LLPS-Hos-0263
WDR75

▼ OVERVIEW

Status: Reviewed
Protein Name: WD repeat-containing protein 75; U3 small nucleolar RNA-associated protein 17 homolog
Gene Name: WDR75, UTP17
Ensembl Gene: ENSG00000115368.9
Ensembl Protein: ENSP00000314193.4
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...As a first step in elucidating these mechanisms we have carried out a proteomic analysis to draw up a list of proteins present within nucleoli of HeLa cells. This analysis allowed the identification of 213 different nucleolar proteins."
HeLa cells12429849
Nucleolus
"...Finally, 221 proteins were found as nucleolar with No/Cyto > 1 and No/Nuc > 1."
HCT116 cells20026476

▼ FUNCTION

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVEEENIRVV  RCGGSELNFR  RAVFSADSKY  IFCVSGDFVK  VYSTVTEECV  HILHGHRNLV  60
61    TGIQLNPNNH  LQLYSCSLDG  TIKLWDYIDG  ILIKTFIVGC  KLHALFTLAQ  AEDSVFVIVN  120
121   KEKPDIFQLV  SVKLPKSSSQ  EVEAKELSFV  LDYINQSPKC  IAFGNEGVYV  AAVREFYLSV  180
181   YFFKKKTTSR  FTLSSSRNKK  HAKNNFTCVA  CHPTEDCIAS  GHMDGKIRLW  RNFYDDKKYT  240
241   YTCLHWHHDM  VMDLAFSVTG  TSLLSGGRES  VLVEWRDATE  KNKEFLPRLG  ATIEHISVSP  300
301   AGDLFCTSHS  DNKIIIIHRN  LEASAVIQGL  VKDRSIFTGL  MIDPRTKALV  LNGKPGHLQF  360
361   YSLQSDKQLY  NLDIIQQEYI  NDYGLIQIEL  TKAAFGCFGN  WLATVEQRQE  KETELELQMK  420
421   LWMYNKKTQG  FILNTKINMP  HEDCITALCF  CNAEKSEQPT  LVTASKDGYF  KVWILTDDSD  480
481   IYKKAVGWTC  DFVGSYHKYQ  ATNCCFSEDG  SLLAVSFEEI  VTIWDSVTWE  LKCTFCQRAG  540
541   KIRHLCFGRL  TCSKYLLGAT  ENGILCCWNL  LSCALEWNAK  LNVRVMEPDP  NSENIAAISQ  600
601   SSVGSDLFVF  KPSEPRPLYI  QKGISREKVQ  WGVFVPRDVP  ESFTSEAYQW  LNRSQFYFLT  660
661   KSQSLLTFST  KSPEEKLTPT  SKQLLAEESL  PTTPFYFILG  KHRQQQDEKL  NETLENELVQ  720
721   LPLTENIPAI  SELLHTPAHV  LPSAAFLCSM  FVNSLLLSKE  TKSAKEIPED  VDMEEEKESE  780
781   DSDEENDFTE  KVQDTSNTGL  GEDIIHQLSK  SEEKELRKFR  KIDYSWIAAL  830
Nucleotide CDS Sequence (FASTA)
1     ATGGTGGAGG  AGGAGAACAT  CCGCGTGGTT  CGTTGTGGCG  GCAGCGAGTT  GAACTTTAGG  60
61    AGAGCTGTGT  TCTCTGCAGA  TTCTAAGTAT  ATCTTCTGTG  TCTCTGGAGA  CTTTGTTAAA  120
121   GTTTACAGCA  CAGTTACAGA  AGAGTGTGTA  CACATACTGC  ATGGACACAG  AAATCTGGTG  180
181   ACTGGAATCC  AGCTTAACCC  CAACAACCAT  CTACAGCTGT  ATTCTTGTTC  CCTTGATGGC  240
241   ACAATTAAAC  TGTGGGACTA  TATAGATGGC  ATCTTAATAA  AGACTTTCAT  AGTTGGATGT  300
301   AAACTTCATG  CCCTCTTTAC  TCTTGCCCAA  GCTGAGGATT  CTGTCTTTGT  TATAGTGAAT  360
361   AAAGAAAAAC  CAGATATATT  TCAGCTGGTT  TCAGTGAAAC  TGCCAAAATC  CTCAAGCCAG  420
421   GAAGTAGAAG  CCAAGGAGCT  GTCCTTTGTT  TTGGATTACA  TAAACCAGTC  ACCCAAGTGC  480
481   ATTGCCTTTG  GAAACGAGGG  AGTATATGTT  GCTGCAGTAC  GGGAATTTTA  CTTGTCTGTT  540
541   TATTTTTTCA  AAAAGAAAAC  AACATCAAGG  TTTACTTTAT  CATCATCAAG  AAATAAGAAG  600
601   CATGCTAAAA  ACAATTTTAC  ATGTGTAGCA  TGTCACCCAA  CGGAAGACTG  CATCGCATCT  660
661   GGTCACATGG  ATGGCAAAAT  TCGTCTTTGG  AGGAATTTTT  ATGATGATAA  GAAATATACG  720
721   TACACATGTT  TACATTGGCA  CCATGATATG  GTTATGGATT  TGGCTTTTTC  AGTGACAGGC  780
781   ACCAGTCTGC  TGAGTGGCGG  TCGTGAATCT  GTACTTGTAG  AGTGGCGCGA  TGCAACAGAG  840
841   AAGAATAAGG  AGTTTCTCCC  GCGTTTAGGA  GCTACTATTG  AACATATCTC  AGTCTCGCCT  900
901   GCAGGAGATT  TATTCTGCAC  TTCTCACTCT  GATAATAAGA  TAATAATTAT  TCACCGAAAC  960
961   CTTGAAGCAT  CCGCAGTAAT  TCAAGGCCTA  GTGAAAGATA  GGAGTATCTT  CACTGGTTTG  1020
1021  ATGATTGATC  CAAGAACTAA  AGCTTTGGTT  TTGAATGGAA  AACCTGGCCA  CCTGCAGTTT  1080
1081  TATTCTCTCC  AGAGTGATAA  ACAGTTATAC  AATTTAGATA  TTATACAGCA  AGAATATATT  1140
1141  AATGATTATG  GTCTGATCCA  AATTGAACTA  ACAAAGGCTG  CATTTGGCTG  CTTTGGTAAC  1200
1201  TGGCTTGCAA  CAGTGGAACA  GCGGCAAGAA  AAGGAAACTG  AGCTTGAATT  GCAAATGAAA  1260
1261  CTGTGGATGT  ATAATAAGAA  AACACAAGGG  TTTATTCTTA  ACACTAAAAT  TAACATGCCA  1320
1321  CACGAAGACT  GCATTACAGC  TCTCTGTTTC  TGTAATGCAG  AAAAATCTGA  ACAGCCCACC  1380
1381  TTGGTTACAG  CTAGCAAAGA  TGGTTACTTC  AAAGTATGGA  TATTAACAGA  TGACTCTGAC  1440
1441  ATATACAAAA  AAGCTGTTGG  CTGGACCTGT  GACTTTGTTG  GTAGTTATCA  CAAGTATCAA  1500
1501  GCAACTAACT  GTTGTTTCTC  CGAAGATGGT  TCTTTACTAG  CAGTTAGTTT  TGAGGAAATA  1560
1561  GTCACAATAT  GGGATTCTGT  AACATGGGAA  CTTAAATGTA  CATTTTGCCA  ACGAGCTGGG  1620
1621  AAAATAAGGC  ACCTTTGCTT  TGGGAGATTG  ACGTGTTCAA  AGTATCTACT  TGGTGCTACT  1680
1681  GAAAATGGCA  TTCTTTGCTG  TTGGAATCTG  CTGAGCTGTG  CATTGGAGTG  GAATGCAAAA  1740
1741  TTAAATGTTA  GAGTTATGGA  ACCCGATCCT  AATTCAGAGA  ATATTGCTGC  AATCTCTCAG  1800
1801  TCTTCAGTGG  GTTCAGACTT  GTTTGTATTT  AAACCTAGTG  AGCCAAGGCC  ATTGTATATT  1860
1861  CAAAAGGGTA  TCTCCAGAGA  GAAAGTCCAG  TGGGGAGTGT  TTGTTCCACG  AGATGTCCCT  1920
1921  GAATCCTTCA  CCTCAGAAGC  TTACCAGTGG  CTAAATAGAT  CCCAGTTTTA  CTTCCTAACA  1980
1981  AAATCACAGA  GTTTATTGAC  ATTCAGTACA  AAGTCTCCAG  AAGAAAAACT  CACACCAACA  2040
2041  AGCAAACAGC  TGCTAGCAGA  AGAAAGTCTT  CCCACAACCC  CATTTTATTT  CATATTGGGA  2100
2101  AAACACAGGC  AACAGCAGGA  TGAAAAACTA  AACGAAACTT  TAGAGAATGA  GCTGGTACAA  2160
2161  CTACCCTTAA  CAGAAAACAT  ACCCGCAATT  AGTGAGCTTC  TTCACACTCC  AGCCCATGTC  2220
2221  CTGCCATCTG  CTGCTTTCCT  GTGCTCCATG  TTTGTAAATT  CATTGCTGCT  GTCTAAAGAG  2280
2281  ACTAAGAGTG  CTAAGGAAAT  TCCTGAAGAT  GTAGATATGG  AAGAAGAAAA  AGAAAGTGAA  2340
2341  GATTCAGATG  AAGAAAATGA  TTTTACCGAA  AAAGTCCAGG  ATACAAGTAA  CACAGGTTTA  2400
2401  GGAGAAGACA  TTATACATCA  GTTGTCAAAA  TCTGAAGAAA  AAGAACTGAG  AAAATTTAGG  2460
2461  AAAATAGACT  ACAGCTGGAT  AGCTGCCCTT  TAA  2493

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ribosome biogenesis
rRNA processing
Transcription
Transcription regulation
Ubl conjugation
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleolus
Cellular Component
Nucleoplasm
Molecular Function
RNA binding
Biological Process
Positive regulation of rRNA processing
Biological Process
Positive regulation of transcription by RNA polymerase I
Biological Process
RRNA processing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-1023Gorilla gorilla99.640.01639
LLPS-Pat-2307Pan troglodytes99.520.01662
LLPS-Poa-2889Pongo abelii99.40.01658
LLPS-Pap-2304Pan paniscus99.40.01662
LLPS-Nol-2413Nomascus leucogenys99.040.01654
LLPS-Paa-2976Papio anubis98.80.01651
LLPS-Cea-0208Cercocebus atys98.80.01653
LLPS-Chs-1248Chlorocebus sabaeus98.80.01651
LLPS-Maf-1519Macaca fascicularis98.80.01651
LLPS-Rhb-1410Rhinopithecus bieti98.80.01649
LLPS-Mam-1465Macaca mulatta98.670.01650
LLPS-Man-1335Macaca nemestrina98.550.01647
LLPS-Aon-2944Aotus nancymaae96.510.01564
LLPS-Caj-0772Callithrix jacchus96.490.01618
LLPS-Mal-3062Mandrillus leucophaeus96.020.01590
LLPS-Eqc-1524Equus caballus93.730.01578
LLPS-Cas-2814Carlito syrichta93.490.01559
LLPS-Urm-0702Ursus maritimus93.490.01566
LLPS-Aim-0108Ailuropoda melanoleuca92.930.01558
LLPS-Ict-3117Ictidomys tridecemlineatus92.650.01555
LLPS-Fec-2220Felis catus92.290.01555
LLPS-Sus-1290Sus scrofa92.180.01545
LLPS-Mup-0293Mustela putorius furo91.680.01475
LLPS-Otg-3646Otolemur garnettii91.490.01559
LLPS-Loa-0677Loxodonta africana91.340.01531
LLPS-Ova-2012Ovis aries91.250.01541
LLPS-Bot-0148Bos taurus91.060.01496
LLPS-Orc-1978Oryctolagus cuniculus90.960.01540
LLPS-Dio-4219Dipodomys ordii89.90.01510
LLPS-Caf-0307Canis familiaris89.760.01509
LLPS-Cap-3350Cavia porcellus88.670.01491
LLPS-Fud-3235Fukomys damarensis88.310.01506
LLPS-Mum-4363Mus musculus84.90.01427
LLPS-Ran-0310Rattus norvegicus84.40.01435
LLPS-Mea-1707Mesocricetus auratus84.160.01422
LLPS-Myl-0296Myotis lucifugus80.860.01350
LLPS-Mod-0509Monodelphis domestica76.750.01285
LLPS-Sah-0640Sarcophilus harrisii76.520.01285
LLPS-Pes-0045Pelodiscus sinensis67.030.01143
LLPS-Lac-2237Latimeria chalumnae65.780.01084
LLPS-Anc-0047Anolis carolinensis64.120.01063
LLPS-Anp-0702Anas platyrhynchos63.070.0 896
LLPS-Gaga-1009Gallus gallus60.890.01012
LLPS-Fia-0074Ficedula albicollis60.470.0 921
LLPS-Ora-0148Ornithorhynchus anatinus60.384e-100 319
LLPS-Tag-2103Taeniopygia guttata60.290.0 989
LLPS-Meg-0568Meleagris gallopavo59.950.0 912
LLPS-Leo-1681Lepisosteus oculatus58.080.0 971
LLPS-Asm-0854Astyanax mexicanus54.480.0 891
LLPS-Orn-0858Oreochromis niloticus53.890.0 894
LLPS-Dar-1216Danio rerio53.780.0 890
LLPS-Icp-0692Ictalurus punctatus53.540.0 890
LLPS-Scf-0846Scleropages formosus53.410.0 907
LLPS-Orl-1613Oryzias latipes53.00.0 874
LLPS-Scm-0529Scophthalmus maximus52.930.0 894
LLPS-Xet-0211Xenopus tropicalis50.890.0 830
LLPS-Gaa-2460Gasterosteus aculeatus50.830.0 840
LLPS-Tar-1214Takifugu rubripes49.080.0 814
LLPS-Pof-0325Poecilia formosa48.510.0 823
LLPS-Ten-3316Tetraodon nigroviridis48.334e-60 208
LLPS-Xim-0566Xiphophorus maculatus47.90.0 796
LLPS-Cis-0676Ciona savignyi36.921e-25 111
LLPS-Cii-0123Ciona intestinalis33.776e-89 300
LLPS-Drm-1252Drosophila melanogaster30.332e-67 247
LLPS-Abg-0228Absidia glauca29.231e-77 277
LLPS-Chr-0595Chlamydomonas reinhardtii29.082e-29 129
LLPS-Hea-0563Helianthus annuus29.029e-50 192
LLPS-Nec-0863Neurospora crassa28.668e-0757.0
LLPS-Usm-0543Ustilago maydis28.021e-51 200
LLPS-Spr-0462Sporisorium reilianum27.81e-53 206
LLPS-Zyt-0094Zymoseptoria tritici27.753e-1894.7
LLPS-Arl-2861Arabidopsis lyrata27.43e-0757.8
LLPS-Amt-0263Amborella trichopoda27.092e-59 221
LLPS-Dac-1954Daucus carota27.037e-53 202
LLPS-Mae-2088Manihot esculenta26.642e-49 191
LLPS-Vir-1272Vigna radiata26.549e-42 167
LLPS-Pot-1162Populus trichocarpa26.451e-43 174
LLPS-Mel-0371Melampsora laricipopulina26.185e-23 109
LLPS-Brn-2210Brassica napus26.172e-46 182
LLPS-Bro-1081Brassica oleracea26.172e-46 182
LLPS-Met-0827Medicago truncatula26.094e-41 166
LLPS-Phn-1433Phaeosphaeria nodorum25.942e-1275.9
LLPS-Phv-0960Phaseolus vulgaris25.942e-38 158
LLPS-Gor-0648Gossypium raimondii25.924e-46 181
LLPS-Pug-0960Puccinia graminis25.912e-1482.0
LLPS-Prp-1878Prunus persica25.818e-48 186
LLPS-Brr-2043Brassica rapa25.749e-44 175
LLPS-Yal-0240Yarrowia lipolytica25.517e-1789.7
LLPS-Thc-0706Theobroma cacao25.477e-46 180
LLPS-Nia-1963Nicotiana attenuata25.462e-44 176
LLPS-Dos-0144Dothistroma septosporum25.432e-1275.5
LLPS-Miv-0467Microbotryum violaceum25.372e-49 192
LLPS-Glm-0884Glycine max25.351e-44 177
LLPS-Coc-0901Corchorus capsularis25.332e-45 179
LLPS-Cus-1271Cucumis sativus25.085e-41 166
LLPS-Via-0747Vigna angularis25.061e-41 167
LLPS-Php-0017Physcomitrella patens25.033e-44 176
LLPS-Asn-0684Aspergillus nidulans25.02e-0655.1
LLPS-Sem-0689Selaginella moellendorffii24.824e-39 160
LLPS-Sol-0583Solanum lycopersicum24.829e-41 165
LLPS-Chc-0253Chondrus crispus24.782e-24 114
LLPS-Orb-0084Oryza barthii24.74e-35 147
LLPS-Art-2668Arabidopsis thaliana24.681e-42 171
LLPS-Sob-1451Sorghum bicolor24.661e-51 197
LLPS-Crn-0303Cryptococcus neoformans24.646e-35 147
LLPS-Orgl-0050Oryza glumaepatula24.581e-43 174
LLPS-Kop-0731Komagataella pastoris24.484e-0654.7
LLPS-Brd-0595Brachypodium distachyon24.461e-44 176
LLPS-Lep-0859Leersia perrieri24.424e-42 169
LLPS-Tra-1680Triticum aestivum24.392e-43 173
LLPS-Ori-0497Oryza indica24.252e-41 167
LLPS-Org-1832Oryza glaberrima24.257e-42 168
LLPS-Orr-2060Oryza rufipogon24.254e-42 169
LLPS-Blg-1154Blumeria graminis24.231e-1482.4
LLPS-Cogr-0723Colletotrichum graminicola24.218e-1995.9
LLPS-Hov-0205Hordeum vulgare24.25e-44 175
LLPS-Ors-1174Oryza sativa24.131e-41 168
LLPS-Orm-0231Oryza meridionalis24.081e-41 167
LLPS-Orni-0251Oryza nivara24.013e-41 166
LLPS-Zem-1011Zea mays23.922e-46 182
LLPS-Mua-0201Musa acuminata23.891e-38 158
LLPS-Sei-0413Setaria italica23.814e-48 187
LLPS-Coo-0699Colletotrichum orbiculare23.732e-1688.6
LLPS-Orp-1607Oryza punctata23.696e-43 171
LLPS-Orbr-0265Oryza brachyantha23.594e-43 173
LLPS-Pyt-0493Pyrenophora teres23.54e-1894.0
LLPS-Cog-0496Colletotrichum gloeosporioides23.112e-1584.7
LLPS-Asfu-0161Aspergillus fumigatus23.052e-0655.8
LLPS-Scc-0119Schizosaccharomyces cryophilus23.047e-31 134
LLPS-Ved-1178Verticillium dahliae22.747e-1067.0
LLPS-Fuv-0800Fusarium verticillioides22.425e-1170.9
LLPS-Ast-0220Aspergillus terreus22.291e-1585.9
LLPS-Gas-0056Galdieria sulphuraria22.252e-29 130
LLPS-Pytr-0879Pyrenophora triticirepentis22.243e-1894.7
LLPS-Scp-0989Schizosaccharomyces pombe22.219e-25 114
LLPS-Scj-0381Schizosaccharomyces japonicus22.22e-1997.4
LLPS-Lem-0110Leptosphaeria maculans22.24e-1790.5
LLPS-Trv-1615Trichoderma virens22.23e-1068.6
LLPS-Beb-0139Beauveria bassiana22.132e-0759.3
LLPS-Gag-0986Gaeumannomyces graminis22.012e-1069.3
LLPS-Aso-1266Aspergillus oryzae21.952e-21 104
LLPS-Trr-0996Trichoderma reesei21.853e-0965.1
LLPS-Osl-0003Ostreococcus lucimarinus21.22e-31 136
LLPS-Scs-0691Sclerotinia sclerotiorum21.063e-1274.7
LLPS-Asc-0242Aspergillus clavatus20.031e-0966.2
LLPS-Tum-0174Tuber melanosporum19.761e-1792.4