• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gaga-1150
DPYSL2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Dihydropyrimidinase-related protein 2
Gene Name: DPYSL2
Ensembl Gene: ENSGALG00000000227.7
Ensembl Protein: ENSGALP00000000304.4
Organism: Gallus gallus
Taxa ID: 9031
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Spindle apparatus, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAEKKQSGRQ  GEEEEVPAFF  KNLGSGSPKP  RQKFCGMFCP  VEGSLENKTI  DFDSLSVGRG  60
61    SNKVVAKQKD  VAHLGPDAQS  VYSRQSGKGG  EPSVDFGRKV  EIRSATGKEA  LQNLNDKSDR  120
121   LLIKGGKIVN  DDQSFYADIY  MEDGLIKQIG  ENLIVPGGVK  TIEAHGRMVI  PGGIDVHTRF  180
181   QMPEQGMTSA  DDFFQGTKAA  LAGGTTMIID  HVVPEPGTSL  LTAFDQWREW  ADSKSCCDYS  240
241   LHVDITEWHK  GVQEEMEALV  KDHGVNSFLV  YMAFKDRFQL  SDSQIYEVLS  VIRDIGATAQ  300
301   VHAENGDIIA  EEQQRILELG  ITGPEGHVLS  RPEEVEAEAV  NRAITIANQT  NCPLYITKVM  360
361   SKSAAEVIAQ  ARKKGTVVYG  EPITASLGTD  GSHYWSKNWA  KAAAFVTSPP  LSPDPTTPDF  420
421   LNSLLSCGDL  QVTGSAHCTF  NTAQKAVGKD  NFTLIPEGTN  GTEERMSIIW  DKAVVTGKMD  480
481   ENQFVAVTST  NAAKIFNLYP  RKGRIAVGSD  ADLVIWDPDS  VKTISAKTHN  ISLEYNIFEG  540
541   MECRGSPLVV  ISQGKIVLED  GNLHVTEGSG  RYIPRKPFPD  FVYKRIKARS  RLAELRGVPR  600
601   GLYDGPVCEV  SVTPKTVTPA  SSAKTSPAKQ  QAPPVRNLHQ  SGFSLSGAQI  DDNIPRRTTQ  660
661   RIVAPPGGRA  NITSLG  676
Nucleotide CDS Sequence (FASTA)
1     ATGTCTTACC  AGGGGAAGAA  GAACATCCCG  CGGATCACGA  GCGATCGTCT  TCTGATCAAA  60
61    GGTGGGAAGA  TCGTCAATGA  CGACCAGTCT  TTCTATGCAG  ACATCTACAT  GGAAGATGGG  120
121   CTCATCAAGC  AAATAGGGGA  GAATCTCATC  GTGCCCGGAG  GAGTGAAAAC  CATCGAAGCC  180
181   CACGGCAGGA  TGGTGATTCC  TGGAGGGATC  GATGTTCACA  CCCGCTTCCA  GATGCCAGAG  240
241   CAGGGGATGA  CTTCTGCTGA  TGACTTCTTC  CAAGGGACCA  AGGCTGCGCT  GGCTGGGGGC  300
301   ACCACCATGA  TCATTGATCA  TGTGGTTCCT  GAGCCCGGGA  CCAGTTTGCT  GACTGCATTT  360
361   GACCAGTGGA  GAGAATGGGC  AGACAGCAAA  TCGTGCTGTG  ATTACTCCCT  GCACGTGGAC  420
421   ATCACCGAGT  GGCACAAAGG  CGTCCAGGAG  GAGATGGAAG  CTCTGGTTAA  AGATCACGGT  480
481   GTGAATTCAT  TCCTGGTTTA  TATGGCTTTC  AAAGACCGCT  TCCAGCTGTC  TGACTCGCAG  540
541   ATCTATGAGG  TCCTGAGTGT  TATCCGGGAT  ATTGGTGCCA  CAGCTCAAGT  GCATGCTGAG  600
601   AATGGTGACA  TCATTGCCGA  GGAGCAGCAA  AGGATCCTGG  AGCTGGGAAT  CACAGGCCCT  660
661   GAAGGGCACG  TGTTGAGCAG  ACCTGAAGAG  GTGGAGGCAG  AAGCTGTGAA  CCGGGCAATC  720
721   ACCATCGCCA  ACCAAACCAA  CTGCCCTCTC  TATATCACCA  AGGTGATGAG  CAAAAGCGCT  780
781   GCTGAAGTCA  TTGCTCAAGC  CAGGAAAAAG  GGCACTGTGG  TGTATGGGGA  GCCCATCACA  840
841   GCCAGCTTGG  GTACTGATGG  ATCTCATTAC  TGGAGCAAGA  ATTGGGCGAA  GGCGGCCGCT  900
901   TTTGTCACTT  CCCCACCACT  GAGTCCTGAC  CCAACCACTC  CTGATTTCCT  CAACTCACTG  960
961   CTGTCCTGCG  GGGACCTCCA  AGTTACTGGC  AGTGCCCACT  GCACCTTCAA  CACTGCTCAG  1020
1021  AAAGCTGTTG  GGAAGGACAA  CTTCACCCTA  ATCCCCGAGG  GGACCAACGG  GACTGAGGAG  1080
1081  AGGATGTCCA  TCATCTGGGA  CAAGGCTGTG  GTGACTGGCA  AGATGGATGA  GAACCAGTTT  1140
1141  GTGGCTGTGA  CCAGCACAAA  TGCAGCTAAA  ATCTTTAACC  TGTACCCACG  GAAGGGCCGT  1200
1201  ATTGCAGTGG  GCTCTGATGC  TGATTTGGTT  ATCTGGGATC  CTGACAGCGT  CAAGACAATC  1260
1261  TCTGCCAAGA  CCCACAACAT  ATCTCTGGAG  TACAACATCT  TTGAAGGCAT  GGAGTGTCGT  1320
1321  GGGTCTCCCC  TGGTGGTTAT  CAGCCAAGGG  AAGATCGTGC  TGGAGGATGG  GAATCTCCAC  1380
1381  GTAACGGAGG  GGTCTGGGAG  GTATATCCCC  AGGAAACCAT  TCCCTGACTT  CGTTTACAAG  1440
1441  CGCATCAAAG  CAAGGAGCAG  GCTGGCCGAG  CTGCGGGGTG  TGCCTCGAGG  TCTCTATGAT  1500
1501  GGGCCGGTCT  GCGAAGTGTC  GGTGACGCCG  AAGACGGTCA  CTCCTGCATC  TTCAGCTAAA  1560
1561  ACATCTCCTG  CCAAACAGCA  AGCCCCACCT  GTGAGGAACC  TGCACCAGTC  TGGCTTTAGC  1620
1621  TTGTCTGGCG  CACAGATCGA  CGACAACATC  CCACGCCGCA  CCACCCAGCG  CATCGTGGCA  1680
1681  CCACCGGGCG  GACGTGCCAA  CATCACCAGC  TTGGGTTAA  1719

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Neurogenesis
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Molecular Function
Microtubule binding
Biological Process
Axon guidance
Biological Process
Brain development
Biological Process
Cytoskeleton organization
Biological Process
Regulation of axon extension

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Meg-1869Meleagris gallopavo99.850.01364
LLPS-Anp-1263Anas platyrhynchos99.410.01363
LLPS-Fia-1222Ficedula albicollis98.960.01356
LLPS-Tag-0297Taeniopygia guttata98.960.01352
LLPS-Mod-2635Monodelphis domestica98.390.01118
LLPS-Sah-3374Sarcophilus harrisii97.850.01116
LLPS-Loa-0186Loxodonta africana97.850.01111
LLPS-Mup-3485Mustela putorius furo97.670.01112
LLPS-Urm-0979Ursus maritimus97.670.01112
LLPS-Orc-1905Oryctolagus cuniculus97.670.01111
LLPS-Anc-0953Anolis carolinensis97.670.01109
LLPS-Chs-3172Chlorocebus sabaeus97.50.01108
LLPS-Otg-1320Otolemur garnettii97.50.01110
LLPS-Poa-3353Pongo abelii97.50.01108
LLPS-Nol-0976Nomascus leucogenys97.50.01108
LLPS-Mum-1917Mus musculus97.320.01109
LLPS-Mea-0509Mesocricetus auratus97.320.01109
LLPS-Ran-1884Rattus norvegicus97.320.01109
LLPS-Cas-0094Carlito syrichta97.320.01109
LLPS-Dio-0281Dipodomys ordii97.140.01104
LLPS-Fud-1562Fukomys damarensis95.280.01105
LLPS-Cap-4203Cavia porcellus95.240.0 934
LLPS-Pes-2105Pelodiscus sinensis95.130.01309
LLPS-Sus-1457Sus scrofa94.980.01307
LLPS-Caj-2608Callithrix jacchus94.680.01301
LLPS-Bot-3366Bos taurus94.680.01305
LLPS-Gog-2250Gorilla gorilla94.530.01303
LLPS-Hos-1645Homo sapiens94.530.01302
LLPS-Pat-1855Pan troglodytes94.530.01302
LLPS-Eqc-2278Equus caballus94.530.01303
LLPS-Myl-2755Myotis lucifugus94.430.01201
LLPS-Cea-0549Cercocebus atys94.390.01299
LLPS-Aon-0098Aotus nancymaae94.390.01299
LLPS-Aim-0482Ailuropoda melanoleuca94.390.01296
LLPS-Ict-0949Ictidomys tridecemlineatus94.390.01302
LLPS-Pap-1881Pan paniscus94.290.01239
LLPS-Mal-4044Mandrillus leucophaeus94.240.01298
LLPS-Paa-1200Papio anubis94.240.01298
LLPS-Man-1139Macaca nemestrina94.240.01298
LLPS-Fec-1144Felis catus94.240.01298
LLPS-Rhb-3581Rhinopithecus bieti94.240.01298
LLPS-Mam-0770Macaca mulatta94.240.01298
LLPS-Caf-1232Canis familiaris93.940.01294
LLPS-Scf-2086Scleropages formosus89.450.01036
LLPS-Gaa-2986Gasterosteus aculeatus88.370.01018
LLPS-Icp-1974Ictalurus punctatus88.190.01025
LLPS-Tar-1468Takifugu rubripes88.050.0 993
LLPS-Orl-0520Oryzias latipes87.480.01020
LLPS-Leo-0682Lepisosteus oculatus87.260.01188
LLPS-Lac-2720Latimeria chalumnae87.020.01208
LLPS-Ten-1971Tetraodon nigroviridis86.730.0 964
LLPS-Dar-0996Danio rerio86.160.01017
LLPS-Asm-2488Astyanax mexicanus83.060.0 931
LLPS-Orn-0150Oreochromis niloticus82.130.01118
LLPS-Scm-2936Scophthalmus maximus81.590.01105
LLPS-Pof-3815Poecilia formosa81.520.01107
LLPS-Xim-3359Xiphophorus maculatus81.140.01106
LLPS-Maf-0803Macaca fascicularis77.180.0 904
LLPS-Ova-3478Ovis aries76.980.0 909
LLPS-Xet-2981Xenopus tropicalis70.870.0 975
LLPS-Cis-1511Ciona savignyi41.032e-132 409
LLPS-Drm-0934Drosophila melanogaster22.623e-0758.5