LLPS-Gog-3420
AGO4
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein argonaute-4 |
| Gene Name: | AGO4, EIF2C4 |
| Ensembl Gene: | ENSGGOG00000036532.1 |
| Ensembl Protein: | ENSGGOP00000018714.2 |
| Organism: | Gorilla gorilla |
| Taxa ID: | 9595 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSGGOT00000026398.2 | ENSGGOP00000018714.2 |
| Ensembl | ENSGGOT00000012532.3 | ENSGGOP00000012179.2 |
| UniProt | G3RSD9, G3RSD9_GORGO | |
| GeneBank | CABD030002420, CABD030002421, CABD030002419 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 LFQPPRRPGL GTVGKPIRLL ANHFQVQIPK IDVYHYDVDI KPEKRPRRVN REVVDTMVRH 60 61 FKMQIFGDRQ PGYDGKRNMY TAHPLPIGRD RVDMEVTLPG EGKDQTFKVS VQWVSVVSLQ 120 121 LLLEALAGHL NEVPDDSVQA LDVITRHLPS MRYTPVGRSF FSPPEGYYHP LGGGREVWFG 180 181 FHQSVRPAMW NMMLNIDVSA TAFYRAQPII EFMCEVLDIQ NINEQTKPLT DSQRVKFTKE 240 241 IRGLKVEVTH CGQMKRKYRV CNVTRRPASH QTFPLQLENG QAMECTVAQY FKQKYSLQLK 300 301 YPHLPCLQVG QEQKHTYLPL EVCNIVAGQR CIKKLTDNQT STMIKATARS APDRQEEISR 360 361 LVKSNSMVGG PDPYLKEFGI VVHNEMTELT GRVLPAPMLQ YGGRNKTVAT PNQGVWDMRG 420 421 KQFYAGIEIK VWAVACFAPQ KQCREDLLKS FTDQLRKISK DAGMPIQGQP CFCKYAQGAD 480 481 SVEPMFKHLK MTYVGLQLIV VILPGKTPVY AEVKRVGDTL LGMATQCVQV KNVVKTSPQT 540 541 LSNLCLKINA KLGGINNVLV PHQRSHSVTQ SGVQWGNHDS LQPPSPQDGH PSRYCATVRV 600 601 QTSRQEISQE LLYSQEVIQD LTNMVRELLI QFYKSTRFKP TRIIYYRGGV SEGQMKQVAW 660 661 PELIAIRKAC ISLEEDYRPG ITYIVVQKRH HTRLFCADKT ERVGKSGNVP AGTTVDSTIT 720 721 HPSEFDFYLC SHAGIQGTSR PSHYQVLWDD NCFTADELQL LTYQLCHTYV RCTRSVSIPA 780 781 PAYYARLVAF RARYHLVDKD HDSAEGSHVS GQSNGRDPQA LAKAVQIHHD TQHTMYFA 838 |
| Nucleotide CDS Sequence (FASTA) |
1 GAGGCGCTGG GACCCGGACC TCCGGCTAGC CTGTTTCAGC CACCTCGTCG TCCTGGCCTT 60 61 GGAACTGTTG GAAAACCAAT TCGACTGTTA GCCAATCATT TTCAGGTTCA GATTCCTAAA 120 121 ATAGATGTGT ATCACTATGA TGTGGATATT AAGCCTGAAA AACGGCCTCG TAGAGTCAAC 180 181 AGGGAGGTAG TAGATACAAT GGTGCGGCAC TTCAAGATGC AAATATTTGG TGATCGGCAG 240 241 CCTGGGTATG ATGGCAAAAG AAACATGTAC ACAGCACATC CACTACCAAT TGGACGGGAT 300 301 AGGGTTGATA TGGAGGTGAC TCTTCCAGGC GAGGGTAAAG ACCAAACATT TAAAGTGTCT 360 361 GTTCAGTGGG TGTCAGTTGT GAGCCTTCAG TTGCTTTTAG AAGCTTTGGC TGGGCACTTG 420 421 AATGAAGTCC CAGATGACTC AGTACAAGCA CTTGATGTTA TCACAAGACA CCTTCCCTCC 480 481 ATGAGGTACA CCCCAGTGGG CCGTTCCTTT TTCTCACCCC CGGAAGGTTA CTACCACCCT 540 541 CTGGGAGGGG GCAGGGAGGT CTGGTTTGGT TTTCATCAGT CTGTGAGACC TGCCATGTGG 600 601 AATATGATGC TCAACATTGA TGTATCTGCA ACTGCTTTCT ACCGGGCTCA GCCTATCATT 660 661 GAGTTCATGT GTGAGGTTTT AGACATTCAG AACATCAATG AACAGACCAA ACCTCTAACA 720 721 GACTCCCAGC GTGTCAAATT TACCAAAGAA ATCAGAGGTC TCAAAGTTGA GGTGACCCAC 780 781 TGTGGACAGA TGAAACGAAA ATACCGAGTT TGTAATGTGA CTAGACGGCC AGCCAGTCAT 840 841 CAAACTTTTC CTTTGCAGCT AGAAAACGGT CAAGCTATGG AATGTACAGT AGCTCAATAT 900 901 TTTAAGCAAA AGTATAGTCT GCAACTGAAA TACCCCCATC TTCCCTGTCT CCAAGTGGGA 960 961 CAAGAACAAA AGCATACATA CTTGCCACTC GAGGTCTGTA ATATAGTGGC AGGACAGCGA 1020 1021 TGTATCAAGA AGCTCACAGA CAATCAGACT TCCACAATGA TCAAAGCTAC AGCAAGATCT 1080 1081 GCTCCTGACA GACAGGAAGA GATCAGTAGA CTGGTGAAGA GCAACAGTAT GGTGGGTGGA 1140 1141 CCTGATCCAT ACCTTAAAGA ATTTGGTATT GTTGTCCACA ATGAAATGAC AGAGCTCACA 1200 1201 GGCAGGGTAC TTCCAGCACC AATGCTGCAA TATGGAGGCC GGAATAAAAC AGTAGCCACA 1260 1261 CCCAACCAGG GTGTCTGGGA CATGCGAGGA AAGCAGTTTT ATGCTGGCAT TGAAATTAAA 1320 1321 GTTTGGGCAG TTGCTTGTTT TGCACCTCAG AAACAATGTA GGGAAGATTT ACTAAAGAGT 1380 1381 TTCACTGACC AGCTGCGTAA AATCTCTAAG GATGCAGGAA TGCCCATCCA GGGTCAGCCA 1440 1441 TGTTTCTGCA AGTATGCACA AGGTGCAGAC AGTGTGGAGC CTATGTTTAA ACATCTGAAA 1500 1501 ATGACTTATG TGGGCCTACA GCTAATAGTG GTTATCCTGC CTGGAAAGAC ACCAGTATAT 1560 1561 GCGGAGGTGA AACGTGTTGG AGATACCCTT CTAGGTATGG CCACACAGTG TGTCCAGGTA 1620 1621 AAAAATGTAG TGAAGACCTC ACCTCAAACC CTTTCCAATC TTTGCCTGAA GATAAATGCA 1680 1681 AAACTTGGAG GAATTAACAA TGTGCTTGTG CCTCATCAAA GGGATGGCCA CCCCAGCCGG 1740 1741 TACTGTGCCA CCGTTCGGGT GCAGACTTCC CGGCAGGAGA TCTCCCAAGA GCTCCTCTAC 1800 1801 AGTCAAGAGG TCATCCAGGA CCTGACTAAC ATGGTTCGAG AGCTGCTGAT TCAGTTCTAC 1860 1861 AAATCCACAC GCTTCAAACC CACTCGGATC ATCTATTACC GTGGAGGGGT ATCTGAGGGA 1920 1921 CAAATGAAAC AGGTAGCTTG GCCAGAACTA ATAGCAATTC GAAAGGCGTG TATTAGCTTG 1980 1981 GAAGAAGATT ACCGGCCAGG AATAACATAT ATTGTGGTGC AAAAAAGACA TCACACACGA 2040 2041 CTCTTCTGTG CAGATAAAAC AGAAAGGGTA GGGAAAAGTG GCAATGTACC AGCAGGCACT 2100 2101 ACAGTGGATA GTACCATCAC ACATCCATCT GAGTTTGACT TTTACCTCTG TAGTCATGCA 2160 2161 GGAATTCAGG GAACCAGCCG TCCCTCACAT TACCAGGTCT TGTGGGATGA CAACTGCTTC 2220 2221 ACTGCAGATG AACTCCAGCT ACTGACTTAC CAGCTGTGTC ACACCTATGT GAGGTGCACT 2280 2281 CGCTCAGTCT CTATTCCAGC CCCTGCATAT TATGCCCGGC TTGTAGCATT TAGGGCAAGG 2340 2341 TATCATCTGG TGGATAAAGA TCATGACAGT GCGGAAGGCA GTCATGTGTC AGGACAGAGC 2400 2401 AACGGCCGGG ATCCTCAGGC CTTGGCTAAG GCTGTGCAAA TCCACCATGA TACCCAGCAC 2460 2461 ACGATGTATT TTGCCTGA 2478 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Micro-ribonucleoprotein complex | |
Cellular Component | Nuclear body | |
Cellular Component | P-body | |
Cellular Component | RISC complex | |
Cellular Component | RISC-loading complex | |
Molecular Function | Double-stranded RNA binding | |
Molecular Function | MiRNA binding | |
Molecular Function | Single-stranded RNA binding | |
Biological Process | Male gonad development | |
Biological Process | Male meiotic nuclear division | |
Biological Process | MiRNA loading onto RISC involved in gene silencing by miRNA | |
Biological Process | MiRNA mediated inhibition of translation | |
Biological Process | MiRNA metabolic process | |
Biological Process | MRNA catabolic process | |
Biological Process | Negative regulation of apoptotic process | |
Biological Process | Pre-miRNA processing | |
Biological Process | Regulation of cell morphogenesis | |
Biological Process | RNA secondary structure unwinding | |
Biological Process | Synaptonemal complex assembly |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ict-2519 | Ictidomys tridecemlineatus | 96.59 | 0.0 | 1665 |
| LLPS-Nol-0097 | Nomascus leucogenys | 96.59 | 0.0 | 1666 |
| LLPS-Cas-2544 | Carlito syrichta | 96.59 | 0.0 | 1666 |
| LLPS-Eqc-3826 | Equus caballus | 96.59 | 0.0 | 1666 |
| LLPS-Man-4410 | Macaca nemestrina | 96.59 | 0.0 | 1666 |
| LLPS-Pat-2495 | Pan troglodytes | 96.59 | 0.0 | 1666 |
| LLPS-Hos-1402 | Homo sapiens | 96.59 | 0.0 | 1666 |
| LLPS-Mal-1255 | Mandrillus leucophaeus | 96.59 | 0.0 | 1666 |
| LLPS-Aim-2354 | Ailuropoda melanoleuca | 96.59 | 0.0 | 1667 |
| LLPS-Fud-0877 | Fukomys damarensis | 96.59 | 0.0 | 1666 |
| LLPS-Caj-3702 | Callithrix jacchus | 96.59 | 0.0 | 1666 |
| LLPS-Cea-4488 | Cercocebus atys | 96.59 | 0.0 | 1666 |
| LLPS-Maf-3540 | Macaca fascicularis | 96.59 | 0.0 | 1665 |
| LLPS-Chs-1227 | Chlorocebus sabaeus | 96.59 | 0.0 | 1666 |
| LLPS-Mam-4442 | Macaca mulatta | 96.47 | 0.0 | 1667 |
| LLPS-Pap-0785 | Pan paniscus | 96.47 | 0.0 | 1667 |
| LLPS-Aon-3889 | Aotus nancymaae | 96.47 | 0.0 | 1666 |
| LLPS-Caf-2301 | Canis familiaris | 96.35 | 0.0 | 1550 |
| LLPS-Paa-0125 | Papio anubis | 96.35 | 0.0 | 1550 |
| LLPS-Ova-0289 | Ovis aries | 96.34 | 0.0 | 1654 |
| LLPS-Mod-4173 | Monodelphis domestica | 96.24 | 0.0 | 1664 |
| LLPS-Gaga-1127 | Gallus gallus | 96.12 | 0.0 | 1662 |
| LLPS-Anp-0369 | Anas platyrhynchos | 96.11 | 0.0 | 1657 |
| LLPS-Ora-0616 | Ornithorhynchus anatinus | 95.97 | 0.0 | 1547 |
| LLPS-Meg-0652 | Meleagris gallopavo | 95.77 | 0.0 | 1656 |
| LLPS-Loa-4171 | Loxodonta africana | 95.64 | 0.0 | 1541 |
| LLPS-Bot-0297 | Bos taurus | 95.53 | 0.0 | 1642 |
| LLPS-Rhb-3748 | Rhinopithecus bieti | 95.42 | 0.0 | 1637 |
| LLPS-Mum-3913 | Mus musculus | 95.42 | 0.0 | 1653 |
| LLPS-Myl-0397 | Myotis lucifugus | 95.3 | 0.0 | 1638 |
| LLPS-Anc-2654 | Anolis carolinensis | 95.18 | 0.0 | 1635 |
| LLPS-Lac-3215 | Latimeria chalumnae | 95.18 | 0.0 | 1653 |
| LLPS-Cap-3194 | Cavia porcellus | 94.59 | 0.0 | 1621 |
| LLPS-Dar-1993 | Danio rerio | 94.48 | 0.0 | 1644 |
| LLPS-Gaa-2231 | Gasterosteus aculeatus | 94.48 | 0.0 | 1643 |
| LLPS-Ten-2210 | Tetraodon nigroviridis | 94.12 | 0.0 | 1640 |
| LLPS-Ran-4389 | Rattus norvegicus | 93.48 | 0.0 | 1154 |
| LLPS-Pof-2916 | Poecilia formosa | 93.16 | 0.0 | 1634 |
| LLPS-Xim-3150 | Xiphophorus maculatus | 93.16 | 0.0 | 1634 |
| LLPS-Orl-1396 | Oryzias latipes | 93.16 | 0.0 | 1636 |
| LLPS-Icp-1751 | Ictalurus punctatus | 93.15 | 0.0 | 1632 |
| LLPS-Orn-0626 | Oreochromis niloticus | 93.04 | 0.0 | 1632 |
| LLPS-Scm-3624 | Scophthalmus maximus | 93.04 | 0.0 | 1636 |
| LLPS-Tar-0919 | Takifugu rubripes | 92.81 | 0.0 | 1630 |
| LLPS-Scf-4126 | Scleropages formosus | 90.24 | 0.0 | 1142 |
| LLPS-Otg-3609 | Otolemur garnettii | 88.13 | 0.0 | 1549 |
| LLPS-Sus-3271 | Sus scrofa | 88.0 | 2e-19 | 98.2 |
| LLPS-Mea-2976 | Mesocricetus auratus | 85.61 | 0.0 | 1415 |
| LLPS-Xet-0879 | Xenopus tropicalis | 82.84 | 0.0 | 1379 |
| LLPS-Mup-0618 | Mustela putorius furo | 82.42 | 0.0 | 1243 |
| LLPS-Leo-0053 | Lepisosteus oculatus | 81.67 | 0.0 | 1420 |
| LLPS-Tag-2430 | Taeniopygia guttata | 81.19 | 0.0 | 1098 |
| LLPS-Urm-3202 | Ursus maritimus | 80.93 | 0.0 | 638 |
| LLPS-Poa-2252 | Pongo abelii | 80.73 | 0.0 | 1408 |
| LLPS-Fec-0286 | Felis catus | 80.73 | 0.0 | 1408 |
| LLPS-Orc-1317 | Oryctolagus cuniculus | 80.61 | 0.0 | 1401 |
| LLPS-Pes-0182 | Pelodiscus sinensis | 79.95 | 0.0 | 1387 |
| LLPS-Sah-2657 | Sarcophilus harrisii | 79.86 | 0.0 | 1393 |
| LLPS-Dio-2699 | Dipodomys ordii | 78.26 | 0.0 | 1363 |
| LLPS-Fia-0927 | Ficedula albicollis | 78.02 | 0.0 | 1366 |
| LLPS-Asm-0287 | Astyanax mexicanus | 76.26 | 0.0 | 1346 |
| LLPS-Tut-0067 | Tursiops truncatus | 75.65 | 0.0 | 1325 |
| LLPS-Drm-0106 | Drosophila melanogaster | 68.17 | 0.0 | 1206 |
| LLPS-Cis-1295 | Ciona savignyi | 65.81 | 0.0 | 1142 |
| LLPS-Cii-0529 | Ciona intestinalis | 65.51 | 0.0 | 1123 |
| LLPS-Cae-0166 | Caenorhabditis elegans | 62.7 | 0.0 | 1106 |
| LLPS-Tra-2271 | Triticum aestivum | 42.96 | 0.0 | 639 |
| LLPS-Met-2300 | Medicago truncatula | 42.94 | 0.0 | 628 |
| LLPS-Arl-0946 | Arabidopsis lyrata | 42.22 | 0.0 | 625 |
| LLPS-Art-0603 | Arabidopsis thaliana | 42.1 | 0.0 | 626 |
| LLPS-Php-1196 | Physcomitrella patens | 42.01 | 0.0 | 622 |
| LLPS-Nia-1214 | Nicotiana attenuata | 42.0 | 0.0 | 619 |
| LLPS-Brn-0167 | Brassica napus | 41.97 | 0.0 | 622 |
| LLPS-Bro-0423 | Brassica oleracea | 41.95 | 0.0 | 622 |
| LLPS-Brr-0679 | Brassica rapa | 41.95 | 0.0 | 621 |
| LLPS-Brd-0980 | Brachypodium distachyon | 41.9 | 0.0 | 625 |
| LLPS-Hea-1410 | Helianthus annuus | 41.84 | 0.0 | 622 |
| LLPS-Sem-1844 | Selaginella moellendorffii | 41.69 | 0.0 | 624 |
| LLPS-Glm-1852 | Glycine max | 41.61 | 0.0 | 621 |
| LLPS-Mua-2226 | Musa acuminata | 41.37 | 0.0 | 618 |
| LLPS-Orni-1010 | Oryza nivara | 41.3 | 0.0 | 623 |
| LLPS-Zem-1049 | Zea mays | 40.28 | 0.0 | 615 |
| LLPS-Orr-2268 | Oryza rufipogon | 40.25 | 0.0 | 621 |