LLPS-Gog-a1112
VPS16
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Vacuolar protein sorting-associated protein 16 homolog |
| Gene Name: | VPS16 |
| Ensembl Gene: | ENSGGOG00000016124.3 |
| Ensembl Protein: | ENSGGOP00000051503.1 |
| Organism: | Gorilla gorilla |
| Taxa ID: | 9595 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSGGOT00000064521.1 | ENSGGOP00000051503.1 |
| Ensembl | ENSGGOT00000016187.3 | ENSGGOP00000015736.2 |
| UniProt | G3RJ59, G3RJ59_GORGO | |
| GeneBank | CABD030115288 | |
| RefSeq | XM_004061715.2 | XP_004061763.1 |
| Entrez | 101145691 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDCYTANWNP LGDSAFYRKY ELYSMDWDLK EELRDCLVAA APYGGPIALL RNPWRKEKAA 60 61 SMRPVLDIYS ASGMPLASLL WKSGPVVSLG WSAEEELLCV QEDGAVLVYG LHGDFRRHFS 120 121 MGNEVLQNRV LDARIFHTEF GSGVAILTGA HRFTLSANVG DLKLRRMPEV PGLQSAPSCW 180 181 TALCQDRVAH ILLAVGPDLY LLDHAACSAV TPPGLAPGVS SFLQMAVSFT YRHLALFTDT 240 241 GYIWMGTASL KEKLCEFNCN IRAPPKQMVW CSRPRSKERA VVVAWERRLM VVGDAPESIQ 300 301 FVLDEDSYLV PELDGVRIFS RSTHEFLHEV PVASEEIFKI ASMAPGALLL EAQKEYEKES 360 361 QKADEYLREI QELGQLTQAV QQCIEAAGHE HQPDMQKSLL RAASFGKCFL DRFPPDSFVH 420 421 MCQDLRVLNA VRDYHIGIPL TYSQYKQLTI QVLLDRLVLR RLYPLAIQIC EYLRLPEVQG 480 481 VSRILAHWAC YKVQQKDVSD EDVARAINQK LGDTPGVSYS DIAARAYGCG RTELAIKLLE 540 541 YEPRSGEQVP LLLKMKRSKL ALSKAIESGD TDLVFTVLLH LKNELNRGDF FMTLRNQPMA 600 601 LSLYRQFCKH QELETLKDLY NQDDNHQELG SFHIRASYAA EERIEGRVAA LQTAADAFYK 660 661 AKNEFAAKAT EDQMRLLRLQ RRLEDELGGQ FLDLSLHDTV TTLILGGHNK RAEQLARDFR 720 721 IPDKRLWWLK LTALADLEDW EELEKFSKSK KSPIGYLPFV EICMKQHNKY EAKKYASRVG 780 781 PEQKVKALLL VGDVAQAADV AIEHRNEAEL SLVLSHCTGA TDGATADKIQ RARAQAQKK 839 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGACTGCT ACACGGCGAA CTGGAACCCA CTCGGGGACT CTGCCTTTTA CCGGAAATAT 60 61 GAGCTGTACA GCATGGACTG GGACCTGAAG GAGGAACTCA GGGATTGCCT GGTAGCTGCT 120 121 GCACCCTATG GGGGCCCCAT TGCACTGCTG AGGAACCCCT GGCGGAAGGA GAAAGCTGCT 180 181 AGTATGAGGC CAGTGCTCGA TATATACTCT GCTTCCGGCA TGCCTCTGGC CAGCCTGCTG 240 241 TGGAAGAGTG GACCCGTGGT GTCCCTGGGC TGGTCAGCTG AGGAGGAGCT GCTCTGTGTG 300 301 CAGGAAGATG GTGCTGTACT GGTTTATGGG CTTCATGGTG ACTTCCGGAG ACACTTCAGC 360 361 ATGGGCAATG AAGTGCTCCA GAACCGGGTT CTGGATGCCC GGATCTTTCA CACTGAGTTT 420 421 GGTTCCGGAG TGGCCATCCT CACAGGGGCC CACCGCTTCA CCCTCAGTGC CAATGTGGGT 480 481 GACCTCAAAC TCCGCCGGAT GCCAGAGGTG CCAGGTCTGC AAAGTGCACC CTCCTGCTGG 540 541 ACTGCGCTGT GCCAGGACCG AGTGGCACAC ATTCTTCTGG CTGTGGGGCC TGACCTTTAC 600 601 CTCTTGGACC ATGCAGCCTG CTCCGCAGTG ACGCCCCCTG GCCTGGCCCC AGGAGTAAGC 660 661 AGCTTCCTAC AGATGGCTGT CTCCTTCACC TACCGACACC TGGCACTCTT CACAGACACA 720 721 GGCTACATCT GGATGGGGAC AGCATCACTC AAGGAGAAGC TATGTGAGTT CAACTGCAAC 780 781 ATCCGGGCAC CTCCAAAGCA GATGGTCTGG TGCAGCCGTC CTCGTAGCAA GGAGAGGGCC 840 841 GTGGTGGTTG CCTGGGAAAG GCGGCTGATG GTGGTGGGCG ATGCACCCGA GAGCATCCAG 900 901 TTTGTGCTGG ATGAGGACTC CTACCTGGTG CCTGAGCTCG ATGGGGTCCG CATCTTCTCC 960 961 CGCAGCACCC ACGAGTTCCT GCATGAGGTT CCAGTGGCCA GCGAGGAGAT CTTCAAAATT 1020 1021 GCCTCAATGG CCCCCGGGGC GCTGCTCCTG GAGGCTCAGA AGGAGTATGA GAAAGAAAGC 1080 1081 CAGAAGGCGG ACGAGTACCT GCGGGAGATC CAGGAGCTGG GCCAGCTGAC CCAGGCCGTG 1140 1141 CAGCAGTGCA TTGAGGCTGC AGGACATGAG CACCAGCCAG ACATGCAGAA GAGTCTGCTC 1200 1201 AGGGCCGCCT CCTTCGGAAA GTGTTTCCTG GACAGATTTC CACCCGACAG CTTCGTGCAC 1260 1261 ATGTGTCAGG ACCTGCGTGT GCTCAATGCT GTTCGGGACT ATCACATCGG GATCCCGCTC 1320 1321 ACCTATAGCC AATACAAGCA GCTCACCATC CAGGTGCTGC TGGACAGGCT CGTGTTGCGG 1380 1381 AGACTTTACC CCCTGGCCAT CCAGATATGC GAGTACTTGC GCCTTCCTGA AGTACAGGGC 1440 1441 GTCAGCAGGA TCCTGGCCCA CTGGGCCTGC TACAAGGTGC AACAGAAGGA TGTCTCAGAT 1500 1501 GAGGATGTGG CTCGAGCCAT TAACCAGAAG CTGGGGGACA CGCCTGGTGT CTCTTACTCT 1560 1561 GACATTGCTG CACGAGCCTA TGGTTGTGGC CGCACGGAGC TGGCCATCAA GCTGCTGGAG 1620 1621 TATGAGCCAC GCTCAGGGGA GCAGGTACCC CTTCTCCTAA AGATGAAGAG GAGCAAACTG 1680 1681 GCACTAAGCA AGGCCATCGA GAGCGGGGAC ACTGACCTGG TGTTCACGGT GTTGCTGCAC 1740 1741 CTGAAGAACG AGCTGAACCG AGGAGATTTT TTCATGACCC TTCGGAATCA GCCCATGGCC 1800 1801 CTGAGTTTGT ACCGACAGTT CTGTAAGCAT CAGGAGCTAG AGACGCTGAA GGACCTTTAC 1860 1861 AATCAGGATG ACAATCACCA GGAATTGGGC AGCTTCCACA TCCGAGCCAG CTATGCTGCA 1920 1921 GAAGAGCGTA TTGAGGGGCG AGTAGCAGCT CTGCAGACAG CCGCCGATGC CTTCTACAAG 1980 1981 GCCAAGAATG AGTTTGCAGC CAAGGCTACA GAGGATCAAA TGCGGCTCCT ACGGCTGCAG 2040 2041 CGGCGCCTAG AAGATGAGCT GGGGGGCCAG TTCCTAGACC TGTCTCTACA TGACACTGTT 2100 2101 ACCACCCTCA TTCTTGGCGG TCACAACAAG CGTGCAGAGC AGCTGGCACG TGACTTCCGC 2160 2161 ATCCCTGACA AGAGGCTCTG GTGGCTGAAG CTGACTGCCC TGGCAGATTT GGAAGATTGG 2220 2221 GAAGAGCTAG AGAAGTTTTC CAAGAGCAAG AAATCACCCA TTGGCTACCT GCCTTTTGTG 2280 2281 GAGATCTGCA TGAAACAACA TAACAAATAC GAAGCCAAGA AGTATGCTTC CCGCGTGGGT 2340 2341 CCCGAGCAGA AGGTCAAGGC TTTGCTTCTT GTTGGCGATG TGGCTCAGGC TGCAGATGTG 2400 2401 GCCATCGAAC ACCGGAATGA GGCTGAGCTG AGCCTCGTAT TGTCCCACTG CACGGGAGCC 2460 2461 ACAGATGGGG CCACAGCTGA CAAGATTCAA CGGGCCAGGG CACAAGCCCA GAAGAAGTGA 2520 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | CORVET complex | |
Cellular Component | Early endosome | |
Cellular Component | Endosome | |
Cellular Component | HOPS complex | |
Cellular Component | Late endosome membrane | |
Cellular Component | Lysosomal membrane | |
Cellular Component | Recycling endosome | |
Molecular Function | Actin binding | |
Biological Process | Autophagosome maturation | |
Biological Process | Endosomal transport | |
Biological Process | Endosome to lysosome transport | |
Biological Process | Intracellular protein transport | |
Biological Process | Regulation of SNARE complex assembly | |
Biological Process | Regulation of vacuole fusion, non-autophagic | |
Biological Process | Vacuole organization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a1150 | Homo sapiens | 0.0 | 1731 | undefined |
| LLPS-Mum-a1130 | Mus musculus | 0.0 | 1691 | undefined |