• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
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  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gaga-3866
RIC8A

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Synembryn-A; Protein Ric-8A
Gene Name: RIC8A, RCJMB04_7f5
Ensembl Gene: ENSGALG00000004191.5
Ensembl Protein: ENSGALP00000071454.1
Organism: Gallus gallus
Taxa ID: 9031
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole body, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MELRTVVATV  ESGEQDAVLK  VLQIYNQEKS  QCFTFDDEER  EERKKMAQLL  IKFLERELQP  60
61    SCQVTCLESI  RILSRDKYCL  EPFTTEEGLK  TLSRHAGIDY  SEELIREVPD  LEVILESLKC  120
121   LCNIVFSSPR  AQELTAEARL  VVGLTKRIKL  YNERSLPHEV  KFFDLRLLFL  LTALRVDIRQ  180
181   QLAQELRGIS  LMTDTLELTL  GVKWMDPYEV  ATEEGLLPPL  PRQETERAME  ILKVLFNITF  240
241   DSSKREVDEE  DAALYRHLGA  LLRHCLMISA  DGEDRTEEFH  SHTVNLLGNL  PLKCLDVLLT  300
301   PKVRPGSLEY  MGVNMDAVNI  LLDFLERRLD  RGHKLKESLT  PVLNLLTESA  RVHRQTRKFL  360
361   KAKVLPPLRD  VKNRPEVGNS  LRNKLVRLMT  HIDTDVKHCA  AEFLFVLCKE  SVSRFVKYTG  420
421   YGNAAGLLAA  RGLMAGGREE  GEYSEDEDTD  TEEYKEAKPN  INPVTGRVEE  KLPNPMEGMT  480
481   EEQKEYEAMK  LVNMFDKLSR  EQVIQPMGIT  PSGNLAPMEN  AIRDMADERS  SSDSDLGLD  539
Nucleotide CDS Sequence (FASTA)
1     ATGGAGCTCA  GGACTGTAGT  GGCCACGGTG  GAAAGCGGGG  AGCAAGATGC  GGTCCTCAAG  60
61    GTGCTTCAGA  TCTACAACCA  GGAGAAATCT  CAGTGCTTCA  CCTTTGATGA  TGAGGAACGG  120
121   GAGGAGAGGA  AGAAAATGGC  CCAGTTGCTG  ATCAAGTTCC  TGGAAAGAGA  GCTCCAGCCA  180
181   TCCTGCCAGG  TCACATGCTT  GGAAAGCATC  CGCATCCTGT  CCCGGGACAA  ATACTGCCTT  240
241   GAGCCTTTCA  CCACTGAGGA  AGGGCTGAAG  ACCCTCTCCA  GGCATGCTGG  CATCGATTAC  300
301   TCAGAGGAGC  TCATCCGAGA  GGTCCCAGAC  TTGGAGGTCA  TCCTGGAATC  CCTCAAATGC  360
361   CTCTGCAACA  TTGTCTTCAG  CAGCCCAAGG  GCACAGGAGC  TGACAGCAGA  AGCCCGGCTG  420
421   GTGGTGGGCC  TGACAAAGCG  CATTAAACTC  TACAACGAGA  GGAGCCTTCC  TCACGAAGTC  480
481   AAGTTCTTTG  ACCTGCGCCT  TCTCTTCCTG  CTGACAGCGC  TGAGAGTGGA  CATCCGGCAG  540
541   CAGCTAGCCC  AGGAGCTCCG  GGGCATCAGC  CTGATGACAG  ATACCCTGGA  GCTGACTCTT  600
601   GGTGTCAAGT  GGATGGACCC  CTATGAAGTT  GCCACTGAGG  AAGGACTGCT  TCCACCTTTG  660
661   CCTCGTCAAG  AGACAGAGCG  AGCCATGGAG  ATCCTGAAAG  TGCTCTTCAA  TATCACTTTT  720
721   GATTCCAGCA  AGAGGGAAGT  GGATGAGGAA  GATGCTGCTT  TGTACCGGCA  CTTGGGTGCC  780
781   CTCCTGCGCC  ACTGCCTCAT  GATCTCTGCT  GATGGGGAGG  ACCGGACAGA  GGAGTTCCAC  840
841   AGCCACACAG  TTAATCTTTT  GGGCAACCTG  CCCCTGAAAT  GTCTGGATGT  TCTCCTGACC  900
901   CCAAAAGTCC  GTCCGGGATC  ACTTGAGTAC  ATGGGTGTCA  ACATGGATGC  AGTTAATATC  960
961   CTGTTGGATT  TCCTAGAACG  ACGTCTTGAC  AGAGGACATA  AGCTGAAGGA  AAGCTTGACC  1020
1021  CCTGTGCTGA  ACCTGCTGAC  CGAGAGTGCC  AGAGTCCACC  GCCAGACAAG  GAAGTTCCTG  1080
1081  AAGGCAAAGG  TGCTGCCTCC  GCTGCGGGAT  GTGAAGAATC  GGCCGGAGGT  GGGGAACTCG  1140
1141  CTGCGGAACA  AGCTGGTGCG  TTTGATGACC  CACATTGACA  CCGACGTGAA  GCACTGTGCA  1200
1201  GCTGAATTCC  TCTTTGTGCT  CTGCAAGGAG  AGCGTGTCGC  GGTTTGTGAA  GTACACAGGC  1260
1261  TATGGGAATG  CAGCTGGGCT  CCTGGCAGCG  CGAGGCCTGA  TGGCTGGTGG  CCGGGAGGAG  1320
1321  GGAGAGTACT  CAGAAGATGA  GGACACAGAC  ACAGAGGAGT  ACAAAGAGGC  AAAGCCCAAC  1380
1381  ATTAATCCTG  TGACAGGACG  TGTTGAGGAG  AAACTCCCCA  ACCCCATGGA  AGGGATGACT  1440
1441  GAAGAGCAGA  AGGAATATGA  AGCCATGAAG  TTAGTCAATA  TGTTCGACAA  GTTGTCCAGA  1500
1501  GAGCAAGTCA  TCCAACCTAT  GGGCATCACG  CCGAGTGGCA  ACCTGGCCCC  CATGGAGAAC  1560
1561  GCCATCCGTG  ATATGGCTGA  TGAGAGGTCC  TCATCTGACT  CAGACCTGGG  GCTGGACTGA  1620

▼ KEYWORD

ID
Family
Cell membrane
Complete proteome
Cytoplasm
Guanine-nucleotide releasing factor
Membrane
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Plasma membrane
Molecular Function
G-protein alpha-subunit binding
Molecular Function
GTPase activator activity
Molecular Function
Guanyl-nucleotide exchange factor activity
Biological Process
G protein-coupled receptor signaling pathway

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Anp-3163Anas platyrhynchos98.520.0 977
LLPS-Fia-1867Ficedula albicollis94.620.0 919
LLPS-Tag-1940Taeniopygia guttata94.060.0 908
LLPS-Pes-3635Pelodiscus sinensis92.530.0 588
LLPS-Anc-1512Anolis carolinensis87.010.0 855
LLPS-Lac-1945Latimeria chalumnae76.210.0 596
LLPS-Leo-1981Lepisosteus oculatus75.330.0 743
LLPS-Xet-1783Xenopus tropicalis72.850.0 704
LLPS-Cas-2674Carlito syrichta69.357e-175 509
LLPS-Gog-1274Gorilla gorilla69.170.0 546
LLPS-Mup-4027Mustela putorius furo68.580.0 581
LLPS-Fec-3306Felis catus68.410.0 601
LLPS-Asm-0961Astyanax mexicanus68.30.0 619
LLPS-Poa-2632Pongo abelii68.280.0 603
LLPS-Mum-3536Mus musculus68.160.0 620
LLPS-Orc-3352Oryctolagus cuniculus68.110.0 581
LLPS-Rhb-3650Rhinopithecus bieti68.10.0 599
LLPS-Man-2310Macaca nemestrina68.10.0 602
LLPS-Caf-2792Canis familiaris68.040.0 615
LLPS-Dar-2488Danio rerio68.00.0 669
LLPS-Eqc-4755Equus caballus67.970.0 617
LLPS-Pat-4908Pan troglodytes67.910.0 598
LLPS-Maf-4275Macaca fascicularis67.910.0 600
LLPS-Chs-3719Chlorocebus sabaeus67.910.0 599
LLPS-Cea-4684Cercocebus atys67.910.0 600
LLPS-Ran-2150Rattus norvegicus67.850.0 617
LLPS-Aim-3877Ailuropoda melanoleuca67.840.0 617
LLPS-Aon-0583Aotus nancymaae67.780.0 601
LLPS-Pap-2848Pan paniscus67.720.0 595
LLPS-Fud-4180Fukomys damarensis67.660.0 607
LLPS-Otg-0382Otolemur garnettii67.60.0 594
LLPS-Urm-3686Ursus maritimus67.550.0 547
LLPS-Hos-1565Homo sapiens67.40.0 595
LLPS-Mal-3343Mandrillus leucophaeus67.340.0 596
LLPS-Ict-3028Ictidomys tridecemlineatus67.290.0 599
LLPS-Mea-4461Mesocricetus auratus67.230.0 612
LLPS-Scf-0074Scleropages formosus67.210.0 638
LLPS-Nol-2555Nomascus leucogenys67.160.0 592
LLPS-Mam-4727Macaca mulatta67.160.0 596
LLPS-Caj-2302Callithrix jacchus67.160.0 598
LLPS-Paa-4639Papio anubis67.160.0 593
LLPS-Icp-2636Ictalurus punctatus67.110.0 610
LLPS-Sus-4036Sus scrofa67.040.0 592
LLPS-Ova-4258Ovis aries66.730.0 566
LLPS-Tut-2003Tursiops truncatus66.730.0 585
LLPS-Bot-0519Bos taurus66.360.0 600
LLPS-Orn-1877Oreochromis niloticus65.650.0 618
LLPS-Gaa-1505Gasterosteus aculeatus63.480.0 576
LLPS-Cap-3542Cavia porcellus62.990.0 548
LLPS-Scm-0568Scophthalmus maximus62.930.0 595
LLPS-Ten-2310Tetraodon nigroviridis61.650.0 578
LLPS-Pof-3037Poecilia formosa61.580.0 596
LLPS-Xim-2683Xiphophorus maculatus61.460.0 596
LLPS-Orl-3529Oryzias latipes60.550.0 609
LLPS-Tar-2150Takifugu rubripes57.21e-171 503
LLPS-Myl-2326Myotis lucifugus49.242e-113 352
LLPS-Cii-0608Ciona intestinalis34.981e-51 190