LLPS-Hos-0091
ATP5F1B

▼ OVERVIEW

Status: Reviewed
Protein Name: ATP synthase subunit beta, mitochondrial; ATP synthase F1 subunit beta
Gene Name: ATP5F1B, ATP5B, ATPMB, ATPSB
Ensembl Gene: ENSG00000110955.8
Ensembl Protein: ENSP00000262030.3
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli."
HeLa cells15635413
Nucleolus
"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."
N/A26980300
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLGFVGRVAA  APASGALRRL  TPSASLPPAQ  LLLRAAPTAV  HPVRDYAAQT  SPSPKAGAAT  60
61    GRIVAVIGAV  VDVQFDEGLP  PILNALEVQG  RETRLVLEVA  QHLGESTVRT  IAMDGTEGLV  120
121   RGQKVLDSGA  PIKIPVGPET  LGRIMNVIGE  PIDERGPIKT  KQFAPIHAEA  PEFMEMSVEQ  180
181   EILVTGIKVV  DLLAPYAKGG  KIGLFGGAGV  GKTVLIMELI  NNVAKAHGGY  SVFAGVGERT  240
241   REGNDLYHEM  IESGVINLKD  ATSKVALVYG  QMNEPPGARA  RVALTGLTVA  EYFRDQEGQD  300
301   VLLFIDNIFR  FTQAGSEVSA  LLGRIPSAVG  YQPTLATDMG  TMQERITTTK  KGSITSVQAI  360
361   YVPADDLTDP  APATTFAHLD  ATTVLSRAIA  ELGIYPAVDP  LDSTSRIMDP  NIVGSEHYDV  420
421   ARGVQKILQD  YKSLQDIIAI  LGMDELSEED  KLTVSRARKI  QRFLSQPFQV  AEVFTGHMGK  480
481   LVPLKETIKG  FQQILAGEYD  HLPEQAFYMV  GPIEEAVAKA  DKLAEEHSS  529
Nucleotide CDS Sequence (FASTA)
1     ATGTTGGGGT  TTGTGGGTCG  GGTGGCCGCT  GCTCCGGCCT  CCGGGGCCTT  GCGGAGACTC  60
61    ACCCCTTCAG  CGTCGCTGCC  CCCAGCTCAG  CTCTTACTGC  GGGCCGCTCC  GACGGCGGTC  120
121   CATCCTGTCA  GGGACTATGC  GGCGCAAACA  TCTCCTTCGC  CAAAAGCAGG  CGCCGCCACC  180
181   GGGCGCATCG  TGGCGGTCAT  TGGCGCAGTG  GTGGACGTCC  AGTTTGATGA  GGGACTACCA  240
241   CCAATTCTAA  ATGCCCTGGA  AGTGCAAGGC  AGGGAGACCA  GACTGGTTTT  GGAGGTGGCC  300
301   CAGCATTTGG  GTGAGAGCAC  AGTAAGGACT  ATTGCTATGG  ATGGTACAGA  AGGCTTGGTT  360
361   AGAGGCCAGA  AAGTACTGGA  TTCTGGTGCA  CCAATCAAAA  TTCCTGTTGG  TCCTGAGACT  420
421   TTGGGCAGAA  TCATGAATGT  CATTGGAGAA  CCTATTGATG  AAAGAGGTCC  CATCAAAACC  480
481   AAACAATTTG  CTCCCATTCA  TGCTGAGGCT  CCAGAGTTCA  TGGAAATGAG  TGTTGAGCAG  540
541   GAAATTCTGG  TGACTGGTAT  CAAGGTTGTC  GATCTGCTAG  CTCCCTATGC  CAAGGGTGGC  600
601   AAAATTGGGC  TTTTTGGTGG  TGCTGGAGTT  GGCAAGACTG  TACTGATCAT  GGAGTTAATC  660
661   AACAATGTCG  CCAAAGCCCA  TGGTGGTTAC  TCTGTGTTTG  CTGGTGTTGG  TGAGAGGACC  720
721   CGTGAAGGCA  ATGATTTATA  CCATGAAATG  ATTGAATCTG  GTGTTATCAA  CTTAAAAGAT  780
781   GCCACCTCTA  AGGTAGCGCT  GGTATATGGT  CAAATGAATG  AACCACCTGG  TGCTCGTGCC  840
841   CGGGTAGCTC  TGACTGGGCT  GACTGTGGCT  GAATACTTCA  GAGACCAAGA  AGGTCAAGAT  900
901   GTACTGCTAT  TTATTGATAA  CATCTTTCGC  TTCACCCAGG  CTGGTTCAGA  GGTGTCTGCA  960
961   TTATTGGGCC  GAATCCCTTC  TGCTGTGGGC  TATCAGCCTA  CCCTGGCCAC  TGACATGGGT  1020
1021  ACTATGCAGG  AAAGAATTAC  CACTACCAAG  AAGGGATCTA  TCACCTCTGT  ACAGGCTATC  1080
1081  TATGTGCCTG  CTGATGACTT  GACTGACCCT  GCCCCTGCTA  CTACGTTTGC  CCATTTGGAT  1140
1141  GCTACCACTG  TACTGTCGCG  TGCCATTGCT  GAGCTGGGCA  TCTATCCAGC  TGTGGATCCT  1200
1201  CTAGACTCCA  CCTCTCGTAT  CATGGATCCC  AACATTGTTG  GCAGTGAGCA  TTACGATGTT  1260
1261  GCCCGTGGGG  TGCAAAAGAT  CCTGCAGGAC  TACAAATCCC  TCCAGGATAT  CATTGCCATC  1320
1321  CTGGGTATGG  ATGAACTTTC  TGAGGAAGAC  AAGTTGACCG  TGTCCCGTGC  ACGGAAAATA  1380
1381  CAGCGTTTCT  TGTCTCAGCC  ATTCCAGGTT  GCTGAGGTCT  TCACAGGTCA  TATGGGGAAG  1440
1441  CTGGTACCCC  TGAAGGAGAC  CATCAAAGGA  TTCCAGCAGA  TTTTGGCAGG  TGAATATGAC  1500
1501  CATCTCCCAG  AACAGGCCTT  CTATATGGTG  GGACCCATTG  AAGAAGCTGT  GGCAAAAGCT  1560
1561  GATAAGCTGG  CTGAAGAGCA  TTCATCGTGA  1590

▼ KEYWORD

ID
Family
Acetylation
ATP synthesis
ATP-binding
CF(1)
Complete proteome
Direct protein sequencing
Glycoprotein
Hydrogen ion transport
Ion transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide
Translocase
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell surface
Cellular Component
Extracellular exosome
Cellular Component
Membrane
Cellular Component
Mitochondrial matrix
Cellular Component
Mitochondrial membrane
Cellular Component
Mitochondrial nucleoid
Cellular Component
Mitochondrial proton-transporting ATP synthase complex
Cellular Component
Mitochondrial proton-transporting ATP synthase, catalytic core
Cellular Component
Mitochondrion
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Cellular Component
Proton-transporting ATP synthase complex
Cellular Component
Proton-transporting ATP synthase complex, catalytic core F(1)
Molecular Function
Angiostatin binding
Molecular Function
ATP binding
Molecular Function
MHC class I protein binding
Molecular Function
Proton-transporting ATP synthase activity, rotational mechanism
Molecular Function
Proton-transporting ATPase activity, rotational mechanism
Molecular Function
Transmembrane transporter activity
Biological Process
Angiogenesis
Biological Process
ATP biosynthetic process
Biological Process
Cellular response to interleukin-7
Biological Process
Cristae formation
Biological Process
Generation of precursor metabolites and energy
Biological Process
Lipid metabolic process
Biological Process
Mitochondrial ATP synthesis coupled proton transport
Biological Process
Mitochondrion organization
Biological Process
Negative regulation of cell adhesion involved in substrate-bound cell migration
Biological Process
Osteoblast differentiation
Biological Process
Positive regulation of blood vessel endothelial cell migration
Biological Process
Proton transmembrane transport
Biological Process
Regulation of intracellular pH

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-1153Pan paniscus99.430.0 971
LLPS-Gog-0477Gorilla gorilla99.240.0 968
LLPS-Pat-4529Pan troglodytes99.240.0 969
LLPS-Mal-0298Mandrillus leucophaeus98.870.0 966
LLPS-Maf-0810Macaca fascicularis98.870.0 966
LLPS-Chs-3232Chlorocebus sabaeus98.870.0 966
LLPS-Mam-2932Macaca mulatta98.870.0 967
LLPS-Caj-0023Callithrix jacchus98.680.0 967
LLPS-Rhb-1737Rhinopithecus bieti98.680.0 968
LLPS-Paa-1190Papio anubis98.60.0 621
LLPS-Man-3467Macaca nemestrina98.60.0 621
LLPS-Cas-0967Carlito syrichta97.730.0 961
LLPS-Ict-3002Ictidomys tridecemlineatus97.540.0 960
LLPS-Meg-2017Meleagris gallopavo97.410.0 803
LLPS-Fud-0851Fukomys damarensis97.350.0 961
LLPS-Sus-0927Sus scrofa97.350.0 954
LLPS-Orc-2607Oryctolagus cuniculus97.350.0 955
LLPS-Pes-1564Pelodiscus sinensis97.180.0 799
LLPS-Aim-1211Ailuropoda melanoleuca97.160.0 959
LLPS-Mup-3385Mustela putorius furo97.160.0 961
LLPS-Tut-0049Tursiops truncatus97.160.0 956
LLPS-Otg-1422Otolemur garnettii97.160.0 956
LLPS-Loa-1642Loxodonta africana97.160.0 953
LLPS-Urm-3215Ursus maritimus97.160.0 959
LLPS-Eqc-1531Equus caballus96.970.0 950
LLPS-Bot-0160Bos taurus96.780.0 949
LLPS-Fec-0926Felis catus96.780.0 959
LLPS-Sah-0235Sarcophilus harrisii96.710.0 910
LLPS-Fia-1424Ficedula albicollis96.70.0 900
LLPS-Gaga-0481Gallus gallus96.690.0 885
LLPS-Dio-0136Dipodomys ordii96.60.0 953
LLPS-Ova-0149Ovis aries96.590.0 948
LLPS-Myl-1951Myotis lucifugus96.40.0 946
LLPS-Mum-1073Mus musculus96.220.0 935
LLPS-Orl-1681Oryzias latipes96.160.0 872
LLPS-Lac-0571Latimeria chalumnae96.150.0 618
LLPS-Poa-2323Pongo abelii95.990.0 914
LLPS-Icp-0456Ictalurus punctatus95.950.0 871
LLPS-Ran-1913Rattus norvegicus95.840.0 951
LLPS-Tag-0666Taeniopygia guttata95.741e-153 446
LLPS-Caf-3183Canis familiaris95.640.0 949
LLPS-Tar-2525Takifugu rubripes95.520.0 866
LLPS-Orn-0359Oreochromis niloticus95.520.0 869
LLPS-Scm-0884Scophthalmus maximus95.520.0 868
LLPS-Aon-2498Aotus nancymaae95.40.0 953
LLPS-Ten-0391Tetraodon nigroviridis95.310.0 867
LLPS-Dar-0518Danio rerio95.310.0 868
LLPS-Xim-2403Xiphophorus maculatus95.10.0 868
LLPS-Pof-1555Poecilia formosa95.10.0 868
LLPS-Asm-2589Astyanax mexicanus94.880.0 863
LLPS-Gaa-2187Gasterosteus aculeatus94.660.0 856
LLPS-Leo-1382Lepisosteus oculatus94.640.0 890
LLPS-Mod-0268Monodelphis domestica94.510.0 911
LLPS-Scf-0436Scleropages formosus94.020.0 870
LLPS-Ora-1658Ornithorhynchus anatinus93.350.0 748
LLPS-Nol-1686Nomascus leucogenys93.270.0 865
LLPS-Xet-0466Xenopus tropicalis93.00.0 886
LLPS-Drm-0289Drosophila melanogaster91.220.0 825
LLPS-Anc-0493Anolis carolinensis89.960.0 889
LLPS-Cap-2440Cavia porcellus88.280.0 871
LLPS-Cae-0619Caenorhabditis elegans86.280.0 809
LLPS-Cea-0318Cercocebus atys84.270.0 780
LLPS-Cus-1897Cucumis sativus83.336e-31 120
LLPS-Ori-0800Oryza indica81.420.0 692
LLPS-Orbr-0320Oryza brachyantha81.370.0 670
LLPS-Sem-1466Selaginella moellendorffii81.240.0 653
LLPS-Mae-2516Manihot esculenta81.220.0 742
LLPS-Pug-1169Puccinia graminis81.20.0 758
LLPS-Amt-0394Amborella trichopoda81.010.0 742
LLPS-Put-0421Puccinia triticina80.990.0 754
LLPS-Orp-1301Oryza punctata80.910.0 728
LLPS-Cii-0025Ciona intestinalis80.820.0 746
LLPS-Prp-0057Prunus persica80.80.0 738
LLPS-Gor-1246Gossypium raimondii80.80.0 737
LLPS-Chr-0840Chlamydomonas reinhardtii80.770.0 732
LLPS-Orgl-0844Oryza glumaepatula80.640.0 739
LLPS-Orb-0020Oryza barthii80.640.0 739
LLPS-Orm-0820Oryza meridionalis80.640.0 739
LLPS-Miv-0243Microbotryum violaceum80.60.0 730
LLPS-Sei-1160Setaria italica80.590.0 740
LLPS-Cis-1236Ciona savignyi80.580.0 744
LLPS-Gas-1158Galdieria sulphuraria80.470.0 735
LLPS-Lep-1008Leersia perrieri80.430.0 739
LLPS-Orni-0261Oryza nivara80.430.0 736
LLPS-Orr-0564Oryza rufipogon80.430.0 737
LLPS-Thc-0797Theobroma cacao80.420.0 734
LLPS-Zem-0753Zea mays80.380.0 740
LLPS-Sob-1010Sorghum bicolor80.380.0 739
LLPS-Viv-0275Vitis vinifera80.380.0 736
LLPS-Sol-0818Solanum lycopersicum80.340.0 737
LLPS-Scj-1365Schizosaccharomyces japonicus80.170.0 716
LLPS-Abg-1614Absidia glauca80.174e-174 506
LLPS-Sot-0573Solanum tuberosum80.170.0 738
LLPS-Org-0732Oryza glaberrima80.170.0 736
LLPS-Ved-0521Verticillium dahliae80.170.0 706
LLPS-Coc-0345Corchorus capsularis80.170.0 734
LLPS-Ors-0639Oryza sativa80.170.0 736
LLPS-Brd-0256Brachypodium distachyon80.130.0 735
LLPS-Dac-0107Daucus carota80.130.0 733
LLPS-Nec-0733Neurospora crassa80.080.0 716
LLPS-Mua-1067Musa acuminata79.960.0 736
LLPS-Mel-0576Melampsora laricipopulina79.920.0 749
LLPS-Usm-0750Ustilago maydis79.920.0 726
LLPS-Nia-1432Nicotiana attenuata79.750.0 734
LLPS-Hov-0136Hordeum vulgare79.70.0 730
LLPS-Tra-1752Triticum aestivum79.70.0 728
LLPS-Tum-1140Tuber melanosporum79.660.0 706
LLPS-Trv-0667Trichoderma virens79.660.0 707
LLPS-Trr-0257Trichoderma reesei79.660.0 707
LLPS-Phn-0953Phaeosphaeria nodorum79.640.0 588
LLPS-Pot-1580Populus trichocarpa79.540.0 734
LLPS-Scp-0519Schizosaccharomyces pombe79.530.0 713
LLPS-Beb-0652Beauveria bassiana79.530.0 708
LLPS-Spr-0495Sporisorium reilianum79.50.0 720
LLPS-Hea-0312Helianthus annuus79.490.0 730
LLPS-Asg-0437Ashbya gossypii79.480.0 709
LLPS-Fuv-0830Fusarium verticillioides79.240.0 708
LLPS-Fuo-1083Fusarium oxysporum79.240.0 707
LLPS-Nef-0000Neosartorya fischeri79.240.0 708
LLPS-Cogr-0772Colletotrichum graminicola79.10.0 706
LLPS-Mao-0892Magnaporthe oryzae78.980.0 697
LLPS-Asc-1372Aspergillus clavatus78.950.0 709
LLPS-Asfu-0172Aspergillus fumigatus78.950.0 707
LLPS-Kop-0798Komagataella pastoris78.830.0 705
LLPS-Fus-1271Fusarium solani78.810.0 704
LLPS-Pyt-0595Pyrenophora teres78.80.0 703
LLPS-Via-0056Vigna angularis78.690.0 725
LLPS-Asn-0743Aspergillus nidulans78.590.0 698
LLPS-Ast-0279Aspergillus terreus78.540.0 677
LLPS-Sac-1039Saccharomyces cerevisiae78.390.0 708
LLPS-Osl-0568Ostreococcus lucimarinus78.380.0 723
LLPS-Art-0089Arabidopsis thaliana78.360.0 721
LLPS-Coo-1120Colletotrichum orbiculare78.290.0 712
LLPS-Met-0634Medicago truncatula78.270.0 717
LLPS-Glm-1667Glycine max78.220.0 721
LLPS-Asf-0227Aspergillus flavus78.110.0 706
LLPS-Aso-0110Aspergillus oryzae78.110.0 706
LLPS-Phv-0044Phaseolus vulgaris78.060.0 715
LLPS-Brn-0003Brassica napus77.940.0 719
LLPS-Bro-1755Brassica oleracea77.940.0 720
LLPS-Blg-0757Blumeria graminis77.830.0 696
LLPS-Crn-0136Cryptococcus neoformans77.80.0 726
LLPS-Chc-0172Chondrus crispus77.780.0 699
LLPS-Yal-0733Yarrowia lipolytica77.730.0 707
LLPS-Cog-0400Colletotrichum gloeosporioides77.590.0 708
LLPS-Scc-0324Schizosaccharomyces cryophilus77.560.0 702
LLPS-Zyt-0856Zymoseptoria tritici77.520.0 688
LLPS-Brr-1255Brassica rapa77.520.0 716
LLPS-Php-0045Physcomitrella patens77.490.0 702
LLPS-Map-0028Magnaporthe poae77.240.0 693
LLPS-Gag-0303Gaeumannomyces graminis77.040.0 691
LLPS-Cym-0525Cyanidioschyzon merolae76.650.0 704
LLPS-Arl-0197Arabidopsis lyrata76.630.0 723
LLPS-Lem-0870Leptosphaeria maculans75.570.0 689
LLPS-Tru-0881Triticum urartu75.40.0 715
LLPS-Asni-0880Aspergillus niger75.05e-85 268
LLPS-Pytr-0208Pyrenophora triticirepentis74.680.0 691
LLPS-Dos-0037Dothistroma septosporum73.880.0 637
LLPS-Vir-0063Vigna radiata71.520.0 663