LLPS-Hos-0475
FAHD1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase |
| Gene Name: | FAHD1, C16orf36, YISKL |
| Ensembl Gene: | ENSG00000180185.11 |
| Ensembl Protein: | ENSP00000482534.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins." | N/A | 26980300 |
▼ FUNCTION
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000615972.1 | ENSP00000482534.1 |
| Ensembl | ENST00000427358.3 | ENSP00000398053.2 |
| Ensembl | ENST00000382666.5 | ENSP00000372112.4 |
| Ensembl | ENST00000382668.7 | ENSP00000372114.4 |
| UniProt | Q6P587, FAHD1_HUMAN, B1AK40, B1AK41, Q6FIC7, Q96RY1, Q9H0N6 | |
| GeneBank | CR533499, AL031722, BC063017, AK094199, AL136720, AE006639, AC012180 | CAB66654.1, CAG38530.1, AAK61295.1, BAC04308.1, AAH63017.1 |
| RefSeq | NM_001018104.2, NM_001142398.1, NM_031208.3 | NP_001018114.1, NP_001135870.1, NP_112485.1 |
| Entrez | 81889 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGIMAASRPL SRFWEWGKNI VCVGRNYADH VREMRSAVLS EPVLFLKPST AYAPEGSPIL 60 61 MPAYTRNLHH ELELGVVMGK RCRAVPEAAA MDYVGGYALC LDMTARDVQD ECKKKGLPWT 120 121 LAKSFTASCP VSAFVPKEKI PDPHKLKLWL KVNGELRQEG ETSSMIFSIP YIISYVSKII 180 181 TLEEGDIILT GTPKGVGPVK ENDEIEAGIH GLRQGLTLSP KLECSSAITA HCSLELPGSS 240 241 NPPSASRF 248 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGAATCA TGGCAGCATC CAGGCCATTG TCCCGCTTCT GGGAGTGGGG AAAGAACATC 60 61 GTCTGCGTGG GGAGGAACTA CGCGGACCAC GTCAGGGAGA TGCGCAGCGC GGTGTTGAGC 120 121 GAGCCCGTGC TGTTCCTGAA GCCGTCCACG GCCTACGCGC CCGAGGGCTC GCCCATCCTC 180 181 ATGCCCGCGT ACACTCGCAA CCTGCACCAC GAGCTGGAGC TGGGCGTGGT GATGGGCAAG 240 241 CGCTGCCGCG CAGTCCCCGA GGCTGCGGCC ATGGACTACG TGGGCGGCTA TGCCCTGTGC 300 301 CTGGATATGA CCGCCCGGGA CGTGCAGGAC GAGTGCAAGA AGAAGGGGCT GCCCTGGACT 360 361 CTGGCGAAGA GCTTCACGGC GTCCTGCCCG GTCAGCGCGT TCGTGCCCAA GGAGAAGATC 420 421 CCTGACCCTC ACAAGCTGAA GCTCTGGCTC AAGGTCAACG GCGAACTCAG ACAGGAGGGT 480 481 GAGACATCCT CCATGATTTT TTCCATCCCC TACATCATCA GCTATGTTTC TAAGATCATA 540 541 ACCTTGGAAG AAGGAGATAT TATCTTGACT GGGACGCCAA AGGGAGTTGG ACCGGTTAAA 600 601 GAAAACGATG AGATCGAGGC TGGCATACAC GGGCTGGTCA GTATGACATT TAAAGTGGAA 660 661 AAGCCAGAAT ATTGA 675 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Mitochondrial matrix | |
Cellular Component | Mitochondrion | |
Cellular Component | Nucleoplasm | |
Molecular Function | Acetylpyruvate hydrolase activity | |
Molecular Function | Acylpyruvate hydrolase activity | |
Molecular Function | Fumarylpyruvate hydrolase activity | |
Molecular Function | Metal ion binding | |
Molecular Function | Oxaloacetate decarboxylase activity | |
Biological Process | Tricarboxylic acid cycle |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Nol-2326 | Nomascus leucogenys | 100.0 | 5e-161 | 452 |
| LLPS-Pap-2712 | Pan paniscus | 100.0 | 9e-156 | 439 |
| LLPS-Poa-4027 | Pongo abelii | 99.53 | 2e-155 | 438 |
| LLPS-Pat-3487 | Pan troglodytes | 99.19 | 0.0 | 507 |
| LLPS-Rhb-3314 | Rhinopithecus bieti | 99.06 | 5e-155 | 437 |
| LLPS-Mal-3180 | Mandrillus leucophaeus | 99.06 | 4e-155 | 437 |
| LLPS-Chs-4310 | Chlorocebus sabaeus | 99.06 | 6e-155 | 437 |
| LLPS-Gog-2983 | Gorilla gorilla | 98.39 | 2e-180 | 503 |
| LLPS-Aon-4827 | Aotus nancymaae | 95.28 | 3e-150 | 425 |
| LLPS-Caj-0326 | Callithrix jacchus | 95.28 | 4e-150 | 425 |
| LLPS-Otg-3996 | Otolemur garnettii | 94.26 | 3e-145 | 413 |
| LLPS-Aim-3793 | Ailuropoda melanoleuca | 93.78 | 7e-145 | 412 |
| LLPS-Mam-1195 | Macaca mulatta | 93.55 | 2e-164 | 463 |
| LLPS-Man-4211 | Macaca nemestrina | 93.55 | 2e-166 | 468 |
| LLPS-Maf-0841 | Macaca fascicularis | 93.55 | 2e-166 | 468 |
| LLPS-Cea-4836 | Cercocebus atys | 93.55 | 2e-166 | 468 |
| LLPS-Tut-2023 | Tursiops truncatus | 93.33 | 8e-146 | 414 |
| LLPS-Eqc-3558 | Equus caballus | 92.82 | 3e-144 | 410 |
| LLPS-Paa-0045 | Papio anubis | 92.74 | 3e-165 | 465 |
| LLPS-Urm-3574 | Ursus maritimus | 91.87 | 9e-143 | 407 |
| LLPS-Myl-2278 | Myotis lucifugus | 91.47 | 1e-142 | 406 |
| LLPS-Bot-3932 | Bos taurus | 90.91 | 6e-146 | 414 |
| LLPS-Sus-3818 | Sus scrofa | 90.57 | 6e-144 | 409 |
| LLPS-Mea-2247 | Mesocricetus auratus | 89.95 | 7e-140 | 399 |
| LLPS-Ran-1677 | Rattus norvegicus | 89.47 | 1e-139 | 398 |
| LLPS-Fec-1897 | Felis catus | 89.4 | 2e-142 | 406 |
| LLPS-Mum-4057 | Mus musculus | 89.0 | 7e-140 | 399 |
| LLPS-Cas-2159 | Carlito syrichta | 88.7 | 1e-153 | 434 |
| LLPS-Mup-2750 | Mustela putorius furo | 88.63 | 4e-139 | 397 |
| LLPS-Loa-4211 | Loxodonta africana | 87.68 | 6e-138 | 394 |
| LLPS-Sah-3452 | Sarcophilus harrisii | 81.82 | 2e-131 | 378 |
| LLPS-Mod-2871 | Monodelphis domestica | 80.18 | 6e-130 | 374 |
| LLPS-Gaga-3934 | Gallus gallus | 76.21 | 8e-118 | 343 |
| LLPS-Anc-3641 | Anolis carolinensis | 76.08 | 8e-110 | 323 |
| LLPS-Meg-2414 | Meleagris gallopavo | 75.96 | 1e-118 | 345 |
| LLPS-Fia-0079 | Ficedula albicollis | 75.73 | 1e-116 | 340 |
| LLPS-Dio-0834 | Dipodomys ordii | 72.73 | 7e-110 | 322 |
| LLPS-Pes-3532 | Pelodiscus sinensis | 72.51 | 1e-109 | 322 |
| LLPS-Scm-2021 | Scophthalmus maximus | 68.9 | 6e-109 | 320 |
| LLPS-Orn-3796 | Oreochromis niloticus | 68.12 | 8e-108 | 318 |
| LLPS-Tar-0497 | Takifugu rubripes | 68.12 | 1e-107 | 317 |
| LLPS-Lac-3437 | Latimeria chalumnae | 67.94 | 6e-107 | 315 |
| LLPS-Scf-3858 | Scleropages formosus | 67.94 | 4e-110 | 323 |
| LLPS-Leo-2779 | Lepisosteus oculatus | 67.94 | 2e-111 | 327 |
| LLPS-Orl-0679 | Oryzias latipes | 67.63 | 3e-107 | 316 |
| LLPS-Tag-2217 | Taeniopygia guttata | 67.48 | 3e-96 | 288 |
| LLPS-Xet-2692 | Xenopus tropicalis | 67.32 | 5e-105 | 311 |
| LLPS-Gaa-2253 | Gasterosteus aculeatus | 66.5 | 1e-105 | 312 |
| LLPS-Asm-4035 | Astyanax mexicanus | 66.32 | 3e-92 | 278 |
| LLPS-Pof-0642 | Poecilia formosa | 66.06 | 3e-108 | 318 |
| LLPS-Xim-4113 | Xiphophorus maculatus | 65.91 | 1e-108 | 319 |
| LLPS-Icp-3186 | Ictalurus punctatus | 65.7 | 2e-103 | 306 |
| LLPS-Dar-3946 | Danio rerio | 64.71 | 9e-107 | 315 |
| LLPS-Brd-1647 | Brachypodium distachyon | 58.38 | 4e-77 | 239 |
| LLPS-Nia-2423 | Nicotiana attenuata | 57.65 | 4e-79 | 245 |
| LLPS-Sol-1980 | Solanum lycopersicum | 57.65 | 3e-78 | 243 |
| LLPS-Bro-2127 | Brassica oleracea | 56.59 | 7e-81 | 249 |
| LLPS-Brr-2364 | Brassica rapa | 56.59 | 8e-81 | 249 |
| LLPS-Brn-1381 | Brassica napus | 56.59 | 5e-81 | 249 |
| LLPS-Glm-0380 | Glycine max | 56.22 | 4e-77 | 239 |
| LLPS-Hea-0427 | Helianthus annuus | 56.16 | 6e-80 | 246 |
| LLPS-Orm-1827 | Oryza meridionalis | 55.84 | 1e-72 | 228 |
| LLPS-Orbr-2330 | Oryza brachyantha | 55.84 | 4e-73 | 229 |
| LLPS-Thc-2356 | Theobroma cacao | 55.5 | 4e-77 | 239 |
| LLPS-Orr-0594 | Oryza rufipogon | 55.33 | 1e-72 | 228 |
| LLPS-Ors-0440 | Oryza sativa | 55.33 | 1e-72 | 228 |
| LLPS-Orgl-1726 | Oryza glumaepatula | 55.33 | 1e-72 | 228 |
| LLPS-Ori-1856 | Oryza indica | 55.33 | 1e-72 | 228 |
| LLPS-Orni-0831 | Oryza nivara | 55.33 | 1e-72 | 228 |
| LLPS-Phv-2141 | Phaseolus vulgaris | 55.22 | 1e-75 | 236 |
| LLPS-Cus-2061 | Cucumis sativus | 55.1 | 6e-74 | 231 |
| LLPS-Php-1404 | Physcomitrella patens | 54.95 | 1e-77 | 240 |
| LLPS-Hov-0888 | Hordeum vulgare | 54.93 | 6e-75 | 235 |
| LLPS-Viv-0981 | Vitis vinifera | 54.9 | 3e-77 | 239 |
| LLPS-Cii-0923 | Ciona intestinalis | 54.76 | 2e-85 | 261 |
| LLPS-Dac-1477 | Daucus carota | 54.73 | 2e-78 | 243 |
| LLPS-Prp-0840 | Prunus persica | 54.59 | 3e-77 | 239 |
| LLPS-Gas-0162 | Galdieria sulphuraria | 54.59 | 3e-68 | 216 |
| LLPS-Tra-3038 | Triticum aestivum | 54.46 | 4e-75 | 234 |
| LLPS-Mae-2151 | Manihot esculenta | 54.11 | 8e-77 | 239 |
| LLPS-Gor-2140 | Gossypium raimondii | 54.07 | 7e-74 | 231 |
| LLPS-Orp-1172 | Oryza punctata | 53.81 | 2e-74 | 233 |
| LLPS-Art-1952 | Arabidopsis thaliana | 53.59 | 2e-76 | 238 |
| LLPS-Pot-2054 | Populus trichocarpa | 53.55 | 2e-75 | 237 |
| LLPS-Orb-0520 | Oryza barthii | 53.4 | 4e-73 | 229 |
| LLPS-Sei-2514 | Setaria italica | 53.33 | 3e-74 | 232 |
| LLPS-Arl-2300 | Arabidopsis lyrata | 53.11 | 5e-76 | 236 |
| LLPS-Mua-2581 | Musa acuminata | 53.11 | 3e-76 | 237 |
| LLPS-Lep-2211 | Leersia perrieri | 52.94 | 2e-72 | 228 |
| LLPS-Org-0467 | Oryza glaberrima | 52.86 | 1e-73 | 230 |
| LLPS-Sem-1483 | Selaginella moellendorffii | 52.85 | 2e-63 | 204 |
| LLPS-Sob-0290 | Sorghum bicolor | 52.83 | 2e-74 | 233 |
| LLPS-Amt-1505 | Amborella trichopoda | 52.63 | 2e-76 | 238 |
| LLPS-Lem-0288 | Leptosphaeria maculans | 52.06 | 2e-66 | 213 |
| LLPS-Zem-1302 | Zea mays | 51.9 | 9e-72 | 226 |
| LLPS-Met-2245 | Medicago truncatula | 51.67 | 9e-75 | 233 |
| LLPS-Mel-1414 | Melampsora laricipopulina | 51.52 | 9e-72 | 226 |
| LLPS-Cym-0367 | Cyanidioschyzon merolae | 51.52 | 5e-63 | 206 |
| LLPS-Phn-0983 | Phaeosphaeria nodorum | 51.02 | 3e-65 | 209 |
| LLPS-Zyt-1519 | Zymoseptoria tritici | 50.76 | 8e-62 | 200 |
| LLPS-Vir-0369 | Vigna radiata | 50.75 | 5e-65 | 207 |
| LLPS-Nec-1559 | Neurospora crassa | 50.26 | 9e-63 | 203 |
| LLPS-Pytr-0811 | Pyrenophora triticirepentis | 50.0 | 2e-63 | 204 |
| LLPS-Dos-0957 | Dothistroma septosporum | 50.0 | 3e-59 | 194 |
| LLPS-Abg-1889 | Absidia glauca | 50.0 | 1e-68 | 224 |
| LLPS-Coc-0091 | Corchorus capsularis | 49.76 | 1e-57 | 203 |
| LLPS-Ast-0683 | Aspergillus terreus | 49.75 | 5e-61 | 198 |
| LLPS-Drm-2164 | Drosophila melanogaster | 49.02 | 5e-62 | 200 |
| LLPS-Pug-0484 | Puccinia graminis | 48.74 | 3e-68 | 217 |
| LLPS-Cogr-0382 | Colletotrichum graminicola | 48.72 | 9e-61 | 198 |
| LLPS-Cae-1039 | Caenorhabditis elegans | 48.5 | 4e-68 | 216 |
| LLPS-Mao-1558 | Magnaporthe oryzae | 48.48 | 2e-63 | 205 |
| LLPS-Scj-1582 | Schizosaccharomyces japonicus | 48.19 | 3e-56 | 186 |
| LLPS-Crn-1069 | Cryptococcus neoformans | 48.17 | 7e-68 | 216 |
| LLPS-Yal-0837 | Yarrowia lipolytica | 47.8 | 2e-66 | 213 |
| LLPS-Map-0993 | Magnaporthe poae | 47.72 | 8e-61 | 198 |
| LLPS-Tum-1251 | Tuber melanosporum | 47.67 | 5e-58 | 191 |
| LLPS-Aso-0944 | Aspergillus oryzae | 47.45 | 1e-57 | 189 |
| LLPS-Blg-0408 | Blumeria graminis | 47.44 | 9e-60 | 196 |
| LLPS-Scs-0543 | Sclerotinia sclerotiorum | 47.42 | 3e-59 | 194 |
| LLPS-Usm-1194 | Ustilago maydis | 47.32 | 8e-68 | 216 |
| LLPS-Ved-1554 | Verticillium dahliae | 47.18 | 1e-60 | 197 |
| LLPS-Coo-0955 | Colletotrichum orbiculare | 47.18 | 5e-58 | 191 |
| LLPS-Spr-1213 | Sporisorium reilianum | 46.85 | 4e-67 | 214 |
| LLPS-Miv-1234 | Microbotryum violaceum | 46.77 | 8e-64 | 205 |
| LLPS-Trr-0910 | Trichoderma reesei | 46.67 | 1e-57 | 190 |
| LLPS-Kop-0953 | Komagataella pastoris | 46.57 | 1e-58 | 192 |
| LLPS-Asf-1069 | Aspergillus flavus | 46.52 | 3e-50 | 171 |
| LLPS-Gag-1220 | Gaeumannomyces graminis | 45.96 | 1e-58 | 192 |
| LLPS-Trv-1594 | Trichoderma virens | 45.71 | 1e-56 | 187 |
| LLPS-Asni-0007 | Aspergillus niger | 45.7 | 4e-50 | 171 |
| LLPS-Cog-0903 | Colletotrichum gloeosporioides | 45.59 | 4e-57 | 189 |
| LLPS-Nef-0361 | Neosartorya fischeri | 45.45 | 3e-50 | 170 |
| LLPS-Asc-0755 | Aspergillus clavatus | 45.18 | 1e-55 | 184 |
| LLPS-Asn-1551 | Aspergillus nidulans | 44.97 | 5e-51 | 172 |
| LLPS-Put-0813 | Puccinia triticina | 44.59 | 1e-64 | 208 |
| LLPS-Pyt-1387 | Pyrenophora teres | 44.59 | 2e-56 | 187 |
| LLPS-Asfu-1238 | Aspergillus fumigatus | 44.44 | 1e-48 | 166 |
| LLPS-Fus-1433 | Fusarium solani | 43.84 | 3e-57 | 189 |
| LLPS-Tru-1287 | Triticum urartu | 43.65 | 1e-44 | 155 |
| LLPS-Beb-1283 | Beauveria bassiana | 43.6 | 5e-59 | 194 |
| LLPS-Fuo-1515 | Fusarium oxysporum | 43.54 | 6e-57 | 188 |
| LLPS-Fuv-1596 | Fusarium verticillioides | 43.54 | 4e-56 | 186 |
| LLPS-Chc-0947 | Chondrus crispus | 43.14 | 1e-47 | 164 |
| LLPS-Scc-1163 | Schizosaccharomyces cryophilus | 42.93 | 7e-49 | 166 |
| LLPS-Chr-1428 | Chlamydomonas reinhardtii | 42.13 | 6e-41 | 145 |
| LLPS-Scp-1324 | Schizosaccharomyces pombe | 40.48 | 6e-51 | 172 |
| LLPS-Asg-1311 | Ashbya gossypii | 38.6 | 1e-42 | 152 |
| LLPS-Sac-1536 | Saccharomyces cerevisiae | 36.4 | 2e-43 | 154 |