• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gaga-2098

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Nucleoside diphosphate kinase
Ensembl Gene: ENSGALG00000002932.6
Ensembl Protein: ENSGALP00000034078.3
Organism: Gallus gallus
Taxa ID: 9031
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAANCERTFI  AIKPDGVQRG  LVGEIIKRFE  QKGFRLVAMK  FVHASEDLLK  QHYIDLKDRP  60
61    FYPGLVKYMN  SGPVVAMVWE  GLNVVKTGRV  MLGETNPADS  KPGTIRGDFC  IQVGRNIIHG  120
121   SDSVESAQKE  ISLWFKPAEL  IDYRSCAHDW  VYE  153
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGCCA  ACTGCGAGCG  CACCTTCATC  GCCATCAAAC  CCGACGGCGT  GCAGCGGGGG  60
61    CTGGTGGGGG  AGATCATCAA  ACGCTTCGAG  CAGAAGGGCT  TCCGCCTGGT  GGCCATGAAG  120
121   TTCGTGCACG  CCTCTGAAGA  CCTCCTGAAG  CAGCATTACA  TCGACCTGAA  GGATCGGCCC  180
181   TTCTACCCCG  GCCTGGTGAA  GTACATGAAC  TCCGGCCCCG  TTGTGGCCAT  GGTGTGGGAA  240
241   GGGCTCAACG  TGGTGAAAAC  AGGCAGGGTG  ATGCTGGGGG  AAACCAACCC  TGCAGACTCA  300
301   AAGCCTGGCA  CCATCCGCGG  GGATTTCTGC  ATCCAAGTGG  GAAGAAACAT  CATCCATGGC  360
361   AGCGACTCTG  TAGAAAGCGC  CCAGAAGGAG  ATCAGCCTTT  GGTTCAAACC  AGCAGAGCTC  420
421   ATCGACTACA  GATCATGTGC  ACATGACTGG  GTCTATGAGT  GA  462

▼ KEYWORD

ID
Family
ATP-binding
Cell membrane
Complete proteome
Cytoplasm
Kinase
Magnesium
Membrane
Metal-binding
Nucleotide metabolism
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Extracellular space
Cellular Component
Lamellipodium
Cellular Component
Mitochondrion
Cellular Component
Plasma membrane
Cellular Component
Ruffle
Molecular Function
ATP binding
Molecular Function
G-quadruplex DNA binding
Molecular Function
GDP binding
Molecular Function
Metal ion binding
Molecular Function
Nucleoside diphosphate kinase activity
Molecular Function
Transcription coactivator activity
Biological Process
CTP biosynthetic process
Biological Process
GTP biosynthetic process
Biological Process
Integrin-mediated signaling pathway
Biological Process
Negative regulation of apoptotic process
Biological Process
Positive regulation of epithelial cell proliferation
Biological Process
Positive regulation of keratinocyte differentiation
Biological Process
Positive regulation of transcription by RNA polymerase II
Biological Process
Regulation of epidermis development
Biological Process
UTP biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Anp-1188Anas platyrhynchos95.427e-108 315
LLPS-Fia-0297Ficedula albicollis93.468e-104 305
LLPS-Ran-2747Rattus norvegicus93.383e-102 297
LLPS-Mum-3355Mus musculus93.383e-102 296
LLPS-Ict-2742Ictidomys tridecemlineatus93.387e-103 298
LLPS-Dio-0702Dipodomys ordii92.728e-102 296
LLPS-Aon-3542Aotus nancymaae92.721e-100 298
LLPS-Caj-4820Callithrix jacchus92.724e-100 296
LLPS-Gog-2523Gorilla gorilla92.723e-102 297
LLPS-Pap-3243Pan paniscus92.722e-100 297
LLPS-Hos-0577Homo sapiens92.722e-100 297
LLPS-Paa-2078Papio anubis92.054e-100 296
LLPS-Mea-3209Mesocricetus auratus92.054e-100 295
LLPS-Maf-1353Macaca fascicularis92.054e-100 296
LLPS-Chs-3883Chlorocebus sabaeus92.054e-102 296
LLPS-Mam-0601Macaca mulatta92.054e-100 296
LLPS-Man-2171Macaca nemestrina92.054e-100 296
LLPS-Loa-1246Loxodonta africana92.051e-101 295
LLPS-Pat-2325Pan troglodytes92.053e-100 297
LLPS-Pes-0831Pelodiscus sinensis91.53e-103 303
LLPS-Tag-2899Taeniopygia guttata91.452e-100 296
LLPS-Myl-0484Myotis lucifugus91.395e-102 296
LLPS-Cea-0891Cercocebus atys91.395e-102 296
LLPS-Nol-2914Nomascus leucogenys91.397e-100 296
LLPS-Orc-1414Oryctolagus cuniculus91.395e-101 294
LLPS-Rhb-3876Rhinopithecus bieti91.397e-102 296
LLPS-Mal-1451Mandrillus leucophaeus91.31e-72 223
LLPS-Ova-1987Ovis aries90.732e-99 294
LLPS-Sah-1150Sarcophilus harrisii90.735e-99 293
LLPS-Bot-1429Bos taurus90.072e-99 290
LLPS-Mup-2997Mustela putorius furo90.073e-99 290
LLPS-Aim-0256Ailuropoda melanoleuca90.078e-98 290
LLPS-Fec-0372Felis catus90.076e-100 291
LLPS-Anc-1683Anolis carolinensis89.543e-102 301
LLPS-Caf-3415Canis familiaris89.41e-97 290
LLPS-Eqc-1639Equus caballus89.45e-100 291
LLPS-Scf-0329Scleropages formosus88.891e-99 290
LLPS-Sus-4350Sus scrofa88.743e-99 289
LLPS-Ora-1646Ornithorhynchus anatinus88.742e-98 287
LLPS-Poa-0055Pongo abelii88.747e-97 283
LLPS-Otg-0906Otolemur garnettii88.746e-98 286
LLPS-Leo-1710Lepisosteus oculatus88.241e-98 287
LLPS-Xet-2825Xenopus tropicalis88.243e-98 286
LLPS-Cap-3342Cavia porcellus88.081e-97 285
LLPS-Icp-2795Ictalurus punctatus88.02e-97 285
LLPS-Asm-3069Astyanax mexicanus87.584e-100 291
LLPS-Lac-0845Latimeria chalumnae87.581e-98 288
LLPS-Fud-0534Fukomys damarensis87.428e-97 283
LLPS-Urm-2711Ursus maritimus86.751e-96 282
LLPS-Dar-0548Danio rerio86.271e-98 287
LLPS-Meg-2448Meleagris gallopavo85.471e-67 213
LLPS-Mod-4228Monodelphis domestica82.357e-92 272
LLPS-Gaa-3238Gasterosteus aculeatus79.612e-87 259
LLPS-Ten-1987Tetraodon nigroviridis79.612e-87 259
LLPS-Pof-2823Poecilia formosa79.612e-87 259
LLPS-Ere-0810Erinaceus europaeus79.561e-73 224
LLPS-Xim-2711Xiphophorus maculatus78.952e-86 257
LLPS-Drm-1179Drosophila melanogaster76.476e-85 253
LLPS-Cii-0206Ciona intestinalis76.353e-81 244
LLPS-Cas-2261Carlito syrichta73.511e-73 224
LLPS-Orn-2533Oreochromis niloticus72.117e-78 235
LLPS-Tar-0331Takifugu rubripes71.979e-79 237
LLPS-Cis-0717Ciona savignyi71.711e-79 239
LLPS-Orl-1734Oryzias latipes70.076e-76 230
LLPS-Asfu-0682Aspergillus fumigatus68.921e-72 221
LLPS-Asc-1101Aspergillus clavatus68.248e-72 219
LLPS-Asn-1100Aspergillus nidulans68.02e-72 221
LLPS-Aso-0310Aspergillus oryzae67.577e-71 217
LLPS-Tut-0603Tursiops truncatus67.571e-73 224
LLPS-Asf-0954Aspergillus flavus67.577e-71 217
LLPS-Nef-0065Neosartorya fischeri67.576e-72 220
LLPS-Scm-0905Scophthalmus maximus66.674e-73 223
LLPS-Cae-0582Caenorhabditis elegans66.451e-69 214
LLPS-Zyt-0185Zymoseptoria tritici66.238e-73 222
LLPS-Gag-0605Gaeumannomyces graminis65.543e-69 213
LLPS-Osl-0043Ostreococcus lucimarinus65.545e-67 207
LLPS-Miv-1345Microbotryum violaceum65.545e-65 202
LLPS-Ast-1374Aspergillus terreus64.92e-71 218
LLPS-Map-0268Magnaporthe poae64.862e-68 214
LLPS-Mao-0725Magnaporthe oryzae64.673e-70 218
LLPS-Dos-0487Dothistroma septosporum64.673e-70 217
LLPS-Beb-0386Beauveria bassiana64.673e-70 218
LLPS-Kop-0829Komagataella pastoris64.246e-70 214
LLPS-Php-2118Physcomitrella patens64.241e-65 204
LLPS-Ved-0359Verticillium dahliae64.248e-71 217
LLPS-Fus-0377Fusarium solani64.242e-70 216
LLPS-Mae-1840Manihot esculenta63.585e-66 207
LLPS-Scs-0464Sclerotinia sclerotiorum63.511e-68 211
LLPS-Cogr-0321Colletotrichum graminicola63.512e-68 211
LLPS-Lem-0032Leptosphaeria maculans63.333e-68 210
LLPS-Asni-0348Aspergillus niger63.333e-68 210
LLPS-Spr-0986Sporisorium reilianum63.331e-65 204
LLPS-Usm-0005Ustilago maydis63.331e-65 204
LLPS-Gor-1800Gossypium raimondii63.166e-68 213
LLPS-Sol-0752Solanum lycopersicum62.912e-65 208
LLPS-Thc-1359Theobroma cacao62.913e-67 211
LLPS-Dac-1241Daucus carota62.914e-65 204
LLPS-Trr-0983Trichoderma reesei62.914e-69 213
LLPS-Phn-0691Phaeosphaeria nodorum62.846e-67 207
LLPS-Pyt-0088Pyrenophora teres62.673e-68 212
LLPS-Pytr-0962Pyrenophora triticirepentis62.673e-68 212
LLPS-Met-0090Medicago truncatula62.424e-65 202
LLPS-Brd-2418Brachypodium distachyon62.424e-64 200
LLPS-Glm-1537Glycine max62.424e-64 200
LLPS-Mua-0702Musa acuminata62.422e-64 201
LLPS-Hea-0410Helianthus annuus62.426e-64 199
LLPS-Sob-0803Sorghum bicolor62.421e-64 201
LLPS-Blg-0333Blumeria graminis62.255e-69 214
LLPS-Sot-0895Solanum tuberosum62.255e-65 205
LLPS-Trv-0248Trichoderma virens62.254e-68 210
LLPS-Fuo-0053Fusarium oxysporum62.259e-69 212
LLPS-Viv-2186Vitis vinifera62.254e-66 207
LLPS-Amt-1931Amborella trichopoda62.251e-64 203
LLPS-Abg-0163Absidia glauca62.163e-65 205
LLPS-Cog-0041Colletotrichum gloeosporioides62.02e-67 213
LLPS-Sem-0677Selaginella moellendorffii61.841e-64 204
LLPS-Via-0359Vigna angularis61.743e-64 200
LLPS-Hov-0601Hordeum vulgare61.742e-65 203
LLPS-Prp-0041Prunus persica61.743e-63 197
LLPS-Zem-0452Zea mays61.742e-63 198
LLPS-Nec-0306Neurospora crassa61.593e-65 207
LLPS-Yal-0405Yarrowia lipolytica61.598e-67 207
LLPS-Crn-1070Cryptococcus neoformans61.591e-64 201
LLPS-Lep-1732Leersia perrieri61.497e-64 199
LLPS-Tra-2500Triticum aestivum61.075e-65 202
LLPS-Orp-2063Oryza punctata61.075e-64 199
LLPS-Phv-1553Phaseolus vulgaris61.071e-63 198
LLPS-Brn-2013Brassica napus60.932e-64 203
LLPS-Brr-2622Brassica rapa60.932e-64 203
LLPS-Nia-0904Nicotiana attenuata60.931e-64 204
LLPS-Orbr-0814Oryza brachyantha60.938e-65 204
LLPS-Asg-1190Ashbya gossypii60.814e-66 205
LLPS-Arl-0793Arabidopsis lyrata60.533e-65 206
LLPS-Bro-0840Brassica oleracea60.535e-65 205
LLPS-Art-2410Arabidopsis thaliana60.531e-65 206
LLPS-Orgl-1894Oryza glumaepatula60.49e-64 199
LLPS-Orb-0917Oryza barthii60.49e-64 199
LLPS-Ori-0748Oryza indica60.49e-64 199
LLPS-Orni-1143Oryza nivara60.49e-64 199
LLPS-Orm-0093Oryza meridionalis60.49e-64 199
LLPS-Orr-1967Oryza rufipogon60.49e-64 199
LLPS-Org-1126Oryza glaberrima60.49e-64 199
LLPS-Tru-0714Triticum urartu60.42e-64 201
LLPS-Ors-1399Oryza sativa60.49e-64 199
LLPS-Cus-0604Cucumis sativus60.268e-64 202
LLPS-Sei-2051Setaria italica60.265e-65 205
LLPS-Pot-1649Populus trichocarpa60.262e-63 201
LLPS-Sac-0006Saccharomyces cerevisiae58.829e-66 204