LLPS-Hos-0133
FAM193A
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Protein FAM193A; Protein IT14 |
| Gene Name: | FAM193A, C4orf8, RES4-22 |
| Ensembl Gene: | ENSG00000125386.15 |
| Ensembl Protein: | ENSP00000421200.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Client |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| P-body | "...Analysis of correlated patterns between endogenous preys uncovers the spatial organization of RNA regulatory structures and enables the definition of 144 core components of SGs and PBs." | N/A | 29395067 |
| Stress granule | "...Analysis of correlated patterns between endogenous preys uncovers the spatial organization of RNA regulatory structures and enables the definition of 144 core components of SGs and PBs." | N/A | 29395067 |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000505311.5 | ENSP00000421200.1 |
| Ensembl | ENST00000502458.5 | ENSP00000427505.1 |
| Ensembl | ENST00000512465.5 | ENSP00000423852.1 |
| Ensembl | ENST00000382839.7 | ENSP00000372290.3 |
| Ensembl | ENST00000513898.5 | ENSP00000421369.1 |
| Ensembl | ENST00000545951.5 | ENSP00000443617.1 |
| Ensembl | ENST00000637812.1 | ENSP00000490564.1 |
| Ensembl | ENST00000513350.2 | ENSP00000427260.1 |
| Ensembl | ENST00000324666.9 | ENSP00000324587.5 |
| UniProt | P78312, F193A_HUMAN, B7ZM85, B9EGR0, E9PFA1, O43607, P78311, P78313, Q9UEG8 | |
| GeneBank | AB001563, BC136646, AB000459, BC144340, AB000460, AL110117, AB000461, AF040966 | BAA19117.1, AAI36647.1, BAA19116.1, AAB97012.1, BAA31858.1, AAI44341.1, BAA19118.1 |
| RefSeq | NM_001256666.1, NM_001256667.1, NM_001256668.1, NM_003704.3, XM_006713930.2 | NP_001243595.1, NP_001243596.1, NP_001243597.1, NP_003695.3, XP_006713993.2 |
| Entrez | 8603 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSPADAKRGA KRRKNKRGGG GGSGGGNGGA SSGKAGPAAA LRGSQAAGLA APGSAAGLVG 60 61 GAAAANGPLG AGASAGGAAP GGYFETPFSF GMNHRTPPYP AGDYCLLCRS ERKDSSFLES 120 121 GIKTASKLAL SMAPKGNSVL HLPLWVCPDC RRTVEKEERH GGLDQPVSQD FLLHSSLGGS 180 181 QPEAGSGGRL ALGAQTLPSD TACSCEACSE RREISAEADR EPQQLQNYWS EVRYTVRCIY 240 241 RQAGTPLADD QDQSLVPDKE GVKELVDRLC ERDPYQLYQR LEQQAREYVL EMKVRLLRQL 300 301 SAAAKVKAPS GLQGPPQAHQ FISLLLEEYG ALCQAARSIS TFLGTLENEH LKKFQVTWEL 360 361 HNKHLFENLV FSEPLLQSNL PALVSQIRLG TTTHDTCSED TYSTLLQRYQ RSEEELRRVA 420 421 EEWLECQKRI DAYVDEQMTM KTKQRMLTED WELFKQRRFI EEQLTNKKAV TGENNFTDTM 480 481 RHMLSSRLSM PDCPNCNYRR RCACDDCSLS HILTCGIMDP PVTDDIHIHQ LPLQVDPAPD 540 541 YLAERSPPSV SSASSGSGSS SPITIQQHPR LILTDSGSAP TFCSDDEDVA PLSAKFADIY 600 601 PLSNYDDTEV VANMNGIHSE LNGGGENMAL KDESPQISST SSSSSEADDE EADGESSGEP 660 661 PGAPKEDGVL GSRSPRTEES KADSPPPSYP TQQAEQAPNT CECHVCKQEA SGLTPSAMTA 720 721 GALPPGHQFL SPEKPTHPAL HLYPHIHGHV PLHTVPHLPR PLIHPTLYAT PPFTHSKALP 780 781 PAPVQNHTNK HQVFNASLQD HIYPSCFGNT PEWNSSKFIS LWGSEVMNDK NWNPGTFLPD 840 841 TISGSEILGP TLSETRPEAL PPPSSNETPA VSDSKEKKNA AKKKCLYNFQ DAFMEANKVV 900 901 MATSSATSSV SCTATTVQSS NSQFRVSSKR PPSVGDVFHG ISKEDHRHSA PAAPRNSPTG 960 961 LAPLPALSPA ALSPAALSPA STPHLANLAA PSFPKTATTT PGFVDTRKSF CPAPLPPATD 1020 1021 GSISAPPSVC SDPDCEGHRC ENGVYDPQQD DGDESADEDS CSEHSSSTST STNQKEGKYC 1080 1081 DCCYCEFFGH GGPPAAPTSR NYAEMREKLR LRLTKRKEEQ PKKMDQISER ESVVDHRRVE 1140 1141 DLLQFINSSE TKPVSSTRAA KRARHKQRKL EEKARLEAEA RAREHLHLQE EQRRREEEED 1200 1201 EEEEEDRFKE EFQRLQELQK LRAVKKKKKE RPSKDCPKLD MLTRNFQAAT ESVPNSGNIH 1260 1261 NGSLEQTEEP ETSSHSPSRH MNHSEPRPGL GADGDAADPV DTRDSKFLLP KEVNGKQHEP 1320 1321 LSFFFDIMQH HKEGNGKQKL RQTSKASSEP ARRPTEPPKA TEGQSKPRAQ TESKAKVVDL 1380 1381 MSITEQKREE RKVNSNNNNK KQLNHIKDEK SNPTPMEPTS PGEHQQNSKL VLAESPQPKG 1440 1441 KNKKNKKKKG DRVNNSIDDV FLPKDIDLDS VDMDETEREV EYFKRFCLDS ARQTRQRLSI 1500 1501 NWSNFSLKKA TFAAH 1515 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAGGTCC GCCTGCTCCG GCAGCTGTCG GCTGCGGCCA AGGTGAAGGC ACCATCTGGC 60 61 CTGCAGGGCC CGCCGCAAGC GCACCAGTTC ATCTCCCTCC TGCTTGAGGA GTACGGCGCC 120 121 CTCTGCCAGG CCGCACGCTC CATCAGCACC TTCCTTGGCA CTCTGGAAAA TGAACACTTG 180 181 AAAAAGTTCC AAGTGACGTG GGAACTGCAT AATAAACACC TGTTTGAAAA TCTGGTCTTT 240 241 TCGGAGCCAC TTCTTCAGAG CAACTTGCCC GCACTGGTGT CACAGATCAG GCTAGGAACC 300 301 ACCACACACG ACACCTGCAG TGAGGACACA TACAGTACCT TGCTGCAGAG GTACCAGCGT 360 361 TCCGAGGAGG AGCTGCGCAG AGTCGCCGAG GAGTGGCTGG AGTGCCAGAA GAGGATCGAC 420 421 GCCTATGTCG ACGAGCAGAT GACAATGAAA ACCAAGCAGC GCATGTTAAC AGAAGACTGG 480 481 GAGCTTTTTA AACAAAGAAG ATTCATTGAA GAACAGTTAA CCAATAAGAA AGCAGTTACT 540 541 GGCGAGAACA ACTTCACAGA CACCATGAGG CACATGTTAT CGTCCCGGCT GAGCATGCCC 600 601 GACTGCCCCA ACTGCAACTA CAGGAGAAGA TGTGCTTGCG ATGACTGCAG TCTCTCACAC 660 661 ATCCTCACGT GTGGTATCAT GGACCCCCCC GTCACTGATG ACATCCACAT TCACCAGCTC 720 721 CCACTTCAAG TGGATCCTGC TCCTGACTAT CTTGCTGAGA GGAGCCCGCC CAGTGTGTCA 780 781 TCTGCAAGCT CGGGGTCCGG CTCCAGCTCT CCCATCACAA TTCAGCAGCA CCCCAGGCTC 840 841 ATCCTCACAG ACAGTGGCTC GGCACCAACT TTTTGTAGTG ATGATGAAGA TGTTGCACCA 900 901 TTGTCAGCCA AATTTGCTGA TATTTATCCA TTGAGTAATT ATGATGATAC CGAGGTGGTG 960 961 GCCAACATGA ATGGAATCCA CAGCGAATTG AATGGTGGCG GGGAAAACAT GGCCCTGAAG 1020 1021 GATGAGTCTC CTCAGATAAG CAGTACCAGC AGTAGTTCCT CAGAAGCTGA TGATGAAGAA 1080 1081 GCGGACGGCG AGAGTAGTGG GGAGCCCCCA GGGGCCCCGA AGGAAGATGG AGTGCTGGGA 1140 1141 AGCAGGAGCC CCAGGACAGA GGAGAGCAAA GCAGACAGTC CACCCCCATC CTACCCAACA 1200 1201 CAGCAGGCTG AACAAGCTCC AAACACTTGT GAATGTCATG TTTGTAAGCA GGAAGCTTCT 1260 1261 GGACTGACAC CATCTGCAAT GACAGCCGGA GCCCTTCCTC CTGGCCATCA GTTCTTGAGC 1320 1321 CCAGAGAAGC CCACACACCC TGCACTGCAC CTTTACCCTC ACATCCATGG ACATGTGCCT 1380 1381 TTGCACACTG TTCCACACCT GCCACGCCCT CTCATCCACC CCACCTTGTA TGCAACGCCC 1440 1441 CCCTTCACAC ACAGTAAGGC TTTACCGCCA GCACCTGTTC AGAATCACAC AAATAAGCAT 1500 1501 CAGGTATTCA ATGCATCTCT TCAAGACCAT ATTTATCCGA GCTGTTTTGG GAATACTCCA 1560 1561 GAGTGGAATA GTTCTAAATT TATAAGTCTT TGGGGATCAG AAGTGATGAA TGATAAGAAC 1620 1621 TGGAATCCTG GCACTTTCTT GCCAGATACA ATTTCTGGGA GTGAAATATT AGGGCCAACA 1680 1681 CTCTCAGAAA CAAGACCGGA AGCCCTTCCA CCTCCATCTA GCAATGAAAC ACCTGCAGTC 1740 1741 TCGGATAGTA AAGAGAAAAA GAATGCTGCA AAAAAGAAAT GTTTATACAA TTTCCAAGAT 1800 1801 GCTTTCATGG AAGCAAATAA AGTTGTCATG GCCACGTCAT CAGCCACGTC CTCTGTGTCC 1860 1861 TGCACAGCTA CCACAGTGCA GTCCAGCAAC AGCCAGTTCA GAGTGTCATC CAAGAGACCT 1920 1921 CCTTCAGTAG GTGACGTGTT TCATGGCATC AGCAAGGAGG ACCACAGACA CTCGGCCCCA 1980 1981 GCCGCCCCGA GGAATAGCCC CACGGGCTTG GCCCCCCTCC CAGCGCTCTC GCCTGCTGCG 2040 2041 CTGTCACCTG CTGCGCTCTC ACCTGCCTCC ACACCTCACC TTGCAAATCT TGCAGCCCCA 2100 2101 TCATTCCCCA AAACAGCAAC CACAACTCCT GGGTTTGTGG ACACACGCAA GAGTTTCTGT 2160 2161 CCTGCACCCC TACCCCCGGC CACAGATGGC TCCATTAGCG CCCCTCCAAG TGTCTGCAGT 2220 2221 GACCCTGACT GCGAAGGGCA CCGCTGCGAG AATGGTGTCT ACGACCCACA GCAGGATGAT 2280 2281 GGGGACGAGA GTGCAGATGA GGACAGCTGC TCTGAGCACA GCTCCAGCAC CTCGACCTCC 2340 2341 ACCAACCAGA AGGAGGGCAA GTACTGCGAC TGCTGCTACT GCGAATTCTT TGGGCACGGC 2400 2401 GGGCCTCCAG CTGCACCAAC AAGTAGAAAT TATGCAGAAA TGAGGGAAAA GCTTCGCTTA 2460 2461 CGGCTGACCA AGAGGAAAGA GGAGCAACCT AAAAAAATGG ACCAGATCTC AGAAAGGGAA 2520 2521 AGCGTCGTTG ACCATCGGAG GGTGGAGGAT TTGTTGCAGT TTATAAATAG CTCCGAAACC 2580 2581 AAACCAGTGA GCAGCACGCG TGCAGCGAAG CGAGCAAGGC ATAAGCAAAG GAAGCTGGAG 2640 2641 GAGAAAGCTC GCCTAGAAGC AGAGGCCAGG GCCCGGGAGC ACCTGCACCT CCAGGAGGAG 2700 2701 CAGAGGCGGC GGGAGGAGGA GGAGGATGAG GAAGAAGAGG AGGATCGTTT CAAGGAGGAA 2760 2761 TTTCAGCGGC TTCAGGAGCT TCAGAAGCTA AGAGCTGTAA AAAAGAAGAA GAAGGAGAGG 2820 2821 CCAAGTAAAG ACTGCCCCAA GTTGGACATG CTCACTAGAA ATTTCCAGGC AGCAACAGAG 2880 2881 TCTGTTCCTA ACTCTGGAAA CATCCACAAT GGCTCACTAG AGCAAACTGA AGAACCAGAA 2940 2941 ACCTCTTCTC ACTCCCCATC CAGGCATATG AACCACTCAG AGCCCAGGCC AGGGCTAGGG 3000 3001 GCTGATGGGG ATGCTGCAGA CCCCGTCGAC ACCAGAGACT CCAAATTTCT CCTCCCCAAG 3060 3061 GAGGTGAATG GGAAGCAGCA TGAGCCACTC TCTTTTTTCT TCGACATCAT GCAGCACCAT 3120 3121 AAAGAAGGAA ATGGCAAGCA GAAGCTGAGG CAGACCAGCA AGGCCAGCAG CGAGCCAGCG 3180 3181 AGGAGGCCCA CAGAGCCCCC CAAGGCCACA GAGGGGCAGT CCAAGCCCCG GGCCCAGACT 3240 3241 GAGTCAAAGG CTAAGGTGGT CGACCTCATG TCCATCACAG AGCAGAAAAG AGAGGAGAGA 3300 3301 AAAGTCAACA GTAATAACAA TAACAAAAAG CAGCTGAACC ACATCAAGGA CGAAAAGTCA 3360 3361 AACCCAACCC CTATGGAGCC CACCTCTCCC GGTGAGCATC AGCAGAACAG CAAGCTGGTG 3420 3421 CTGGCAGAGT CCCCTCAGCC AAAGGGCAAG AACAAGAAAA ATAAGAAGAA GAAAGGAGAC 3480 3481 AGAGTCAACA ATTCAATTGA TGGAGTTTCG CTCTTGTTGC CCAGTCTGGG GTACAATGGT 3540 3541 GCAATCTTGG CTCACTGCAA CCTTCGCCTC CCAGGTTCAA GCGATTGTGC TGCCTCAGCC 3600 3601 TCCCAAGTAG TTGGAATTAC AGATGATGTC TTTCTACCTA AAGATATTGA CCTAGACAGT 3660 3661 GTGGATATGG ATGAGACAGA GAGGGAAGTG GAATATTTCA AAAGGTTCTG CTTGGATTCT 3720 3721 GCTAGACAGA CCCGACAAAG ACTGTCTATC AACTGGTCCA ATTTTAGCTT GAAAAAAGCC 3780 3781 ACCTTTGCTG CCCACTGA 3798 |
▼ ANNOTATION
| Domain | ||||
| SMART | LCR-eXXXplorer | CDD | ||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gog-3778 | Gorilla gorilla | 98.97 | 0.0 | 915 |
| LLPS-Poa-3699 | Pongo abelii | 98.86 | 0.0 | 1936 |
| LLPS-Nol-4626 | Nomascus leucogenys | 98.81 | 0.0 | 2367 |
| LLPS-Chs-1157 | Chlorocebus sabaeus | 97.76 | 0.0 | 2339 |
| LLPS-Rhb-1854 | Rhinopithecus bieti | 97.63 | 0.0 | 2343 |
| LLPS-Pap-0460 | Pan paniscus | 96.51 | 0.0 | 2352 |
| LLPS-Asm-3470 | Astyanax mexicanus | 96.49 | 6e-26 | 120 |
| LLPS-Maf-2041 | Macaca fascicularis | 95.68 | 0.0 | 2355 |
| LLPS-Mal-4351 | Mandrillus leucophaeus | 95.68 | 0.0 | 2353 |
| LLPS-Cea-2617 | Cercocebus atys | 95.61 | 0.0 | 2352 |
| LLPS-Paa-3102 | Papio anubis | 95.55 | 0.0 | 2360 |
| LLPS-Pat-0764 | Pan troglodytes | 95.54 | 0.0 | 2367 |
| LLPS-Caj-1635 | Callithrix jacchus | 94.0 | 0.0 | 2303 |
| LLPS-Mam-4363 | Macaca mulatta | 92.75 | 0.0 | 1907 |
| LLPS-Anc-3151 | Anolis carolinensis | 91.38 | 7e-26 | 120 |
| LLPS-Scf-1310 | Scleropages formosus | 90.11 | 4e-32 | 141 |
| LLPS-Man-3780 | Macaca nemestrina | 89.7 | 0.0 | 2122 |
| LLPS-Cas-0525 | Carlito syrichta | 89.54 | 0.0 | 1602 |
| LLPS-Tar-0700 | Takifugu rubripes | 89.01 | 9e-32 | 140 |
| LLPS-Scm-0077 | Scophthalmus maximus | 89.01 | 3e-31 | 138 |
| LLPS-Loa-0601 | Loxodonta africana | 89.0 | 0.0 | 1373 |
| LLPS-Eqc-0638 | Equus caballus | 88.65 | 0.0 | 2173 |
| LLPS-Sus-1022 | Sus scrofa | 88.1 | 0.0 | 1661 |
| LLPS-Orl-2737 | Oryzias latipes | 87.91 | 1e-31 | 139 |
| LLPS-Xim-2111 | Xiphophorus maculatus | 87.1 | 9e-32 | 140 |
| LLPS-Pof-1098 | Poecilia formosa | 87.1 | 8e-32 | 140 |
| LLPS-Ict-2248 | Ictidomys tridecemlineatus | 86.99 | 0.0 | 1773 |
| LLPS-Orn-2356 | Oreochromis niloticus | 86.81 | 9e-32 | 139 |
| LLPS-Orc-1521 | Oryctolagus cuniculus | 86.58 | 0.0 | 2119 |
| LLPS-Urm-2799 | Ursus maritimus | 86.48 | 0.0 | 2126 |
| LLPS-Otg-2083 | Otolemur garnettii | 86.4 | 0.0 | 1724 |
| LLPS-Fud-2131 | Fukomys damarensis | 86.03 | 0.0 | 1737 |
| LLPS-Fec-0101 | Felis catus | 85.96 | 0.0 | 2097 |
| LLPS-Caf-3739 | Canis familiaris | 85.93 | 0.0 | 2091 |
| LLPS-Aim-1345 | Ailuropoda melanoleuca | 85.68 | 0.0 | 1732 |
| LLPS-Mup-3972 | Mustela putorius furo | 85.3 | 0.0 | 2083 |
| LLPS-Cap-0098 | Cavia porcellus | 85.27 | 0.0 | 2089 |
| LLPS-Tut-0188 | Tursiops truncatus | 85.03 | 0.0 | 1582 |
| LLPS-Ran-0773 | Rattus norvegicus | 84.56 | 0.0 | 2064 |
| LLPS-Mea-2983 | Mesocricetus auratus | 84.49 | 0.0 | 2085 |
| LLPS-Mum-4394 | Mus musculus | 84.04 | 0.0 | 2071 |
| LLPS-Pes-1650 | Pelodiscus sinensis | 82.94 | 0.0 | 1340 |
| LLPS-Tag-3331 | Taeniopygia guttata | 82.87 | 0.0 | 1235 |
| LLPS-Anp-2804 | Anas platyrhynchos | 82.76 | 0.0 | 1234 |
| LLPS-Meg-3110 | Meleagris gallopavo | 82.11 | 0.0 | 1213 |
| LLPS-Fia-1086 | Ficedula albicollis | 81.74 | 0.0 | 1485 |
| LLPS-Gaga-3232 | Gallus gallus | 81.24 | 0.0 | 1115 |
| LLPS-Bot-4611 | Bos taurus | 80.6 | 0.0 | 1907 |
| LLPS-Mod-4268 | Monodelphis domestica | 78.74 | 0.0 | 1649 |
| LLPS-Sah-4116 | Sarcophilus harrisii | 77.78 | 0.0 | 1803 |
| LLPS-Xet-3039 | Xenopus tropicalis | 76.79 | 8e-19 | 97.1 |
| LLPS-Icp-4055 | Ictalurus punctatus | 75.93 | 9e-18 | 94.0 |
| LLPS-Dio-4073 | Dipodomys ordii | 75.78 | 0.0 | 1667 |
| LLPS-Leo-3843 | Lepisosteus oculatus | 74.55 | 2e-16 | 89.7 |
| LLPS-Lac-3909 | Latimeria chalumnae | 74.09 | 0.0 | 1065 |
| LLPS-Gaa-0345 | Gasterosteus aculeatus | 74.07 | 1e-17 | 93.2 |
| LLPS-Dar-2635 | Danio rerio | 73.21 | 3e-18 | 95.5 |
| LLPS-Ova-4282 | Ovis aries | 72.38 | 0.0 | 1384 |
| LLPS-Ten-3801 | Tetraodon nigroviridis | 72.22 | 3e-17 | 92.4 |
| LLPS-Myl-1592 | Myotis lucifugus | 68.85 | 3e-19 | 98.6 |
| LLPS-Ora-1047 | Ornithorhynchus anatinus | 63.37 | 0.0 | 592 |
| LLPS-Cis-1337 | Ciona savignyi | 35.94 | 5e-30 | 127 |