DrLLPS - Data resource of LLPS

LLPS-Gog-4094

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Small nuclear ribonucleoprotein E
Ensembl Gene:	ENSGGOG00000042851.1
Ensembl Protein:	ENSGGOP00000050803.1
Organism:	Gorilla gorilla
Taxa ID:	9595
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Arabidopsis thaliana	LLPS-Art-1157	Q8LAK5	Client	Nucleolus	36.14	9e-164	507

▼ FUNCTION

Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSGGOT00000053539.1	ENSGGOP00000050803.1
UniProt		A0A2I2ZUK4, A0A2I2ZUK4_GORGO
GeneBank	CABD030014388

▼ SEQUENCE

Protein Sequence (FASTA)
1 MEYHGQGQKV QKVMVQPINL IFRYLQNRSR IQQVNMRIEG CIIGFDEYTN LVLDYAEEIH 60 61 SKAKSRKQLG RLMLKGDDIP LLQSVSN 87
Nucleotide CDS Sequence (FASTA)
1 ATGGAGTACC ATGGCCAGGG CCAGAAAGTG CAAAAGGTGA TGGTGCAGCC CATCAACCTC 60 61 ATCTTCAGAT ACTTACAAAA TAGATCACGG ATTCAACAAG TGAATATGAG GATAGAAGGC 120 121 TGTATCATTG GTTTTGATGA GTATACGAAC CTTGTATTAG ATTATGCAGA AGAGATTCAT 180 181 TCTAAAGCAA AGTCAAGAAA ACAACTGGGT CGGCTCATGC TAAAAGGAGA TGATATTCCT 240 241 CTGCTGCAAA GCGTCTCCAA CTAG 264

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0694	RNA-binding
KW-0747	Spliceosome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005829	Cellular Component	Cytosol
GO:0005681	Cellular Component	Spliceosomal complex
GO:0005685	Cellular Component	U1 snRNP
GO:0005686	Cellular Component	U2 snRNP
GO:0005687	Cellular Component	U4 snRNP
GO:0046540	Cellular Component	U4/U6 x U5 tri-snRNP complex
GO:0005682	Cellular Component	U5 snRNP
GO:0003723	Molecular Function	RNA binding
GO:0000387	Biological Process	Spliceosomal snRNP assembly

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Anp-1679	Anas platyrhynchos	88.46	1e-25	95.9
LLPS-Cea-0221	Cercocebus atys	85.87	1e-37	127
LLPS-Aon-0410	Aotus nancymaae	85.87	1e-37	127
LLPS-Sus-1687	Sus scrofa	85.87	1e-37	127
LLPS-Chs-0232	Chlorocebus sabaeus	85.87	1e-37	127
LLPS-Ora-0383	Ornithorhynchus anatinus	85.87	1e-37	127
LLPS-Maf-1040	Macaca fascicularis	85.87	1e-37	127
LLPS-Mum-0529	Mus musculus	85.87	1e-37	127
LLPS-Caj-2198	Callithrix jacchus	85.87	1e-37	127
LLPS-Fud-0021	Fukomys damarensis	85.87	1e-37	127
LLPS-Paa-2891	Papio anubis	85.87	1e-37	127
LLPS-Mal-1871	Mandrillus leucophaeus	85.87	1e-37	127
LLPS-Ran-4029	Rattus norvegicus	85.87	7e-38	128
LLPS-Loa-0094	Loxodonta africana	85.87	1e-37	127
LLPS-Man-3072	Macaca nemestrina	85.87	1e-37	127
LLPS-Mod-0079	Monodelphis domestica	85.87	1e-37	127
LLPS-Fec-1937	Felis catus	85.87	1e-37	127
LLPS-Pat-2920	Pan troglodytes	85.87	1e-37	127
LLPS-Pap-0625	Pan paniscus	85.87	1e-37	127
LLPS-Hos-1716	Homo sapiens	85.87	1e-37	127
LLPS-Rhb-1656	Rhinopithecus bieti	85.87	1e-37	127
LLPS-Mam-2330	Macaca mulatta	85.87	1e-37	127
LLPS-Cap-3636	Cavia porcellus	85.87	1e-37	127
LLPS-Poa-1107	Pongo abelii	85.87	1e-37	127
LLPS-Ict-1676	Ictidomys tridecemlineatus	85.87	1e-37	127
LLPS-Anc-2881	Anolis carolinensis	85.87	1e-37	127
LLPS-Gaga-1050	Gallus gallus	85.87	1e-37	127
LLPS-Cas-2173	Carlito syrichta	85.87	1e-37	127
LLPS-Urm-0532	Ursus maritimus	85.53	3e-37	128
LLPS-Mea-3204	Mesocricetus auratus	85.42	5e-09	52.4
LLPS-Sah-2404	Sarcophilus harrisii	85.14	5e-36	122
LLPS-Meg-0453	Meleagris gallopavo	85.14	5e-36	122
LLPS-Fia-0540	Ficedula albicollis	85.14	9e-36	122
LLPS-Pes-1784	Pelodiscus sinensis	85.14	4e-36	124
LLPS-Nol-3959	Nomascus leucogenys	85.14	5e-36	122
LLPS-Otg-2497	Otolemur garnettii	85.0	2e-27	101
LLPS-Dio-2084	Dipodomys ordii	84.78	2e-37	127
LLPS-Mup-2159	Mustela putorius furo	84.78	1e-36	125
LLPS-Myl-0521	Myotis lucifugus	84.78	5e-37	126
LLPS-Aim-1780	Ailuropoda melanoleuca	83.87	5e-35	120
LLPS-Xet-1023	Xenopus tropicalis	82.89	9e-36	122
LLPS-Xim-3649	Xiphophorus maculatus	82.61	5e-35	121
LLPS-Ten-0665	Tetraodon nigroviridis	82.61	6e-35	120
LLPS-Caf-0834	Canis familiaris	82.61	4e-36	124
LLPS-Eqc-2460	Equus caballus	81.63	2e-18	78.6
LLPS-Bot-0061	Bos taurus	81.52	1e-33	117
LLPS-Scm-2139	Scophthalmus maximus	81.52	7e-35	120
LLPS-Leo-0097	Lepisosteus oculatus	80.43	8e-35	120
LLPS-Orl-0957	Oryzias latipes	80.43	4e-34	118
LLPS-Dar-2215	Danio rerio	80.43	2e-34	119
LLPS-Tar-0445	Takifugu rubripes	80.26	2e-34	119
LLPS-Icp-0989	Ictalurus punctatus	80.22	9e-34	117
LLPS-Scf-1804	Scleropages formosus	79.35	1e-34	119
LLPS-Asm-1648	Astyanax mexicanus	78.95	1e-34	120
LLPS-Gaa-1827	Gasterosteus aculeatus	78.95	4e-34	118
LLPS-Pof-1124	Poecilia formosa	78.46	6e-26	98.2
LLPS-Ova-0477	Ovis aries	78.26	1e-33	117
LLPS-Lac-0800	Latimeria chalumnae	76.62	7e-32	112
LLPS-Vir-0066	Vigna radiata	67.44	9e-13	62.8
LLPS-Cii-1314	Ciona intestinalis	66.67	5e-27	100
LLPS-Orgl-0048	Oryza glumaepatula	66.67	3e-10	57.8
LLPS-Nia-0082	Nicotiana attenuata	66.2	1e-23	95.9
LLPS-Sol-0831	Solanum lycopersicum	64.79	7e-24	92.4
LLPS-Thc-1507	Theobroma cacao	64.79	1e-23	92.4
LLPS-Sot-0444	Solanum tuberosum	64.79	7e-24	92.4
LLPS-Cus-0367	Cucumis sativus	64.79	3e-24	93.2
LLPS-Gor-1540	Gossypium raimondii	64.79	3e-24	93.2
LLPS-Orp-1049	Oryza punctata	64.41	3e-17	75.5
LLPS-Drm-0923	Drosophila melanogaster	64.0	1e-26	99.8
LLPS-Met-0266	Medicago truncatula	63.38	8e-24	92.0
LLPS-Pot-0529	Populus trichocarpa	63.38	2e-23	91.3
LLPS-Mae-0547	Manihot esculenta	63.38	1e-23	91.7
LLPS-Prp-0131	Prunus persica	63.38	7e-24	92.4
LLPS-Cis-1068	Ciona savignyi	63.16	1e-26	99.4
LLPS-Phv-0206	Phaseolus vulgaris	62.67	6e-25	95.1
LLPS-Arl-0820	Arabidopsis lyrata	61.97	7e-23	89.7
LLPS-Art-1157	Arabidopsis thaliana	61.97	7e-23	89.7
LLPS-Zem-1051	Zea mays	61.97	1e-22	89.0
LLPS-Bro-2112	Brassica oleracea	61.97	4e-23	90.5
LLPS-Glm-0189	Glycine max	61.33	4e-24	93.2
LLPS-Php-0713	Physcomitrella patens	61.33	7e-24	92.4
LLPS-Via-1883	Vigna angularis	61.33	3e-24	93.2
LLPS-Tru-0446	Triticum urartu	60.81	5e-23	90.1
LLPS-Dac-0725	Daucus carota	60.61	7e-19	79.7
LLPS-Brn-1863	Brassica napus	60.56	2e-22	88.2
LLPS-Brr-1822	Brassica rapa	60.56	5e-22	87.4
LLPS-Ori-0296	Oryza indica	60.0	3e-23	90.9
LLPS-Orb-1379	Oryza barthii	60.0	2e-14	69.7
LLPS-Sem-1378	Selaginella moellendorffii	60.0	1e-21	86.7
LLPS-Mua-0653	Musa acuminata	60.0	1e-23	91.7
LLPS-Orni-1123	Oryza nivara	60.0	3e-23	90.9
LLPS-Hea-1088	Helianthus annuus	60.0	8e-24	92.0
LLPS-Lep-0615	Leersia perrieri	60.0	3e-23	90.9
LLPS-Brd-0280	Brachypodium distachyon	60.0	5e-23	90.1
LLPS-Tra-1787	Triticum aestivum	60.0	5e-23	90.1
LLPS-Sei-0753	Setaria italica	60.0	1e-22	89.0
LLPS-Ors-1052	Oryza sativa	60.0	3e-23	90.9
LLPS-Orbr-0625	Oryza brachyantha	60.0	3e-23	90.9
LLPS-Sob-1055	Sorghum bicolor	60.0	3e-23	90.9
LLPS-Org-0625	Oryza glaberrima	60.0	3e-23	90.9
LLPS-Hov-0885	Hordeum vulgare	58.9	1e-19	82.8
LLPS-Amt-0278	Amborella trichopoda	58.67	3e-22	88.2
LLPS-Orm-1373	Oryza meridionalis	58.33	6e-15	68.9
LLPS-Viv-0060	Vitis vinifera	57.33	9e-23	89.4
LLPS-Gas-0234	Galdieria sulphuraria	56.94	6e-20	82.0
LLPS-Chr-0670	Chlamydomonas reinhardtii	56.0	1e-23	91.7
LLPS-Cae-1675	Caenorhabditis elegans	54.79	3e-22	88.2
LLPS-Chc-0922	Chondrus crispus	54.05	3e-20	82.8
LLPS-Abg-1006	Absidia glauca	53.85	4e-17	74.3
LLPS-Osl-0580	Ostreococcus lucimarinus	52.0	5e-19	79.7
LLPS-Kop-0548	Komagataella pastoris	50.0	2e-18	78.6
LLPS-Spr-0209	Sporisorium reilianum	50.0	7e-18	76.6
LLPS-Blg-0429	Blumeria graminis	49.37	3e-16	72.8
LLPS-Usm-0337	Ustilago maydis	49.32	1e-16	73.6
LLPS-Cog-0863	Colletotrichum gloeosporioides	48.75	4e-16	72.4
LLPS-Tum-1393	Tuber melanosporum	47.44	1e-15	71.2
LLPS-Cogr-0401	Colletotrichum graminicola	46.91	4e-16	72.4
LLPS-Coo-1532	Colletotrichum orbiculare	46.88	1e-08	52.4
LLPS-Asni-1292	Aspergillus niger	46.15	1e-14	68.6
LLPS-Asn-0146	Aspergillus nidulans	46.15	2e-14	67.8
LLPS-Scc-0826	Schizosaccharomyces cryophilus	45.9	4e-09	53.9
LLPS-Trv-0087	Trichoderma virens	45.68	4e-16	72.4
LLPS-Gag-0366	Gaeumannomyces graminis	45.57	1e-13	66.2
LLPS-Map-0119	Magnaporthe poae	45.57	1e-13	65.9
LLPS-Nec-1291	Neurospora crassa	45.0	3e-14	67.4
LLPS-Asf-0333	Aspergillus flavus	44.87	5e-14	67.0
LLPS-Ast-0830	Aspergillus terreus	44.87	4e-14	67.0
LLPS-Miv-1280	Microbotryum violaceum	44.87	2e-13	65.1
LLPS-Scj-0407	Schizosaccharomyces japonicus	44.59	1e-12	63.2
LLPS-Trr-0752	Trichoderma reesei	44.44	2e-15	70.5
LLPS-Ved-1414	Verticillium dahliae	44.3	4e-15	69.7
LLPS-Crn-0609	Cryptococcus neoformans	43.9	1e-14	68.6
LLPS-Asc-0614	Aspergillus clavatus	43.59	7e-14	66.2
LLPS-Pyt-0498	Pyrenophora teres	43.59	6e-13	63.9
LLPS-Nef-0646	Neosartorya fischeri	43.59	7e-14	66.6
LLPS-Pytr-0511	Pyrenophora triticirepentis	43.59	6e-13	63.9
LLPS-Asfu-0545	Aspergillus fumigatus	43.59	7e-14	66.6
LLPS-Mao-0156	Magnaporthe oryzae	43.04	1e-12	63.2
LLPS-Lem-0031	Leptosphaeria maculans	43.04	4e-13	64.7
LLPS-Zyt-0841	Zymoseptoria tritici	42.86	4e-14	67.4
LLPS-Dos-0364	Dothistroma septosporum	42.86	6e-14	66.6
LLPS-Beb-0284	Beauveria bassiana	42.5	4e-14	67.0
LLPS-Fus-0644	Fusarium solani	42.5	4e-14	67.0
LLPS-Fuo-0149	Fusarium oxysporum	42.5	1e-12	63.5
LLPS-Asg-0417	Ashbya gossypii	41.98	3e-12	62.4
LLPS-Scp-0193	Schizosaccharomyces pombe	41.89	2e-13	65.1
LLPS-Mel-0804	Melampsora laricipopulina	41.43	3e-09	53.9
LLPS-Yal-0578	Yarrowia lipolytica	41.33	7e-11	58.2
LLPS-Fuv-0241	Fusarium verticillioides	41.25	2e-12	62.4
LLPS-Phn-1043	Phaeosphaeria nodorum	41.25	1e-12	62.8
LLPS-Sac-1237	Saccharomyces cerevisiae	40.0	2e-12	62.8
LLPS-Pug-0784	Puccinia graminis	39.53	3e-12	62.0
LLPS-Put-0875	Puccinia triticina	39.53	3e-12	62.0
LLPS-Orr-2360	Oryza rufipogon	35.71	1e-13	66.6

LLPS-Gog-4094

Protein Sequence

Nucleotide Sequence