LLPS-Gog-1701
ANG
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Angiogenin; Ribonuclease 5; RNase 5 |
| Gene Name: | ANG, RNASE5 |
| Ensembl Gene: | ENSGGOG00000044112.1 |
| Ensembl Protein: | ENSGGOP00000035667.1 |
| Organism: | Gorilla gorilla |
| Taxa ID: | 9595 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSGGOT00000058676.1 | ENSGGOP00000035667.1 |
| UniProt | Q71MJ0, ANGI_GORGO | |
| GeneBank | AF441662 | AAL61644.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVMGLGVLLL IFVLGLGLTP PTLAQDNSRY THFLTQHYDA KPQGRDDRYC ESIMRRRGLT 60 61 SPCKDINTFI HGNKRSIKAI CENKNGNPHR ENLRISKSSF QVTTCKLHGG SPWPPCQYRA 120 121 TAGFRNVVVA CENGLPVHLD QSIFRRP 147 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTGATGG GCCTGGGCGT TTTGTTGTTG ATCTTCGTGC TGGGTCTGGG TCTGACCCCA 60 61 CCGACCCTGG CTCAGGATAA CTCCAGGTAC ACACACTTCC TGACCCAGCA CTATGATGCC 120 121 AAACCACAGG GCCGGGATGA CAGATACTGT GAAAGCATCA TGAGGAGACG GGGCCTGACC 180 181 TCACCCTGCA AAGACATCAA CACATTTATT CATGGCAACA AGCGCAGCAT CAAGGCCATC 240 241 TGTGAAAACA AGAATGGAAA CCCTCACAGA GAAAACCTAA GAATAAGCAA GTCTTCTTTC 300 301 CAGGTCACCA CTTGCAAGCT ACATGGAGGG TCCCCCTGGC CTCCATGCCA GTACCGAGCC 360 361 ACAGCGGGGT TCAGAAACGT TGTTGTTGCT TGTGAAAATG GCTTACCTGT CCACTTGGAT 420 421 CAGTCAATTT TCCGTCGTCC GTAA 444 |
▼ KEYWORD
ID | Family |
Angiogenesis | |
Complete proteome | |
Cytoplasmic vesicle | |
Developmental protein | |
Differentiation | |
Disulfide bond | |
DNA-binding | |
Endonuclease | |
Hydrolase | |
Nuclease | |
Nucleus | |
Protein synthesis inhibitor | |
Pyrrolidone carboxylic acid | |
Reference proteome | |
Secreted | |
Signal | |
Stress response
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Angiogenin-PRI complex | |
Cellular Component | Basement membrane | |
Cellular Component | Cytoplasmic vesicle | |
Cellular Component | Extracellular space | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleus | |
Molecular Function | Actin binding | |
Molecular Function | Copper ion binding | |
Molecular Function | DNA binding | |
Molecular Function | Endonuclease activity | |
Molecular Function | Heparin binding | |
Molecular Function | Protein homodimerization activity | |
Molecular Function | Ribonuclease activity | |
Molecular Function | Signaling receptor binding | |
Biological Process | Actin filament polymerization | |
Biological Process | Activation of phospholipase A2 activity | |
Biological Process | Activation of phospholipase C activity | |
Biological Process | Angiogenesis | |
Biological Process | Cell differentiation | |
Biological Process | Diacylglycerol biosynthetic process | |
Biological Process | Negative regulation of smooth muscle cell proliferation | |
Biological Process | Negative regulation of translation | |
Biological Process | Positive regulation of endothelial cell proliferation | |
Biological Process | Positive regulation of protein secretion | |
Biological Process | Response to hypoxia | |
Biological Process | RRNA transcription |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-0673 | Homo sapiens | 99.32 | 3e-94 | 276 |
| LLPS-Pat-2672 | Pan troglodytes | 98.64 | 5e-93 | 273 |
| LLPS-Pap-4459 | Pan paniscus | 97.96 | 3e-92 | 271 |
| LLPS-Fec-0820 | Felis catus | 79.31 | 1e-71 | 219 |
| LLPS-Mum-4745 | Mus musculus | 78.4 | 1e-68 | 211 |
| LLPS-Aim-3665 | Ailuropoda melanoleuca | 76.38 | 2e-67 | 208 |
| LLPS-Eqc-3397 | Equus caballus | 74.8 | 1e-66 | 206 |
| LLPS-Ran-3792 | Rattus norvegicus | 74.6 | 2e-65 | 203 |
| LLPS-Sus-4171 | Sus scrofa | 69.05 | 8e-59 | 187 |
| LLPS-Myl-4151 | Myotis lucifugus | 68.5 | 5e-63 | 196 |
| LLPS-Mea-3790 | Mesocricetus auratus | 68.0 | 3e-57 | 182 |
| LLPS-Tut-1144 | Tursiops truncatus | 65.0 | 1e-55 | 177 |
| LLPS-Ova-2631 | Ovis aries | 63.64 | 1e-56 | 180 |
| LLPS-Sah-3663 | Sarcophilus harrisii | 63.2 | 5e-55 | 176 |
| LLPS-Mod-2599 | Monodelphis domestica | 63.08 | 1e-54 | 175 |
| LLPS-Otg-4132 | Otolemur garnettii | 61.11 | 3e-52 | 169 |
| LLPS-Bot-3710 | Bos taurus | 54.86 | 1e-45 | 152 |
| LLPS-Anc-2992 | Anolis carolinensis | 47.54 | 3e-31 | 115 |
| LLPS-Pes-1234 | Pelodiscus sinensis | 44.09 | 2e-27 | 105 |
| LLPS-Scf-0689 | Scleropages formosus | 42.98 | 5e-24 | 96.3 |
| LLPS-Leo-3562 | Lepisosteus oculatus | 41.18 | 1e-19 | 85.1 |
| LLPS-Anp-1105 | Anas platyrhynchos | 39.17 | 6e-16 | 75.1 |
| LLPS-Fia-0019 | Ficedula albicollis | 38.52 | 2e-16 | 76.3 |
| LLPS-Dar-3055 | Danio rerio | 37.4 | 2e-18 | 82.0 |
| LLPS-Orn-2991 | Oreochromis niloticus | 37.19 | 9e-14 | 68.9 |
| LLPS-Gaga-2109 | Gallus gallus | 36.52 | 1e-13 | 68.6 |
| LLPS-Asm-3805 | Astyanax mexicanus | 36.36 | 8e-20 | 85.5 |
| LLPS-Meg-1872 | Meleagris gallopavo | 36.36 | 3e-15 | 72.8 |
| LLPS-Icp-1321 | Ictalurus punctatus | 35.0 | 2e-11 | 62.4 |
| LLPS-Xim-3648 | Xiphophorus maculatus | 32.23 | 2e-14 | 70.1 |
| LLPS-Pof-4012 | Poecilia formosa | 32.17 | 2e-12 | 65.5 |
| LLPS-Poa-2028 | Pongo abelii | 31.58 | 9e-07 | 48.9 |
| LLPS-Orl-0867 | Oryzias latipes | 31.45 | 6e-11 | 60.8 |
| LLPS-Orc-4045 | Oryctolagus cuniculus | 29.25 | 5e-06 | 47.0 |
| LLPS-Loa-4565 | Loxodonta africana | 27.74 | 1e-06 | 48.9 |