCCTGGG  CATCAGGCAG  660
661   CTGGAAAGGC  CCCTGCCCCT  CACCTCCGTG  TGTTACCCCC  AGGACCTCCC  CAGACCTCTC  720
721   AGGTCCAGGG  AGTTCCCTCA  GTTTGAACCT  CAGAGGTATC  CAGCATGTGC  ACAGATGCTG  780
781   CCTCCCAATC  TTTCCCCACA  TGCTCCATGG  AACTATCATT  ACCATTGTCC  TGGAAGTCCC  840
841   GATCACCAGG  TGCCATATGG  CCATGACTAC  CCTCGAGCAG  CCTACCAGCA  AGTGATCCAG  900
901   CCGGCTCTGC  CTGGGCAGCC  CCTGCCTGGA  GCCAGTGTGA  GAGGCCTGCA  CCCTGTGCAG  960
961   AAGGTTATCC  TGAATTATCC  CAGCCCCTGG  GACCACGAAG  AGAGGCCCGC  ACAGAGAGAC  1020
1021  TGCTCCTTTC  CGGGGCTTCC  AAGGCACCAG  GACCAGCCAC  ATCACCAGCC  ACCTAATAGA  1080
1081  GCTGGTGCTC  CTGGGGAGTC  CTTGGAGTGC  CCTGCAGAGC  TGAGACCACA  GGTTCCCCAG  1140
1141  CCTCCGTCCC  CAGCTGCTGT  GCCTAGACCC  CCTAGCAACC  CTCCAGCCAG  AGGAACTCTA  1200
1201  AAAACAAGCA  ATTTGCCAGA  AGAATTGCGG  AAAGTCTTTA  TCACTTATTC  GATGGACACA  1260
1261  GCTATGGAGG  TGGTGAAATT  CGTGAACTTT  TTGTTGGTAA  ATGGCTTCCA  AACTGCAATT  1320
1321  GACATATTTG  AGGATAGAAT  CCGAGGCATT  GATATCATTA  AATGGATGGA  GCGCTACCTT  1380
1381  AGGGATAAGA  CCGTGATGAT  AATCGTAGCA  ATCAGCCCCA  AATACAAACA  GGACGTGGAA  1440
1441  GGCGCTGAGT  CGCAGCTGGA  CGAGGATGAG  CATGGCTTAC  ATACTAAGTA  CATTCATCGA  1500
1501  ATGATGCAGA  TTGAGTTCAT  AAAACAAGGA  AGCATGAATT  TCAGATTCAT  CCCTGTGCTC  1560
1561  TTCCCAAATG  CTAAGAAGGA  GCATGTGCCC  ACCTGGCTTC  AGAACACTCA  TGTCTACAGC  1620
1621  TGGCCCAAGA  ATAAAAAAAA  CATCCTGCTG  CGGCTGCTGA  GAGAGGAAGA  GTATGTGGCT  1680
1681  CCTCCACGGG  GGCCTCTGCC  CACCCTTCAG  GTGGTTCCCT  TGTGA  1725

▼ KEYWORD

ID
Family
Alternative splicing
Complete proteome
Disease mutation
Polymorphism
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
Signaling receptor binding
Biological Process
B cell apoptotic process
Biological Process
Humoral immune response
Biological Process
Immunoglobulin secretion
Biological Process
Intracellular signal transduction
Biological Process
Positive regulation of defense response to virus by host
Biological Process
Positive regulation of I-kappaB kinase/NF-kappaB signaling

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-3214Dipodomys ordii100.05e-63 209
LLPS-Pap-2764Pan paniscus99.30.01017
LLPS-Pat-3488Pan troglodytes99.130.01019
LLPS-Poa-0726Pongo abelii98.430.01005
LLPS-Gog-2386Gorilla gorilla97.910.01013
LLPS-Rhb-2348Rhinopithecus bieti95.750.0 959
LLPS-Cea-2742Cercocebus atys95.740.0 957
LLPS-Chs-3150Chlorocebus sabaeus95.580.0 956
LLPS-Maf-4780Macaca fascicularis95.420.0 955
LLPS-Mam-3762Macaca mulatta95.30.0 966
LLPS-Paa-1420Papio anubis94.950.0 958
LLPS-Man-3077Macaca nemestrina94.770.0 955
LLPS-Aon-2899Aotus nancymaae93.270.0 939
LLPS-Mal-3927Mandrillus leucophaeus91.650.0 908
LLPS-Caj-2481Callithrix jacchus90.550.0 892
LLPS-Otg-1282Otolemur garnettii88.320.0 889
LLPS-Nol-2724Nomascus leucogenys88.150.0 845
LLPS-Eqc-4633Equus caballus87.870.0 866
LLPS-Fec-2746Felis catus86.440.0 863
LLPS-Urm-1159Ursus maritimus86.370.0 857
LLPS-Ora-0378Ornithorhynchus anatinus86.113e-96 299
LLPS-Myl-2687Myotis lucifugus84.960.0 838
LLPS-Sus-2390Sus scrofa84.60.0 837
LLPS-Aim-3726Ailuropoda melanoleuca84.370.0 741
LLPS-Mup-1965Mustela putorius furo84.250.0 831
LLPS-Loa-2597Loxodonta africana83.540.0 825
LLPS-Bot-2064Bos taurus83.010.0 821
LLPS-Cap-4534Cavia porcellus82.30.0 804
LLPS-Fud-3182Fukomys damarensis81.950.0 806
LLPS-Lac-3529Latimeria chalumnae81.562e-89 288
LLPS-Ere-0990Erinaceus europaeus81.360.0 810
LLPS-Ict-4591Ictidomys tridecemlineatus81.30.0 622
LLPS-Ova-2491Ovis aries81.060.0 803
LLPS-Caf-0257Canis familiaris79.650.0 793
LLPS-Mum-3954Mus musculus77.270.0 722
LLPS-Cas-0023Carlito syrichta76.460.0 775
LLPS-Ran-2965Rattus norvegicus75.830.0 711
LLPS-Orc-0203Oryctolagus cuniculus72.570.0 713
LLPS-Sah-1418Sarcophilus harrisii72.430.0 675
LLPS-Mod-2847Monodelphis domestica71.950.0 675
LLPS-Mea-2314Mesocricetus auratus69.682e-102 317
LLPS-Xet-1136Xenopus tropicalis66.293e-71 238
LLPS-Tag-0884Taeniopygia guttata65.631e-150 447
LLPS-Anp-2571Anas platyrhynchos65.162e-151 448
LLPS-Xim-3730Xiphophorus maculatus62.073e-59 209
LLPS-Pof-2915Poecilia formosa62.073e-61 207
LLPS-Tar-3342Takifugu rubripes59.785e-59 207
LLPS-Scm-1526Scophthalmus maximus59.553e-58 207
LLPS-Ten-1259Tetraodon nigroviridis59.511e-55 191
LLPS-Pes-1509Pelodiscus sinensis58.250.0 539
LLPS-Gaa-1951Gasterosteus aculeatus58.053e-51 180
LLPS-Asm-1527Astyanax mexicanus55.756e-52 189
LLPS-Orn-1655Oreochromis niloticus55.753e-53 186
LLPS-Icp-1908Ictalurus punctatus54.751e-53 194
LLPS-Fia-3206Ficedula albicollis54.371e-145 438
LLPS-Gaga-1626Gallus gallus52.323e-147 442
LLPS-Anc-3394Anolis carolinensis51.216e-145 437
LLPS-Meg-1859Meleagris gallopavo50.084e-139 421
LLPS-Dar-0754Danio rerio47.255e-44 167
LLPS-Orl-4070Oryzias latipes45.921e-43 166
LLPS-Leo-3755Lepisosteus oculatus40.48e-63 222
LLPS-Scf-4095Scleropages formosus39.237e-58 207
LLPS-Cii-2155Ciona intestinalis36.813e-24 110
LLPS-Cis-0757Ciona savignyi33.914e-1479.0