• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gaga-0177
DBR1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Lariat debranching enzyme
Gene Name: DBR1, RCJMB04_5i14
Ensembl Gene: ENSGALG00000043797.2
Ensembl Protein: ENSGALP00000055797.2
Organism: Gallus gallus
Taxa ID: 9031
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-bodyPredicted from orthologs(View)

▼ FUNCTION

Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKVAVAGCCH  GALDKMYYSG  EKKAPVLTVF  IGGNHEASNH  LQELPYGGWV  APNIYYLGYA  60
61    GVVRFRGVRI  GGISGIFKSH  DYRKGHFECP  PYNQQTIRSA  YHVRNIEVFK  LKQLKHPMDI  120
121   FMSHDWPQSI  YHYGNKKQLL  KMKSFFRQEV  ESNTLGSPAA  SELLQHLKPN  YWFSAHLHVK  180
181   FAAFMQHETK  SKEELPKATK  FLALDKCLPH  RDFLQIIDIE  HDPTAGDSLE  YDAEWIAVLK  240
241   ATNSLINVTQ  SSWSVPENNG  LHAKWDYSAT  EEAIKEVLEE  LNHNLKIPCN  FTLTTTCYDP  300
301   SKPQKNMEPV  HTINPQTTEF  CAQFGLTDIN  DRIQQVKEEG  SVRGEYEEEE  EEMDSSGSAE  360
361   EPSEYNTDNS  GLSSINPDEI  MLDDEGGDED  LSTCSVDPSP  DHPPEFSASF  SDIRIMPDSM  420
421   AVSSDDAMDS  TNEELEKSGV  NKQVEEKSLN  ERPLKRVGGS  ENGNSGIKIK  RRNQAIYAAE  480
481   DEDEAK  486
Nucleotide CDS Sequence (FASTA)
1     ATGAAGGTGG  CGGTGGCGGG  GTGCTGCCAT  GGCGCACTGG  ATAAGATGTA  CTACTCCGGC  60
61    GAGAAGAAGG  CCCCGGTGCT  GACGGTGTTC  ATCGGTGGGA  ACCACGAGGC  CTCTAACCAC  120
121   CTGCAGGAGC  TGCCCTACGG  CGGATGGGTG  GCGCCCAACA  TCTACTACCT  CGGTTACGCG  180
181   GGCGTGGTGC  GGTTCCGCGG  TGTGAGGATC  GGCGGCATAT  CGGGCATCTT  CAAGTCGCAC  240
241   GATTACCGGA  AAGGCCACTT  TGAATGTCCA  CCATACAACC  AGCAAACAAT  CAGAAGTGCT  300
301   TACCACGTCA  GGAACATCGA  GGTCTTCAAA  CTTAAGCAGT  TAAAGCATCC  AATGGACATA  360
361   TTTATGTCAC  ATGATTGGCC  ACAGAGCATA  TATCACTACG  GAAACAAGAA  ACAGCTGCTT  420
421   AAAATGAAAT  CCTTCTTCCG  TCAAGAAGTG  GAGAGCAACA  CATTAGGAAG  CCCTGCTGCT  480
481   TCTGAGCTTC  TGCAGCATCT  GAAACCTAAT  TACTGGTTTT  CAGCACATCT  CCATGTTAAG  540
541   TTTGCAGCTT  TCATGCAACA  CGAGACAAAA  TCCAAAGAAG  AGCTACCAAA  AGCAACCAAG  600
601   TTTTTGGCTC  TGGATAAATG  TCTGCCTCAC  AGAGACTTTT  TGCAGATAAT  AGACATTGAG  660
661   CATGATCCTA  CTGCAGGTGA  CTCACTGGAG  TATGATGCTG  AATGGATTGC  AGTCCTCAAG  720
721   GCCACCAACA  GTCTGATTAA  TGTGACTCAG  AGCTCATGGA  GTGTGCCTGA  AAATAATGGC  780
781   CTCCACGCAA  AGTGGGATTA  CAGTGCAACG  GAAGAGGCCA  TCAAGGAAGT  GTTAGAAGAG  840
841   CTGAATCATA  ACCTCAAAAT  TCCTTGTAAC  TTCACCTTGA  CAACTACTTG  TTATGACCCC  900
901   AGCAAGCCAC  AAAAAAACAT  GGAACCAGTT  CACACCATCA  ATCCGCAGAC  CACTGAGTTT  960
961   TGTGCCCAGT  TTGGTCTCAC  TGACATAAAT  GACAGAATCC  AGCAGGTTAA  GGAAGAGGGC  1020
1021  TCAGTACGTG  GAGAATATGA  AGAGGAAGAA  GAGGAAATGG  ACAGTAGTGG  GTCAGCCGAG  1080
1081  GAACCTAGTG  AATATAATAC  TGATAACTCT  GGGCTTTCGT  CCATTAATCC  AGATGAAATA  1140
1141  ATGCTGGATG  ATGAAGGTGG  TGATGAAGAT  TTGAGCACAT  GTTCTGTGGA  TCCTTCCCCC  1200
1201  GATCATCCTC  CTGAGTTTTC  TGCAAGTTTT  TCTGACATCA  GGATCATGCC  AGATTCCATG  1260
1261  GCGGTATCAT  CTGATGATGC  TATGGACTCC  ACCAATGAGG  AACTAGAGAA  ATCTGGTGTG  1320
1321  AATAAGCAGG  TGGAGGAGAA  GAGCTTGAAT  GAGAGACCTT  TAAAGCGTGT  TGGTGGTAGT  1380
1381  GAAAATGGGA  ACAGTGGCAT  TAAAATTAAG  AGAAGGAATC  AAGCCATCTA  TGCTGCAGAG  1440
1441  GATGAAGATG  AAGCAAAATA  A  1461

▼ KEYWORD

ID
Family
Complete proteome
Hydrolase
mRNA processing
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Molecular Function
RNA lariat debranching enzyme activity
Biological Process
MRNA splicing, via spliceosome
Biological Process
RNA splicing, via transesterification reactions

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Meg-1982Meleagris gallopavo97.560.0 750
LLPS-Anp-0429Anas platyrhynchos93.620.0 749
LLPS-Tag-0800Taeniopygia guttata91.510.0 792
LLPS-Fia-1696Ficedula albicollis83.960.0 803
LLPS-Pes-0725Pelodiscus sinensis82.630.0 727
LLPS-Ora-3350Ornithorhynchus anatinus75.310.0 649
LLPS-Ova-1383Ovis aries69.670.0 613
LLPS-Orc-2024Oryctolagus cuniculus68.580.0 584
LLPS-Sah-0055Sarcophilus harrisii67.220.0 639
LLPS-Lac-1266Latimeria chalumnae66.910.0 620
LLPS-Chr-0818Chlamydomonas reinhardtii66.673e-63 221
LLPS-Mod-1952Monodelphis domestica66.180.0 638
LLPS-Anc-2789Anolis carolinensis65.620.0 614
LLPS-Hos-2992Homo sapiens64.180.0 606
LLPS-Poa-3202Pongo abelii64.130.0 605
LLPS-Paa-0319Papio anubis63.790.0 596
LLPS-Cea-1614Cercocebus atys63.790.0 597
LLPS-Fec-1557Felis catus63.620.0 604
LLPS-Pap-3654Pan paniscus63.620.0 597
LLPS-Mam-2381Macaca mulatta63.60.0 594
LLPS-Man-1282Macaca nemestrina63.60.0 594
LLPS-Maf-2857Macaca fascicularis63.60.0 594
LLPS-Ict-1179Ictidomys tridecemlineatus63.570.0 600
LLPS-Nol-3300Nomascus leucogenys63.570.0 600
LLPS-Tut-0247Tursiops truncatus63.540.0 622
LLPS-Pat-2708Pan troglodytes63.430.0 598
LLPS-Rhb-0804Rhinopithecus bieti63.430.0 597
LLPS-Chs-0949Chlorocebus sabaeus63.410.0 592
LLPS-Caj-1377Callithrix jacchus63.30.0 611
LLPS-Eqc-0416Equus caballus63.250.0 597
LLPS-Aon-0128Aotus nancymaae63.160.0 605
LLPS-Urm-2006Ursus maritimus63.060.0 598
LLPS-Bot-3989Bos taurus62.870.0 612
LLPS-Aim-1879Ailuropoda melanoleuca62.850.0 593
LLPS-Caf-1244Canis familiaris62.50.0 592
LLPS-Mea-1047Mesocricetus auratus62.360.0 596
LLPS-Myl-2832Myotis lucifugus62.080.0 586
LLPS-Mup-3091Mustela putorius furo61.940.0 593
LLPS-Sus-3056Sus scrofa61.620.0 615
LLPS-Fud-2413Fukomys damarensis61.610.0 586
LLPS-Loa-1329Loxodonta africana61.580.0 602
LLPS-Xet-2028Xenopus tropicalis61.440.0 587
LLPS-Crn-0206Cryptococcus neoformans61.365e-58 208
LLPS-Ran-0237Rattus norvegicus61.330.0 592
LLPS-Otg-2106Otolemur garnettii61.120.0 590
LLPS-Cas-0974Carlito syrichta60.690.0 589
LLPS-Mum-1355Mus musculus60.510.0 591
LLPS-Leo-3105Lepisosteus oculatus60.375e-163 480
LLPS-Mal-3641Mandrillus leucophaeus59.962e-154 456
LLPS-Yal-0129Yarrowia lipolytica59.889e-53 190
LLPS-Beb-1468Beauveria bassiana59.525e-51 187
LLPS-Gog-1695Gorilla gorilla59.140.0 547
LLPS-Asn-1201Aspergillus nidulans59.063e-54 198
LLPS-Dar-2319Danio rerio57.74e-153 456
LLPS-Ten-0609Tetraodon nigroviridis57.054e-154 457
LLPS-Lem-0368Leptosphaeria maculans56.731e-49 184
LLPS-Asfu-0444Aspergillus fumigatus56.141e-48 183
LLPS-Ast-0659Aspergillus terreus56.143e-50 187
LLPS-Aso-0988Aspergillus oryzae55.562e-47 178
LLPS-Scs-0903Sclerotinia sclerotiorum55.117e-49 182
LLPS-Put-1283Puccinia triticina55.17e-25 112
LLPS-Dos-0075Dothistroma septosporum55.064e-52 191
LLPS-Asc-1004Aspergillus clavatus54.971e-48 183
LLPS-Fuo-0338Fusarium oxysporum54.495e-48 178
LLPS-Pytr-1292Pyrenophora triticirepentis54.391e-47 178
LLPS-Fuv-1380Fusarium verticillioides53.892e-42 162
LLPS-Pyt-0700Pyrenophora teres53.81e-46 176
LLPS-Blg-1089Blumeria graminis53.599e-51 187
LLPS-Phn-0665Phaeosphaeria nodorum53.226e-48 178
LLPS-Asf-0827Aspergillus flavus52.724e-51 190
LLPS-Nia-2614Nicotiana attenuata52.412e-83 267
LLPS-Cii-1068Ciona intestinalis52.374e-118 361
LLPS-Brr-0075Brassica rapa52.151e-85 276
LLPS-Brn-0360Brassica napus52.151e-84 273
LLPS-Bro-0162Brassica oleracea51.972e-84 273
LLPS-Sol-0096Solanum lycopersicum51.574e-80 262
LLPS-Nec-0753Neurospora crassa51.374e-46 174
LLPS-Sot-0925Solanum tuberosum51.221e-78 256
LLPS-Mao-0674Magnaporthe oryzae51.192e-46 176
LLPS-Ved-0741Verticillium dahliae51.161e-44 169
LLPS-Art-2904Arabidopsis thaliana50.838e-82 266
LLPS-Met-1899Medicago truncatula50.665e-81 264
LLPS-Viv-1488Vitis vinifera50.651e-80 263
LLPS-Trv-0737Trichoderma virens50.541e-46 176
LLPS-Tar-1815Takifugu rubripes50.544e-155 460
LLPS-Arl-1899Arabidopsis lyrata50.52e-80 263
LLPS-Vir-1250Vigna radiata50.472e-80 263
LLPS-Pof-2980Poecilia formosa50.373e-159 470
LLPS-Cus-1992Cucumis sativus50.332e-77 254
LLPS-Via-1330Vigna angularis50.312e-79 260
LLPS-Phv-0567Phaseolus vulgaris50.161e-79 261
LLPS-Sem-1619Selaginella moellendorffii50.162e-75 248
LLPS-Gas-1068Galdieria sulphuraria50.07e-64 219
LLPS-Coo-0669Colletotrichum orbiculare50.08e-43 164
LLPS-Org-0180Oryza glaberrima49.845e-82 266
LLPS-Xim-0569Xiphophorus maculatus49.822e-155 460
LLPS-Drm-0875Drosophila melanogaster49.727e-96 306
LLPS-Miv-1164Microbotryum violaceum49.711e-48 181
LLPS-Gag-0998Gaeumannomyces graminis49.718e-45 171
LLPS-Hea-0311Helianthus annuus49.672e-76 252
LLPS-Glm-0294Glycine max49.542e-82 268
LLPS-Prp-0866Prunus persica49.513e-76 252
LLPS-Icp-0621Ictalurus punctatus49.482e-154 459
LLPS-Asm-0002Astyanax mexicanus49.486e-156 462
LLPS-Mae-0863Manihot esculenta49.322e-77 255
LLPS-Scf-1873Scleropages formosus49.312e-159 472
LLPS-Cogr-0496Colletotrichum graminicola49.27e-45 171
LLPS-Orn-0552Oreochromis niloticus49.24e-158 468
LLPS-Cis-0883Ciona savignyi49.088e-112 342
LLPS-Dio-2563Dipodomys ordii49.075e-25 103
LLPS-Zem-0052Zea mays48.852e-78 257
LLPS-Sei-2174Setaria italica48.853e-80 262
LLPS-Scm-1796Scophthalmus maximus48.756e-151 449
LLPS-Nef-1297Neosartorya fischeri48.76e-42 163
LLPS-Sob-0392Sorghum bicolor48.523e-78 257
LLPS-Dac-0317Daucus carota48.523e-77 254
LLPS-Amt-1141Amborella trichopoda48.044e-72 243
LLPS-Gaa-2668Gasterosteus aculeatus47.493e-145 435
LLPS-Scp-1418Schizosaccharomyces pombe47.014e-60 211
LLPS-Pug-0057Puccinia graminis46.82e-56 204
LLPS-Php-1569Physcomitrella patens46.772e-71 239
LLPS-Lep-0824Leersia perrieri46.714e-81 265
LLPS-Orgl-0702Oryza glumaepatula46.563e-78 259
LLPS-Orp-1064Oryza punctata46.237e-79 258
LLPS-Tum-0448Tuber melanosporum46.132e-74 247
LLPS-Zyt-0172Zymoseptoria tritici46.136e-66 226
LLPS-Tru-0607Triticum urartu45.92e-74 249
LLPS-Osl-1081Ostreococcus lucimarinus45.898e-92 291
LLPS-Hov-0970Hordeum vulgare45.432e-83 271
LLPS-Brd-0606Brachypodium distachyon45.283e-81 265
LLPS-Tra-0984Triticum aestivum45.016e-82 266
LLPS-Trr-1127Trichoderma reesei44.861e-48 181
LLPS-Thc-0273Theobroma cacao44.477e-86 277
LLPS-Ors-0734Oryza sativa44.29e-83 268
LLPS-Coc-1257Corchorus capsularis43.43e-77 265
LLPS-Asni-1195Aspergillus niger43.376e-74 246
LLPS-Orbr-0964Oryza brachyantha43.287e-77 253
LLPS-Usm-1001Ustilago maydis42.953e-60 213
LLPS-Orni-2201Oryza nivara42.599e-80 265
LLPS-Kop-0621Komagataella pastoris41.768e-47 174
LLPS-Pot-1071Populus trichocarpa41.673e-74 247
LLPS-Scj-1073Schizosaccharomyces japonicus41.362e-84 273
LLPS-Ori-0036Oryza indica41.243e-78 261
LLPS-Chc-0407Chondrus crispus41.021e-60 213
LLPS-Mua-0109Musa acuminata40.733e-76 253
LLPS-Orr-0905Oryza rufipogon40.71e-79 259
LLPS-Orb-1178Oryza barthii40.438e-78 254
LLPS-Cae-0038Caenorhabditis elegans39.941e-70 239
LLPS-Mel-1043Melampsora laricipopulina39.027e-65 223
LLPS-Asg-0186Ashbya gossypii37.828e-35 139
LLPS-Abg-1294Absidia glauca37.141e-67 231
LLPS-Spr-0804Sporisorium reilianum36.934e-60 213
LLPS-Fus-1270Fusarium solani36.834e-53 191
LLPS-Scc-0226Schizosaccharomyces cryophilus36.474e-74 247
LLPS-Sac-1315Saccharomyces cerevisiae34.81e-47 175
LLPS-Cym-0846Cyanidioschyzon merolae33.971e-35 140