LLPS-Gaga-0461
RPS27A
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Ubiquitin-40S ribosomal protein S27a; Ubiquitin carboxyl extension protein 80 |
| Gene Name: | RPS27A, UBA80 |
| Ensembl Gene: | ENSGALG00000036790.3 |
| Ensembl Protein: | ENSGALP00000050085.1 |
| Organism: | Gallus gallus |
| Taxa ID: | 9031 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSGALT00000059625.2 | ENSGALP00000050085.1 |
| UniProt | P79781, RS27A_CHICK, P02248, P02249, P02250, P62973, Q29120, Q91887, Q91888 | |
| GeneBank | U67931 | AAC60279.1 |
| RefSeq | NM_001287205.1, NM_204953.1 | NP_001274134.1, NP_990284.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 60 61 IQKESTLHLV LRLRGGAKKR KKKSYTTPKK NKHKRKKVKL AVLKYYKVDE NGKISRLRRE 120 121 CPSEECGAGV FMASHFDRHY CGKCCLTYCF NKPEDK 156 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCAGATCT TCGTGAAGAC CCTTACGGGG AAGACCATCA CCCTCGAGGT TGAGCCCTCC 60 61 GATACTATAG AAAATGTGAA AGCTAAGATT CAGGATAAGG AAGGAATTCC TCCTGATCAG 120 121 CAGCGACTGA TTTTTGCTGG GAAGCAGCTG GAAGATGGCC GCACGCTGTC TGACTACAAT 180 181 ATCCAGAAAG AATCAACTCT TCACCTTGTG CTGAGACTGC GTGGTGGTGC TAAGAAAAGA 240 241 AAGAAGAAGT CTTACACCAC CCCCAAGAAG AACAAGCATA AGAGGAAGAA GGTTAAACTT 300 301 GCCGTGCTGA AGTACTACAA GGTGGATGAG AACGGCAAGA TCAGTCGTCT GCGCCGAGAG 360 361 TGCCCCTCTG AGGAGTGTGG GGCGGGAGTC TTCATGGCTA GCCACTTCGA CAGACACTAT 420 421 TGTGGCAAGT GTTGTCTGAC ATACTGCTTC AATAAGCCTG AAGACAAGTA A 471 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosolic small ribosomal subunit | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Molecular Function | Metal ion binding | |
Molecular Function | Protein tag | |
Molecular Function | Structural constituent of ribosome | |
Molecular Function | Ubiquitin protein ligase binding | |
Biological Process | DNA repair | |
Biological Process | Modification-dependent protein catabolic process | |
Biological Process | Protein ubiquitination | |
Biological Process | Translation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Poa-0492 | Pongo abelii | 100.0 | 3e-46 | 153 |
| LLPS-Caf-0970 | Canis familiaris | 100.0 | 3e-46 | 153 |
| LLPS-Ten-3003 | Tetraodon nigroviridis | 100.0 | 1e-46 | 155 |
| LLPS-Cap-0753 | Cavia porcellus | 100.0 | 2e-46 | 155 |
| LLPS-Eqc-0489 | Equus caballus | 100.0 | 3e-46 | 153 |
| LLPS-Mam-2507 | Macaca mulatta | 100.0 | 1e-45 | 155 |
| LLPS-Xet-2382 | Xenopus tropicalis | 100.0 | 2e-45 | 155 |
| LLPS-Gaga-1028 | Gallus gallus | 100.0 | 9e-46 | 155 |
| LLPS-Cas-3350 | Carlito syrichta | 100.0 | 1e-46 | 155 |
| LLPS-Ict-1795 | Ictidomys tridecemlineatus | 100.0 | 1e-45 | 155 |
| LLPS-Meg-1150 | Meleagris gallopavo | 100.0 | 2e-46 | 155 |
| LLPS-Dar-1034 | Danio rerio | 100.0 | 3e-46 | 154 |
| LLPS-Pof-2838 | Poecilia formosa | 100.0 | 1e-45 | 156 |
| LLPS-Pat-0259 | Pan troglodytes | 100.0 | 1e-45 | 155 |
| LLPS-Pap-1953 | Pan paniscus | 100.0 | 1e-46 | 155 |
| LLPS-Urm-0071 | Ursus maritimus | 100.0 | 3e-46 | 153 |
| LLPS-Mod-0352 | Monodelphis domestica | 100.0 | 3e-46 | 153 |
| LLPS-Fec-1352 | Felis catus | 100.0 | 3e-46 | 153 |
| LLPS-Scm-2850 | Scophthalmus maximus | 100.0 | 3e-46 | 153 |
| LLPS-Lac-1356 | Latimeria chalumnae | 100.0 | 1e-45 | 155 |
| LLPS-Man-2336 | Macaca nemestrina | 100.0 | 1e-45 | 155 |
| LLPS-Loa-0751 | Loxodonta africana | 100.0 | 9e-46 | 155 |
| LLPS-Otg-2019 | Otolemur garnettii | 100.0 | 3e-46 | 153 |
| LLPS-Pes-3306 | Pelodiscus sinensis | 100.0 | 3e-46 | 153 |
| LLPS-Fia-0016 | Ficedula albicollis | 100.0 | 8e-84 | 250 |
| LLPS-Orn-1888 | Oreochromis niloticus | 100.0 | 5e-46 | 153 |
| LLPS-Rhb-0892 | Rhinopithecus bieti | 100.0 | 1e-45 | 155 |
| LLPS-Drm-1532 | Drosophila melanogaster | 100.0 | 3e-46 | 153 |
| LLPS-Tar-0351 | Takifugu rubripes | 100.0 | 8e-48 | 159 |
| LLPS-Tut-1385 | Tursiops truncatus | 100.0 | 3e-46 | 153 |
| LLPS-Dio-0121 | Dipodomys ordii | 100.0 | 3e-46 | 153 |
| LLPS-Gaa-1391 | Gasterosteus aculeatus | 100.0 | 3e-46 | 153 |
| LLPS-Scf-0937 | Scleropages formosus | 100.0 | 4e-46 | 154 |
| LLPS-Bot-1742 | Bos taurus | 100.0 | 3e-46 | 153 |
| LLPS-Ran-0638 | Rattus norvegicus | 100.0 | 3e-46 | 153 |
| LLPS-Mal-4560 | Mandrillus leucophaeus | 100.0 | 2e-46 | 155 |
| LLPS-Paa-3014 | Papio anubis | 100.0 | 2e-46 | 155 |
| LLPS-Aim-0615 | Ailuropoda melanoleuca | 100.0 | 3e-46 | 153 |
| LLPS-Mup-0650 | Mustela putorius furo | 100.0 | 3e-46 | 153 |
| LLPS-Ova-0465 | Ovis aries | 100.0 | 3e-46 | 153 |
| LLPS-Myl-3697 | Myotis lucifugus | 100.0 | 2e-46 | 155 |
| LLPS-Maf-3163 | Macaca fascicularis | 100.0 | 3e-46 | 153 |
| LLPS-Mum-1162 | Mus musculus | 100.0 | 1e-45 | 155 |
| LLPS-Mea-3845 | Mesocricetus auratus | 100.0 | 1e-45 | 155 |
| LLPS-Ora-2070 | Ornithorhynchus anatinus | 100.0 | 3e-46 | 153 |
| LLPS-Chs-3388 | Chlorocebus sabaeus | 100.0 | 9e-46 | 155 |
| LLPS-Leo-0992 | Lepisosteus oculatus | 100.0 | 4e-46 | 154 |
| LLPS-Aon-0943 | Aotus nancymaae | 100.0 | 1e-45 | 155 |
| LLPS-Sah-0420 | Sarcophilus harrisii | 100.0 | 2e-45 | 155 |
| LLPS-Cea-1543 | Cercocebus atys | 100.0 | 1e-45 | 155 |
| LLPS-Gog-1546 | Gorilla gorilla | 100.0 | 1e-45 | 155 |
| LLPS-Fud-0415 | Fukomys damarensis | 100.0 | 1e-45 | 155 |
| LLPS-Asm-0675 | Astyanax mexicanus | 100.0 | 3e-46 | 154 |
| LLPS-Caj-0025 | Callithrix jacchus | 100.0 | 7e-46 | 155 |
| LLPS-Anc-0583 | Anolis carolinensis | 99.36 | 3e-84 | 251 |
| LLPS-Tag-1666 | Taeniopygia guttata | 99.36 | 4e-82 | 246 |
| LLPS-Hos-1383 | Homo sapiens | 99.36 | 3e-83 | 249 |
| LLPS-Orc-2063 | Oryctolagus cuniculus | 99.36 | 3e-83 | 249 |
| LLPS-Sus-1493 | Sus scrofa | 99.36 | 3e-83 | 249 |
| LLPS-Gas-0937 | Galdieria sulphuraria | 98.7 | 3e-46 | 155 |
| LLPS-Ere-0040 | Erinaceus europaeus | 98.7 | 6e-46 | 152 |
| LLPS-Cym-0118 | Cyanidioschyzon merolae | 98.68 | 1e-45 | 152 |
| LLPS-Icp-0451 | Ictalurus punctatus | 98.68 | 1e-45 | 152 |
| LLPS-Xim-1886 | Xiphophorus maculatus | 98.08 | 4e-82 | 246 |
| LLPS-Nol-1323 | Nomascus leucogenys | 96.15 | 2e-79 | 239 |
| LLPS-Anp-0389 | Anas platyrhynchos | 90.38 | 2e-73 | 224 |
| LLPS-Cii-0124 | Ciona intestinalis | 89.74 | 3e-68 | 210 |
| LLPS-Fus-0037 | Fusarium solani | 87.5 | 3e-67 | 208 |
| LLPS-Fuo-0875 | Fusarium oxysporum | 86.93 | 7e-66 | 204 |
| LLPS-Asfu-0561 | Aspergillus fumigatus | 86.84 | 4e-66 | 205 |
| LLPS-Nef-0603 | Neosartorya fischeri | 86.84 | 4e-66 | 205 |
| LLPS-Pyt-0818 | Pyrenophora teres | 86.84 | 1e-65 | 204 |
| LLPS-Nec-0928 | Neurospora crassa | 86.84 | 6e-60 | 189 |
| LLPS-Blg-0185 | Blumeria graminis | 86.75 | 2e-65 | 203 |
| LLPS-Tum-0367 | Tuber melanosporum | 86.75 | 9e-59 | 186 |
| LLPS-Scs-0172 | Sclerotinia sclerotiorum | 86.75 | 1e-59 | 188 |
| LLPS-Scj-0929 | Schizosaccharomyces japonicus | 86.39 | 1e-60 | 191 |
| LLPS-Cogr-0774 | Colletotrichum graminicola | 86.36 | 3e-61 | 192 |
| LLPS-Coo-0622 | Colletotrichum orbiculare | 86.36 | 3e-61 | 192 |
| LLPS-Fuv-0391 | Fusarium verticillioides | 86.27 | 2e-65 | 203 |
| LLPS-Trv-0048 | Trichoderma virens | 86.18 | 3e-65 | 203 |
| LLPS-Ved-0851 | Verticillium dahliae | 86.18 | 5e-60 | 189 |
| LLPS-Ast-0886 | Aspergillus terreus | 86.18 | 1e-59 | 188 |
| LLPS-Trr-0288 | Trichoderma reesei | 86.18 | 3e-65 | 203 |
| LLPS-Lem-0567 | Leptosphaeria maculans | 86.18 | 3e-65 | 203 |
| LLPS-Aso-0223 | Aspergillus oryzae | 86.18 | 2e-59 | 188 |
| LLPS-Cus-1956 | Cucumis sativus | 86.18 | 8e-70 | 216 |
| LLPS-Asf-0166 | Aspergillus flavus | 86.18 | 2e-59 | 188 |
| LLPS-Asc-0256 | Aspergillus clavatus | 86.18 | 1e-59 | 189 |
| LLPS-Asn-0798 | Aspergillus nidulans | 86.18 | 4e-59 | 187 |
| LLPS-Mel-0740 | Melampsora laricipopulina | 86.09 | 1e-66 | 207 |
| LLPS-Yal-0844 | Yarrowia lipolytica | 85.71 | 8e-57 | 181 |
| LLPS-Gor-1581 | Gossypium raimondii | 85.62 | 7e-70 | 214 |
| LLPS-Sob-1218 | Sorghum bicolor | 85.62 | 5e-69 | 213 |
| LLPS-Nia-1655 | Nicotiana attenuata | 85.62 | 2e-70 | 216 |
| LLPS-Sot-0384 | Solanum tuberosum | 85.62 | 3e-70 | 216 |
| LLPS-Pytr-0322 | Pyrenophora triticirepentis | 85.53 | 5e-64 | 200 |
| LLPS-Bro-2922 | Brassica oleracea | 85.53 | 9e-69 | 212 |
| LLPS-Viv-1123 | Vitis vinifera | 85.53 | 2e-69 | 215 |
| LLPS-Beb-0357 | Beauveria bassiana | 85.53 | 2e-59 | 188 |
| LLPS-Arl-2180 | Arabidopsis lyrata | 85.53 | 1e-68 | 212 |
| LLPS-Brn-0949 | Brassica napus | 85.53 | 9e-69 | 212 |
| LLPS-Asni-0084 | Aspergillus niger | 85.53 | 1e-59 | 188 |
| LLPS-Gag-0533 | Gaeumannomyces graminis | 85.06 | 9e-60 | 189 |
| LLPS-Map-1024 | Magnaporthe poae | 85.06 | 9e-60 | 189 |
| LLPS-Mao-0242 | Magnaporthe oryzae | 85.06 | 9e-60 | 189 |
| LLPS-Orm-0643 | Oryza meridionalis | 84.97 | 2e-68 | 211 |
| LLPS-Orr-0651 | Oryza rufipogon | 84.97 | 2e-68 | 211 |
| LLPS-Prp-0886 | Prunus persica | 84.97 | 2e-69 | 213 |
| LLPS-Org-0078 | Oryza glaberrima | 84.97 | 2e-68 | 211 |
| LLPS-Ors-1040 | Oryza sativa | 84.97 | 2e-68 | 211 |
| LLPS-Pot-1864 | Populus trichocarpa | 84.97 | 2e-69 | 213 |
| LLPS-Orbr-0671 | Oryza brachyantha | 84.97 | 2e-68 | 211 |
| LLPS-Mae-0966 | Manihot esculenta | 84.97 | 1e-69 | 214 |
| LLPS-Sei-1257 | Setaria italica | 84.97 | 2e-68 | 211 |
| LLPS-Brd-0971 | Brachypodium distachyon | 84.97 | 2e-68 | 211 |
| LLPS-Sol-1654 | Solanum lycopersicum | 84.97 | 2e-69 | 213 |
| LLPS-Orb-1679 | Oryza barthii | 84.97 | 2e-68 | 211 |
| LLPS-Ori-0817 | Oryza indica | 84.97 | 2e-68 | 211 |
| LLPS-Thc-0133 | Theobroma cacao | 84.97 | 2e-69 | 213 |
| LLPS-Art-1828 | Arabidopsis thaliana | 84.87 | 1e-68 | 211 |
| LLPS-Php-1308 | Physcomitrella patens | 84.87 | 2e-68 | 211 |
| LLPS-Pug-0932 | Puccinia graminis | 84.77 | 3e-64 | 201 |
| LLPS-Spr-0432 | Sporisorium reilianum | 84.67 | 2e-65 | 203 |
| LLPS-Dos-0207 | Dothistroma septosporum | 84.52 | 5e-65 | 202 |
| LLPS-Zyt-0364 | Zymoseptoria tritici | 84.52 | 2e-65 | 203 |
| LLPS-Met-0117 | Medicago truncatula | 84.42 | 2e-70 | 216 |
| LLPS-Glm-2928 | Glycine max | 84.42 | 3e-70 | 216 |
| LLPS-Scc-1145 | Schizosaccharomyces cryophilus | 84.35 | 3e-54 | 174 |
| LLPS-Phv-1555 | Phaseolus vulgaris | 84.31 | 2e-69 | 214 |
| LLPS-Hea-0635 | Helianthus annuus | 84.31 | 3e-69 | 213 |
| LLPS-Usm-0081 | Ustilago maydis | 84.0 | 2e-65 | 203 |
| LLPS-Mua-1204 | Musa acuminata | 83.87 | 4e-68 | 210 |
| LLPS-Via-2060 | Vigna angularis | 83.77 | 1e-69 | 214 |
| LLPS-Scp-0227 | Schizosaccharomyces pombe | 83.67 | 6e-54 | 174 |
| LLPS-Amt-0376 | Amborella trichopoda | 83.66 | 4e-69 | 213 |
| LLPS-Sac-1422 | Saccharomyces cerevisiae | 82.78 | 2e-55 | 178 |
| LLPS-Miv-0951 | Microbotryum violaceum | 82.58 | 1e-63 | 200 |
| LLPS-Asg-0428 | Ashbya gossypii | 82.43 | 2e-57 | 183 |
| LLPS-Kop-0878 | Komagataella pastoris | 81.58 | 7e-58 | 184 |
| LLPS-Hov-0711 | Hordeum vulgare | 81.46 | 9e-61 | 199 |
| LLPS-Tra-1330 | Triticum aestivum | 81.46 | 3e-64 | 201 |
| LLPS-Osl-0423 | Ostreococcus lucimarinus | 81.33 | 4e-62 | 195 |
| LLPS-Cog-0303 | Colletotrichum gloeosporioides | 79.22 | 9e-52 | 169 |
| LLPS-Put-0373 | Puccinia triticina | 74.84 | 7e-56 | 183 |
| LLPS-Orl-0733 | Oryzias latipes | 60.0 | 1e-51 | 169 |