LLPS-Hos-0243
EIF5
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Stress granule | "...Using an RNA-mediated interference-based screen, we identify 101 human genes required for SG assembly, 39 genes required for PB assembly, and 31 genes required for coordinate SG and PB assembly." | U2OS cells | 18794846 |
| Stress granule | "...283 proteins identified as APEX hits in HEK293T cells or previously shown to associate with SGs." | N/A | 29373831 |
| Nucleolus, Others | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000560763.5 | ENSP00000452636.1 |
| Ensembl | ENST00000560338.5 | ENSP00000453633.1 |
| Ensembl | ENST00000558265.5 | ENSP00000453856.1 |
| Ensembl | ENST00000216554.7 | ENSP00000216554.3 |
| Ensembl | ENST00000558316.5 | ENSP00000453396.1 |
| Ensembl | ENST00000559130.5 | ENSP00000452615.1 |
| Ensembl | ENST00000558506.1 | ENSP00000453743.1 |
| Ensembl | ENST00000559532.5 | ENSP00000453468.1 |
| Ensembl | ENST00000392715.6 | ENSP00000376477.2 |
| Ensembl | ENST00000561325.5 | ENSP00000452883.1 |
| UniProt | P55010, IF5_HUMAN, Q53XB3, Q9H5N2, Q9UG48 | |
| GeneBank | U49436, AL080102, BC007728, AK026933, BC032866, BX537367, CH471061 | BAB15593.1, EAW81809.1, CAD97610.1, AAH32866.1, CAB45711.1, AAC50572.1, AAH07728.1 |
| RefSeq | NM_001969.4, NM_183004.4 | NP_001960.2, NP_892116.2 |
| Entrez | 1983 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSVNVNRSVS DQFYRYKMPR LIAKVEGKGN GIKTVIVNMV DVAKALNRPP TYPTKYFGCE 60 61 LGAQTQFDVK NDRYIVNGSH EANKLQDMLD GFIKKFVLCP ECENPETDLH VNPKKQTIGN 120 121 SCKACGYRGM LDTHHKLCTF ILKNPPENSD SGTGKKEKEK KNRKGKDKEN GSVSSSETPP 180 181 PPPPPNEINP PPHTMEEEED DDWGEDTTEE AQRRRMDEIS DHAKVLTLSD DLERTIEERV 240 241 NILFDFVKKK KEEGVIDSSD KEIVAEAERL DVKAMGPLVL TEVLFNEKIR EQIKKYRRHF 300 301 LRFCHNNKKA QRYLLHGLEC VVAMHQAQLI SKIPHILKEM YDADLLEEEV IISWSEKASK 360 361 KYVSKELAKE IRVKAEPFIK WLKEAEEESS GGEEEDEDEN IEVVYSKAAS VPKVETVKSD 420 421 NKDDDIDIDA I 431 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTGTCA ATGTCAACCG CAGCGTGTCA GACCAGTTCT ATCGCTACAA GATGCCCCGT 60 61 CTGATTGCCA AGGTTGAGGG CAAAGGCAAT GGAATCAAGA CAGTTATAGT CAACATGGTT 120 121 GACGTTGCAA AGGCGCTTAA TCGGCCTCCA ACGTATCCCA CCAAATATTT TGGTTGTGAG 180 181 CTGGGAGCAC AGACCCAGTT TGATGTTAAG AATGACCGTT ACATTGTCAA TGGATCTCAT 240 241 GAGGCGAATA AGCTGCAAGA CATGTTGGAT GGATTCATTA AAAAATTTGT TCTCTGTCCT 300 301 GAATGTGAGA ATCCTGAAAC AGATTTGCAT GTCAATCCAA AGAAGCAAAC AATAGGTAAT 360 361 TCTTGTAAAG CCTGTGGCTA TCGAGGCATG CTTGACACAC ATCATAAACT CTGCACATTC 420 421 ATTCTCAAAA ACCCACCTGA GAATAGTGAC AGTGGTACAG GAAAGAAAGA AAAAGAAAAG 480 481 AAAAACAGAA AGGGCAAAGA CAAGGAAAAT GGCTCCGTAT CCAGCAGTGA GACACCACCA 540 541 CCACCACCAC CACCAAATGA AATTAATCCT CCTCCACATA CAATGGAAGA AGAGGAGGAT 600 601 GATGACTGGG GAGAAGATAC AACTGAGGAA GCTCAAAGGC GTCGAATGGA TGAAATCAGT 660 661 GACCATGCAA AAGTTCTGAC ACTCAGTGAT GATTTGGAAA GAACAATTGA GGAGAGGGTC 720 721 AATATCCTCT TTGATTTTGT TAAGAAAAAG AAAGAAGAGG GTGTTATTGA TTCATCTGAC 780 781 AAAGAAATCG TTGCTGAAGC AGAAAGACTG GATGTAAAAG CCATGGGCCC TCTTGTTCTA 840 841 ACTGAAGTTC TTTTTAATGA GAAGATTAGA GAACAGATTA AGAAATACAG GCGCCATTTC 900 901 CTACGATTTT GTCACAACAA CAAAAAAGCC CAACGGTACC TTCTTCATGG TTTGGAGTGT 960 961 GTGGTAGCAA TGCATCAAGC TCAGCTTATC TCCAAGATTC CACATATCTT GAAGGAGATG 1020 1021 TACGATGCAG ACCTTTTAGA AGAAGAGGTC ATCATCAGCT GGTCGGAAAA GGCCTCTAAG 1080 1081 AAATATGTCT CCAAAGAACT TGCCAAAGAG ATTCGTGTCA AAGCAGAACC ATTTATAAAA 1140 1141 TGGTTGAAGG AGGCAGAGGA AGAATCTTCT GGTGGCGAAG AAGAAGATGA AGATGAGAAC 1200 1201 ATTGAGGTGG TGTATTCGAA GGCTGCCAGT GTACCGAAAG TTGAGACTGT AAAGTCAGAC 1260 1261 AACAAGGATG ACGACATCGA TATTGATGCC ATTTAA 1296 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Cellular Component | Plasma membrane | |
Molecular Function | Cadherin binding | |
Molecular Function | Eukaryotic initiation factor eIF2 binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | RNA binding | |
Molecular Function | Translation factor activity, RNA binding | |
Molecular Function | Translation initiation factor activity | |
Biological Process | Activation of GTPase activity | |
Biological Process | Formation of translation preinitiation complex | |
Biological Process | Regulation of translational initiation | |
Biological Process | Translational initiation |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-0033 | Gorilla gorilla | 100.0 | 0.0 | 686 |
| LLPS-Aon-3837 | Aotus nancymaae | 100.0 | 4e-43 | 153 |
| LLPS-Pat-1426 | Pan troglodytes | 99.77 | 0.0 | 726 |
| LLPS-Pap-1977 | Pan paniscus | 99.77 | 0.0 | 726 |
| LLPS-Nol-2781 | Nomascus leucogenys | 99.54 | 0.0 | 711 |
| LLPS-Poa-1437 | Pongo abelii | 99.3 | 0.0 | 711 |
| LLPS-Mam-0476 | Macaca mulatta | 99.07 | 0.0 | 707 |
| LLPS-Man-2667 | Macaca nemestrina | 99.07 | 0.0 | 707 |
| LLPS-Chs-1687 | Chlorocebus sabaeus | 99.07 | 0.0 | 707 |
| LLPS-Maf-0469 | Macaca fascicularis | 99.07 | 0.0 | 707 |
| LLPS-Rhb-1219 | Rhinopithecus bieti | 98.84 | 0.0 | 707 |
| LLPS-Mal-0796 | Mandrillus leucophaeus | 97.69 | 0.0 | 704 |
| LLPS-Myl-3457 | Myotis lucifugus | 97.45 | 0.0 | 716 |
| LLPS-Cea-1608 | Cercocebus atys | 97.45 | 0.0 | 703 |
| LLPS-Otg-0735 | Otolemur garnettii | 97.22 | 0.0 | 711 |
| LLPS-Dio-1240 | Dipodomys ordii | 97.22 | 0.0 | 701 |
| LLPS-Loa-1722 | Loxodonta africana | 96.98 | 0.0 | 701 |
| LLPS-Mea-2559 | Mesocricetus auratus | 96.98 | 0.0 | 701 |
| LLPS-Caj-0237 | Callithrix jacchus | 96.75 | 0.0 | 697 |
| LLPS-Cas-0560 | Carlito syrichta | 96.52 | 0.0 | 697 |
| LLPS-Ict-1244 | Ictidomys tridecemlineatus | 96.52 | 0.0 | 699 |
| LLPS-Sus-0198 | Sus scrofa | 96.52 | 0.0 | 709 |
| LLPS-Mod-0160 | Monodelphis domestica | 96.3 | 0.0 | 697 |
| LLPS-Sah-1387 | Sarcophilus harrisii | 96.3 | 0.0 | 697 |
| LLPS-Eqc-0729 | Equus caballus | 96.29 | 0.0 | 695 |
| LLPS-Mum-1720 | Mus musculus | 96.29 | 0.0 | 697 |
| LLPS-Caf-0315 | Canis familiaris | 96.06 | 0.0 | 696 |
| LLPS-Urm-1059 | Ursus maritimus | 96.06 | 0.0 | 696 |
| LLPS-Ran-1355 | Rattus norvegicus | 96.06 | 0.0 | 696 |
| LLPS-Aim-0589 | Ailuropoda melanoleuca | 96.06 | 0.0 | 696 |
| LLPS-Fud-0257 | Fukomys damarensis | 96.06 | 0.0 | 699 |
| LLPS-Paa-2897 | Papio anubis | 95.95 | 0.0 | 696 |
| LLPS-Fec-1859 | Felis catus | 95.94 | 0.0 | 689 |
| LLPS-Mup-1460 | Mustela putorius furo | 95.82 | 0.0 | 695 |
| LLPS-Ova-2113 | Ovis aries | 95.82 | 0.0 | 692 |
| LLPS-Bot-0338 | Bos taurus | 95.82 | 0.0 | 706 |
| LLPS-Anp-1748 | Anas platyrhynchos | 94.06 | 2e-66 | 214 |
| LLPS-Ora-1817 | Ornithorhynchus anatinus | 92.93 | 0.0 | 676 |
| LLPS-Cap-0037 | Cavia porcellus | 92.11 | 0.0 | 692 |
| LLPS-Fia-0994 | Ficedula albicollis | 91.69 | 0.0 | 661 |
| LLPS-Tut-0111 | Tursiops truncatus | 91.6 | 0.0 | 610 |
| LLPS-Tag-1699 | Taeniopygia guttata | 91.45 | 0.0 | 660 |
| LLPS-Pes-0699 | Pelodiscus sinensis | 91.39 | 0.0 | 659 |
| LLPS-Gaga-1535 | Gallus gallus | 90.79 | 0.0 | 554 |
| LLPS-Anc-0200 | Anolis carolinensis | 90.28 | 0.0 | 667 |
| LLPS-Orc-2190 | Oryctolagus cuniculus | 88.17 | 0.0 | 642 |
| LLPS-Meg-0877 | Meleagris gallopavo | 87.41 | 0.0 | 652 |
| LLPS-Xet-0230 | Xenopus tropicalis | 84.0 | 1e-125 | 371 |
| LLPS-Lac-0372 | Latimeria chalumnae | 82.23 | 0.0 | 628 |
| LLPS-Asm-1349 | Astyanax mexicanus | 75.98 | 0.0 | 567 |
| LLPS-Leo-0301 | Lepisosteus oculatus | 74.88 | 0.0 | 582 |
| LLPS-Scf-0107 | Scleropages formosus | 74.7 | 0.0 | 582 |
| LLPS-Dar-1420 | Danio rerio | 73.63 | 0.0 | 564 |
| LLPS-Xim-2819 | Xiphophorus maculatus | 73.52 | 0.0 | 590 |
| LLPS-Orl-2039 | Oryzias latipes | 73.46 | 0.0 | 578 |
| LLPS-Pof-0912 | Poecilia formosa | 73.29 | 0.0 | 587 |
| LLPS-Tar-2344 | Takifugu rubripes | 73.22 | 0.0 | 578 |
| LLPS-Orn-2381 | Oreochromis niloticus | 73.11 | 0.0 | 572 |
| LLPS-Icp-1391 | Ictalurus punctatus | 73.1 | 0.0 | 562 |
| LLPS-Cae-1198 | Caenorhabditis elegans | 72.6 | 2e-69 | 233 |
| LLPS-Ten-0435 | Tetraodon nigroviridis | 72.1 | 0.0 | 573 |
| LLPS-Scm-3797 | Scophthalmus maximus | 71.73 | 0.0 | 573 |
| LLPS-Gaa-1751 | Gasterosteus aculeatus | 71.56 | 0.0 | 570 |
| LLPS-Mel-0365 | Melampsora laricipopulina | 66.44 | 5e-63 | 215 |
| LLPS-Usm-0040 | Ustilago maydis | 65.97 | 1e-61 | 212 |
| LLPS-Spr-0627 | Sporisorium reilianum | 65.97 | 5e-62 | 213 |
| LLPS-Scc-0183 | Schizosaccharomyces cryophilus | 65.52 | 1e-63 | 216 |
| LLPS-Put-0003 | Puccinia triticina | 65.07 | 2e-61 | 210 |
| LLPS-Pug-1073 | Puccinia graminis | 65.07 | 3e-61 | 210 |
| LLPS-Scj-0618 | Schizosaccharomyces japonicus | 64.54 | 1e-57 | 200 |
| LLPS-Zyt-0031 | Zymoseptoria tritici | 64.14 | 1e-54 | 193 |
| LLPS-Abg-1780 | Absidia glauca | 63.51 | 2e-62 | 213 |
| LLPS-Fuo-0960 | Fusarium oxysporum | 62.5 | 5e-52 | 186 |
| LLPS-Fuv-0275 | Fusarium verticillioides | 62.5 | 4e-52 | 186 |
| LLPS-Dos-0408 | Dothistroma septosporum | 62.07 | 3e-52 | 187 |
| LLPS-Trv-0610 | Trichoderma virens | 62.07 | 1e-52 | 187 |
| LLPS-Cog-1039 | Colletotrichum gloeosporioides | 62.07 | 3e-52 | 187 |
| LLPS-Sem-0147 | Selaginella moellendorffii | 61.97 | 3e-52 | 187 |
| LLPS-Ved-0773 | Verticillium dahliae | 61.81 | 6e-52 | 186 |
| LLPS-Fus-0872 | Fusarium solani | 61.81 | 2e-51 | 184 |
| LLPS-Trr-0669 | Trichoderma reesei | 61.38 | 8e-52 | 185 |
| LLPS-Coo-0034 | Colletotrichum orbiculare | 61.11 | 1e-51 | 185 |
| LLPS-Org-0021 | Oryza glaberrima | 60.58 | 7e-51 | 184 |
| LLPS-Orm-0964 | Oryza meridionalis | 60.58 | 1e-50 | 183 |
| LLPS-Orr-0796 | Oryza rufipogon | 60.58 | 1e-50 | 183 |
| LLPS-Prp-1677 | Prunus persica | 60.58 | 2e-50 | 182 |
| LLPS-Orbr-0626 | Oryza brachyantha | 60.58 | 1e-50 | 183 |
| LLPS-Ors-0421 | Oryza sativa | 60.58 | 7e-51 | 184 |
| LLPS-Orp-0520 | Oryza punctata | 60.58 | 1e-50 | 183 |
| LLPS-Gas-0309 | Galdieria sulphuraria | 60.58 | 2e-48 | 177 |
| LLPS-Orgl-0429 | Oryza glumaepatula | 60.58 | 6e-51 | 184 |
| LLPS-Lep-1549 | Leersia perrieri | 60.58 | 3e-50 | 182 |
| LLPS-Orni-0103 | Oryza nivara | 60.58 | 7e-51 | 184 |
| LLPS-Sol-1836 | Solanum lycopersicum | 60.58 | 6e-49 | 183 |
| LLPS-Ori-2092 | Oryza indica | 60.58 | 7e-51 | 184 |
| LLPS-Orb-0738 | Oryza barthii | 60.58 | 7e-51 | 184 |
| LLPS-Asg-0817 | Ashbya gossypii | 60.53 | 7e-57 | 199 |
| LLPS-Cogr-0173 | Colletotrichum graminicola | 60.0 | 4e-51 | 184 |
| LLPS-Php-0364 | Physcomitrella patens | 59.86 | 1e-50 | 184 |
| LLPS-Gag-0566 | Gaeumannomyces graminis | 59.86 | 2e-51 | 184 |
| LLPS-Tru-0092 | Triticum urartu | 59.85 | 2e-50 | 182 |
| LLPS-Nia-1095 | Nicotiana attenuata | 59.85 | 2e-50 | 183 |
| LLPS-Amt-0382 | Amborella trichopoda | 59.85 | 4e-50 | 182 |
| LLPS-Pot-0586 | Populus trichocarpa | 59.85 | 3e-49 | 179 |
| LLPS-Via-1176 | Vigna angularis | 59.85 | 2e-49 | 179 |
| LLPS-Sot-0865 | Solanum tuberosum | 59.85 | 3e-50 | 182 |
| LLPS-Thc-1416 | Theobroma cacao | 59.85 | 4e-50 | 182 |
| LLPS-Glm-0811 | Glycine max | 59.85 | 1e-48 | 177 |
| LLPS-Yal-0546 | Yarrowia lipolytica | 59.72 | 4e-55 | 194 |
| LLPS-Coc-1786 | Corchorus capsularis | 59.56 | 2e-45 | 168 |
| LLPS-Asni-0959 | Aspergillus niger | 59.44 | 3e-51 | 184 |
| LLPS-Zem-0742 | Zea mays | 59.42 | 7e-49 | 180 |
| LLPS-Pytr-0383 | Pyrenophora triticirepentis | 59.31 | 7e-52 | 186 |
| LLPS-Pyt-0317 | Pyrenophora teres | 59.31 | 5e-52 | 186 |
| LLPS-Blg-0456 | Blumeria graminis | 59.31 | 6e-50 | 179 |
| LLPS-Sac-0319 | Saccharomyces cerevisiae | 59.18 | 6e-53 | 188 |
| LLPS-Map-0185 | Magnaporthe poae | 59.18 | 2e-50 | 182 |
| LLPS-Crn-0123 | Cryptococcus neoformans | 59.18 | 1e-55 | 195 |
| LLPS-Sei-0307 | Setaria italica | 59.15 | 3e-51 | 185 |
| LLPS-Phv-0557 | Phaseolus vulgaris | 59.12 | 1e-48 | 177 |
| LLPS-Chr-0187 | Chlamydomonas reinhardtii | 58.87 | 2e-49 | 180 |
| LLPS-Ast-0191 | Aspergillus terreus | 58.74 | 7e-50 | 180 |
| LLPS-Asf-0078 | Aspergillus flavus | 58.74 | 1e-50 | 182 |
| LLPS-Aso-0800 | Aspergillus oryzae | 58.74 | 1e-50 | 182 |
| LLPS-Lem-0410 | Leptosphaeria maculans | 58.62 | 6e-52 | 186 |
| LLPS-Hea-1927 | Helianthus annuus | 58.62 | 2e-50 | 182 |
| LLPS-Nec-0206 | Neurospora crassa | 58.5 | 1e-50 | 182 |
| LLPS-Mao-1398 | Magnaporthe oryzae | 58.5 | 8e-50 | 180 |
| LLPS-Sob-0205 | Sorghum bicolor | 58.45 | 2e-50 | 182 |
| LLPS-Tra-0628 | Triticum aestivum | 58.45 | 1e-50 | 183 |
| LLPS-Brd-1399 | Brachypodium distachyon | 58.45 | 6e-51 | 184 |
| LLPS-Met-0357 | Medicago truncatula | 58.45 | 3e-50 | 182 |
| LLPS-Hov-0817 | Hordeum vulgare | 58.45 | 1e-50 | 183 |
| LLPS-Viv-0103 | Vitis vinifera | 58.39 | 3e-48 | 176 |
| LLPS-Cus-0247 | Cucumis sativus | 58.39 | 6e-50 | 181 |
| LLPS-Kop-0457 | Komagataella pastoris | 58.39 | 6e-51 | 182 |
| LLPS-Dac-0482 | Daucus carota | 58.39 | 2e-48 | 177 |
| LLPS-Asfu-0649 | Aspergillus fumigatus | 58.04 | 5e-50 | 181 |
| LLPS-Nef-0177 | Neosartorya fischeri | 58.04 | 5e-50 | 181 |
| LLPS-Asn-0372 | Aspergillus nidulans | 58.04 | 4e-49 | 178 |
| LLPS-Phn-0848 | Phaeosphaeria nodorum | 57.93 | 2e-50 | 182 |
| LLPS-Mua-2236 | Musa acuminata | 57.93 | 5e-49 | 178 |
| LLPS-Art-0460 | Arabidopsis thaliana | 57.66 | 2e-49 | 179 |
| LLPS-Arl-0953 | Arabidopsis lyrata | 57.66 | 7e-49 | 178 |
| LLPS-Gor-1682 | Gossypium raimondii | 57.34 | 3e-47 | 171 |
| LLPS-Asc-0578 | Aspergillus clavatus | 57.34 | 5e-50 | 181 |
| LLPS-Bro-0639 | Brassica oleracea | 57.25 | 4e-48 | 175 |
| LLPS-Brn-2043 | Brassica napus | 56.93 | 7e-48 | 176 |
| LLPS-Brr-0774 | Brassica rapa | 56.52 | 1e-47 | 174 |
| LLPS-Mae-0550 | Manihot esculenta | 56.25 | 1e-46 | 172 |
| LLPS-Chc-0573 | Chondrus crispus | 54.48 | 4e-43 | 162 |
| LLPS-Osl-0757 | Ostreococcus lucimarinus | 54.11 | 6e-46 | 170 |
| LLPS-Cis-0432 | Ciona savignyi | 53.81 | 3e-132 | 395 |
| LLPS-Cii-0195 | Ciona intestinalis | 52.76 | 2e-131 | 393 |
| LLPS-Cym-0735 | Cyanidioschyzon merolae | 51.7 | 1e-45 | 172 |
| LLPS-Drm-0826 | Drosophila melanogaster | 47.54 | 1e-120 | 367 |
| LLPS-Scp-0486 | Schizosaccharomyces pombe | 41.93 | 1e-79 | 258 |
| LLPS-Miv-0112 | Microbotryum violaceum | 40.31 | 3e-84 | 270 |
| LLPS-Beb-0935 | Beauveria bassiana | 39.55 | 1e-69 | 233 |
| LLPS-Tum-1070 | Tuber melanosporum | 37.28 | 5e-70 | 233 |