LLPS-Gaga-3090
CHMP6
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Charged multivesicular body protein 6; Chromatin-modifying protein 6 |
| Gene Name: | CHMP6, RCJMB04_7k13 |
| Ensembl Gene: | ENSGALG00000026428.3 |
| Ensembl Protein: | ENSGALP00000041343.2 |
| Organism: | Gallus gallus |
| Taxa ID: | 9031 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Paraspeckle, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSGALT00000044736.3 | ENSGALP00000041343.2 |
| UniProt | Q5ZL55, CHMP6_CHICK | |
| GeneBank | AJ719879 | CAG31538.1 |
| RefSeq | NM_001031529.1 | NP_001026700.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGNLFGRKRR SRVTEQDKAV LQLKQQRDKL RQYQKRISLG LERERELARQ LLKEGKKEKA 60 61 MLLLKKKRYQ EQLLDKTDNQ ISNLERMVQD IEFTQIEMKV IEGLKIGNEC LNKMHQVMSI 120 121 EEVERIIGET QDAVEYQRQI DEILAGSLTE EDEDAILEEL NAITQEQLEL PDVPSEPLPE 180 181 EPPEATPVKN RPKPELVAAS 200 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGAATC TGTTCGGGCG GAAGCGGCGC AGCCGCGTCA CGGAGCAGGA CAAGGCCGTG 60 61 CTGCAATTGA AGCAGCAGAG GGATAAACTG CGGCAGTACC AGAAGCGGAT CAGTCTGGGC 120 121 CTGGAGCGGG AGCGGGAGCT CGCCCGGCAG CTGCTGAAGG AGGGCAAGAA GGAAAAAGCT 180 181 ATGCTCTTGT TGAAGAAGAA GCGTTACCAG GAGCAGCTGC TGGATAAGAC AGACAACCAG 240 241 ATCAGCAACC TGGAGCGGAT GGTCCAGGAT ATCGAGTTCA CTCAGATCGA AATGAAGGTC 300 301 ATTGAGGGCC TGAAAATAGG CAACGAATGT CTGAACAAAA TGCACCAGGT TATGTCAATA 360 361 GAAGAAGTGG AAAGAATAAT AGGTGAAACC CAGGATGCTG TGGAGTACCA GAGGCAAATA 420 421 GATGAGATAC TGGCTGGGAG CCTGACTGAG GAAGATGAAG ATGCCATTCT AGAGGAATTA 480 481 AACGCTATCA CTCAGGAACA GTTGGAGCTT CCAGACGTTC CTTCTGAGCC ACTCCCAGAG 540 541 GAGCCCCCAG AAGCAACACC CGTCAAGAAC AGGCCAAAAC CAGAGCTGGT GGCAGCATCT 600 601 TAA 603 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | ESCRT III complex | |
Cellular Component | Late endosome membrane | |
Molecular Function | Protein N-terminus binding | |
Molecular Function | Protein-containing complex binding | |
Biological Process | Midbody abscission | |
Biological Process | Mitotic metaphase plate congression | |
Biological Process | Negative regulation of epidermal growth factor-activated receptor activity | |
Biological Process | Nucleus organization | |
Biological Process | Protein transport | |
Biological Process | Regulation of protein catabolic process | |
Biological Process | Vacuolar transport | |
Biological Process | Viral budding via host ESCRT complex |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Meg-2570 | Meleagris gallopavo | 98.5 | 2e-68 | 213 |
| LLPS-Fia-2428 | Ficedula albicollis | 93.98 | 3e-70 | 219 |
| LLPS-Anp-0623 | Anas platyrhynchos | 92.54 | 2e-69 | 215 |
| LLPS-Dio-3113 | Dipodomys ordii | 89.19 | 3e-15 | 71.6 |
| LLPS-Anc-2373 | Anolis carolinensis | 87.0 | 5e-72 | 224 |
| LLPS-Cas-3186 | Carlito syrichta | 87.0 | 5e-53 | 176 |
| LLPS-Tag-1452 | Taeniopygia guttata | 86.5 | 1e-78 | 240 |
| LLPS-Man-0973 | Macaca nemestrina | 85.0 | 6e-52 | 173 |
| LLPS-Hos-1575 | Homo sapiens | 85.0 | 5e-52 | 173 |
| LLPS-Rhb-1201 | Rhinopithecus bieti | 85.0 | 4e-52 | 173 |
| LLPS-Cea-0503 | Cercocebus atys | 85.0 | 5e-52 | 173 |
| LLPS-Caj-2696 | Callithrix jacchus | 85.0 | 2e-52 | 174 |
| LLPS-Gog-1586 | Gorilla gorilla | 85.0 | 5e-52 | 173 |
| LLPS-Mal-4253 | Mandrillus leucophaeus | 85.0 | 6e-52 | 173 |
| LLPS-Paa-3702 | Papio anubis | 85.0 | 6e-52 | 173 |
| LLPS-Pes-3689 | Pelodiscus sinensis | 84.96 | 2e-63 | 201 |
| LLPS-Pap-0242 | Pan paniscus | 84.0 | 3e-51 | 171 |
| LLPS-Eqc-0872 | Equus caballus | 83.23 | 9e-61 | 196 |
| LLPS-Urm-3903 | Ursus maritimus | 83.0 | 7e-52 | 172 |
| LLPS-Aon-4111 | Aotus nancymaae | 83.0 | 2e-51 | 171 |
| LLPS-Mup-3269 | Mustela putorius furo | 83.0 | 3e-51 | 170 |
| LLPS-Ere-0330 | Erinaceus europaeus | 82.76 | 2e-29 | 111 |
| LLPS-Xet-1140 | Xenopus tropicalis | 82.0 | 6e-57 | 185 |
| LLPS-Pof-3733 | Poecilia formosa | 81.82 | 4e-58 | 188 |
| LLPS-Chs-2784 | Chlorocebus sabaeus | 81.59 | 3e-65 | 206 |
| LLPS-Bot-2013 | Bos taurus | 81.59 | 1e-65 | 207 |
| LLPS-Maf-3296 | Macaca fascicularis | 81.34 | 8e-56 | 182 |
| LLPS-Ova-2530 | Ovis aries | 81.34 | 4e-57 | 185 |
| LLPS-Xim-3701 | Xiphophorus maculatus | 81.21 | 2e-57 | 186 |
| LLPS-Cap-4035 | Cavia porcellus | 81.09 | 6e-65 | 205 |
| LLPS-Pat-2496 | Pan troglodytes | 80.85 | 6e-16 | 76.3 |
| LLPS-Tar-3897 | Takifugu rubripes | 80.61 | 9e-56 | 182 |
| LLPS-Sah-0198 | Sarcophilus harrisii | 80.6 | 3e-57 | 185 |
| LLPS-Tut-1662 | Tursiops truncatus | 80.2 | 1e-62 | 200 |
| LLPS-Mod-1629 | Monodelphis domestica | 80.1 | 2e-65 | 207 |
| LLPS-Ict-1363 | Ictidomys tridecemlineatus | 80.1 | 2e-64 | 204 |
| LLPS-Orn-3318 | Oreochromis niloticus | 80.0 | 6e-57 | 185 |
| LLPS-Ten-3425 | Tetraodon nigroviridis | 80.0 | 1e-56 | 184 |
| LLPS-Caf-3684 | Canis familiaris | 79.85 | 6e-57 | 184 |
| LLPS-Mea-1888 | Mesocricetus auratus | 79.6 | 1e-61 | 197 |
| LLPS-Ran-3844 | Rattus norvegicus | 79.6 | 3e-62 | 199 |
| LLPS-Icp-0077 | Ictalurus punctatus | 79.39 | 1e-56 | 184 |
| LLPS-Gaa-3930 | Gasterosteus aculeatus | 79.39 | 5e-57 | 185 |
| LLPS-Sus-3538 | Sus scrofa | 79.1 | 3e-61 | 196 |
| LLPS-Mum-3229 | Mus musculus | 79.1 | 2e-61 | 197 |
| LLPS-Aim-2870 | Ailuropoda melanoleuca | 79.1 | 2e-54 | 178 |
| LLPS-Otg-4601 | Otolemur garnettii | 78.61 | 8e-62 | 197 |
| LLPS-Ora-2321 | Ornithorhynchus anatinus | 78.52 | 4e-55 | 180 |
| LLPS-Scm-1149 | Scophthalmus maximus | 78.44 | 6e-55 | 180 |
| LLPS-Fec-1971 | Felis catus | 78.11 | 5e-62 | 198 |
| LLPS-Dar-0842 | Danio rerio | 77.58 | 3e-55 | 181 |
| LLPS-Loa-3971 | Loxodonta africana | 76.12 | 2e-58 | 189 |
| LLPS-Leo-0378 | Lepisosteus oculatus | 75.0 | 2e-63 | 201 |
| LLPS-Asm-1868 | Astyanax mexicanus | 73.81 | 1e-50 | 169 |
| LLPS-Fud-3503 | Fukomys damarensis | 73.63 | 3e-56 | 183 |
| LLPS-Orl-1974 | Oryzias latipes | 73.05 | 5e-51 | 170 |
| LLPS-Scf-2150 | Scleropages formosus | 72.91 | 4e-61 | 196 |
| LLPS-Mam-0244 | Macaca mulatta | 72.64 | 6e-60 | 192 |
| LLPS-Lac-0307 | Latimeria chalumnae | 71.53 | 3e-51 | 168 |
| LLPS-Poa-3520 | Pongo abelii | 71.14 | 4e-43 | 149 |
| LLPS-Cis-1701 | Ciona savignyi | 56.55 | 3e-32 | 121 |
| LLPS-Nol-2610 | Nomascus leucogenys | 56.1 | 2e-13 | 69.7 |
| LLPS-Cii-2331 | Ciona intestinalis | 56.02 | 2e-31 | 119 |
| LLPS-Drm-1427 | Drosophila melanogaster | 55.0 | 1e-25 | 104 |
| LLPS-Abg-0527 | Absidia glauca | 49.47 | 4e-23 | 97.4 |
| LLPS-Spr-1293 | Sporisorium reilianum | 47.47 | 4e-22 | 94.7 |
| LLPS-Tum-1080 | Tuber melanosporum | 47.47 | 2e-22 | 95.1 |
| LLPS-Usm-0920 | Ustilago maydis | 46.46 | 4e-21 | 92.0 |
| LLPS-Crn-0091 | Cryptococcus neoformans | 46.34 | 2e-18 | 84.3 |
| LLPS-Nec-0825 | Neurospora crassa | 45.52 | 2e-14 | 72.8 |
| LLPS-Gag-1342 | Gaeumannomyces graminis | 45.45 | 5e-19 | 85.9 |
| LLPS-Pug-1330 | Puccinia graminis | 45.14 | 2e-15 | 75.9 |
| LLPS-Map-0707 | Magnaporthe poae | 44.44 | 4e-19 | 86.3 |
| LLPS-Cae-1769 | Caenorhabditis elegans | 44.09 | 2e-20 | 90.1 |
| LLPS-Trv-1245 | Trichoderma virens | 43.0 | 9e-18 | 82.4 |
| LLPS-Mao-1317 | Magnaporthe oryzae | 43.0 | 2e-19 | 87.0 |
| LLPS-Nia-0595 | Nicotiana attenuata | 42.5 | 1e-11 | 64.7 |
| LLPS-Prp-1321 | Prunus persica | 42.5 | 1e-10 | 62.0 |
| LLPS-Glm-0917 | Glycine max | 42.5 | 4e-12 | 66.2 |
| LLPS-Asni-0359 | Aspergillus niger | 42.25 | 3e-09 | 58.5 |
| LLPS-Trr-0078 | Trichoderma reesei | 42.0 | 6e-18 | 82.8 |
| LLPS-Phv-2570 | Phaseolus vulgaris | 41.88 | 3e-11 | 63.5 |
| LLPS-Via-1578 | Vigna angularis | 41.88 | 2e-11 | 64.3 |
| LLPS-Fus-0886 | Fusarium solani | 41.86 | 2e-16 | 78.6 |
| LLPS-Asg-1422 | Ashbya gossypii | 41.56 | 1e-10 | 62.0 |
| LLPS-Put-0296 | Puccinia triticina | 41.46 | 3e-15 | 75.1 |
| LLPS-Fuo-1475 | Fusarium oxysporum | 41.38 | 2e-16 | 78.6 |
| LLPS-Fuv-0791 | Fusarium verticillioides | 41.38 | 2e-16 | 78.6 |
| LLPS-Amt-1720 | Amborella trichopoda | 41.25 | 6e-13 | 68.6 |
| LLPS-Nef-1169 | Neosartorya fischeri | 41.0 | 3e-16 | 78.2 |
| LLPS-Asfu-1628 | Aspergillus fumigatus | 41.0 | 4e-16 | 77.8 |
| LLPS-Pytr-0115 | Pyrenophora triticirepentis | 40.96 | 9e-14 | 70.9 |
| LLPS-Cogr-1523 | Colletotrichum graminicola | 40.96 | 1e-15 | 76.3 |
| LLPS-Sol-0949 | Solanum lycopersicum | 40.62 | 2e-10 | 61.2 |
| LLPS-Sac-1540 | Saccharomyces cerevisiae | 40.59 | 4e-13 | 68.9 |
| LLPS-Beb-0910 | Beauveria bassiana | 40.43 | 2e-17 | 81.3 |
| LLPS-Art-2131 | Arabidopsis thaliana | 40.37 | 1e-10 | 62.0 |
| LLPS-Bro-1548 | Brassica oleracea | 40.37 | 1e-10 | 63.2 |
| LLPS-Arl-2097 | Arabidopsis lyrata | 40.37 | 8e-11 | 62.4 |
| LLPS-Mel-1040 | Melampsora laricipopulina | 40.24 | 2e-15 | 75.5 |
| LLPS-Cog-0952 | Colletotrichum gloeosporioides | 40.21 | 2e-18 | 84.3 |
| LLPS-Coo-1212 | Colletotrichum orbiculare | 40.21 | 3e-18 | 84.0 |
| LLPS-Blg-1459 | Blumeria graminis | 40.21 | 2e-17 | 81.3 |
| LLPS-Ast-0851 | Aspergillus terreus | 40.0 | 2e-16 | 79.0 |
| LLPS-Asc-1539 | Aspergillus clavatus | 40.0 | 4e-13 | 68.9 |
| LLPS-Asn-0322 | Aspergillus nidulans | 40.0 | 3e-13 | 69.3 |
| LLPS-Lem-1096 | Leptosphaeria maculans | 40.0 | 1e-13 | 70.9 |
| LLPS-Pyt-0532 | Pyrenophora teres | 39.76 | 1e-13 | 70.5 |
| LLPS-Hov-1341 | Hordeum vulgare | 39.75 | 9e-11 | 62.4 |
| LLPS-Phn-0768 | Phaeosphaeria nodorum | 39.44 | 2e-09 | 58.2 |
| LLPS-Sem-0226 | Selaginella moellendorffii | 39.38 | 4e-09 | 58.5 |
| LLPS-Hea-1721 | Helianthus annuus | 39.38 | 1e-09 | 58.9 |
| LLPS-Brd-0437 | Brachypodium distachyon | 39.13 | 2e-10 | 61.6 |
| LLPS-Zem-1489 | Zea mays | 38.75 | 2e-10 | 61.6 |
| LLPS-Ved-0136 | Verticillium dahliae | 38.55 | 1e-11 | 64.3 |
| LLPS-Zyt-1345 | Zymoseptoria tritici | 38.55 | 5e-13 | 68.9 |
| LLPS-Tra-1227 | Triticum aestivum | 38.55 | 1e-10 | 62.0 |
| LLPS-Aso-0271 | Aspergillus oryzae | 37.0 | 1e-14 | 73.2 |
| LLPS-Asf-1168 | Aspergillus flavus | 37.0 | 1e-14 | 73.6 |
| LLPS-Dac-1804 | Daucus carota | 36.56 | 5e-12 | 65.9 |
| LLPS-Dos-1455 | Dothistroma septosporum | 36.14 | 3e-12 | 66.6 |
| LLPS-Miv-1235 | Microbotryum violaceum | 35.96 | 2e-13 | 68.9 |
| LLPS-Kop-0474 | Komagataella pastoris | 35.56 | 2e-12 | 67.0 |
| LLPS-Scj-1175 | Schizosaccharomyces japonicus | 35.48 | 5e-11 | 63.2 |
| LLPS-Met-1461 | Medicago truncatula | 35.48 | 1e-10 | 62.4 |
| LLPS-Cus-1833 | Cucumis sativus | 35.11 | 3e-11 | 63.5 |
| LLPS-Yal-1378 | Yarrowia lipolytica | 35.0 | 1e-13 | 70.9 |
| LLPS-Mua-1201 | Musa acuminata | 34.41 | 4e-11 | 63.5 |
| LLPS-Viv-0432 | Vitis vinifera | 34.07 | 1e-09 | 59.3 |
| LLPS-Gor-0912 | Gossypium raimondii | 34.07 | 7e-10 | 60.1 |
| LLPS-Brr-2659 | Brassica rapa | 34.04 | 9e-11 | 62.4 |
| LLPS-Brn-2035 | Brassica napus | 34.04 | 1e-10 | 62.0 |
| LLPS-Thc-2084 | Theobroma cacao | 34.04 | 3e-10 | 61.6 |
| LLPS-Sob-2029 | Sorghum bicolor | 33.33 | 2e-10 | 61.6 |
| LLPS-Sei-1089 | Setaria italica | 33.33 | 3e-10 | 61.2 |
| LLPS-Coc-2127 | Corchorus capsularis | 32.99 | 3e-11 | 66.2 |
| LLPS-Scp-0369 | Schizosaccharomyces pombe | 32.63 | 7e-10 | 60.1 |
| LLPS-Orp-1429 | Oryza punctata | 32.26 | 1e-08 | 57.0 |
| LLPS-Pot-0130 | Populus trichocarpa | 32.26 | 5e-09 | 57.4 |
| LLPS-Ors-1696 | Oryza sativa | 32.26 | 2e-09 | 58.9 |
| LLPS-Orr-1832 | Oryza rufipogon | 32.26 | 2e-09 | 58.9 |
| LLPS-Orm-0266 | Oryza meridionalis | 32.26 | 3e-09 | 58.9 |
| LLPS-Org-0468 | Oryza glaberrima | 32.26 | 2e-09 | 58.5 |
| LLPS-Orb-0124 | Oryza barthii | 32.26 | 2e-09 | 58.5 |
| LLPS-Ori-0580 | Oryza indica | 32.26 | 2e-09 | 58.5 |
| LLPS-Orni-1895 | Oryza nivara | 32.26 | 2e-09 | 58.5 |
| LLPS-Lep-1697 | Leersia perrieri | 32.26 | 3e-09 | 58.5 |
| LLPS-Mae-2445 | Manihot esculenta | 31.18 | 6e-09 | 57.4 |
| LLPS-Orgl-1353 | Oryza glumaepatula | 31.18 | 2e-08 | 56.2 |
| LLPS-Vir-1562 | Vigna radiata | 30.86 | 9e-07 | 50.4 |
| LLPS-Scc-1553 | Schizosaccharomyces cryophilus | 30.0 | 1e-10 | 62.0 |
| LLPS-Php-2367 | Physcomitrella patens | 29.17 | 6e-09 | 57.8 |