• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gog-3116

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cortactin
Ensembl Gene: ENSGGOG00000003011.3
Ensembl Protein: ENSGGOP00000029047.1
Organism: Gorilla gorilla
Taxa ID: 9595
LLPS Type: Scaffold


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Droplet, Centrosome/Spindle pole body, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ SEQUENCE

Protein Sequence (FASTA)
1     MWKASAGHAV  SIAQDDAGAD  DWETDPDFVN  DVSEKEQRWG  AKTVQGSGHQ  EHINIHKLRE  60
61    NVFQEHQTLK  EKELETGPKA  SHGYGGKFGV  EQDRMDKSAV  GHEYQSKLSK  HCSQVDSVRG  120
121   FGGKFGVQMD  RVDQSAVGFE  YQGKTEKHAS  QKDYSSGFGG  KYGVQADRVD  KSAVGFDYQG  180
181   KTEKHESQRD  YSKGFGGKYG  IDKDKVDKSA  VGFEYQGKTE  KHESQKDYVK  GFGGKFGVQT  240
241   DRQDKCALGW  DHQEKLQLHE  SQKDYSKGFG  GKYGVQKDRM  DKNASTFEDV  TQVSSAYQKT  300
301   VPVEAVTSKT  SNIRANFENL  AKEKEQEDRR  KAEAERAQRM  AKERQEQEEA  RRKLEEQARA  360
361   KTETPPASPA  PQPPEERLPS  SPVYEDAASF  KAELSYRGPV  SGTEPEPVYS  MEAADYREAG  420
421   SQQGLAYATE  AVYESAEAPG  HYPAEDSTYD  EYENDLGITA  VALYDYQAAG  DDEISFDPDD  480
481   IITNIEMIDD  GWWRGVCKGR  FRELAFSCVR  VALVPIKCSR  DLPGQARGLR  SALWRVGRKD  540
541   CPRLGASSRV  SLLGRRGLGL  MEVNPELSHP  EHRSCHVRWE  ICLCHTVTAC  RIRKLISFLR  600
601   SREAGPVPSC  SQVGGVSFQK  VTWKCLGTWV  PEHP  634
Nucleotide CDS Sequence (FASTA)
1     ATGTGGAAAG  CTTCAGCAGG  CCACGCTGTG  TCCATCGCCC  AGGATGACGC  GGGGGCCGAT  60
61    GACTGGGAGA  CCGACCCCGA  TTTTGTGAAT  GATGTGAGTG  AGAAGGAGCA  AAGATGGGGT  120
121   GCCAAGACGG  TGCAGGGCTC  CGGGCACCAG  GAGCATATCA  ACATACACAA  GCTGAGGGAG  180
181   AATGTCTTTC  AAGAGCATCA  GACCCTTAAG  GAGAAGGAAC  TTGAAACAGG  ACCAAAAGCT  240
241   TCCCACGGCT  ATGGAGGGAA  ATTTGGTGTG  GAACAAGACC  GAATGGATAA  GTCAGCTGTC  300
301   GGCCACGAAT  ATCAGTCGAA  ACTTTCCAAG  CACTGCTCGC  AGGTGGACTC  GGTCCGTGGC  360
361   TTCGGAGGCA  AGTTTGGTGT  CCAGATGGAC  AGAGTTGATC  AGTCTGCTGT  AGGCTTTGAA  420
421   TACCAGGGGA  AGACTGAGAA  GCATGCCTCC  CAGAAAGACT  ACTCCAGTGG  TTTTGGCGGC  480
481   AAGTACGGCG  TGCAGGCCGA  CCGAGTAGAC  AAGAGCGCGG  TGGGCTTCGA  CTACCAGGGC  540
541   AAGACGGAGA  AGCACGAGTC  ACAGAGAGAT  TACTCCAAAG  GTTTTGGCGG  CAAATACGGT  600
601   ATCGACAAGG  ACAAAGTGGA  TAAGAGCGCC  GTCGGCTTTG  AGTATCAAGG  CAAAACGGAG  660
661   AAGCACGAGT  CCCAGAAAGA  CTATGTGAAA  GGGTTTGGAG  GAAAATTTGG  TGTGCAGACA  720
721   GACAGACAAG  ACAAATGTGC  CCTTGGCTGG  GATCACCAGG  AGAAATTGCA  GCTGCATGAA  780
781   TCCCAAAAAG  ACTACTCCAA  AGGATTCGGC  GGGAAGTATG  GGGTGCAGAA  GGATCGGATG  840
841   GATAAGAATG  CGTCAACCTT  TGAGGATGTC  ACCCAGGTGT  CCTCTGCCTA  CCAGAAGACA  900
901   GTACCTGTCG  AAGCTGTGAC  CAGCAAAACA  AGTAACATCA  GAGCTAACTT  TGAAAACCTC  960
961   GCTAAGGAGA  AAGAGCAGGA  GGACAGGCGG  AAGGCGGAGG  CGGAGAGAGC  CCAGCGGATG  1020
1021  GCCAAGGAGC  GGCAGGAGCA  GGAAGAGGCC  AGGAGGAAGC  TGGAGGAGCA  AGCCAGAGCC  1080
1081  AAAACGGAAA  CGCCCCCTGC  GTCGCCCGCA  CCTCAGCCAC  CCGAGGAGAG  GCTGCCCTCG  1140
1141  AGCCCCGTCT  ATGAGGATGC  GGCTTCCTTC  AAGGCAGAGC  TGAGCTACAG  AGGCCCTGTG  1200
1201  AGTGGGACGG  AGCCGGAGCC  CGTGTACAGC  ATGGAGGCCG  CTGACTACCG  AGAGGCCGGC  1260
1261  AGCCAGCAGG  GCCTGGCCTA  TGCCACAGAG  GCTGTCTACG  AAAGCGCAGA  GGCCCCGGGC  1320
1321  CACTATCCCG  CAGAGGACAG  CACCTACGAT  GAGTATGAGA  ACGATCTGGG  GATCACAGCC  1380
1381  GTCGCCCTGT  ACGACTACCA  GGCTGCGGGC  GATGATGAGA  TCTCATTTGA  CCCTGATGAC  1440
1441  ATCATCACCA  ACATCGAGAT  GATTGACGAC  GGCTGGTGGC  GCGGGGTGTG  CAAGGGCCGC  1500
1501  TTCAGGGAGC  TCGCATTCTC  TTGTGTGCGT  GTTGCCCTCG  TGCCCATCAA  GTGCAGTCGG  1560
1561  GACCTCCCAG  GACAAGCACG  AGGCCTCAGG  TCGGCCCTGT  GGCGGGTAGG  CAGGAAGGAC  1620
1621  TGTCCCAGAC  TAGGGGCTTC  CTCTAGAGTC  TCACTGCTGG  GGAGGAGAGG  ACTGGGCCTG  1680
1681  ATGGAAGTTA  ACCCGGAGCT  AAGTCACCCA  GAGCACAGGA  GCTGCCATGT  CAGATGGGAA  1740
1741  ATCTGCCTAT  GTCATACCGT  GACAGCCTGC  AGGATCAGGA  AACTCATCTC  CTTCCTGAGG  1800
1801  AGCCGGGAGG  CTGGACCAGT  CCCGTCGTGC  AGTCAGGTGG  GCGGTGTGTC  TTTCCAGAAG  1860
1861  GTCACGTGGA  AATGTCTCGG  GACTTGGGTC  CCGGAGCACC  CGTGA  1905

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-4768Pan troglodytes98.90.01143
LLPS-Hos-1531Homo sapiens98.90.01144
LLPS-Poa-3787Pongo abelii97.210.0 880
LLPS-Eqc-4327Equus caballus94.290.0 633
LLPS-Pap-0075Pan paniscus92.190.0 885
LLPS-Maf-0228Macaca fascicularis91.640.0 879
LLPS-Cea-4308Cercocebus atys91.450.0 877
LLPS-Mal-2543Mandrillus leucophaeus91.450.0 877
LLPS-Paa-4645Papio anubis91.280.0 877
LLPS-Chs-2046Chlorocebus sabaeus91.260.0 876
LLPS-Rhb-0638Rhinopithecus bieti91.170.01043
LLPS-Man-3217Macaca nemestrina90.890.0 873
LLPS-Caj-0470Callithrix jacchus87.50.0 980
LLPS-Mup-2499Mustela putorius furo86.80.0 810
LLPS-Tut-0593Tursiops truncatus86.540.0 727
LLPS-Aon-0785Aotus nancymaae86.270.0 813
LLPS-Dio-3837Dipodomys ordii86.060.0 832
LLPS-Otg-0090Otolemur garnettii85.50.0 821
LLPS-Mum-4858Mus musculus85.50.0 812
LLPS-Mea-2796Mesocricetus auratus85.060.0 801
LLPS-Mam-1251Macaca mulatta85.020.0 957
LLPS-Cap-1560Cavia porcellus84.760.0 818
LLPS-Ran-3421Rattus norvegicus84.390.0 802
LLPS-Sus-1466Sus scrofa84.20.0 800
LLPS-Loa-4441Loxodonta africana83.890.0 786
LLPS-Leo-1444Lepisosteus oculatus83.750.0 551
LLPS-Fec-3931Felis catus83.460.0 797
LLPS-Urm-1195Ursus maritimus83.370.0 733
LLPS-Myl-1986Myotis lucifugus83.30.0 800
LLPS-Aim-3320Ailuropoda melanoleuca82.790.0 806
LLPS-Tag-1170Taeniopygia guttata82.440.0 744
LLPS-Caf-2662Canis familiaris82.310.0 799
LLPS-Dar-2039Danio rerio82.190.0 535
LLPS-Bot-1238Bos taurus81.970.0 770
LLPS-Ova-3100Ovis aries81.80.0 716
LLPS-Ict-3294Ictidomys tridecemlineatus81.670.0 797
LLPS-Fud-4396Fukomys damarensis81.230.0 834
LLPS-Orc-1338Oryctolagus cuniculus80.780.0 761
LLPS-Pof-1331Poecilia formosa80.563e-1170.1
LLPS-Xim-1785Xiphophorus maculatus80.562e-1170.9
LLPS-Orl-2247Oryzias latipes79.694e-179 525
LLPS-Anp-1985Anas platyrhynchos78.930.0 757
LLPS-Nol-4080Nomascus leucogenys78.860.0 845
LLPS-Meg-0083Meleagris gallopavo78.810.0 745
LLPS-Gaga-1204Gallus gallus78.810.0 711
LLPS-Gaa-0356Gasterosteus aculeatus78.052e-1273.2
LLPS-Fia-1403Ficedula albicollis77.120.0 732
LLPS-Anc-3562Anolis carolinensis75.230.0 718
LLPS-Sah-0364Sarcophilus harrisii74.950.0 638
LLPS-Xet-0789Xenopus tropicalis74.790.0 540
LLPS-Pes-3071Pelodiscus sinensis74.50.0 735
LLPS-Ora-0646Ornithorhynchus anatinus74.12e-163 481
LLPS-Scf-1827Scleropages formosus73.677e-178 523
LLPS-Orn-1651Oreochromis niloticus73.393e-177 522
LLPS-Mod-2671Monodelphis domestica71.799e-1168.6
LLPS-Ten-3506Tetraodon nigroviridis70.312e-169 501
LLPS-Scm-3866Scophthalmus maximus64.819e-1375.1
LLPS-Lac-0136Latimeria chalumnae64.510.0 589
LLPS-Drm-1357Drosophila melanogaster64.291e-0965.1
LLPS-Tar-3040Takifugu rubripes61.81e-22 105
LLPS-Fuo-0907Fusarium oxysporum61.545e-0653.9
LLPS-Fuv-1159Fusarium verticillioides61.546e-0653.5
LLPS-Cis-1988Ciona savignyi60.347e-1685.1
LLPS-Yal-1565Yarrowia lipolytica59.092e-0861.6
LLPS-Trr-0728Trichoderma reesei58.979e-0653.1
LLPS-Icp-4083Ictalurus punctatus58.750.0 593
LLPS-Cii-0216Ciona intestinalis58.625e-1479.3
LLPS-Beb-1515Beauveria bassiana58.145e-0653.9
LLPS-Blg-1241Blumeria graminis56.826e-0860.1
LLPS-Abg-1460Absidia glauca54.764e-0653.9
LLPS-Asm-3007Astyanax mexicanus51.022e-0758.2
LLPS-Scp-0959Schizosaccharomyces pombe48.846e-0653.9
LLPS-Scj-1334Schizosaccharomyces japonicus42.424e-0757.4
LLPS-Cas-3817Carlito syrichta42.03e-1170.1
LLPS-Scc-0314Schizosaccharomyces cryophilus41.462e-0758.2
LLPS-Pug-1460Puccinia graminis39.664e-0654.3