LLPS-Hos-0533
LCA5

▼ OVERVIEW

Status: Reviewed
Protein Name: Lebercilin; Leber congenital amaurosis 5 protein
Gene Name: LCA5, C6orf152
Ensembl Gene: ENSG00000135338.13
Ensembl Protein: ENSP00000358861.4
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A17546029, 21606596
NucleolusPredicted from orthologsN/A(View)

▼ FUNCTION

Might be involved in minus end-directed microtubule transport.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGERAGSPGT  DQERKAGKHH  YSYLSDFETP  QSSGRSSLVS  SSPASVRRKN  PKRQTSDGQV  60
61    HHQAPRKPSP  KGLPNRKGVR  VGFRSQSLNR  EPLRKDTDLV  TKRILSARLL  KINELQNEVS  120
121   ELQVKLAELL  KENKSLKRLQ  YRQEKALNKF  EDAENEISQL  IFRHNNEITA  LKERLRKSQE  180
181   KERATEKRVK  DTESELFRTK  FSLQKLKEIS  EARHLPERDD  LAKKLVSAEL  KLDDTERRIK  240
241   ELSKNLELST  NSFQRQLLAE  RKRAYEAHDE  NKVLQKEVQR  LYHKLKEKER  ELDIKNIYSN  300
301   RLPKSSPNKE  KELALRKNAA  CQSDFADLCT  KGVQTMEDFK  PEEYPLTPET  IMCYENKWEE  360
361   PGHLTLDLQS  QKQDRHGEAG  ILNPIMEREE  KFVTDEELHV  VKQEVEKLED  EWEREELDKK  420
421   QKEKASLLER  EEKPEWETGR  YQLGMYPIQN  MDKLQGEEEE  RLKREMLLAK  LNEIDRELQD  480
481   SRNLKYPVLP  LLPDFESKLH  SPERSPKTYR  FSESSERLFN  GHHLQDISFS  TPKGEGQNSG  540
541   NVRSPASPNE  FAFGSYVPSF  AKTSERSNPF  SQKSSFLDFQ  RNSMEKLSKD  GVDLITRKEK  600
601   KANLMEQLFG  ASGSSTISSK  SSDPNSVASS  KGDIDPLNFL  PGNKGSRDQE  HDEDEGFFLS  660
661   EGRSFNPNRH  RLKHADDKPA  VKAADSVEDE  IEEVALR  697
Nucleotide CDS Sequence (FASTA)
1     ATGGGGGAAA  GAGCAGGAAG  TCCAGGTACT  GATCAAGAAA  GAAAGGCAGG  CAAACACCAT  60
61    TATTCTTACT  TATCTGATTT  TGAAACGCCA  CAGTCTTCTG  GCCGATCATC  GCTGGTCAGT  120
121   TCTTCACCTG  CAAGTGTTAG  GAGAAAAAAT  CCTAAAAGAC  AAACTTCAGA  TGGCCAAGTA  180
181   CATCACCAAG  CCCCTCGGAA  ACCAAGCCCT  AAGGGTCTAC  CAAACAGAAA  GGGAGTCCGA  240
241   GTGGGATTTC  GCTCCCAGAG  CCTCAATAGA  GAGCCACTTC  GGAAAGATAC  TGATCTTGTT  300
301   ACAAAACGGA  TTCTGTCTGC  AAGACTGCTA  AAAATCAATG  AGTTGCAGAA  TGAAGTATCT  360
361   GAACTCCAGG  TCAAGTTAGC  TGAGCTGCTA  AAAGAAAATA  AATCTTTGAA  AAGGCTTCAG  420
421   TACAGACAGG  AGAAAGCCCT  GAATAAGTTT  GAAGATGCCG  AAAATGAAAT  CTCACAACTT  480
481   ATATTTCGTC  ATAACAATGA  GATTACAGCA  CTCAAAGAAC  GCTTAAGAAA  ATCTCAAGAG  540
541   AAAGAACGGG  CAACTGAGAA  AAGGGTAAAA  GATACAGAAA  GTGAACTATT  TAGGACAAAA  600
601   TTTTCCTTAC  AGAAACTGAA  AGAGATCTCT  GAAGCTAGAC  ACCTACCTGA  ACGAGATGAT  660
661   TTGGCAAAGA  AACTAGTTTC  AGCAGAGTTA  AAGTTAGATG  ACACCGAGAG  AAGAATTAAG  720
721   GAGCTATCGA  AAAACCTTGA  ACTGAGTACT  AACAGTTTCC  AACGACAGTT  GCTTGCTGAA  780
781   AGGAAAAGGG  CATATGAGGC  TCATGATGAA  AATAAAGTTC  TTCAAAAGGA  GGTACAGCGA  840
841   CTATATCACA  AATTAAAGGA  AAAGGAGAGA  GAACTGGATA  TAAAAAATAT  ATATTCTAAT  900
901   CGTCTGCCAA  AGTCCTCTCC  AAATAAAGAG  AAAGAACTTG  CATTAAGAAA  AAATGCTGCA  960
961   TGCCAGAGTG  ATTTTGCAGA  CCTGTGTACA  AAAGGAGTAC  AAACCATGGA  AGACTTCAAG  1020
1021  CCAGAAGAAT  ATCCTTTAAC  TCCAGAAACA  ATTATGTGTT  ACGAAAACAA  ATGGGAAGAA  1080
1081  CCAGGACATC  TTACTTTGGA  CTTGCAATCT  CAAAAGCAAG  ACAGGCATGG  AGAAGCAGGG  1140
1141  ATTCTAAACC  CAATTATGGA  AAGAGAAGAA  AAATTTGTTA  CAGATGAAGA  ACTCCATGTC  1200
1201  GTAAAACAGG  AGGTTGAAAA  GCTGGAGGAT  GAATGGGAAA  GAGAAGAACT  TGATAAAAAG  1260
1261  CAAAAAGAAA  AGGCATCTTT  ACTGGAAAGA  GAAGAAAAGC  CAGAGTGGGA  AACTGGAAGG  1320
1321  TACCAACTAG  GAATGTATCC  AATTCAGAAT  ATGGATAAAT  TGCAAGGAGA  GGAAGAAGAA  1380
1381  AGACTGAAGA  GAGAAATGCT  ACTTGCTAAA  CTGAATGAAA  TTGACAGAGA  ACTCCAAGAT  1440
1441  TCTCGAAATC  TAAAATACCC  TGTTTTGCCA  TTGTTACCTG  ATTTTGAATC  AAAACTACAC  1500
1501  TCCCCAGAGA  GAAGCCCCAA  AACATACAGG  TTCTCTGAAT  CCTCAGAGAG  ATTATTTAAT  1560
1561  GGGCATCATT  TGCAAGACAT  CAGTTTCTCA  ACTCCAAAAG  GAGAAGGTCA  GAATTCAGGA  1620
1621  AATGTTAGAA  GTCCAGCCTC  CCCTAATGAG  TTCGCATTTG  GTAGCTACGT  GCCTTCGTTT  1680
1681  GCAAAAACAT  CAGAGAGGTC  AAATCCATTT  AGTCAAAAAA  GTAGTTTTTT  GGATTTCCAA  1740
1741  AGAAACAGTA  TGGAAAAACT  TAGTAAAGAT  GGTGTAGATT  TAATTACAAG  AAAAGAGAAA  1800
1801  AAAGCTAATT  TGATGGAACA  GTTATTTGGT  GCCAGTGGTA  GCAGCACCAT  TTCCTCCAAA  1860
1861  AGCAGTGACC  CAAATTCTGT  GGCTTCCAGT  AAAGGAGACA  TTGACCCTCT  AAATTTTCTC  1920
1921  CCTGGGAATA  AAGGCAGCAG  AGATCAAGAA  CATGATGAAG  ATGAAGGCTT  TTTCCTCAGT  1980
1981  GAAGGAAGAA  GTTTTAATCC  AAATAGGCAC  CGATTAAAAC  ATGCAGACGA  TAAACCAGCA  2040
2041  GTAAAAGCAG  CTGATTCTGT  AGAAGATGAA  ATTGAAGAAG  TAGCACTGAG  ATGA  2094

▼ KEYWORD

ID
Family
Cell projection
Cilium
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Leber congenital amaurosis
Phosphoprotein
Polymorphism
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axoneme
Cellular Component
Cilium
Cellular Component
Microtubule organizing center
Molecular Function
Protein-containing complex binding
Biological Process
Intraciliary transport

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-0472Pan troglodytes99.140.01248
LLPS-Poa-0499Pongo abelii99.00.01087
LLPS-Pap-2902Pan paniscus98.850.01239
LLPS-Gog-1435Gorilla gorilla98.850.01246
LLPS-Nol-1319Nomascus leucogenys96.270.01207
LLPS-Mam-2291Macaca mulatta95.410.01191
LLPS-Man-0023Macaca nemestrina95.270.01190
LLPS-Maf-0472Macaca fascicularis95.270.01186
LLPS-Rhb-3501Rhinopithecus bieti95.120.01186
LLPS-Chs-0630Chlorocebus sabaeus95.120.01184
LLPS-Mal-0948Mandrillus leucophaeus94.260.01179
LLPS-Paa-1459Papio anubis91.690.01126
LLPS-Cea-0132Cercocebus atys90.670.01129
LLPS-Aon-1842Aotus nancymaae90.480.01132
LLPS-Caj-1237Callithrix jacchus90.10.01098
LLPS-Urm-1782Ursus maritimus83.570.01011
LLPS-Mup-1216Mustela putorius furo83.120.01016
LLPS-Eqc-0764Equus caballus83.00.0 996
LLPS-Caf-1394Canis familiaris82.350.0 944
LLPS-Orc-2720Oryctolagus cuniculus81.00.0 977
LLPS-Cas-1772Carlito syrichta80.30.0 623
LLPS-Sus-3544Sus scrofa80.030.0 970
LLPS-Tut-1469Tursiops truncatus79.00.0 961
LLPS-Loa-0567Loxodonta africana78.290.0 955
LLPS-Aim-3087Ailuropoda melanoleuca77.20.0 608
LLPS-Fud-0150Fukomys damarensis76.750.0 938
LLPS-Ict-1369Ictidomys tridecemlineatus75.710.0 926
LLPS-Fec-2025Felis catus75.680.0 890
LLPS-Otg-0427Otolemur garnettii75.430.0 868
LLPS-Mea-0410Mesocricetus auratus74.380.0 570
LLPS-Myl-3802Myotis lucifugus73.530.0 882
LLPS-Cap-2386Cavia porcellus71.450.0 872
LLPS-Ova-1268Ovis aries70.570.0 845
LLPS-Bot-2770Bos taurus70.390.0 817
LLPS-Mum-2187Mus musculus67.510.0 821
LLPS-Ran-3392Rattus norvegicus64.980.0 791
LLPS-Lac-0144Latimeria chalumnae61.076e-99 327
LLPS-Tag-2059Taeniopygia guttata57.822e-110 347
LLPS-Leo-1111Lepisosteus oculatus55.053e-86 293
LLPS-Mod-3082Monodelphis domestica53.050.0 566
LLPS-Sah-2921Sarcophilus harrisii52.381e-176 525
LLPS-Icp-2118Ictalurus punctatus50.03e-70 249
LLPS-Dar-1170Danio rerio48.891e-63 230
LLPS-Pes-0805Pelodiscus sinensis48.868e-154 469
LLPS-Cii-1593Ciona intestinalis47.112e-51 194
LLPS-Gaga-0387Gallus gallus46.475e-141 436
LLPS-Anc-0886Anolis carolinensis45.584e-131 410
LLPS-Scm-3125Scophthalmus maximus45.354e-56 209
LLPS-Anp-2654Anas platyrhynchos45.222e-140 434
LLPS-Fia-1047Ficedula albicollis45.161e-142 440
LLPS-Orn-1269Oreochromis niloticus44.984e-64 230
LLPS-Ora-1716Ornithorhynchus anatinus44.222e-132 413
LLPS-Xet-2973Xenopus tropicalis42.523e-111 356
LLPS-Cis-1360Ciona savignyi42.42e-43 171
LLPS-Asm-2237Astyanax mexicanus42.219e-66 237
LLPS-Tar-1262Takifugu rubripes41.671e-39 160
LLPS-Pof-0539Poecilia formosa35.445e-76 266
LLPS-Xim-1548Xiphophorus maculatus35.242e-72 256
LLPS-Gaa-0375Gasterosteus aculeatus35.035e-74 257
LLPS-Orl-2339Oryzias latipes34.182e-71 253
LLPS-Drm-1051Drosophila melanogaster28.571e-1378.6